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| 1 | High adsorption of Cd(Ⅱ)by modification of synthetic zeolites Y,A and mordenite with thiourea显示文摘Zeolites Y,A and mordenite(ZY,ZA and ZM)were obtained from diatomite in a template-free system,and the products were modified by thiourea(TU).Characterization studies results indicated that the TU molecules were loaded onto the exterior surfaces of the synthetic zeolites as well as the channels.Elemental analysis and energy-dispersive X-ray spectrometer proved that the TU molecules loaded on to ZA were more than ZY and ZM.Removal of Cd(Ⅱ)was investigated,and itwas found that themodified zeolites have higher removal capacity,modified ZA is especially noticeable.In the adsorption experiments,the effects of various parameters such as sorbent content,contact time,concentration of cadmium solution,pH,selectivity and regeneration were discussed.At the best removal efficiency by modified zeolites,the maximum adsorption capacity is 94.3 mg·g^−1,103.2 mg·g^−1 and 89.7 mg·g^−1 at 25℃,respectively.The sorbents show good efficiency for the removal of Cd(Ⅱ)in the presence of different multivalent cations and have good regeneration effect.For the modified samples,removal experiments take place via ion exchange and complexation processes. | Shaoqing Zhang Tianming Lv Yang Mu Jiqi Zheng Changgong Meng | 2020 | Chinese Journal of Chemical Engineering2020，28，12： | 5 |
| 2 | The HuaBiao project:whole-exome sequencing of 5000 Han Chinese individuals显示文摘Next-generation sequencing technologies have significantly accelerated the identification of disease-causing mutations and facilitated the emergence of personalized medicine(Genomes Project Consortium et al.,2015;Goodwin et al.,2016;Sirugo et al.,2019).In comparison with whole-genome sequencing,whole-exome sequencing(WES),which covers the coding regions of the genome,offers a cost-efficacy balance.WES provides deeper sequencing depth(>100)and allows the more accurate detection of rare variants that are tailored for clinical applications(Lek et al.,2016). | Meng Hao Weilin Pu Yi Li Shaoqing Wen Chang Sun Yanyun Ma Hongxiang Zheng Xingdong Chen Jingze Tan Guoqing Zhang Menghan Zhang Shuhua Xu Yi Wang Hui Li Jiucun Wang Li Jin | 2021 | Journal of Genetics and Genomics2021，48，11： | 2 |
| 3 | Triggering the biocontrol of Botrytis cinerea by Trichoderma harzianum through inhibition of pathogenicity and virulence related proteins显示文摘This study reports a strain of Trichoderma harzianum CCTCC-SBW0162 with potential to enhance biocontrol activity against gray mold pathogen, Botrytis cinerea, and with a pivotal role in tomato(Solanum esculentum) plant growth enhancement. A total of 254 Trichoderma isolates were screened by in vitro antagonistic assay. Of these, 10 were selected for greenhouse experiments based on their greater inhibition of B. cinerea.The in vitro antagonistic assay and greenhouse experiments indicated that T. harzianum CCTCC-SBW0162 gave the highest inhibition rate(90.6%) and disease reduction(80.7%). Also, to study the possible mechanism associated with antifungal activity of CCTCC-SBW0162 against B. cinerea, molecular docking was used to assess the interactions between CCTCC-SBW0162-derived metabolites, and pathogencity and virulence related proteins of B. cinerea. The molecular docking results indicated that the combination of harzianopyridone,harzianolide and anthraquinone C derived from CCTCCSBW0162 could synergistically improve antifungal activity against B. cinerea through the inhibition/modification of pathogenicity and virulence related proteins.However, this computerized modeling work emphasized the need for further study in the laboratory to confirm the effect T. harzianum-derived metabolites against the proteins of B. cinerea and their interactions. | Kandasamy SARAVANAKUMAR Zhixiang LU Hai XIA Meng WANG Jianan SUN Shaoqing WANG Qiang-qiang WANG Yaqian LI Jie CHEN | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 1 |
| 4 | Preparation and Osteogenic Efficacy of Emodin-loaded Hydroxyapatite Electrospun Fibers显示文摘Biological scaffolds have been the focus of bone tissue engineering research in recent years. In this paper, emodin (EM), macromolecular compound polycaprolactone (PCL), and hydroxyapatite (HA) were used as raw materials to prepare EM/PCL/HA fibers containing different EM ratios by electrospinning, and the properties and osteogenic efficacy of EM/PCL/HA were studied. Scanning electron microscopy, transmission electron microscopy, and atomic force microscopy were used to characterize the structures of HA and the electrospun fibers. Results showed that HA has high crystallinity and loose porous structure, and the electrospun fibers have a smooth and flat surface. In vitro release results showed that EM was slowly released from EM/PCL/HA within 216 h. Cell proliferation assay in mouse embryonic osteoblast precursor cells (MC3T3-E1) exhibited that 5% EM/PCL/HA had the best effect on promoting cell proliferation. Alkaline phosphatase (ALP) and mineralized nodules staining results also showed that 5% EM/PCL/HA had the best effect on promoting osteogenic differentiation. qRT-PCR results showed that the mRNA expression level of osteoblast differentiation markers, namely, bone morphogenetic protein (BMP)-2, BMP-9, and osteocalcin were significantly upregulated by 5% EM/PCL/HA treatment. These results indicate that EM/PCL/HA is a potential osteogenic material, which can provide a reference for the development of bone injury repair materials. | Yiwen Pan Mu He Shaoqing Chen Yanyan Meng Cheli Wang Xinye Ni | 2023 | Journal of Bionic Engineering2023，20，3： | 1 |
| 5 | Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and C0X2显示文摘Dear Editor,Pathological neo-vascularization is a hallmark of cancer and several diseases.Accumulating evidence supports the notion that antiangiogenic treatment can abolish tumor angiogenesis to achieve Ion ger disease-free survival.Although growth factors and their receptors function as the main drivers in angiogenesis,the involvement of other regulators,e.g.,Cyclooxygenase-2(COX2),^(1) should also be con sidered,especially for managi ng the resista nee to therapies against receptor tyrosine kinases(RTKs). | Shanmei Chen Junnan Feng Chuanke Zhao Lixin Wang Lin Meng Caiyun Liu Shaoqing Cai Yanxing Jia Like Qu Chengchao Shou | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 6 | Core activated sludge communities are influenced little by immigration:Case study of a membrane bioreactor plant显示文摘Microbial immigrants arriving with influent wastewater may influence activated sludge(AS)ecosystems.However,the extent to which immigration impacts AS communities is still debated.To explore the intensity of immigration impact,we used sequencing technology to track the raw wastewater and AS communities from a membrane bioreactor plant over a 12-month period.We first distinguished core populations from peripheral ones in both raw wastewater and AS based on their occurrence frequency and abundance.The results showed that core OTUs(≥80%occurrence frequency)made up a large fraction(>90%)of total sequences,while peripheral OTUs composed the majority of all detected OTUs but merely occupied a few sequences.A significant difference in core communities between the influent and AS was found,as well as between the compositions of core and peripheral populations.Additionally,the persistent functional bacteria of AS,although not numerically dominant,accounted for 96.24%of the total sequences related to nutrient turnover,suggesting the presence of a small number of longstanding and core functional bacteria in the AS ecosystem.Importantly,64%of the 5188 OTUs in AS,which accounted for 91.51%of the sequences,exhibited positive growth rates,which suggested that their apparent abundances were due to growth within the plant,not from immigration.Taken together,these results demonstrated that the impact of influent populations on core AS communities was limited.Overall,this work provides quantitative insights into the impact of immigration,which is expected to advance our understanding of the AS community assembly. | Shaoqing Zhang Fangang Meng | 2021 | Journal of Environmental Sciences2021，33，4： | 0 |
| 7 | Structure-based development of potent and selective type-II kinase inhibitors of RIPK1显示文摘Receptor-interacting serine/threonine-protein kinase 1(RIPK1)functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases.A number of allosteric RIPK1 inhibitors(RIPK1i)have been developed,and some of them have already advanced into clinical evaluation.Recently,selective RIPK1i that interact with both the allosteric pocket and the ATP-binding site of RIPK1 have started to emerge.Here,we report the rational development of a new series of type-II RIPK1i based on the rediscovery of a reported but mechanistically atypical RIPK3i.We also describe the structure-guided lead optimization of a potent,selective,and orally bioavailable RIPK1i,62,which exhibits extraordinary efficacies in mouse models of acute or chronic inflammatory diseases.Collectively,62 provides a useful tool for evaluating RIPK1 in animal disease models and a promising lead for further drug development. | Ying Qin Dekang Li Chunting Qi Huaijiang Xiang Huyan Meng Jingli Liu Shaoqing Zhou Xinyu Gong Ying Li Guifang Xu Rui Zu Hang Xie Yechun Xu Gang Xu Zheng Zhang Shi Chen Lifeng Pan Ying Li Li Tan | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 8 | An Intelligent Data Routing Scheme for Multi-UAV Avionics System Based on Integrated Communication Effectiveness显示文摘The rapid development of information technology promotes the transformation and development of future air combat,frommechanization to informatization,intelligence,and multiplatform integration.For the multiplatform avionics system in the unmanned aerial vehicle(UAV)-based network,we aim to address the data routing and sharing issues and propose an integrated communication effectiveness metric.The proposed integrated communication effectiveness is a hierarchical metric consisting of link effectiveness,node effectiveness,and data effectiveness.The link quality,link stability,node honesty,node ability,and data value are concurrently taken into account.We give the normal mathematical expression for the integrated communication effectiveness.We propose a hop-by-hop routing scheme based on a Q-learning algorithm considering the proposed effectiveness metric.Simulation results demonstrate that the proposed scheme is able to find the most efficient routing in the UAV network. | Yan Zou Meng Wu Shaoqing Zhang Feiyan Li Jiarun Chen Yazhuo Wang Chuan Lin Guangjie Han | 2022 | 国际计算机前沿大会会议论文集2022，，2： | 0 |
| 9 | “Form”and“Ideographic”Construct the Era of Architectural Features显示文摘With the progress of human society,the development of architectural features is also very fast.The research on the era of building features under the construction of“table shape”and“ideology”has received great attention.The form of architectural features is accumulated over many years,and the accumulated experience is not available in other ways.The transformation of form and meaning is relative.According to the different architectural structures obtained from the macroscopic and microscopic differences,a unique architectural feature is formed.The simple algorithm is used to construct the system model of the building characteristics of the era of Linyi in order to better analyze,in order to improve our country’s architectural influence. | Yujia Niu Shaoqing Meng Nini Zhang | 2020 | Journal of World Architecture2020，4，5： | 0 |
| 10 | Tank-dependence of the functionality and network differentiation of activated sludge community in a full-scale anaerobic/anoxic/aerobic municipal sewage treatment plant显示文摘Understanding the structures and dynamics of bacterial communities in activated sludge(AS)in full-scale wastewater treatment plants(WWTPs)is of both engineering and ecological significance.Previous investigations have mainly focused on the AS communities of WWTP aeration tanks,and the differences and interactions between the communities in anaerobic and anoxic tanks of the AS system remain poorly understood.Here,we investigated the structures of bacterial communities and their inter-connections in three tanks(anaerobic,anoxic,and aerobic)and influent from a full-scale WWTP with conventional anaerobic/anoxic/aerobic(A/A/O)process over a year to explore their functionality and network differentiation.High-throughput sequencing showed that community compositions did not differ appreciably between the different tanks,likely due to the continuous sludge community interchange between tanks.However,network analysis showed significant differences in inter-species relationships,OTU topological roles,and keystone populations in the different AS communities.Moreover,the anoxic network is expected to be more unstable and easily affected by environmental disturbance.Tank-associated environmental factors,including dissolved oxygen,pH,and nutrients,were found to affect the relative abundance of functional genera(i.e.,AOB,NOB,PAOs,and denitrifiers),suggesting that these groups were more susceptible to environmental variables than other bacteria.Therefore,this work could assist in improving our understanding of tank-associated microbial ecology,particularly the response of functional bacteria to seasonal variations in WWTPs employing A/A/O process. | Hongcan Cui Ronghua Xu Zhong Yu Yuanyuan Yao Shaoqing Zhang Fangang Meng | 2023 | Frontiers of Environmental Science & Engineering2023，17，3： | 0 |
| 11 | Developmental expression amphioxus Branchiostoma pattern of calmodulin gene in belcheri tsingtauense显示文摘我们在头索动物文昌鱼(Branchiostoma belcheri tsingtauense ) 调查了 AmphiCaM 的发展表示模式。我们有教养并且在不同发展阶段(鸡蛋和幼虫) 取样了动物,并且在原处使用了杂交并且在 AmphiCaM 记录空间、时间的变化的北弄污表示。滋养的道从迟了的神经轴胚阶段统治发展到成年阶段。AmphiCaM 表示在迟了的神经轴胚阶段期间在滋养的道显著地增加了并且仍然保持在成年人提高了。我们的结果显示 AmphiCaM 在文昌鱼涉及滋养的道的区别;并且而且,在进化期间在凸轮基因的功能提供卓见进变化。 | LUAN Jing GENG Jinpei FANG Shaoqing SU Zhiping ZHANGJingxuan XU Hongyan WANGYing LUMin YIN Weili MENG Guangxiao | 2010 | Chinese Journal of Oceanology and Limnology2010，28，6： | 0 |
| 12 | Novel QTLs from Wild Rice Oryza longistaminata Confer Strong Tolerance to High Temperature at Seedling Stage显示文摘Global warming poses a threat to rice production.Breeding heat-tolerant rice is an effective and economical approach to address this challenge.African rice is a valuable genetic resource for developing heat-tolerant crops due to its intricate mechanism for adapting to high temperatures.Oryza longistaminata,a widely distributed wild rice species in Africa,may harbor an even richer gene pool for heat tolerance,which remains untapped.In this study,we identified three heat tolerance QTLs from O.longistaminata at the seedling stage,including novel heat tolerance loci qTT4 and qTT5.Our findings demonstrated that the O.longistaminata alleles for these two QTLs can enhance the heat tolerance of rice seedlings.Remarkably,qTT5 was mapped to a region spanning approximately 287.2 kb,which contains 46 expressing genes.Through the analysis of Gene Ontology and expression differences under heat induction,we identified four candidate genes.Our results lay the foundation for discovering heat tolerance genes underlying O.longistaminata and developing new genetic resources for heat-tolerant rice breeding. | FAN Fengfeng CAI Meng LUO Xiong LIU Manman YUAN Huanran CHENG Mingxing Ayaz AHMAD LI Nengwu LI Shaoqing | 2023 | Rice science2023，30，6： | 0 |
| 13 | A Study on Informatization Teaching Efficacy in Higher Vocational Education in Guangzhou,China显示文摘China has been vigorously promoting the construction and development of Informatization teaching efficacy education.Informatization teaching efficacy was used as an indicator of the psychological state of teachers.This article analyzes relevant literature at home and abroad and determines the five dimensions that affect teachers’informatization teaching efficacy in informatization teaching. | Shaoqing Meng P.C.Lai | 2023 | Journal of Architectural Research and Development2023，7，6： | 0 |
| 14 | Correction: Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2显示文摘Correction to:Signal Transduction and Targeted Therapy http://gffzzd3cc09b8251d45dfsbbf0cc0nwxwu6w5f.ffgz.tsg.suse.edu.cn/10.1038/s41392-021-00739-5,published online 03 December 2021 After online publication of the letter1,the author found two images in the supplement materials were used incorrectly,Additionally,there is an error in the chemical structure of Aiphanol in Figs.1a and 1s that needs to be corrected.The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected. | Shanmei Chen Junnan Feng Chuanke Zhao Lixin Wang Lin Meng Caiyun Liu Shaoqing Cai Yanxing Jia Like Qu Chengchao Shou | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
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