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| 1 | Opportunities and challenges of the Sponge City construction related to urban water issues in China显示文摘Waterlogging is one of the major water issues in most cities of China and directly restricts their urbanization processes.The construction of Sponge City is an effective approach to solving the urban water issues,particularly for the waterlogging.In this study,both the urban issues emerged at the stage of rapid urbanization in China and the demands as well as problems of Sponge City construction related with the water issues were investigated,and the opportunities and challenges for the Sponge City construction in the future were also proposed.It was found that the current stormwater management focused on the construction of gray infrastructures(e.g.,drainage network and water tank) based on the fast discharge idea,which was costly and hard to catch up with the rapid expansion of city and its impervious surface,while green infrastructures(e.g.,river,lake and wetland)were ignored.Moreover,the current construction of Sponge City was still limited to low impacted development(LID) approach which was concentrated on source control measures without consideration of the critical functions of surrounding landscapes(i.e.,mountain,river,wetland,forest,farmland and lake),while application of the integrated urban water system approach and its supported technologies including municipal engineering,urban hydrology,environmental science,social science and ecoscape were relatively weak and needed to be improved.Besides,the lack of special Sponge City plan and demonstration area was also a considerable problem.In this paper,some perspectives on Good Sponge City Construction were proposed such as the point that idea of urban plan and construction should conform to the integral and systematic view of sustainable urban development.Therefore,both the basic theoretical research and the basic infrastructure construction such as monitoring system,drainage facility and demonstration area should be strengthened,meanwhile,the reformation and innovation in the urban water management system and the education system should also be urgently performed.The study was expected to provide a deeper thinking for the current Sponge City construction in China and to give some of suggestions for the future directions to urban plan and construction,as well as urban hydrology discipline. | XIA Jun ZHANG YongYong XIONG LiHua HE Shan WANG LongFeng YU ZhongBo | 2017 | Science China Earth Sciences2017，60，4： | 65 |
| 2 | Stress changes on major faults caused by M_w7.9 Wenchuan earthquake,May 12,2008显示文摘On May 12,2008,a magnitude 7.9 earthquake ruptured the Longmenshan fault system in Sichuan Province,China,collapsing buildings and killing tens of thousands people.As predicted,aftershocks may last for at least one year,and moreover,large aftershocks are likely to occur.Therefore,it is critical to outline the areas with potential aftershocks before reconstruction and resettling people as to avoid future disasters.It is demonstrated that the redistribution of stress induced by an earthquake should trigger successive seismic activity.Based on static stress triggering theory,we calculated the coseismic stress changes on major faults induced by the Wenchuan earthquake,with elastic dislocation the-ory and the multilayered crustal model.We also discuss the stress distribution and its significance for future seismic activity under the impact of the Wenchuan earthquake.It is shown that coulomb failure stress(CFS) increases obviously on the Daofu-Kangding segment of the Xianshuihe Fault,the Maqu and Nanping segment of the Eastern Kunlun Fault,the Qingchuan Fault,southern segment of the Min-jiang Fault,Pengxian-Guanxian Fault,Jiangyou-Guangyuan Fault,and Jiangyou-Guanxian Fault.The increased stress raises the probability of earthquake occurrence on these faults.Since these areas are highly populated,earthquake monitoring and early disaster alarm system are needed.CFS increases with a magnitude of 0.03―0.06 MPa on the Qingchuan Fault,which is close to the northern end of the rapture of Wenchuan earthquake.The occurrence of some strong aftershocks,including three events with magnitude higher than 5.0,indicates that the seismic activities have been triggered by the main shock.Aftershocks seem to migrate northwards.Since the CFS change on the Lueyang-Mianxian Fault located on the NEE of the Qingchuan Fault is rather small(±0.01 MPa),the migration of aftershocks might be terminated in the area near Hanzhong City.The CFS change on the western Qinling Fault is around 10 Pa,and the impact of static triggering can be neglected.The increment of CFS on the Pengxian-Guanxian Fault and Beichuan-Yingxiu Fault southwest to the main rupture is 0.005―0.015 MPa,which would facilitate earthquake triggering in these areas.Very few aftershocks in these areas indicate that the accumulated stress has not been released sufficiently.High seismic risk is predicated in these areas due to coseismic CFS loading.The Wenchuan earthquake released the accumulated CFS on the Fubianhe Fault,the Huya Fault,the Ha'nan-Qingshanwan Fault,and the Diebu-Bailongjiang Fault.The decrement of CFS changes on the Longquanshan Fault east to Chengdu City is about 0.002 MPa.The seismic activity will be depressed by decrement of CFS on these faults. | SHAN Bin XIONG Xiong ZHENG Yong DIAO FaQi | 2009 | Science China Earth Sciences2009，52，5： | 47 |
| 3 | Stress changes on major faults caused by 2013 Lushan earthquake and its relationship with 2008 Wenchuan earthquake显示文摘On April 20, 2013, an Ms7.0 earthquake occurred in Ya'an-Lushan region, Sichuan Province, China, killing and injuring morethan one thousand people. Therefore, it is critical to outline the areas with potential aftershocks before reconstruction andre-settlement as to avoid future disasters. Based on the elastic dislocation theory and multi-layered lithospheric model, we calculate the co-and post-seismic stress changes caused by the Wenchuan and Lushan earthquakes to discuss the relationshipbetween Mw7.9 Wenchuan earthquake and Ms7.0 Lushan earthquake, the influences on the distribution of aftershock caused bythe Lushan earthquake, and the stress changes on major faults in this region. It is shown that the Coulomb failure stress increment on the hypocenter of Lushan earthquake caused by the Wenchuan earthquake is about 0.0037-0.0113 MPa. And the possible maximum value (0.0113 MPa) is larger than the threshold of stress triggering. Therefore, the occurrence of Lushanearthquake is probably effectively promoted by the Wenchuan earthquake. The aftershock distribution is well explained by theco-seismic stress changes of Lushan earthquake. By the two ends of the rupture of Lushan earthquake with increased Coulombfailure stress, a lack of aftershock recordings indicates the high seismic hazard. The stress accumulation and correspondingseismic hazard on the Kangding-Dafu segment of the Xinshuihe fault, the Beichuan-Yingxiu fault, the Pengxian-Guanxianfault, and the Ya'an fault are further increased by the Lushan earthquake and post-seismic process of Wenchuan earthquake. | SHAN Bin XIONG Xiong ZHENG Yong JIN BiKai LIU ChengLi XIE ZhuJun HSU HouTze | 2013 | Science China Earth Sciences2013，56，7： | 49 |
| 4 | Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior显示文摘为过去的几十年,在中国的传染疾病侧面在社会、经济的方面,环境,食物的质量,水,住房,和公共健康基础结构与快速的开发一直在变。尤其是, 5 应具报的传染疾病几乎被根除了,并且 18 另外的应具报的传染疾病的发生显著地被减少了。出人意料地,包括 HIV,普鲁斯病,梅毒,和登革热发烧,超过 10 应具报的传染疾病的发生一直在增加。不过,经常的传染疾病爆发 / 事件每年几乎被报导了,并且进口了传染疾病自从 2015,增加了。已知的病原体的新病原体和超过 100 新遗传型或 serotypes 被识别了。一些传染疾病似乎被各种各样的因素加重,包括快速的都市化,大量候鸟工人,在气候的变化,生态学,和政策,例如把农田还给森林。这评论在设法出现和 re-emerging 从中国总结当前的经验和课传染疾病,特别生态学的效果,气候,和行为,它应该在帮助另外的国家控制并且阻止传染疾病有优点。 | Qiyong Liu Wenbo Xu Shan Lu Jiafu Jiang Jieping Zhou Zhujun Shao Xiaobo Liu Lei Xu Yanwen Xiong Han Zheng Sun Jin Hai Jiang Wuchun Cao Jianguo Xu | 2018 | Frontiers of Medicine2018，12，1： | 23 |
| 5 | Deep Structural Framework and Genetic Analysis of Gold Concentration Areas in the Northwestern Jiaodong Peninsula, China: A New Understanding based on High-Resolution Reflective Seismic Survey显示文摘The gold concentration areas in the northwestern Jiaodong Peninsula constituted an important gold metallogenetic region in Eastern China during the Mesozoic. The deep geological bodies' texture characteristic is important for exploring the resources thoroughly and understanding the metallogenic process. The detailed textures were revealed using high-resolution seismic profiles through the three major ore-controlling structures-Sanshandao fault zone, Jiaojia fault zone and Zhaoping fault zone. This study aims to establish a deep structural framework of this area. Based on their formation mechanism, the fault structures developed in the area can be divided into regional and local fault structures. The structural styles are characterised by superimposing their compressional, strike-slip and extensional multi-stage activities. The crust is cut by vertical structures corresponding to a left-lateral strike-slip fault system on the surface. Nearby these structures are the arc-shape structures formed by multi-stage magma intrusions into the upper crust. Bounded by the Tancheng–Lujiang and Muping–Jimo fault zones, the current Jiaodong block, developed a series of NE-trending strike-slip fault systems, was probably formed by the assemblage of several obliquely aligned blocks. The intensive magmatism and hydrothermal activity between the blocks induced large-scale mineralisation. It provides a new angle of view for understanding the cratonic destruction and large ore-concentration formed during the Mesozoic. | YU Xuefeng SHAN Wei XIONG Yuxin GENG Ke SUN Yuqin CHI Naijie GUO Baokui LI Dapeng LI Hongkui SONG Yingxin YANG Deping | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 19 |
| 6 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 7 | Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B显示文摘AIM: To investigate the combined diagnostic accuracy of acoustic radiation force impulse(ARFI), aspartate aminotransferase to platelet ratio index(APRI) and Forns index for a non-invasive assessment of liver fibrosis in patients with chronic hepatitis B(CHB). METHODS: In this prospective study, 206 patients had CHB with liver fibrosis stages F0-F4 classified by METAVIR and 40 were healthy volunteers were measured by ARFI, APRI and Forns index separately or combined as indicated. RESULTS: ARFI, APRI or Forns index demonstrated a significant correlation with the histological stage(all P < 0.001). According to the AUROC of ARFI and APRI for evaluating fibrotic stages more than F2, ARFI showed an enhanced diagnostic accuracy than APRI(P < 0.05). The combined measurement of ARFI and APRI exhibited better accuracy than ARFI alone when evaluating ≥ F2 fibrotic stage(Z = 2.77, P = 0.006). Combination of ARFI, APRI and Forns index did not obviously improve the diagnostic accuracy compared to the combination of ARFI and APRI(Z = 0.958, P = 0.338). CONCLUSION: ARFI + APRI showed enhanced diagnostic accuracy than ARFI or APRI alone for significant liver fibrosis and ARFI + APRI + Forns index shows the same effect with ARFI + APRI. | Chang-Feng Dong Jia Xiao Ling-Bo Shan Han-Ying Li Yong-Jia Xiong Gui-Lin Yang Jing Liu Si-Min Yao Sha-Xi Li Xiao-Hua Le Jing Yuan Bo-Ping Zhou George L Tipoe Ying-Xia Liu | 2016 | World Journal of Hepatology2016，8，14： | 18 |
| 8 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 9 | Upper Paleozoic coal measures and unconventional natural gas systems of the Ordos Basin,China显示文摘在 Ordos 盆的上面的古生代的煤措施由黑暗 mudstone 和煤床组成并且是为煤气的产生的重要来源岩石。煤气的累积包括煤床甲烷(CBM ) ,在不同结构的区域的紧密的煤气、常规的气体。CBM 累积主要在 Ordos 盆的边缘的区域被散布,并且在 3.5 氠睯爠湡 ? 潣污甠?污祬栠獡氠睯洠瑥慨敮猠牯瑰潩 ? 慣慰楣祴愠摮椠獴瀠牯 ? 湡 ? 業牣景慲瑣牵獥愠敲瀠潯汲 ? 敤敶潬数被估计吗? | Xuan Tang Jinchuan Zhang Yansheng Shan Jinyu Xiong | 2012 | Geoscience Frontiers2012，3，6： | 8 |
| 10 | Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study显示文摘 | Chen-Hong Wang Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Xiao-Mei Tong Hong Liu Guo-Fang Ding Bin Yi Xin-Nian Pan Dan-Ni Zhong Ling Liu Mei Li Cui-Qing Li Shi-Wen Xia Hong-Yun Wang Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Ruo-Bing Shan De-Zhi Mu Xiao-Hong Liu Si-Qi Zhuang Jing Guo Li Liu Jia-Jun Zhu Hong Xiong | 2016 | Chinese Medical Journal2016，，22： | 8 |
| 11 | Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution显示文摘The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits,which is of fundamental importance for neuroscience research.Here,we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R)for high-throughput,high-quality brain mapping.Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion,the VISo R system effectively eliminates motion blur to obtain undistorted images.By continuously imaging moving samples without stopping,the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours,at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation,imaging,3D image reconstruction and quantification.Our approach is compatible with immunofluorescence methods,enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains.Using this system,we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming conditions.Our results indicate the involvement of multiple subcortical areas in stress response.Intriguingly,neuronal activation in these areas exhibits striking individual variability among different animals,suggesting the necessity of sufficient cohort size for such studies. | Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-Ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-Ning Zhou Fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi | 2019 | National Science Review2019，6，5： | 7 |
| 12 | Transcriptome analysis of blood stasis syndrome in subjects with hypertension显示文摘OBJECTIVE:To screen for m RNAs associated with blood stasis syndrome and to explore the genetic mechanisms of blood stasis syndrome in hypertension.METHODS:This study involved groups of patients with hypertension and blood stasis,including those with Qi deficiency,Qi stagnation,cold retention and heat retention;as well as hypertensive patients without blood stasis and healthy individuals.Human umbilical vein endothelial cells were co-cultured with the sera of these healthy individuals and patients with blood stasis syndrome.Total RNA was extracted from these cells and assessed by a high-throughput sequencing method(Solexa)and digital gene expression.Differentially expressed genes among these six groups were compared using whole genome sequences,and m RNAs associated with blood stasis syndrome identified.Differences in gene use and gene ontology function were an-alyzed.Genes enriched significantly and their pathways were determined,as were network interactions,and encoded proteins.Gene identities were confirmed by real-time polymerase chain reactions.RESULTS:Compared with cells cultured in sera of the blood stasis groups,those culture in sera of healthy individuals and of the non-blood stasis group showed 11 and 301 differences,respectively in stasis-related genes.Genes identified as differing between the blood stasis and healthy groups included activating transcription factor 4,activating transcription factor 3,DNA-damage inducible transcription factor 3,Tribbles homolog 3,CCAAT/enhancer binding protein-β,and Jun proto-oncogene(JUN).Pathway and protein interaction network analyses showed that these genes were associated with endoplasmic reticulum stress.Cells cultured in sera of patients with blood stasis and Qi deficiency,Qi stagnation,heat retention,and cold retention were compared with cells cultured in sera of patients with the other types blood stasis syndrome.The comparison showed differences in expression of 28,28,34,and 32 specific genes,respectively.CONCLUSION:The pathogenesis of blood stasis syndrome in hypertension is related to endoplasmic reticulum stress and involves the differential expression of the activating transcription factor 4,activating transcription factor 3,DNA-damage inducible transcription factor 3,Tribbles homolog 3,CCAAT/enhancer binding protein-β,and JUN genes. | He Ling Fang Meixia Chen Liguo Zhou Jianhua Yuan Jing Xu Jing Shan Yan Xu Qingyun Xiong Tingting | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 7 |
| 13 | Adsorption behavior of Pd(Ⅱ) from aqueous solutions by D201 resin显示文摘The adsorption and desorption behaviors of Pd(Ⅱ) on D201 resin were investigated. The effects of parameters including HCl concentrations, initial metal ion concentrations, contact time, and temperature on the adsorption of Pd(Ⅱ) were studied by batch method. The HCl concentration for studying the effects was set from 0.01 to 2 mol·L-1 and the optimal adsorption condition is in 0.01 mol·L-1 HCl solution. The adsorption isotherm of Pd(Ⅱ) on D201 resin was determined and the equilibrium data fitted the Langmuir model better than the Freundlich model. The maximum uptake capacity of Pd(Ⅱ) was 253 mg·g-1 at 298 K. The adsorption could be best described by the liquid film diffusion model. The enthalpy variation (ΔH) and entropy change (ΔS) of adsorption were equal to 2.49 kJ·mol-1 and 74.8 J·(mol·K)-1 respectively, indicating that the adsorption was endothermic in nature. Furthermore, the negative value of ΔG showed that movement of adsorbate from the solution to adsorbent surface was a spontaneous process. Pd(Ⅱ) could be eluted with 0.5 mol·L-1 HNO 3 solution. Thomas model was applied to experimental column data to determine the characteristic parameters of the column useful for process design. | XIONG Chunhua ZHU Shan YAO Caiping CHEN Qing | 2011 | Rare Metals2011，30，5： | 6 |
| 14 | Flexible smart sensing skin for“Fly-by-Feel”morphing aircraft显示文摘Flexible smart sensing skin is a key enabling technology for the future'Fly-by-Feel'control of morphing aircraft.It represents the next-generation skin of aircraft that can exhibit a more powerful sensing function than a conventional one and could be mounted on arbitrary curvilinear surfaces,especially for advanced autonomic,morphing aircraft.Recent significant technical advances in flexible electronics have overcome many historic drawbacks of conventional smart skin,e.g.,only a limited number of discrete block sensors can be integrated due to the inevitable structural damage and heavy guidelines.Herein,we review the key developments in flexible sensors technology and highlight both the state-of-the-art devices and the potential applications for the measurement of aircraft.We begin with the importance of flexible smart skin for morphing aircraft and then expand to the latest progress in various types of flexible sensors.Then we highlight flexible sensors as smart skin to measure aerodynamic parameters and monitor the structural health,and further to achieve the Fly-by-Feel control.Finally,the challenges and opportunities on flexible smart sensing skin are discussed,from the functional design to practical applications. | HUANG YongAn ZHU Chen XIONG WenNan WANG Yu JIANG YongGang QIU Lei GUO DongLiang HOU Chao JIANG Shan YANG ZhaoXi WANG Bo WANG Lu YIN ZhouPing | 2022 | Science China(Technological Sciences)2022，65，1： | 6 |
| 15 | Development of Novel Cytoplasmic Male Sterile Source from Dongxiang Wild Rice(Oryza rufipogon)显示文摘This study was conducted to develop and characterize a novel cytoplasmic male sterile(CMS)source which was identified from Dongxiang wild rice(Oryza rufipogon)by crossing Dongxiang wild rice as female with Zhongzao 35,an indica inbred variety,as male and continuous backcrossing with Zhongzao 35.Observation under optical microscope manifested that this novel CMS belonged to typical abortion type with less pollen compared with wild abortive type cytoplasm(CMS-WA).Sequential planting showed that this novel CMS has complete and stable male sterility.Testcross experiment showed that all the 24 tested materials including maintainer and restorer lines of CMS-WA and Honglian type cytoplasm(CMS-HL)and other indica inbred varieties are the maintainers with complete maintaining ability,suggesting that this novel CMS has fertility restoration totally different from CMS-WA and CMS-HL and belongs to a novel type of CMS.So far,we only discovered a unique fertility restoration source for this novel CMS.Inheritance analysis showed that the fertility restoration of this CMS was governed by three pairs of independent dominant genes.Prospect for application of this novel CMS system in hybrid rice breeding was also discussed. | SHEN Xian-hua YAN Song HUANG Ren-liang ZHU Shan XIONG Hong-liang SHEN Lin-jun | 2013 | Rice science2013，20，5： | 5 |
| 16 | Modeling of co- and post-seismic surface deformation and gravity changes of M W 6.9 Yushu, Qinghai,earthquake显示文摘Based on the elastic dislocation theory, multilayered crustal model, and rupture model obtained by seismic waveform inversion, we calculated the coand post-seismic surface deformation and gravity changes caused by the Yushu M W 6.9 earthquake occurred on April 14, 2010. The observed GPS velocity field and gravity field in Yushu areas are disturbed by the coand post-seismic effects induced by Yushu earthquake, thus the theoretical coand post-seismic deformation and gravity changes will provide important modification for the background tectonic movement of Yushu and surrounding regions. The time relaxation results show that the influences of Yushu earthquake on Yushu and surrounding areas will last as long as 30 to 50 years. The maximum horizontal displacement, vertical uplift and settlement are about 1.96, 0.27 and 0.16 m, respectively, the maximal positive and negative value of gravity changes are 8.892×10-7 m·s-2 and -4.861×10-7 m·s-2 , respectively. Significant spatial variations can be found on the coand post-seismic effects: The co-seismic effect mainly concentrates in the region near the rupture fault, while viscoelastic relaxation mostly acts on the far field. Therefore, when using the geodetic data to research tectonic motion, we should not only consider the effect of co-seismic caused by earthquake, but also pay attention to the effect of viscoelastic relaxation. | Chengli Liu Bin Shan Yong Zheng Ying Jiang Xiong Xiong | 2011 | Earthquake Science2011，24，2： | 5 |
| 17 | Prevalence, risk factors, and survival associated with pulmonary hypertension and heart failure among patients with underlying coronary artery disease: a national prospective, multicenter registry study in China显示文摘Background: Coronary artery disease (CAD) is the commonest cause of heart failure (HF), whereas pulmonary hypertension (PH) has not been established or reported in this patient population. Therefore, we assessed the prevalence, risk factors, and survival in CAD-associated HF (CAD-HF) complicated with PH.Methods: Symptomatic CAD-HF patients were continuously enrolled in this prospective, multicenter registry study. Echocardiography, coronary arteriography, left and right heart catheterization (RHC), and other baseline clinical data were recorded. Patients were followed up and their survival was recorded.Results: One hundred and eighty-two CAD-HF patients were enrolled, including 142 with HF with a preserved ejection fraction (heart failure with preserved ejection fraction [HFpEF];left ventricular ejection fraction [LVEF] ≥50%) and 40 with a reduced ejection fraction (heart failure with reduced ejection fraction [HFrEF];LVEF < 50%). PH was diagnosed with RHC in 77.5% of patients. Patients with PH showed worse hemodynamic parameters and higher mortality. HFrEF-PH patients had worse survival than HFpEF-PH patients. CAD-HF patients with an enlarged left ventricular end-diastolic diameter and reduced hemoglobin were at higher risk of PH. Nitrate treatment reduced the risk of PH. Elevated creatinine and mean pulmonary arterial pressure (mPAP), diastolic pressure gradient (DPG) ≥7 mmHg, and previous myocardial infarction (MI) entailed a higher risk of mortality in CAD-HF patients with PH.Conclusions: PH is common in CAD-HF and worsens the hemodynamics and survival in these patients. Left ventricle enlargement and anemia increase the risk of PH in CAD-HF. Patients may benefit from nitrate medications. Renal impairment, elevated mPAP, DPG ≥7 mmHg, and previous MI are strong predictors of mortality in CAD-HF-PH patients.Trial Registration: ClinicalTrials.gov, NCT02164526. | Li Huang Lingpin Pang Qing Gu Tao Yang Wen Li Ruilin Quan Weiqing Su Weifeng Wu Fangming Tang Xiulong Zhu Jieyan Shen Jingzhi Sun Guangliang Shan Changming Xiong Shian Huang Jianguo He | 2022 | Chinese Medical Journal2022，，15： | 4 |
| 18 | Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients显示文摘AIM:To investigate the association of serum gammaglutamyl transferase(GGT) levels with chronic hepatitis B infection and hepatitis B e antigen(HBe Ag) seroconversion.METHODS:A retrospective study was performed on clinical data collected from patients who had been positive for hepatitis B surface antigen for > 6 mo and who were antiviral-treatment na?ve(n = 215) attending the Hepatitis Clinic at Nanjing Drum Tower Hospital between August 2010 and December 2013. Healthy individuals without liver disease(n = 83) were included as controls. Patients were categorized into four groups based on disease status as recommended by the European Association for the Study of the Liver:immune tolerance(IT; n = 47),HBe Ag-positive hepatitis(EPH; n = 93),HBe Ag-negative hepatitis(ENH;n = 20),and inactive carrier(IC; n = 55). Prediction of complete response(CR) based on serum GGT was also examined in EPH patients(n = 33) treated for 48 wk with nucleos(t)ide analogue(NA) therapy,including lamivudine plus adefovir combination therapy(n = 20) or entecavir monotherapy(n = 13). CR was defined as a serum hepatitis B virus DNA level < 500 copies/m L and HBe Ag seroconversion by 48 wk of treatment. RESULTS:Serum GGT levels were significantly increased in EPH and ENH patients relative to the IT,IC,and healthy control groups(P < 0.01 for all). However,no significant difference in serum GGT levels was found between the EPH and ENH groups. Baseline serum GGT levels were significantly higher in patients who achieved CR(7/33; 21.2%) compared to patients in the non-CR group(26/33; 78.8%; P = 0.011). In addition,the decline in serum GGT was greater in CR patients compared to non-CR patients after 24 wk and 48 wk of treatment(P = 0.012 and P = 0.008,respectively). The receiver operating characteristic curve yielded a sensitivity of 85.71% and a specificity of 61.54% at a threshold value of 0.89 times the upper limit of normal for baseline serum GGT in the prediction of CR following NA therapy. CONCLUSION:Serum GGT is significantly elevated in EPH and ENH patients and is a potential biomarker for the prediction of HBe Ag seroconversion following NA therapy. | Rui Huang Chen-Chen Yang Yong Liu Juan Xia Ran Su Ya-Li Xiong Gui-Yang Wang Zhen-Hua Sun Xiao-Min Yan Shan Lu Chao Wu | 2015 | World Journal of Gastroenterology2015，21，34： | 4 |
| 19 | Bio-regeneration of π-complexation desulfurization adsorbents显示文摘The coupling of adsorption desulfurization and biodesulfurization is a new approach to produce clean fuels. Sulfur compounds are firstly adsorbed on adsorbents, and then the ad-sorbents are regenerated by microbial conversion. p-Complexation adsorbent, Cu(I)-Y, was ob-tained by ion exchanging Y-type zeolite with Cu2+ and then by auto-reduction in helium at 450℃ for 3 h. Dibenzothiophene (DBT) was used as a model compound. The effects of cell concentra-tion, volume of oil phase, the ratio of aqueous phase to adsorbent on DBT desorption by a bac-terium were studied. The amounts of DBT desorbed and 2-HBP produced can be apparently increased with addition of n-octane. BDS activity can be improved by increasing cell concentra-tion and the ratio of water-to-adsorbent. 89% of DBT desorbed from the adsorbents can be converted to 2-HBP within 6 h and almost 100% within 24 h, when the volume ratio of oil-to-water was 1/5 mL/mL, the cell concentration was 60 g·L?1, and the ratio of adsorbent-to-oil was 0.03 g·mL?1. The amount of 2-HBP produced was strongly dependent on the volume ratio of oil-to- water, cell concentration and amount of adsorbent. Adsorption capacity of the regenerated ad-sorbent is 95% that of the fresh one after being desorbed with Pseudomonas delafieldii R-8, washed with n-octane, dried at 100℃ for 24 h and auto-reduced in He. | LI Wangliang1,2, XING Jianmin1, XIONG Xiaochao1,2, SHAN Guobin1,2 & LIU Huizhou1 1. Laboratory of Separation Science and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China 2. Graduate School of the Chinese Academy of Sciences,Beijing 100039, China | 2005 | Science China Chemistry2005，48，6： | 4 |
| 20 | A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modules显示文摘ABSTRACTSingle 粒子分析,能从千被认为是信号的一般水准或弄平百万粒子设计,是一个有效方法学习生物大分子的三维的结构。在单个粒子分析的一个内在的假设是所有分析粒子必须有相同作文和符合构造。因此,在作文或符合构造的标本异质为高分辨率的分析提起了大挑战。为有多重符合构造的粒子,不精密的排列和取向参数愿望与减少的分辨率和涂的密度产出一张平均地图。除广泛的分类途径以外,这里在平衡附近基于 macromolecular 建筑群由取向和位置在其亲戚的多重僵硬模块组成的假设轻视变化,我们建议一个新方法作为本地优化精炼打电话到地址为一个改进决定的这 conformational 异质。关键想法是优化每个僵硬模块的取向和移动参数然后重建他们的三维的结构个别地。用有相对变化在之间的 80S/70S 核糖体的模仿的数据大(60S/50S ) 并且小(40S/30S ) 子单元,我们测试了这个算法并且发现两个子单元的分辨率显著地被改进。我们的方法为 macromolecular 建筑群的高分辨率的单个粒子分析向一个 proof-of-principle 答案提供动态符合构造。 | Hong Shan Zihao wang Fa Zhang Yong Xiong Chang-Cheng Yin Fei Sun | 2016 | Protein & Cell2016，7，1： | 4 |
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