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| 1 | Dynamic Modeling and Simulation of Multi-body Systems Using the Udwadia-Kalaba Theory显示文摘Laboratory experiments were conducted for falling U-chain,but explicit analytic form of the general equations of motion was not presented.Several modeling methods were developed for fish robots,however they just focused on the whole fish's locomotion which does little favor to understand the detailed swimming behavior of fish.Udwadia-Kalaba theory is used to model these two multi-body systems and obtain explicit analytic equations of motion.For falling U-chain,the mass matrix is non-singular.Second-order constraints are used to get the constraint force and equations of motion and the numerical simulation is conducted.Simulation results show that the chain tip falls faster than the freely falling body.For fish robot,two-joint Carangiform fish robot is focused on.Quasi-steady wing theory is used to approximately calculate fluid lift force acting on the caudal fin.Based on the obtained explicit analytic equations of motion(the mass matrix is singular),propulsive characteristics of each part of the fish robot are obtained.Through these two cases of U chain and fish robot,how to use Udwadia-Kalaba equation to obtain the dynamical model is shown and the modeling methodology for multi-body systems is presented.It is also shown that Udwadia-Kalaba theory is applicable to systems whether or not their mass matrices are singular.In the whole process of applying Udwadia-Kalaba equation,Lagrangian multipliers and quasi-coordinates are not used.Udwadia-Kalaba theory is creatively applied to dynamical modeling of falling U-chain and fish robot problems and explicit analytic equations of motion are obtained. | ZHAO Han ZHEN Shengchao CHEN Ye-Hwa | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 22 |
| 2 | Whole-Genome Sequencing and Analysis of the Chinese Herbal Plant Panax notoginseng显示文摘 | Wei Chen Ling Kui Guanghui Zhang Shusheng Zhu Jing Zhang Xiao Wang Min Yang Huichuan Huang Yixiang Liu Yong Wang Yahe Li Lipin Zeng Wen Wang Xiahong He Yang Dong Shengchao Yang | 2017 | Molecular Plant2017，10，6： | 21 |
| 3 | Genome of Plant Maca (Lepidium meyenil) Illuminates Genomic Basis for High-Altitude Adaptation in the Central Andes显示文摘Maca (Lepidium meyenii Walp, 2n = 8x = 64 ) ,属于 Brassicaceae 家庭,经济植物在秘鲁(4000-4500 m ) 在中央安第斯山脉岭被栽培。认为快速中央安第斯山脉高举发生 5-10 百万年以前(妈) ,一个进化问题关于象 maca 那样的植物怎么在一个短地质的时期以内获得高高度的改编产生。这里,我们报导 maca 的高质量的染色体集会,在里面它二仔细 spaced maca 特定的整个染色体的复制(WGD;6.7 妈) 被识别。在 maca 和密切相关的 Brassicaceae 种类之间的比较 genomic 分析揭示了经由 WGD 涉及不能生活的压力反应,荷尔蒙发信号小径,和第二等的代谢物生合成的 maca 基因和基因家庭的扩大。保留和许多复制基因的随后的功能的分叉可以说明词法、生理的变化(即,小叶形状和自我富饶) 在在高高度的环境的 maca。另外,一些复制 maca 基因在词法改编与功能被识别(即,叶卷应答) 并且不能生活的压力反应(即, GLYCINE 富有的 RNA 有约束力的蛋白质和 DNA-DAMAGE-REPAIR/TOLERATION 2 ) 在积极选择下面。一起, maca 染色体提供有用信息在安第斯山脉在植物的高高度的改编理解 WGD 的重要角色。 | Jing Zhang Yang Tian Liang Yan GuanghuiZhang Xiao Wang Yan Zeng Jiajin Zhang Xiao Ma Yuntao Tan Ni Long Yangzi Wang Yujin Ma Yuqi He Yu Xue Shumei Hao Shengchao Yang Wen Wang Liangsheng Zhang Yang Dong Wei Chen Jun Sheng | 2016 | Molecular Plant2016，9，7： | 9 |
| 4 | Adaptive Robust Control for a Lower Limbs Rehabilitation Robot Running Under Passive Training Mode显示文摘This paper focuses on the problem of the adaptive robust control of a lower limbs rehabilitation robot(LLRR) that is a nonlinear system running under passive training mode. In reality, uncertainties including modeling error, initial condition deviation, friction force and other unknown external disturbances always exist in a LLRR system. So, it is necessary to consider the uncertainties in the unilateral man-machine dynamical model of the LLRR we described. In the dynamical model, uncertainties are(possibly fast) time-varying and bounded. However, the bounds are unknown. Based on the dynamical model, we design an adaptive robust control with an adaptive law that is leakagetype based and on the framework of Udwadia-Kalaba theory to compensate for the uncertainties and to realize tracking control of the LLRR. Furthermore, the effectiveness of designed control is shown with numerical simulations. | Xiaolong Chen Han Zhao Shengchao Zhen Hao Sun | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，2： | 2 |
| 5 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 6 | Overwhelming electrochemical oxygen reduction reaction of zinc-nitrogen-carbon from biomass resource chitosan via a facile carbon bath method显示文摘Developing high efficiency and low cost electrocatalysts is critical for the enhancement of oxygen reduction reaction(ORR),which is the fundamental for the development and commercialization of renewable energy conversion technology.Herein,zinc-nitrogen-carbon(Zn-N-C)was prepared by using biomass resource chitosan via a facile carbon bath method.The obtained Zn-N-C delivered a high specific surface area(794.7 cm^2/g)together with pore volume(0.49 cm^3/g).During the electrochemical evaluation of oxygen reduction reaction(ORR),Zn-N-C displayed high activity for ORR with an onset pote ntial E0=0.96 VRHE and a half wave potential E1/2=0.86 VRHE,which were more positive than those of the comme rcial 20 wt%Pt/C benchmark catalyst(E0=0.96 VRHE and E1/2=0.81 VRHE).In addition,the ZnN-C catalyst also had a better stability and methanol tolerance than those of the Pt/C catalyst. | Libing Hu Feng Yu Fu Wang Shengchao Yang Banghua Peng Long Chen Gang Wang Juan Hou Bin Dai Zhi-Qun Tian | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 7 | All-optical modulation of quantum states by nonlinear metasurface显示文摘Metasurfaces have proven themselves an exotic ability to harness light at nano-scale,being important not only for classical but also for quantum optics.Dynamic manipulation of the quantum states is at the heart of quantum information processing;however,such function has been rarely realized with metasurfaces so far.Here,we report an all-optical dynamic modulation of the photonic quantum states using the nonlinear metasurface.The metasurface consists of a metallic nanostructure combined with a photoisomerizable azo layer.By tuning the plasmonic resonance through optically switching the azo molecules between their binary isomeric states,we have realized dynamic control of transmission efficiencies of orthogonally polarized photons and also the phase delay between them,thereby an entangled state was efficiently controlled.As an illustration,a quantum state distillation has been demonstrated to recover a Bell state from a non-maximally entangled one to that with fidelities higher than 98%.Our work would enrich the functions of the metasurface in the quantum world,from static to dynamic modulation,making the quantum metasurface going practical. | Di Zhang Yang Chen Shengchao Gong Wei Wu Wei Cai Mengxin Ren Xifeng Ren Shuang Zhang Guangcan Guo Jingjun Xu | 2022 | Light(Science & Applications)2022，11，3： | 1 |
| 8 | Metabolic engineering of Yarrowia lipolytica for scutellarin production显示文摘Scutellarin related drugs have superior therapeutic effects on cerebrovascular and cardiovascular diseases.Here,an optimal biosynthetic pathway for scutellarin was constructed in Yarrowia lipolytica platform due to its excellent metabolic potential.By integrating multi-copies of core genes from different species,the production of scutellarin was increased from 15.11 mg/L to 94.79 mg/L and the ratio of scutellarin to the main by-product was improved about 110-fold in flask condition.Finally,the production of scutellarin was improved 23-fold and reached to 346 mg/L in fed-batch bioreactor,which was the highest reported titer for de novo production of scutellarin in microbes.Our results represent a solid basis for further production of natural products on unconventional yeasts and have a potential of industrial implementation. | Yina Wang Xiaonan Liu Bihuan Chen Wei Liu Zhaokuan Guo Xiangyu Liu Xiaoxi Zhu Jiayu Liu Jin Zhang Jing Li Lei Zhang Yadi Gao Guanghui Zhang Yan Wang MIqbal Choudhary Shengchao Yang Huifeng Jiang | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 1 |
| 9 | Analysis of changes in the Panax notoginseng glycerolipidome in response to long-term chilling and heat显示文摘Long-term moderately high or low temperatures can damage economically important plants.In the present study,we treated Panax notoginseng,an important traditional Chinese medicine,with temperatures of 10,20,and 30℃for 30 days.We then investigated P.notoginseng glycerolipidome responses to these moderate temperature stresses using an ESI/MS-MS-based lipidomic approach.Both long-term chilling(LTC,10℃)and long-term heat(LTH,30℃)decreased photo pigment levels and photosynthetic rate.LTH-induced degradation of photo pigments and glycerolipids may further cause the decline of photosynthesis and thereafter the senescence of leaves.LTC-induced photosynthesis decline is attributed to the degradation of photo synthetic pigments rather than the degradation of chloroplastidic lipids.P.notoginseng has an especially high level of lysophosphatidylglycerol,which may indicate that either P.notoginseng phospholipase A acts in a special manner on phosphatidylglycerol(PG),or that phospholipase B acts.The ratio of sulfoquinovosyldiacylglycerol(SQDG)to PG increased significantly after LTC treatment,which may indicate that SQDG partially substitutes for PG.After LTC treatment,the increase in the degree of unsaturation of plastidic lipids was less than that of extraplastidic lipids,and the increase in the unsaturation of PG was the largest among the ten lipid classes tested.These results indicate that increasing the level of unsaturated PG may play a special role in maintaining the function and stability of P.notoginseng photosystems after LTC treatment. | Tao Liu Jia Chen Furong Xu Xiahong He Shengchao Yang Youyong Zhu Weiqi Li Guowei Zheng | 2020 | Plant Diversity2020，42，2： | 1 |
| 10 | A New Species of the Genus Rhabdophis Fitzinger,1843(Squamata:Colubridae)in Southwestern Sichuan,China显示文摘The genus Rhabdophis is a group of widely distributed snakes with more than 20 species.Recent field surveys uncovered a species in southwestern China,which has long been considered as R.pentasupralabialis.Combined molecular and morphological analyses revealed it as a new species Rhabdophis chiwen sp.nov.Based on 12 specimens,this new species is distinguished by the following characters:1)dorsal body saddlebrown,dorsal scales typically with black margins forming spots and stripes,the margin of the outer row forming two faint dorsolateral black cross-bars alongside body;2)ventral scales 151–159,the outer margin of ventral scales and several lateral rows of dorsal scales forming ventrolateral longitudinal brownish-red coloration,with faint black spots in the middle of ventral scales;3)a black oblique stripe present below eyes,often with a black spot between the 2 nd and 3 rd supralabial and a black stripe on the 5 th supralabial;4)eyes dark khaki,pupils black;5)infralabials usually 7,the first four in contact with anterior chin-shields;6)temporal scales 1+1;7)dorsal scales in 15 rows,feebly keeled except the outer 1–2 rows;8)anal scale divided;subcaudals 45–59;9)preocular 1 and postoculars 3(occasionally 2);10)body medium-sized(snout-vent length:adult males 404–431 mm,adult females 409–476 mm);11)tail moderate(tail length/total length in adult males 0.205–0.238,in adult females0.172–0.193).With the discovery of this new species,the total number of species in genus Rhabdophis is 28 with 12 th species known to occur in China. | Yige PIAO Zening CHEN Yanqing WU Shengchao SHI Hirohiko TAKEUCHI Teppei JONO Masaya FUKUDA Akira MORI Yezhong TANG Qin CHEN Li DING | 2020 | Asian Herpetological Research2020，11，2： | 0 |
| 11 | A Novel Trajectory Tracking Control of AGV Based on Udwadia-Kalaba Approach显示文摘Dear Editor,This letter is about an automated guided vehicle(AGV)trajectory tracking control method based on Udwadia-Kalaba(U-K)approach.This method provides a novel,concise and explicit motion equation for constrained mechanical systems with holonomic and/or nonholonomic constraints as well as constraints that may be ideal or nonideal.In this letter. | Rongrong Yu Han Zhao Shengchao Zhen Kang Huang Xianmin Chen Hao Sun Ke Shao | 2024 | IEEE/CAA Journal of Automatica Sinica2024，11，4： | 0 |
| 12 | A Systematic Approach for Designing Analytical Dynamics and Servo Control of Constrained Mechanical Systems显示文摘A systematic approach for designing analytical dynamics and servo control of constrained mechanical systems is proposed. Fundamental equation of constrained mechanical systems is first obtained according to Udwadia-Kalaba approach which is applicable to holonomic and nonholonomic constrained systems no matter whether they satisfy the D’Alember’s principle.The performance specifications are modeled as servo constraints.Constraint-following servo control is used to realize the servo constraints. For this inverse dynamics control problem, the determination of control inputs is based on the Moore-Penrose generalized inverse to complete the specified motion. Secondorder constraints are used in the dynamics and servo control.Constraint violation suppression methods can be adopted to eliminate constraint drift in the numerical simulation. Furthermore,this proposed approach is applicable to not only fully actuated but also underactuated and redundantly actuated mechanical systems. Two-mass spring system and coordinated robot system are presented as examples for illustration. | Xiaoli Liu Shengchao Zhen Kang Huang Han Zhao Ye-Hwa Chen Ke Shao | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，4： | 0 |
| 13 | Effects of Organic and Medium and Trace Element Fertilizers on Yield and Quality of Panax notoginseng显示文摘[Objectives]This study aimed to investigate the effects of organic and medium and trace element fertilizers(Ca,Zn,B)on yield and quality of Panax notoginseng to provide theoretical support for rational fertilization in cultivation of P.notoginseng.[Methods]Five fertilization treatments,control(CK),organic fertilizer(OM),zinc fertilizer(ZF),boron fertilizer(BF)and lime(LF),were designed.A two-consecutive-year field plot trail was conducted.The biological traits,yield and saponin content of P.notoginseng were determined.[Results]The application of organic fertilizer had no significant effect on the biological traits of P.notoginseng.Trace element fertilizers significantly increased the scape length of P.notoginseng.Among the treatments,ZF significantly increased the single flower weight but reduced the inflorescence diameter,while the effects of BF were opposite to those of ZF;LF significantly increased the stem thickness and reduced the plant height.All treatments significantly increased the seedling rate of three-year-old P.notoginseng,and the increase in the LF group(20.49%)was the largest,followed by those in the ZF(16.80%)and OM(16.40%)groups,and the increase in the BF group(13.08%)was the smallest.Although OM,ZF and BF treatments caused the root weight of individual plants to decrease,the final yield of each treatment was higher than that of the control group,and the increases in the BF and LF groups exceeded 17%(P<0.05).The total saponin outputs of all the treatments except OM were significantly higher than that of the control group.[Conclusions]Under the conditions of this test,the supplementation of organic and medium and trace element fertilizers on the basis of conventional fertilization will help to increase the yield of P.notoginseng.However,the reduction of the total saponin output of P.notoginseng caused by organic fertilizer cannot be ignored. | Yongquan ZHU Junwen CHEN Guangqiang LONG Tongbin ZHU Shusheng ZHU Shengchao YANG | 2020 | Medicinal Plant2020，11，3： | 0 |
| 14 | Comparative genomics reveals the diversification of triterpenoid biosynthesis and origin of ocotilloltype triterpenes in Panax显示文摘Gene duplication is assumed to be the major force driving the evolution of metabolite biosynthesis in plants.Freed from functional burdens,duplicated genes can mutate toward novelties until fixed due to selective fitness.However,the extent to which this mechanism has driven the diversification of metabolite biosynthesis remains to be tested.Here we performed comparative genomics analysis and functional characterization to evaluate the impact of gene duplication on the evolution of triterpenoid biosynthesis using Panax species as models.Wefound that whole-genome duplications(WGDs)occurred independently in Araliaceae and Apiaceae lineages.Comparative genomics revealed the evolutionary trajectories of triterpenoid biosynthesis in plants,which was mainly promoted by WGDs and tandem duplication.Lanosterol synthase(LAS)was likely derived from a tandemduplicate of cycloartenol synthase that predated the emergence of Nymphaeales.Under episodic diversifying selection,the LAS gene duplicates produced by g whole-genome triplication have given rise to triterpene biosynthesis in core eudicots through neofunctionalization.Moreover,functional characterization revealed that oxidosqualene cyclases(OSCs)responsible for synthesizing dammarane-type triterpenes in Panax species were also capable of producing ocotilloltype triterpenes.Genomic and biochemical evidence suggested that Panax genes encoding the above OSCs originated from the specialization of one OSC gene duplicate produced from a recent WGD shared by Araliaceae(Pg-b).Our results reveal the crucial role of gene duplication in diversification of triterpenoid biosynthesis in plants and provide insight into the origin of ocotillol-type triterpenes in Panax species. | Zijiang Yang Xiaobo Li Ling Yang Sufang Peng Wanling Song Yuan Lin Guisheng Xiang Ying Li Shuang Ye Chunhua Ma Jianhua Miao Guanghui Zhang Wei Chen Shengchao Yang Yang Dong | 2023 | Plant Communications2023，4，4： | 0 |
| 15 | Recognition System for Diagnosing Pneumonia and Bronchitis Using Children’s Breathing Sounds Based on Transfer Learning显示文摘Respiratory infections in children increase the risk of fatal lung disease,making effective identification and analysis of breath sounds essential.However,most studies have focused on adults ignoring pediatric patients whose lungs are more vulnerable due to an imperfect immune system,and the scarcity of medical data has limited the development of deep learning methods toward reliability and high classification accuracy.In this work,we collected three types of breath sounds from children with normal(120 recordings),bronchitis(120 recordings),and pneumonia(120 recordings)at the posterior chest position using an off-the-shelf 3M electronic stethoscope.Three features were extracted from the wavelet denoised signal:spectrogram,mel-frequency cepstral coefficients(MFCCs),and Delta MFCCs.The recog-nition model is based on transfer learning techniques and combines fine-tuned MobileNetV2 and modified ResNet50 to classify breath sounds,along with software for displaying analysis results.Extensive experiments on a real dataset demonstrate the effectiveness and superior performance of the proposed model,with average accuracy,precision,recall,specificity and F1 scores of 97.96%,97.83%,97.89%,98.89%and 0.98,respectively,achieving superior performance with a small dataset.The proposed detection system,with a high-performance model and software,can help parents perform lung screening at home and also has the potential for a vast screening of children for lung disease. | Jianying Shi Shengchao Chen Benguo Yu Yi Ren Guanjun Wang Chenyang Xue | 2023 | Intelligent Automation & Soft Computing2023，37，9： | 0 |
| 16 | A New Species of Trimeresurus Lacépède, 1804(Squamata: Viperidae) from Southwestern China, Vietnam, Thailand and Myanmar显示文摘The pit vipers of the genus Trimeresurus Lacépède, 1804 is one of the largest groups of Asian snakes, distributed from India to China and Indonesia. Recent surveys in Jiangcheng and Simao, Yunnan Province, China resulted in a new species previously allocated to T. albolabris. Combining morphological and molecular data, we describe it as Trimeresurus guoi sp. nov. The new species morphologically differs from T. albolabris in the yellow green ventral color;an indistinct ventrolateral line;the a bsence of a postocular stripe;the firebrickred iris;a dark red stripe on dorsal tail;hemipenes with relatively weak sparse papillae, reaching 23 rd subcaudal when unextruded. Molecularly, the new species forms a clearly divergent lineage(BPP 1.00/UFB 100). Uncorrected pairwise distances of mitochondrial gene Cyt b between the new species and other known species of the subgenus Trimeresurus range from 0.052(T. albolabris) to 0.071(T. insularis). | Zening CHEN Shengchao SHI Jun GAO Gernot VOGEL Zhaobin SONG Li DING Rong DAI | 2021 | Asian Herpetological Research2021，12，2： | 0 |
| 17 | BATON:symphony of random testing and concolic testing through machine learning and taint analysis显示文摘Random testing is scalable but often fails to hit corner program behaviors,while systematic testing(e.g.,concolic execution)is promising to cover corner program behaviors but is not scalable to explore all program behaviors.Prior attempts to integrate random testing with systematic testing lack targeted guidance.In this paper,we propose a guided hybrid testing approach,named BATon,to synergize random testing with concolic testing.It integrates the knowledge inside test cases and their executions into a conditional execution graph,and uses such knowledge to guide test case generation.Specifically,we learn classification models for some conditionals in the conditional execution graph in a demand-driven way.These models are used to guide random testing to reach and cover partially-covered conditionals.We further employ targeted concolic testing to cover conditionals that cannot be fully covered by guided random testing.We implemented BATon for Java and evaluated it on three benchmarks.The results show that BATon improved branch coverage and mutation score over random testing by 16.2%–29.4%and 19.0%–30.0%,over adaptive random testing by 16.8%–33.8%and 19.4%–34.2%,over concolic testing by 2.3%–29.9%and 2.9%–30.1%,and over simple hybrid testing by 1.6%–14.5%and 1.4%–18.7%. | Bihuan CHEN Yang LIU Xin PENG Yijian WU Shengchao QIN | 2023 | Science China(Information Sciences)2023，66，3： | 0 |
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