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| 1 | Recent advances in the surgical treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condition of the patient. Liver resection(LR) is one of the most efficient treatments for patients with HCC, with an expected 5-year survival of 38%-61% depending on the stage of the disease. Improved liver function assessment, increased understanding of segmental liver anatomy from advanced imaging studies, and surgical technical progress are important factors that have led to reduced mortality in patients with HCC. The indication for LR may be expanded due to emerging evidences from laparoscopic hepatectomies and combined treatments with newly developed chemotherapies. Liver transplantation(LT) is considered as an ideal treatment for removal of existing tumors and the injured/preneoplastic underlying liver tissue with impaired liver function and the risk of multicentric carcinogenesis that results from chronically injured liver. However, LT is restricted to patients with minimal risk of tumor recurrence under immunosuppression. The expansion of criteria for LT in HCC patients is still under trial and discussion. Limited availability of grafts, as well as the risk and the cost of transplantation have led to considerable interest in expansion of the donor pool, living donor-related transplantation, and combined treatment involving LR and LT. This highlight presents evidence concerning recent studies evaluating LR and LT in HCC patients. In addition, alternative therapies for the treatment of early stage tumors and the management of patients on transplant waiting lists are discussed. | Zenichi Morise Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata Jin Kawase Satoshi Arakawa Rie Yoshida Masashi Isetani | 2014 | World Journal of Gastroenterology2014，20，39： | 24 |
| 2 | Pure laparoscopic hepatectomy for hepatocellular carcinoma with chronic liver disease显示文摘Pure laparoscopic hepatectomy is a less invasive procedure than conventional open hepatectomy for the resection of hepatic lesions. Increases in experiences with the technique, in combination with advances in technology, have promoted the popularity of pure laparoscopic hepatectomy. However, indications for usage and potential contraindications of the procedure remain unresolved. The characteristics and specific advantages of the procedure, especially for hepatocellular carcinoma(HCC) patients with chronic liver diseases,are reviewed and discussed in this paper. For cirrhotic patients with liver tumors, pure laparoscopic hepatectomy minimizes destruction of the collateral blood and lymphatic flow from laparotomy and mobilization, and mesenchymal injury from compression. Therefore, pure laparoscopic hepatectomy has the specific advantage of minimal postoperative ascites production that leads to lowering the risk of disturbance in water or electrolyte balance and hypoproteinemia. It minimizes complications that routinely trigger postoperative serious liver failure. Under adequate patient positioning and port arrangement, the partial resection of the liver in the area of subphrenic space, peri-inferior vena cava area or next to the attachment of retro-peritoneum is facilitated in pure laparoscopic surgery by providing good vision and manipulation in the small operative field.Furthermore, the features of reduced post-operative adhesion, good vision, and manipulation within the small area between the adhesions make this procedure safer in the context of repeat hepatectomy procedures.These improved features are especially advantageous for patients with liver cirrhosis and multicentric and/or metachronous HCCs. | Zenichi Morise Norihiko Kawabe Jin Kawase Hirokazu Tomishige Hidetoshi Nagata Hisanori Ohshima Satoshi Arakawa Rie Yoshida Masashi Isetani | 2013 | World Journal of Hepatology2013，5，9： | 21 |
| 3 | Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy显示文摘AIM:To examine whether administration of lentinan,purifiedβ-1,3-glucan,can prolong survival in advanced gastric cancer patients receiving S-1-based chemotherapy.METHODS:Since 2004,78 patients with metastatic or recurrent gastric cancer have received S-1-based chemotherapy as first-line treatment.Survival,side effects,and the ratio of granulocytes/lymphocytes(G/L ratio)were compared between 2 groups of patients who received chemo-immunotherapy using lentinan and chemotherapy alone.RESULTS:Median overall survival was significantly longer in the former group than in the latter group[689 d(95%CI:431-2339 d)vs 565 d(95%CI:323-662 d),P=0.0406].In addition,the G/L ratio in patients who received lentinan was maintained around or below 2,which was significantly lower than that in patients who received chemotherapy alone(P<0.001).CONCLUSION:Chemo-immunotherapy with lentinan offers a significant advantage over S-1-based chemotherapy alone in terms of survival in patients with advanced gastric cancer. | Kenji Ina Ryuichi Furuta Takae Kataoka Satoshi Kayukawa Takashi Yoshida Takaya Miwa Yoshitaka Yamamura Yuuki Takeuchi | 2011 | World Journal of Clinical Oncology2011，2，10： | 10 |
| 4 | Postoperative bile leakage managed successfully by intrahepatic biliary ablation with ethanol显示文摘我们报导手术后的倔强的胆汁漏的一个案例与乙醇由肝内的胆汁的脱离成功地设法。与肝细胞癌诊断的一个 75 岁的人包括有尾的脑叶和前面的片断的部分经历了扩大以后的 segmentectomy。纳入胆汁管的前面的分支的肝的肿瘤小心地被分开并且 resected。手术后地从肝表面排干的液体包含了全部的胆红素的高集中,在每天的 150 mL 的经常的体积。在 d 上 32 在外科以后,引流管的 fistulogram 表明了前面的胆汁管的改进。内视镜后退胆管造影术表明了近似前面的胆汁管和外部前面的胆汁管的没有改进的完全的阻塞。在 d 上 46 在外科以后,一后退 transhepatic 胆汁的排水(RTBD ) 试管在开的外科下面被插入到前面的胆汁管。然而,拿的 RTBD 的对比研究 7 瞬间外科以后表明尽管有延长保守管理,管仍然是专利,我们因此决定执行孤立的胆汁管的乙醇脱离。四 mL 纯乙醇被注入孤立的前面的胆汁管十分钟,过程一个星期正在被重复五次。追随者 23 尝试,胆汁果汁的体积每天到达了不到 10 mL。RTBD 二天以后被夹钳并且搬迁。在 RTBD 移动以后,病人没有抱怨或症状。没有肝脓肿形成,后续磁性的回声成像表明了注射乙醇的前面的片断的萎缩。 | Tetsuya Shimizu Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Satoshi Matsumoto Yoshiaki Mizuguchi Shigeki Yokomuro Yasuo Arima Koho Akimaru Takashi Tajiri | 2006 | World Journal of Gastroenterology2006，12，21： | 9 |
| 5 | 胆道肿瘤临床实践指南(英文第三版)显示文摘日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。 | Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) | 2021 | 中华消化外科杂志2021，20，4： | 7 |
| 6 | Caudal approach to pure laparoscopic posterior sectionectomy under the laparoscopy-specific view显示文摘AIM:To study our novel caudal approach laparoscopic posterior-sectionectomy with parenchymal transection prior to mobilization under laparoscopy-specific view.METHODS:Points of the procedure are:(1) Patients are put in left lateral position and posterior sector is not mobilized;(2) Glissonian pedicle of the sector is encircled and clamped extra-hepatically and divided afterward during the transection;(3) Dissection of inferior vena cava(IVC) anterior wall behind the liver is started from caudal.Simultaneously,liver transection is performed to search right hepatic vein(RHV) from caudal;(4) Liver transection proceeds to the bifurcation of the vessels from caudal to cranial,exposing the surfaces of IVC and RHV.Since the remnant liver sinks down,the cutting surface is well-opend;and(5) After the completion of transection,dissection of the resected liver from retroperitoneum is easily performed using the gravity.This approach was performed for a 63 years old woman with liver metastasis close to RHV.RESULTS:RHV exposure is required for R0 resection of the lesion.Although the cutting plane is horizontal in supine position and the gravity obstructs the exposure in the small subphrenic space,the use of specific characteristics of laparoscopic hepatectomy,such as the good vision for the dorsal part of the liver and IVC and facilitated dissection using the gravity with the patient positioning,made the complete RHV exposure during the liver transection easy to perform.The operation time was 341 min and operative blood loss was 1356 mL.Her postoperative hospital stay was uneventfull and she is well without any signs of recurrences 14 mo after surgery.CONCLUSION:The new procedure is feasible and useful for the patients with tumors close to RHV and the need of the exposure of RHV. | Hirokazu Tomishige Zenichi Morise Norihiko Kawabe Hidetoshi Nagata Hisanori Ohshima Jin Kawase Satoshi Arakawa Rie Yoshida Masashi Isetani | 2013 | World Journal of Gastrointestinal Surgery2013，5，6： | 7 |
| 7 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 6 |
| 8 | Xyloglucan for Generating Tensile Stress to Bend Tree Stem显示文摘响应环境变化,被子植物树由形成紧张木头把他们的茎弄弯,它由充满纤维素的 G 组成(凝胶状) 在纤维房间的墙中的层并且在第二等的木部产生反常张力的应力。我们生产了转基因的白杨植物 overexpressing 在房间墙中减少每特定的多糖,,的几 endoglycanases 第二等的木部由主要、第二等的墙层组成。当水平地放了时,转基因的白杨 overexpressing xyloglucanase 的茎的基础区域不能独自在木部的紧张方面由于低紧张向上弯曲。在野类型的植物, xyloglucan 在多重 layering 期间在 G 层的内部表面被发现。在 situ xyloglucan endotransglucosylase ( XET ),活动证明整个 xyloglucan 的加入,潜在地因为墙紧缩,在内部表面层 S1 和 S2 开始了并且在整个G层开发被保留,当为墙松开的 xyloglucan heptasaccharide ( XXXG )的加入发生在膨胀地区的主要的墙中时。我们建议 xyloglucan 网络被 XET 增强形成在墙界限之间的一个进一步的连接并且分泌了 xyloglucans 以便承受在纤维素 G 层 microfibrils 以内创造的张力的压力。 | Kei'ichi Baba Yong Woo Park Tomomi Kaku Rumi Kaida Miyuki Takeuchi Masato Yoshida Yoshihiro Hosoo Yasuhisa Ojio Takashi Okuyama Toru Taniguchi Yasunori Ohmiya Teiji Kondo Ziv Shani Oded Shoseyov Tatsuya Awano Satoshi Serada Naoko Norioka Shigemi Norioka Takahisa Hayashi | 2009 | Molecular Plant2009，2，5： | 4 |
| 9 | A new technique for endoscopic mucosal resection with an insulated-tip electrosurgical knife improves the completeness of resection of intramucosal gastric neoplasms显示文摘 | Shin’ichi Miyamoto Manabu Muto Yasuo Hamamoto Narikazu Boku Atsushi Ohtsu Satoshi Baba Motoki Yoshida Masana Ohkuwa Kouichi Hosokawa Hisao Tajiri Shigeaki Yoshida | 2002 | Gastrointestinal Endoscopy2002，，4： | 3 |
| 10 | Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori -related gastritis显示文摘 | Takeichi Yoshida Jun Kato Takao Maekita Satoshi Yamashita Shotaro Enomoto Takayuki Ando Tohru Niwa Hisanobu Deguchi Kazuki Ueda Izumi Inoue Mikitaka Iguchi Hideyuki Tamai Toshikazu Ushijima Masao Ichinose | 2013 | Gastric Cancer2013，，4： | 3 |
| 11 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 3 |
| 12 | Laparoscopic splenectomy for histiocytic sarcoma of the spleen显示文摘Primary histiocytic sarcoma of the spleen is a rare but potentially lethal condition. It can remain asymptomatic or only mildly symptomatic for a long time. An 81-year-old woman presented with an extremely enlarged spleen. She suffered from progressive anemia and required a red blood cell transfusion once a month. Although computed tomography, ultrasonography, and magnetic resonance imaging were performed for diagnosis, a confirmed diagnosis was not obtained. Her enlarged spleen compressed her stomach, and she suffered from gastritis and a sense of gastric fullness just after meals. She underwent laparoscopic splenectomy for therapeutic and diagnostic purposes. Her postoperative course was uneventful. After surgery, her red blood cell and platelet counts increased markedly. The tumor was diagnosed as splenic histiocytic sarcoma. Post-surgical chemotherapy was not performed, and the patient died of liver failure due to liver metastasis 5 mo after surgery. Laparoscopic splenectomy is minimally invasive and useful for the relief of symptoms related to hematological disorders. However, in cases of an enlarged spleen, optimal views and working space are limited. In such cases, splenic artery ligation can markedly reduce the size of the spleen, thus facilitating the procedure. The case reported herein suggests that laparoscopic splenectomy may be useful for the treatment of splenic malignancy. | Satoshi Yamamoto Tadashi Tsukamoto Akishige Kanazawa Sadatoshi Shimizu Keiichiro Morimura Takahiro Toyokawa Zhang Xiang Katsunobu Sakurai Tatsunari Fukuoka Kayo Yoshida Mamiko Takii Ken Inoue | 2013 | World Journal of Gastrointestinal Surgery2013，5，4： | 2 |
| 13 | The MicroRNA-21/PTEN Pathway Regulates the Sensitivity of HER2-Positive Gastric Cancer Cells to Trastuzumab显示文摘 | Kojiro Eto Masaaki Iwatsuki Masayuki Watanabe Satoshi Ida Takatsugu Ishimoto Shiro Iwagami Yoshifumi Baba Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Hideo Baba | 2014 | Annals of Surgical Oncology2014，，1： | 2 |
| 14 | Long-term results of elective hepatectomy for the treatment of ruptured hepatocellular carcinoma显示文摘 | Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Yoshiaki Mizuguchi Daisuke Kakinuma Yoshinori Ishikawa Tomohiro Kanda Satoshi Matsumoto Koich Bando Koho Akimaru Takashi Tajiri | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，2： | 2 |
| 15 | Rebamipide, a Gastroprotective Drug, Inhibits Indomethacin-Induced Apoptosis in Cultured Rat Gastric Mucosal Cells: Association with the Inhibition of Growth Arrest and DNA Damage-Induced 45α Expression显示文摘 | Yuji Naito Hirokazu Kajikawa Katsura Mizushima Makoto Shimozawa Masaaki Kuroda Kazuhiro Katada Tomohisa Takagi Osamu Handa Satoshi Kokura Hiroshi Ichikawa Norimasa Yoshida Hirofumi Matsui Toshikazu Yoshikawa | 2005 | Digestive Diseases and Sciences2005，，1： | 2 |
| 16 | Myocardial perfusion and fatty acid metabolism in patients with tako-tsubo-like left ventricular dysfunction显示文摘 | Satoshi Kurisu Ichiro Inoue Takuji Kawagoe Masaharu Ishihara Yuji Shimatani Kenji Nishioka Takashi Umemura Suji Nakamura Masashi Yoshida Hikaru Sato | 2003 | Journal of the American College of Cardiology2003，，： | 2 |
| 17 | Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment显示文摘 | Satoshi Kondo Tadahiro Takada Masaru Miyazaki Shuichi Miyakawa Kazuhiro Tsukada Masato Nagino Junji Furuse Hiroya Saito Toshio Tsuyuguchi Masakazu Yamamoto Masato Kayahara Fumio Kimura Hideyuki Yoshitomi Satoshi Nozawa Masahiro Yoshida Keita Wada Satoshi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，1： | 2 |
| 18 | Intraoperative ultrasonographic localization of pulmonary ground-glass opacities显示文摘 | Ryoichi Kondo Kazuo Yoshida Kazutoshi Hamanaka Masahiro Hashizume Toshiki Ushiyama Akira Hyogotani Makoto Kurai Satoshi Kawakami Mana Fukushima Jun Amano | 2009 | The Journal of Thoracic and Cardiovascular Surgery2009，，4： | 2 |
| 19 | Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein显示文摘瞄准:为了在 ischemia-reperfusion (红外) 上调查 rosuvastatin 的保护的效果,并且在内皮的氮的氧化物 synthase (eNOS ) 的表示上决定这个代理人的效果,在老鼠导致了小肠的损害和发炎蛋白质。方法:肠的损坏被为 30 min 夹钳优异 mes 伤寒动脉和腹的箱子在男 Sprague-Dawley 老鼠导致,为 60 min 由灌注列在后面。在生理盐水溶解的 Rosuvastatin intraperitoneally 被管理在局部缺血前的 60 min。肠的粘膜损害和发炎的严厉被几个生物化学的标记,以及由组织检查所见评估。eNOS 的蛋白质层次被西方的污点决定。结果:当粘膜的索引损坏,管腔内血红素和蛋白质的层次显著地在假冒操作组与那些相比在红外组被增加。然而,这些增加被处理显著地以一种剂量依赖者方式与 rosuvastatin 禁止。rosuvastatin 的保护的效果被组织检查所见也证实。到红外的小肠的暴露导致了 thiobarbituric 的重要增加描绘的粘膜发炎酸反应的物质,联系织物的 myeloperoxidase 活动,和老鼠的粘膜内容导致 cytokine 的嗜中性的 chemoattractant-1 (CINC-1 ) 和肿瘤坏死 factor-alpha (TNF-alpha ) 。在红外以后的煽动性的参数的这些增加被预告的处理显著地在 10 mg/kg 的剂量与 rosuvastatin 禁止。而且, CINC-1 和 TNF-alpha 的 mRNA 表示在红外以后被增加,并且这增加被 rosuvastatin 也禁止。eNOS 的粘膜蛋白质层次在红外期间减少了,但是在与 rosuvastatin 对待的老鼠被保存。结论:Rosuvastatin 禁止老鼠红外导致的肠的损害和发炎,和它的保护与 eNOS 的保藏被联系蛋白质。 | Yuji Naito Kazuhiro Katada Tomohisa Takagi Hisato Tsuboi Masaaki Kuroda Osamu Handa Satoshi Kokura Norimasa Yoshida Hiroshi Ichikawa Toshikazu Yoshikawa | 2006 | World Journal of Gastroenterology2006，12，13： | 2 |
| 20 | Sessile serrated adenoma detection rate is correlated with adenoma detection rate显示文摘AIM To investigated the association between adenoma detection rate(ADR) and sessile serrated ADR(SSADR) and significant predictors for sessile serrated adenomas(SSA) detection.METHODS This study is a retrospective, single-center analysis. Total colonoscopies performed by the gastroenterologists at the University of Tokyo Hospital between January and December 2014 were retrospectively identified. Polyps were classified as low-grade or high-grade adenoma, cancer, SSA, or SSA with cytological dysplasia, and the prevalence of each type of polyp was investigated. Predictors of adenoma and SSA detection were examined using logistic generalized estimating equation models. The association between ADR and SSADR for each gastroenterologist was investigated by calculating a correlation coefficient weighted by the number of each gastroenterologist's examination.RESULTS A total of 3691 colonoscopies performed by 35 gastroenterologists were assessed. Overall, 978 (26.5%) low-and 84 (2.2%) high-grade adenomas, 81 (2.2%) cancers, 66 (1.8%) SSAs, and 2 (0.1%) SSAs with cytological dysplasia were detected. Overall ADR was 29.5%(men 33.2%, women 23.8%) and overall SSADR was 1.8%(men 1.7%, women 2.1%). In addition, 672 low-grade adenomas (68.8% of all the detected lowgrade adenomas), 58 (69.9%) high-grade adenomas, 29 (34.5%) cancers, 52 (78.8%) SSAs, and 2 (100%) SSAs with cytological dysplasia were found in the proximal colon. Adenoma detection was the only significant predictor of SSA detection (adjusted OR: 2.53, 95%CI: 1.53-4.20; P < 0.001). The correlation coefficient between ADR and SSADR weighted by the number of each gastroenterologist's examinations was 0.606(P < 0.001).CONCLUSION Our results demonstrated that ADR is correlated to SSADR. In addition, patients with adenomas had a higher prevalence of SSAs than those without adenomas. | Daisuke Ohki Yosuke Tsuji Tomohiro Shinozaki Yoshiki Sakaguchi Chihiro Minatsuki Hiroto Kinoshita Keiko Niimi Satoshi Ono Yoku Hayakawa Shuntaro Yoshida Atsuo Yamada Shinya Kodashima Nobutake Yamamichi Yoshihiro Hirata Tetsuo Ushiku Mitsuhiro Fujishiro Masashi Fukayama Kazuhiko Koike | 2018 | World Journal of Gastrointestinal Oncology2018，10，3： | 2 |
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