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| 1 | Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis显示文摘 | Hashem B. El–Serag K. Lenhard Rudolph | 2007 | Gastroenterology2007，，7： | 22 |
| 2 | Mismatch repair genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6,HMSH2) in the pathogenesis of hepatocellular carcinoma显示文摘AIM: DNA misrnatch repair (MMR) is an impotent mechanism for maintaining fidelity of genomic DNA. Abnormalities in one or more MMR genes are implicated in the development of many cancers. We investigated the role of expression of MMR genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in hepatocellular carcinogenesis. METHODS: We evaluated the expression level of MMR genes in 33 hepatocellular carcinoma (HCC) cases using the multiplex reverse transcription (RT) PCR assays, as well as in 16 cases of normal adjacent hepatic tissues. Β-actin gene was used as an internal control and calibrator for quantification of gene expression. RESULTS: Out of the 33 studied cases, 25 were HCV positiveand 30 (90.9%) showed reduced expression in one or more of the studied MMR genes. Reduced expression was found in hMSH2 (71.9%), hMLH1 (53.3%), GTBP (51.1%), hPMS2 (33.3%) and hPMS1 (6%). A significant correlation was found between reduced expression of hPMS2(P= 0.0069) and GTBP(P= 0.0034), hPMS2and non-cirrhosis (P= 0.0197),hMLH1 and high grade. On the other hand, 57.1%, 50%, 20%, 18.8%, and 6% of the normal tissues distant to tumors showed reduced expression of hMSH2, hMLH1, GTBP, hPMS2, and hPMS1 respectively. Multivariate analysis revealed a significant correlation between the expression level of hMSH2(P= 0.008), hMLH1 (P= 0.001) and GTBP (P = 0.032)and HCC, between hPMS2, GTBP and HCVassociated HCC (P<0.001, 0.002).CONCLUSION: Reduced expression of MMR genes seemsto play an important role in HCV-associated HCC. hPMS2 islikely involved at an early stage of hepatocarcinogenesis since it was detected in normal adjacent tissues. Reduced expression of hPMS2 provides a growth advantage and stimulates proliferation which encourages malignant transformation in non-cirrhotic HCV-infected patients via acquisition of more genetic damages. | Abdel-Rahman N. Zekri Gelane M. Sabry Abeer A. Bahnassy Kamal A. Shalaby Sabrin A.Abdel-Wahabh Serag Zakaria | 2005 | World Journal of Gastroenterology2005，11，20： | 10 |
| 3 | Association Between Nonalcoholic Fatty Liver Disease and Risk for Hepatocellular Cancer, Based on Systematic Review显示文摘 | Donna L. White Fasiha Kanwal Hashem B. El–Serag | 2012 | Clinical Gastroenterology and Hepatology2012，，12： | 7 |
| 4 | Noninvasive assessment of hepatic fibrosis in Egyptian patients with chronic hepatitis C virus infection显示文摘AIM: To evaluate the accuracy of specific biochemical markers for the assessment of hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection. METHODS: One hundred and fifty-four patients with chronic HCV infection were included in this study; 124 patients were non-cirrhotic, and 30 were cirrhotic. The following measurements were obtained in all patients: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, prothrombin time and concentration, complete blood count, hepatitis B surface antigen (HBsAg), HCVAb, HCV-RNA by quantitative polymerase chain reaction, abdominal ultrasound and ultrasonic-guided liver biopsy. The following ratios, scores and indices were calculated and compared with the results of the histopathological examination: AST/ALT ratio (AAR), age platelet index (API), AST to platelet ratio index (APRI), cirrhosis discriminating score (CDS), Pohl score, G teborg University Cirrhosis Index (GUCI). RESULTS: AAR, APRI, API and GUCI demonstrated good diagnostic accuracy of liver cirrhosis (80.5%, 79.2%, 76.6% and 80.5%, respectively); P values were: < 0.01, < 0.05, < 0.001 and < 0.001, respectively. Among the studied parameters, AAR and GUCI gave the highest diagnostic accuracy (80.5%) with cutoff values of 1.2 and 1.5, respectively. APRI, API and GUCI were significantly correlated with the stage of fibrosis (P < 0.001) and the grade of activity (P < 0.001, < 0.001 and < 0.005, respectively), while CDS only correlated significantly with the stage of fibrosis (P < 0.001) and not with the degree of activity (P > 0.05). In addition, we found significant correlations for the AAR, APRI, API, GUCI and Pohl score between the non-cirrhotic (F0, F1, F2, F3) and cirrhotic (F4) groups (P values: < 0.001, < 0.05, < 0.001, < 0.001 and < 0.005, respectively; CDS did not demonstrate significant correlation (P > 0.05). CONCLUSION: The use of AAR, APRI, API, GUCI and Pohl score measurements may decrease the need for liver biopsies in diagnosing cirrhosis, especially in Egypt, where resources are limited. | Shawky Abdelhamid Fouad Serag Esmat Dalia Omran Laila Rashid Mohamed H Kobaisi | 2012 | World Journal of Gastroenterology2012，18，23： | 6 |
| 5 | Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression显示文摘 | Gary L. Davis Miriam J. Alter Hashem El–Serag Thierry Poynard Linda W. Jennings | 2010 | Gastroenterology2010，，2： | 5 |
| 6 | Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis显示文摘 | Hashem B. El–Serag K. Lenhard Rudolph | 2007 | Gastroenterology2007，，7： | 3 |
| 7 | Epidemiological and clinical characteristics of inflammatory bowel diseases in Cairo,Egypt显示文摘AIM:To study the natural history,patterns and clinical characteristics of inflammatory bowel diseases(IBD)in Egypt.METHODS:We designed a case-series study in the gastroenterology centre of the Internal Medicine department of Cairo University,which is a tertiary care referral centre in Egypt.We included all patients in whom the diagnosis of ulcerative colitis(UC)or Crohn’s disease(CD)was confirmed by clinical,laboratory,endoscopic,histological and/or radiological criteria over the 15 year period from 1995 to 2009,and we studied their sociodemographic and clinical characteristics.Endoscopic examinations were performed by 2 senior experts.This hospital centre serves patients from Cairo,as well as patients referred from all other parts of Egypt.Our centre received 24156 patients over the described time period for gastro-intestinal consultations and/or interventions.RESULTS:A total of 157 patients with established IBD were included in this study.Of these,135 patients were diagnosed with UC(86%of the total),and 22patients,with CD(14%of the total).The mean ages at diagnosis were 27.3 and 29.7,respectively.Strikingly,we noticed a marked increase in the frequency of both UC and CD diagnoses during the most recent 10 years of the 15 year period studied.Regarding the gender distribution,the male:female ratio was 1:1.15 for UC and 2.6:1 for CD.The mean duration of follow up for patients with UC was 6.2±5.18 years,while the mean duration of follow up for patients with CD was 5.52±2.83 years.For patients with UC we found no correlation between the severity of the disease and the presence of extraintestinal manifestations.Eleven patients had surgical interventions during the studied years:4cases of total colectomy and 7 cases of anal surgery.CONCLUSION:We observed a ratio of 6:1 for UC to CD in our series.The incidence of IBD seems to be rising in Egypt. | Serag Esmat Mohamed El Nady Mohamed Elfekki Yehia Elsherif Mazen Naga | 2014 | World Journal of Gastroenterology2014，20，3： | 3 |
| 8 | The Association Between Diabetes and Hepatocellular Carcinoma: A Systematic Review of Epidemiologic Evidence显示文摘 | Hashem B. El–Serag Howard Hampel Fariba Javadi | 2006 | Clinical Gastroenterology and Hepatology2006，，3： | 2 |
| 9 | Low-density lipoprotein receptor genetic polymorphism in chronic hepatitis C virus Egyptian patients affects treatment response显示文摘AIM: To correlate a genetic polymorphism of the low-density lipoprotein(LDL) receptor with antiviral responses in Egyptian chronic hepatitis C virus(HCV) patients.METHODS: Our study included 657 HCV-infected patients with genotype 4 who received interferonbased combination therapy. Patients were divided into two groups based on their response to therapy: 356 were responders, and 301 were non-responders. Patients were compared to 160 healthy controls. All patients and controls underwent a thorough physical examination, measurement of body mass index(BMI) and the following laboratory tests: serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, total bilirubin, direct bilirubin, prothrombin time, prothrombin concentration, INR, complete blood count, serum creatinine, fasting blood sugar, HCV antibody, and hepatitis B surface antigen. All HCV patients were further subjected to the following laboratory tests: HCV-RNA using quantitative polymerase chain reaction(PCR), antinuclear antibodies, thyroid-stimulating hormone, an LDL receptor(LDLR) genotype study of LDLR exon8 c.1171G>A and exon-10 c.1413G>A using real-time PCR-based assays, abdominal ultrasonography, ultrasonographic-guided liver biopsy, and histopathological examination of liver biopsies. Correlations of LDL receptor polymorphisms with HAI, METAVIR score, presence of steatosis, and BMI were performed in all cases.RESULTS: There were no statistically significant differences in response rates between the different types of interferon used or LDLR exon10 c.1413G>A. However, there was a significant difference in the frequency of the LDL receptor exon8 c.1171G>A genotype between cases(AA: 25.9%, GA: 22.2%, GG: 51.9%) and controls(AA: 3.8%, GA: 53.1% and GG: 43.1%)(P < 0.001). There was a statistically significant difference in the frequency of the LDLR exon 8C:1171 G>A polymorphism between responders(AA: 3.6%, GA: 15.2%, GG: 81.2%) and nonresponders(AA: 52.2%, GA: 30.6%, GG: 17.2%)(P < 0.001). The G allele of LDL receptor exon8 c.1171G>A predominated in cases and controls over the A allele, and a statistically significant association with response to interferon was observed. The frequency of the LDLR exon8 c.1171G>A allele in non-responders was: A: 67.4% and G: 32.6 vs A: 11.2% and G: 88.8% in responders(P < 0.001). Therefore, carriers of the A allele exhibited a 16.4 times greater risk for nonresponse. There was a significant association between LDL receptors exon8 c.1171G>A and HAI(P < 0.011). There was a significant association between LDL receptors exon8 c.1171G>A and BMI. The mean BMI level was highest in patients carrying the AA genotype(28.7 ± 4.7 kg/m2) followed by the GA genotype(28.1 ± 4.8 kg/m2). The lowest BMI was the GG genotype(26.6 ± 4.3 kg/m2)(P < 0.001). The only significant associations were found between LDL receptors exon8 c.1171G>A and METAVIR score or steatosis(P < 0.001).CONCLUSION: LDL receptor gene polymorphisms play a role in the treatment response of HCV and the modulation of disease progression in Egyptiansinfected with chronic HCV. | Mazen Naga Mona Amin Dina Algendy Ahmed Elbadry May Fawzi Ayman Foda Serag Esmat Dina Sabry Laila Rashed Samia Gabal Manal Kamal | 2015 | World Journal of Gastroenterology2015，21，39： | 2 |
| 10 | Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction显示文摘 | Manal M. Hassan Ahmed Kaseb Carol J. Etzel Hashem El‐Serag Margaret R. Spitz Ping Chang Katherine S. Hale Mei Liu Asif Rashid Mohamed Shama James L. Abbruzzese Evelyne M. Loyer Harmeet Kaur Hesham M. Hassabo Jean‐Nicolas Vauthey Curtis J. Wray Basmah S. H | 2013 | Mol Carcinog2013，，1： | 2 |
| 11 | Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: A population-based study显示文摘 | Jessica A. Davila Robert O. Morgan Yasser Shaib Katherine A. McGlynn Hashem B. El–Serag | 2004 | Gastroenterology2004，，5： | 2 |
| 12 | Increasing Prevalence of HCC and Cirrhosis in Patients With Chronic Hepatitis C Virus Infection显示文摘 | Fasiha Kanwal Tuyen Hoang Jennifer R. Kramer Steven M. Asch Matthew Bidwell Goetz Angelique Zeringue Peter Richardson Hashem B. El–Serag | 2011 | Gastroenterology2011，，4： | 2 |
| 13 | Obesity: A Challenge to Esophagogastric Junction Integrity显示文摘 | John E. Pandolfino Hashem B. El–Serag Qing Zhang Nimeesh Shah Sudip K. Ghosh Peter J. Kahrilas | 2006 | Gastroenterology2006，，3： | 2 |
| 14 | Time Trends of Gastroesophageal Reflux Disease: A Systematic Review显示文摘 | Hashem B. El–Serag | 2007 | Clinical Gastroenterology and Hepatology2007，，1： | 2 |
| 15 | Statins Are Associated With a Reduced Risk of Hepatocellular Carcinoma in a Large Cohort of Patients With Diabetes显示文摘 | Hashem B. El–Serag Michael L. Johnson Christine Hachem Robert O. Morgana | 2009 | Gastroenterology2009，，5： | 2 |
| 16 | Prevalence of Colorectal Polyps in Pediatric Colonoscopy显示文摘 | Kalpesh Thakkar Abeer Alsarraj Emily Fong Jennifer L. Holub Mark A. Gilger Hashem B. El Serag | 2012 | Digestive Diseases and Sciences2012，，4： | 1 |
| 17 | Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: a population -based study显示文摘 | E1 - Serag HB Siegel AB Davila JA | 2006 | J Hepatol2006，44，1： | 1 |
| 18 | Hepatocellular carcinoma, epidemiology and molecular carcinogenesis 显示文摘 | El - SERAG HB RUDOLPH KL | 2007 | Gastroenterology2007，132，7： | 1 |
| 19 | 荟萃分析:肥胖与胃食管反流病及其并发症发生的风险性 | Hampel H. Abraham N.S. El- Serag H.B. 马卉 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，12： | 1 |
| 20 | The Association Between Barrett’s Esophagus and Helicobacter pylori Infection: A Meta‐Analysis显示文摘 | Lori A.Fischbach HelenaNordenstedt Jennifer R.Kramer SubiGandhi SamDick‐Onuoha AnthonyLewis Hashem B.El‐Serag | 2012 | Helicobacter2012，，3： | 1 |
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