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| 1 | The Inhibitory Effect of Oridonin on the Growth of Fifteen Human Cancer Cell Lines显示文摘OBJECTIVE To study the inhibitory effect of oridonin on the growth of cancer cells. METHODS Fifteen human cancer cell lines were subjected to various concentrations of oridonin in culture medium. The inhibitory rate of cell growth was measured by the MTT assay, and compared with a negative con- trol and 5-Fu-positive control. RESULTS The 50% inhibiting concentration (IC50) and maximal inhibition (Imax) of oridonin shown by studying the growth of the cancer cell lines were as follows: leukemias (HL60 cells: 3.9 μg/ml and 73.8%, K562 cells: 4.3 μg/ml and 76.2%); esophageal cancers(SHEEC cells: 15.4 μg/ml and 99.2%, Eca109 cells: 15.1 μg/ml and 84.6%, TE1 cells: 4.0 μg/ml and 70.2%); gastric cancers (BGC823 cells: 7.6 μg/ml and 98.7%, SGC7901 cells: 12.3 μg/ml and 85.7%); colon cancers (HT29 cells: 13.6 μg/ml and 97.2%, HCT cells: 14.5 μg/ml and 96.5%); liver cancers (Bel7402 cells: 15.2 μg/ml and 89.2%, HepG2 cells: 7.1 μg/ml and 88.3%); pancreatic cancer (PC3 cells: 11.3 μg/ml and 68.4%); lung cancer (A549 cells: 18.6 μg/ml and 98.0% ); breast cancer (MCF7 cells: 18.4 μg/ml and 84.7%); uterine cervix cancer (Hela cells: 13.7 μg/ml and 98.5%). CONCLUSION Oridonin had a relatively wide anti-tumor spectrum, and a relatively strong inhibitory effect on the growth of the 15 human cancer cells. Inhibitory effects were concentration dependent. | Junhui Chen Shaobin Wang Dongyang Chen Guisheng Chang Qingfeng Xin Shoujun Yuan Zhongying Shen | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 32 |
| 2 | Holocene vegetational and climatic variation in westerly-dominated areas of Central Asia inferred from the Sayram Lake in northern Xinjiang,China显示文摘Changes in the vegetation and climate of the westerly-dominated areas in Central Asia during the Holocene were interpreted using pollen-assemblages and charcoal data from a 300-cm-long sediment core of the Sayram Lake,northern Xinjiang.Accele-rator Mass Spectrometry(AMS) radiocarbon dating methods were applied to bulk organic matter of the samples.Artemisia spp./Chenopodiaceae ratios and results from principal component analysis were used to infer that the lake basin was dominated by desert vegetation before ca.9.6 cal.ka BP,which suggests a warm and dry climate in the early Holocene.Desert steppe/steppe expanded during 9.6-5.5 cal.ka BP,indicating a remarkable increase both in the precipitation and temperature during the mid-Holocene.Desert vegetation dominated between 6.5 and 5.5 cal.ka BP,marking an extreme warmer and drier interval.The steppe/meadow steppe recovered,and temperatures decreased from 5.5 cal.ka BP in the late Holocene,as indicated by the increased abundance of Artemisia and the development of meadows.Holocene temperatures and moisture variations in the Sayram Lake areas were similar to those of adjacent areas.This consistency implies that solar radiation was the main driving factor for regional temperature changes,and that the effect of temperature variations was significant on regional changes in humidity.The evolution of climate and environment in the Sayram Lake areas,which were characterized as dry in the early Holocene and relatively humid in the middle-late Holocene,are clearly different from those in monsoonal areas.Dry conditions in the early Holocene in the Sayram Lake areas were closely related to decreased water vapor advection.These conditions were a result of reduced westerly wind speeds and less evaporation upstream,which in turn were caused by seasonal changes in solar radiation superimposed by strong evaporation following warming and drying local climate. | JIANG QingFeng JI JunFeng SHEN Ji Ryo MATSUMOTO TONG GuoBang QIAN Peng REN XueMei YAN DeZhi | 2013 | Science China Earth Sciences2013，56，3： | 32 |
| 3 | A high-resolution climatic change since Holocene inferred from multi-proxy of lake sediment in westerly area of China显示文摘Multi-proxy data are presented and a discuss is made of paleoclimatic and paleoenvironmental changes during Holocene from a 225-cm-long sediment core from Wulungu Lake, located in westerly area of China. The chronology is constructed from six AMS radiocarbon dates on the bulk organic matter. Analyses of pollen, TOC, TN, δ 13Corg, ostracod assemblages and the shell stable isotopes, suggest Holocene climate pattern as follows: temperate and dry (10.0―7.6 cal. ka BP)-warm and wet (7.6―5.3 cal. ka BP) -warm and moist (5.3―3.6 cal. ka BP) -temperate and dry (3.6―2.1 cal. ka BP)-temperate and moist (2.1―1.3 cal. ka BP) -cool and dry (1.3 cal. ka BP―present). With the climatic change, Wulungu Lake experienced two large-scale retreat (5.3―3.6 cal. ka BP and 1.3 cal. ka BP―present) and an obvious transgression (7.6―5.3 cal. ka BP). The records of climatic and environmental evolution of Wulungu Lake were in good accordance with those of adjacent areas. It responded to regional environmental change, global abrupt climate events and followed the westerly climate change mode. | JIANG QingFeng SHEN Ji LIU XingQi ZHANG EnLou XIAO XiaYun | 2007 | Chinese Science Bulletin2007，52，14： | 28 |
| 4 | Effect of chronic corticosterone-induced depression on circadian rhythms and age-related phenotypes in mice显示文摘Disrupted circadian rhythms are a recognized effect of depression,and our previous article demonstrated an association between depression and premature aging,but the underlying mechanisms are not well understood.In the present study,we used a mouse model of chronic corticosterone (CORT)-treated depression to elucidate a mechanism by which depression may be associated with the circadian clock and mediate age-related phenotypes.Mice received a daily injection of 20 mg/kg CORT for 21 consecutive days,and the depression-like behaviors of mice were identified by the sucrose intake test,tail suspension test and open field test.Our findings indicated that CORT injection may be correlatedwith the circadian clock by impairing circadian rhythms or shifting the phase values of clock genes.We also showed that CORT-treated mice exhibited a significant gradual reduction in body weight gain with increased oxidative stress, including reduced activity of antioxidant-related enzymes,reduced glutathione:glutathione disulfide ratio and cytochrome (Cyt)-C level,and elevated reactive oxygen species content.Moreover, chronic CORT injection affected inflammatory responses,the production of mitochondrial ATP and telomere shortening,which may be associated with the Sirtuin 3 (SIRT3)signaling pathway. Additionally,chronic CORT injection disrupted the circadian rhythms of some indexes of aging phenotypes and altered the phase values of these indexes.Our findings suggest that psychologically stressful conditions such as depression are linked to changes in circadian rhythms and agerelated phenotypes. | Lingyan iVla Qichen Shen Song Yang Xiaoxian Xie Qingfeng Xiao Chuanan Yu Lisha Cao Zhengwei Fu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 4 |
| 5 | Ordered mesoporous NiFe_2O_4 with ultrathin framework for low-ppb toluene sensing显示文摘Highly sensitive and selective detection against specific target gases,especially at low-ppb(part per billion)level,remain a great number of challenges in gas sensor applications.In this paper,we first present an ordered mesoporous NiFe_2O_4 for highly sensitive and selective detection against low-ppb toluene.A series of mesoporous NiFe_2O_4 materials were synthesized by templating from mesoporous silica KIT-6 and its framework thickness was reduced from 8.5 to 5 nm by varying the pore size of KIT-6 from 9.4 to 5.6 nm,accompanied with the increase of the specific surface area from 134 to 216 m^2g^(-1).The ordered mesoporous NiFe_2O_4 with both ultrathin framework of 5 nm and large specific surface area of up to 216 m^2g^(-1)exhibits a highest response(R_(gas)/R_(air)-1=77.3)toward 1,000 ppb toluene at 230℃ and is nearly 7.3 and 76.7 times higher than those for the NiFe_2O_4 replica with thick framework and its bulk counterpart respectively,which also possesses a quite low limit of detection(<2 ppb),and good selectivity. | Xiaoyong Lai Kun Cao Guoxin Shen Ping Xue Dan Wang Fang Hu Jianli Zhang Qingfeng Yang Xiaozhong Wang | 2018 | Science Bulletin2018，63，3： | 3 |
| 6 | Fifty years of Quaternary palynology in the Tibetan Plateau显示文摘Quaternary palynology in the Tibetan Plateau(TP)was initiated in the 1960s to meet the needs of economic development in western China.Pollen analysis was conducted for the first time on a 200-m long core of Quaternary lacustrine sediments taken from the main body of the TP in order to study pollen assemblages as well as vegetation and climate changes of glacial(cold)/interglacial(warm)periods.Pollen analysis of alpine snow and ice began at the first scientific expedition to the TP in the 1970s.After the 1980s,a series of international collaborative programs were carried out under Sino-French,Sino-German,Sino-Australian,and Sino-American cooperation,marking the integration of Chinese Quaternary palynology society with the international community.New methods for Quaternary palynology were gradually promoted and applied,changing the vegetational and climatic interpretation of Quaternary palynology from qualitative to quantitative.Since the 1990s,many palynologists have carried out extensive Quaternary palynological studies on fossil pollen sites of more than 60 lakes/sections and alpine glaciers in the TP to discuss the spatiotemporal vegetation changes and climatic and environmental evolution of the TP since the Pleistocene.Over the past half-century,Quaternary palynology in the TP has contributed to the establishment of the Chinese Quaternary pollen database and the study of vegetation and climate evolution since the Last Glacial Maximum(LGM)in the TP.Currently available pollen records revealed the spatial and temporal distribution of vegetation in the TP since the LGM,exhibiting expansions and shrinkages of forest,meadow,grassland and desert in different periods such as the LGM,the last deglaciation,and Holocene optimum period.The paleomonsoon reflected by paleovegetation since the LGM has undergone the changes of weak-strengthening-strong-weakening but still active-shrinking,which is mainly affected by solar insolation. | Lingyu TANG Caiming SHEN Houyuan LU Chuanhai LI Qingfeng MA | 2021 | Science China Earth Sciences2021，64，11： | 3 |
| 7 | Fusion hindrance in the neck evolution of symmetric nuclear reactions显示文摘Fusion hindrance in the radial degree of freedom for massive nuclear reactions is known for a long time. However the present work shows that the fusion hindrance also exists in the neck evolution. We calculate the potential at different distances and different neck parameters by the two-center liquid drop model and then check whether fusion hindrance exists in the neck evolution by examing the sign of slope of potential vs. the neck parameter. The area of fusion hindrance in the neck evolution is shown. | WANG XiaoLin SHEN CaiWan LI QingFeng LIU Ling | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 2 |
| 8 | The clinical feasibility and effect of online cone beam computer tomography-guided intensity-modulated radiotherapy for nasopharyngeal cancer显示文摘 | Jin Wang Sen Bai Nianyong Chen Feng Xu Xiaoqin Jiang Yan Li Qingfeng Xu Yali Shen Hong Zhang Youling Gong Renming Zhong Qingfeng Jiang | 2008 | Radiotherapy and Oncology2008，，： | 1 |
| 9 | Detection of intrafractional tumour position error in radiotherapy utilizing cone beam computed tomography显示文摘 | Feng Xu Jin Wang Sen Bai Yan Li Yali Shen Renming Zhong Xiaoqin Jiang Qingfeng Xu | 2008 | Radiotherapy and Oncology2008，，： | 1 |
| 10 | The surface fractal investigation on the carbon nanotubes modified by the adsorption of PAA显示文摘 | Hou Qingfeng Lu Xiancai Liu Xiandong Hu Baixing Shen Jian | 2005 | Surface and Coating Technology2005，190，23： | 1 |
| 11 | Pressure oxidative leaching of lead-containing copper matte显示文摘 | Bingjie JIN Xianwan YANG Qingfeng SHEN | 2009 | Hydrometallurgy2009，，96： | 1 |
| 12 | Venture Capital Cycle, Opportunities, and Challenges in China显示文摘 | Fung Hung-gay Qingfeng Liu and Xiaoqin Shen | 2004 | The Chinese Economy2004，37，4： | 1 |
| 13 | Pressure oxidative leac- hing of lead - containing copper matte 显示文摘 | Bingjie JIN Xianwan Yang Qingfeng SHEN | 2009 | Hydrometallurgy2009，96，12： | 1 |
| 14 | Investigation on fouling behaviors of low-energy surface and fouling fractal characteristics 显示文摘 | Yang Qingfeng Ding Jie Shen Ziqiu | 2000 | Chemical Engineering Science2000，55，： | 1 |
| 15 | Difficulties in probing density dependent symmetry potential with the HBT interferometry显示文摘Based on the updated UrQMD transport model,the effect of the symmetry potential energy on the two-nucleon HBT correlation is investigated with the help of the coalescence program for constructing clusters,and the CRAB analyzing program of the two-particle HBT correlation.An obvious nonlinear dependence of the neutron-proton(or neutron-neutron) HBT correlation function(Cnp,nn) at small relative momenta on the stiffness factor γ of the symmetry potential energy is found:when γ 0.8,Cnp,nn increases rapidly with increasing γ,while it starts to saturate if γ 0.8.It is also found that both the symmetry potential energy at low densities and the conditions of constructing clusters at the late stage of the whole process influence the two-nucleon HBT correlation with the same power. | LI QingFeng SHEN CaiWan | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，10： | 1 |
| 16 | Pressure oxida- tive leaching of lead - containing copper matte 显示文摘 | Bingjie Jin Xianwan Yang Qingfeng Shen | 2009 | Hy- drometallurgy2009，，96： | 1 |
| 17 | 显示文摘 | Cai Shen Liu Qingfeng Liu Qian | 2004 | Materal Letters2004，58，18： | 1 |
| 18 | Pel- letizing and alkaline leaching of powdery low grade zinc oxide ores 显示文摘 | Feng Linyong Yang Xianwan Shen Qingfeng | 2007 | Hydrometallurgy2007，89，34： | 1 |
| 19 | An investigation of ab initio shell-model interactions derived by no-core shell model显示文摘The microscopic shell-model effective interactions are mainly based on the many-body perturbation theory(MBPT), the first work of which can be traced to Brown and Kuo's first attempt in 1966, derived from the Hamada-Johnston nucleon-nucleon potential.However, the convergence of the MBPT is still unclear. On the other hand, ab initio theories, such as Green's function Monte Carlo(GFMC), no-core shell model(NCSM), and coupled-cluster theory with single and double excitations(CCSD), have made many progress in recent years. However, due to the increasing demanding of computing resources, these ab initio applications are usually limited to nuclei with mass up to A = 16. Recently, people have realized the ab initio construction of valence-space effective interactions, which is obtained through a second-time renormalization, or to be more exactly, projecting the full-manybody Hamiltonian into core, one-body, and two-body cluster parts. In this paper, we present the investigation of such ab initio shell-model interactions, by the recent derived sd-shell effective interactions based on effective J-matrix Inverse Scattering Potential(JISP) and chiral effective-field theory(EFT) through NCSM. In this work, we have seen the similarity between the ab initio shellmodel interactions and the interactions obtained by MBPT or by empirical fitting. Without the inclusion of three-body(3-bd) force,the ab initio shell-model interactions still share similar defects with the microscopic interactions by MBPT, i.e., T = 1 channel is more attractive while T = 0 channel is more repulsive than empirical interactions. The progress to include more many-body correlations and 3-bd force is still badly needed, to see whether such efforts of ab initio shell-model interactions can reach similar precision as the interactions fitted to experimental data. | XiaoBao Wang GuoXiang Dong QingFeng Li CaiWan Shen ShaoYing Yu | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，9： | 0 |
| 20 | Realizing simultaneously excellent energy storage and discharge properties in AgNbO_(3)based antiferroelectric ceramics via La^(3t)and Ta^(5+)co-substitution strategy显示文摘AgNbO_(3)based antiferroelectric(AFE)ceramics have large maximum polarization and low remanent polarization,and thus are important candidates for fabricating dielectric capacitors.However,their energy storage performances have been still large difference with those of lead-based AFEs because of their room-temperature ferrielectric(FIE)behavior.In this study,novel La^(3+)and Ta^(5+)co-substituted AgNbO_(3)ceramics are designed and developed.The introduction of La^(3+)and Ta^(5+)decreases the tolerance factor,reduces the polarizability of B-site cations and increases local structure heterogeneity of AgNbO_(3),which enhance AFE phase stability and refine polarization-electric field(PeE)loops.Besides,adding La^(3+)and Ta^(5+)into AgNbO_(3)ceramics causes the decrease of the grain sizes and the increase of the band gap,which contribute to increased Eb.As a consequence,a high recoverable energy density of 6.79 J/cm3 and large efficiency of 82.1%,which exceed those of many recently reported AgNbO_(3)based ceramics in terms of overall energy storage properties,are obtained in(Ag0.88La0.04)(Nb0.96Ta0.04)O_(3)ceramics.Furthermore,the discharge properties of the ceramic with discharge time of 16 ns and power density of 145.03 MW/cm3 outperform those of many lead-free dielectric ceramics. | Yuqi Zhou Shuaibing Gao Jie Huang Meng Shen Shenglin Jiang Yunbin He Qingfeng Zhang | 2023 | Journal of Materiomics2023，9，2： | 0 |
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