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| 1 | Preliminary results pertaining to coseismic displacement and preseismic strain accumulation of the Lushan M_S7.0 earthquake,as reflected by GPS surveying显示文摘This paper presents the coseismic displacement and preseismic deformation fields of the Lushan MS7.0 earthquake that occurred on April 20,2013.The results are based on GPS observations along the Longmenshan fault and within its vicinity.The coseismic displacement and preseismic GPS results indicate that in the strain release of this earthquake,the thrust rupture is dominant and the laevorotation movement is secondary.Furthermore,we infer that any possible the rupture does not reach the earth’s surface,and the seismogenic fault is most likely one fault to the east of the Guanxian-Anxian fault.Some detailed results are obtainable.(1)The southern segment of the Longmenshan fault is locked preceding the Lushan earthquake.After the Wenchuan earthquake,the strain accumulation rate in the southeast direction accelerates in the epicenter of the Lushan earthquake,and the angle between the principal compressional strain and the seismogenic fault indicates that a sinistral deformation background in the direction of the seismogenic fault precedes the Lushan earthquake.Therefore,it is evident that the Wenchuan MS8.0 earthquake accelerated the pregnancy of the Lushan earthquake.(2)The coseismic displacements reflected by GPS data are mainly located in a region that is 230 km(NW direction)×100 km(SW direction),and coseismic displacements larger than 10 mm lie predominantly in a100-km region(NW direction).(3)On a large scale,the coseismic displacement shows thrust characteristics,but the associated values are remarkably small in the near field(within 70 km)of the earthquake fault.Meanwhile,the thrust movement in this70-km region does not correspond with the attenuation characteristics of the strain release,indicating that the rupture of this earthquake does not reach the earth’s surface.(4)The laevorotation movements are remarkable in the 50-km region,which is located in the hanging wall that is close to the earthquake fault,and the corresponding values in this case correlate with the attenuation characteristics of the strain release. | WU YanQiang JIANG ZaiSen WANG Min CHE Shi LIAO Hua LI Qiang LI Peng YANG YongLin XIANG HePing SHAO ZhiGang WANG WuXing WEI WenXin LIU XiaoXia | 2013 | Chinese Science Bulletin2013，58，28： | 33 |
| 2 | Therapeutic potential of siRNA-mediated combined knockdown of the lAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells显示文摘Livin, apoptosis (XIAP ) 的 X 连接禁止者,和 Survivin 几乎是 apoptosis 的三个著名禁止者在癌症房间只过去表示并且为癌症治疗被认为有势力目标。在现在的学习,我们发现 Livin, XIAP,和 Survivin 同时在膀胱癌症房间被表示。我们推测了那 Livin, XIAP,和 Survivin 可能在房间生长和 apoptosis 上有 synergistic 效果。我们的结果证实了联合那所有这三基因击倒能 synergistically 禁止增长和高级膀胱癌症 T24 房间的转变能力并且把房间 apoptotic 敏感提升到化疗。而且,联合了 Livin, XIAP,和 Survivin 罐头击倒显著地增加许多活跃 caspase-3,活跃 caspase-7,活跃 caspase-9,和 cytosolic Smac。我们的调查结果暗示 Livin, XIAP,和 Survivin 的那联合 silencing 可以是一个有势力为膀胱癌症的多指向的基因治疗。 | Deyong Yang Xishuang Song Jianing Zhang Lin Ye Shujing Wang Xiangyu Che Jianbo Wang Zhiwei Zhang Lina Wang Wei Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 29 |
| 3 | Integral stormwater management master plan and design in an ecological community显示文摘Urban stormwater runoff nearly discharges directly into bodies of water through gray infrastructure in China,such as sewers,impermeable ditches,and pump stations.As urban flooding,water shortage,and other environment problems become serious,integrated water environment management is becoming increasingly complex and challenging.At more than 200 ha,the Oriental Sun City community is a large retirement community located in the eastern side of Beijing.During the beginning of its construction,the project faced a series of serious water environment crises such as eutrophication,flood risk,water shortage,and high maintenance costs.To address these issues,an integral stormwater management master plan was developed based on the concept of low impact development(LID).A large number of LID and green stormwater infrastructure(GSI)approaches were designed and applied in the community to replace traditional stormwater drainage systems completely.These approaches mainly included bioretention(which captured nearly 85th percentile volume of the annual runoff in the site,nearly 5.4×105m3annually),swales(which functioned as a substitute for traditional stormwater pipes),waterscapes,and stormwater wetlands.Finally,a stormwater system plan was proposed by integrating with the gray water system,landscape planning,an architectural master plan,and related consultations that supported the entire construction period.After more than 10 years of planning,designing,construction,and operation,Oriental Sun City has become one of the earliest modern large-scale LID communities in China.Moreover,the project not only addressed the crisis efficiently and effectively,but also yielded economic and ecological benefits. | Wu Che Yang Zhao Zheng Yang Junqi Li Man Shi | 2014 | Journal of Environmental Sciences2014，26，9： | 13 |
| 4 | Effect of sevoflurane on tissue permeability of lung ischemia-reperfusion injury in rats显示文摘Objective:To investigate the effect of sevoflurane on tissue permeability of lung ischemiareperfusion injury(LIRI)in rats.Methods:A total of 45 wistar rats were randomly divided into3 groupsⅠ,Ⅱ,Ⅲ.Modified Eppinger method was adopted to establish the rat lung ischemiareperfusion injury model.GroupⅠserved as the control group,groupⅡas ischemia reperfusion group,groupⅢas sevoflurane ischemia-reperfusion group.Blood gas index,lung permeability index(LPI)change,lung tissue pathology change and lung water content were observed and compared between groups of rats at different time points.Results:During ischemia reperfusion,all rats kept balance of the MAP during different time points,SPO_2 of groupⅡandⅢdecreased significantly thanⅠgroup(P<0.05);after reperfusion lung permeability index in GroupⅡandⅢwas higher than the control group significantly(P<0.05),120 min after reperfusion LPI change and iujury of groupⅢwas significantly lower thanⅡgroup(P<0.05);interstitial and alveolar cavity effusion in of groupⅢwere lower than that of groupⅡ.Conclusions:Sevoflurane pretreatment can reduce the lung tissue permeability,and LIRI plays a protective role in LIRI. | Xiao-Hui Li Zhong-Hua Liu Hong-Bing Ma Yong Li Hui Zhao Jian-Bo Che Wei-Chao Liu Gong-Ning Shi | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，4： | 8 |
| 5 | Consensus by Chinese Expert Panel on Chlamydia trachomatis-Resistant and Chlamydia trachomatis-Persistent Infection显示文摘 | Man-Li Qi Yuan-Li Guo Qian-Qiu Wang Xiang-Sheng Chen Jian-De Han Xiao-Hong Su Wen-Hui Lun Hao Cheng Jin-Hua Xu Hong-Qing Tian Li Che Zhi-Yuan Ya Wen-Li Feng Juan Jiang Ping-Yu Zhou Xian-Biao Zo Hong-Hui Xu Wei-Min Shi Jun Liu Lin Zhu Quan-Zhong Liu | 2017 | Chinese Medical Journal2017，，23： | 7 |
| 6 | Down-regulation of eIF5A-2 prevents epithelial-mesenchymal transition in non-small-cell lung cancer cells显示文摘Background:Epithelial-mesenchymal transition(EMT) is believed to be the critical process in malignant tumor invasion and metastases,and has a great influence on improving the survival rate in non-small-cell lung cancer(NSCLC) patients.Recent studies suggested that eukaryotic initiation factor 5A-2(eIF5A-2) might serve as an adverse prognostic marker of survival.We detected eIF5A-2 in NSCLC A549 cells,and found that the invasive capability correlates with the eIF5A-2 expression.Methods:Transforming growth factor(TGF)-β1 was used to induce EMT in A549 cells.Western blotting,immunofluorescence,wound healing assay,and transwell-matrigel invasion chambers were used to identify phenotype changes.Western blotting was also used to observe changes of the expression of eIF5A-2.We down-regulated the eIF5A-2 expression using an eIF5A-2 siRNA and identified the phenotype changes by western blotting and immunofluorescence.We tested the change of migration and invasion capabilities of A549 cells by the wound healing assay and transwell-matrigel invasion chambers.Results:After stimulating with TGF-β1,almost all A549 cells changed to the mesenchymal phenotype and acquired more migration and invasion capabilities.These cells also had higher eIF5A-2 protein expression.Down-regulation of eIF5A-2 expression with eIF5A-2 siRNA transfection could change the cells from mesenchymal to epithelial phenotype and decrease tumor cell migration and invasive capabilities significantly.Conclusions:The expression of eIF5A-2 was up-regulated following EMT phenotype changes in A549 cells,which correlated with enhanced tumor invasion and metastatic capabilities.Furthermore,in the A549 cell line,the process of EMT phenotype change could be reversed by eIF5A-2 siRNA,with a consequent weakening of both invasive and metastatic capabilities. | Guo-dong XU Xin-bao SHI Le-bo SUN Qing-yun ZHOU Da-wei ZHENG Huo-shun SHI Yong-liang CHE Zi-shan WANG Guo-feng SHAO | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，6： | 6 |
| 7 | Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling显示文摘Glioblastoma(GBM)is a prevalent and highly lethal form of glioma,with rapid tumor progression and frequent recurrence.Excessive outgrowth of pericytes in GBM governs the ecology of the perivascular niche,but their function in mediating chemoresistance has not been fully explored.Herein,we uncovered that pericytes potentiate DNA damage repair(DDR)in GBM cells residing in the perivascular niche,which induces temozolomide(TMZ)chemoresistance.We found that increased pericyte proportion correlates with accelerated tumor recurrence and worse prognosis.Genetic depletion of pericytes in GBM xenografts enhances TMZ-induced cytotoxicity and prolongs survival of tumor-bearing mice.Mechanistically,C-C motif chemokine ligand 5(CCL5)secreted by pericytes activates C-C motif chemokine receptor 5(CCR5)on GBM cells to enable DNA-dependent protein kinase catalytic subunit(DNA-PKcs)-mediated DDR upon TMZ treatment.Disrupting CCL5-CCR5 paracrine signaling through the brain-penetrable CCR5 antagonist maraviroc(MVC)potently inhibits pericyte-promoted DDR and effectively improves the chemotherapeutic efficacy of TMZ.GBM patient-derived xenografts with high CCL5 expression benefit from combined treatment with TMZ and MVC.Our study reveals the role of pericytes as an extrinsic stimulator potentiating DDR signaling in GBM cells and suggests that targeting CCL5-CCR5 signaling could be an effective therapeutic strategy to improve chemotherapeutic efficacy against GBM. | Xiao-Ning Zhang Kai-Di Yang Cong Chen Zhi-Cheng He Qiang-Hu Wang Hua Feng Sheng-Qing Lv Yan Wang Min Mao Qing Liu Yao-Yao Tan Wen-Ying Wang Tian-Ran Li Lin-Rong Che Zhong-Yi Qin Ling-Xiang Wu Min Luo Chun-Hua Luo Yu-Qi Liu Wen Yin Chao Wang Hai-Tao Guo Qing-Rui Li Bin Wang Wei Chen Shuang Wang Yu Shi Xiu-Wu Bian Yi-Fang Ping | 2021 | Cell Research2021，31，10： | 5 |
| 8 | Abnormal interruption of water flow from an artesian well prior to 2008 Wenchuan earthquake显示文摘Water flow from an artesian well stopped on December 17,2007 but recovered when the Wenchuan Ms 8.0 earthquake occurred on May 12,2008.This well is located 90 km south of the epicenter in an extensional tectonic setting,where similar changes of water level and resistivity were observed at two other nearby sites.Our investigation suggests that this phenomenon was not caused by environmental disturbances,such as drought or borehole-drilling activity,but might be a precursor to the earthquake. | Liu Chenglong Che Yongtai Xu Yinju Shi Zheming Yang Xianhe | 2011 | Geodesy and Geodynamics2011，2，2： | 5 |
| 9 | Estimation and inter-comparison of dust aerosols based on MODIS, MISR and AERONET retrievals over Asian desert regions显示文摘This study presents detailed analysis of spatiotemporal variations and trend of dust optical properties i.e., Aerosol Optical Depth(AOD) and Angstrom component over Asian desert regions using thirteen years of data(i.e., 2001–2013) retrieved from Aerosol Robotic Network(AERONET), Moderate Resolution Imaging Spectroradiometer(MODIS) and Multi-angle Imaging Spectroradiometer(MISR). These regions include Solar Village, Dunhuang and Dalangzadgad and are considered as origin of desert aerosols in Asia. Mann–Kendall trend test was used to show the trend of AOD. The relationship of AOD with weather parameters and general AOD trend over different wavelengths has also been shown. AOD's trend has been observed significant throughout the year in Solar Village, while in Dunhuang and Dalanzadgad the significant trend has been found only in peak period(March–June).Analysis show high values of AOD and low values of angstrom in Solar Village during peak period. In Chinese desert regions, high values of AOD have been found during peak period and low values in pre-peak period. Significant relationship has been observed between AOD and average temperature in Solar Village and Dalanzadgad whereas rainfall and wind speed showed no significant impact on AOD in all desert regions. | Ammara Habib Bin Chen Bushra Khalid Saichun Tan Huizheng Che Tariq Mahmood Guangyu Shi Muhammad Tahir Butt | 2019 | Journal of Environmental Sciences2019，31，2： | 5 |
| 10 | Identification of the metabolites of biologically active xanthones isolated from Halenia elliptica D.Don by high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry显示文摘新陈代谢学习在 1-hydroxy-2,3,5-trimethoxyxanthone (HM-1 ) 和 1-hydroxy-2,3,4,7-tetramethoxyxanthone (HM-2 ) 上被执行了,它是从西藏的植物孤立的二生物学上活跃的成分, Halenia elliptica D. 唐,在在 vitro 的老鼠肝微体。联合到离子陷井 time-of-flight 团 spectrometry ( LCMSn-ESI-IT-TOF )的高效液体层析的一个方法被使用在线上分析 HM-1 和 HM-2 的代谢物,并且五代谢物被识别包含 1,5-dihydroxy-2,3-dimethoxyxanthone ( HM-5 ), 1,7-dihydroxy-2,3,4-trimethoxyxanthone ( HM-9 ), 1,4 , 7-trihydroxy-2,3-dimethoxyxanthone ( HM-10 ), 1,4-dihydroxy-2,3,7-trimethoxyxanthone ( HM-11 )和 1,2-dihydroxy-3,4,7-trimethoxyxanthone ( HM-12 )。在这些代谢物之中, HM-9, HM-11,和 HM-12 互相是异构体。结果显示了那 HM-1, HM-2 发生了阶段我在在 vitro 的老鼠微体的 demethylation 的新陈代谢的反应。 | Ru Feng Jian Gong Shi Xiao Wei Liu Chun Tao Che John H.K. Yeung Yan Wang | 2011 | Chinese Chemical Letters2011，22，7： | 4 |
| 11 | Case study of longwave contribution to dust radiative effects over East Asia显示文摘In order to evaluate the impacts of LW contribution to aerosol radiative effects over East Asia,a dust longwave radiative parameterization scheme is integrated into the online mesoscale dust forecasting model GRAPES_CUACE/dust.A case modeling study shows that about half at surface and one third at TOA of the dust negative shortwave radiative forcing are cancelled by its positive longwave forcing over the dust affected area.In the dust layer,longwave radiation emitting by dust cools the atmosphere,which counteracts about 17%of shortwave heating of atmosphere during daytime and results in cooling of atmosphere simply during nighttime.At the same time,the atmosphere beyond the dust layer is warmed because of absorbing the LW radiation emitted by dust layer.Dust longwave contribution exerts more evident impact on the air temperature in lower atmosphere and surface.The surface air temperature cooling rate resulting from the dust solar radiation is cancelled about 40%by dust longwave warming at daytime.At nighttime,dust longwave contribution warms land and sea surface.The online calculation of dust LW radiation reduces about 15%relative errors of predicted AOD based on the dust model with only SW radiative feedback.This case study result suggests that dust longwave contribution has important impacts on the earth-atmosphere energy process,especially on the surface and in the lower atmosphere and should not be neglected in the study of dust radiation effects. | WANG Hong SHI GuangYu ZHU Jing CHEN Bin CHE HuiZheng ZHAO TianLiang | 2013 | Chinese Science Bulletin2013，58，30： | 4 |
| 12 | Microsatellite DNA Variation of the Gametophyte Clones Isolated from Introduced Laminaria japonica (Phaeophyta) and L. longissima of China and Varieties Derived from them显示文摘The variation of 90 Laminaria gametophyte clones representing the introduced Laminaria japonica (Group 1) and Laminaria longissima (Group 2), the varieties of L. japonica (Group 3) and the varieties derived from interspecific hybrids (Group 4) was determined with 18 microsatellite markers. The allelic diversity and Nei's gene diversity of Group 1 were significantly higher than those of Group 2 (2.9 vs. 1.8 and 0.414 vs. 0.161, respectively), demonstrating that the variation of the introduced L. japonica is richer than that of L. longissima. Both allelic diversity and Nei's gene diversity of Group 3 were lower than those of Group 1, indicating that only a portion of variation of L. japonica was incorporated into the varieties of L. japonica. Significant genetic differentiation was detected between four groups and between female (Population 1) and male (Population 2) gametophyte clones in each group. The variation among groups accounted for 39.95%, while that among populations accounted for 21.65% of the total. The genetic distance between Group 1 and Group 4 was obviously longer than that between Group 2 and Group 4 (0.686 vs. 0.291), indicating that maternal gametophyte clone contributed more variation to the hybrids than the paternal gametophyte clone did. | Bing-Jun Li Yuan-Yuan Shi Guan-Pin Yang Shi Che Xiao-Jie Li Yi-Zhou Cong | 2008 | Journal of Integrative Plant Biology2008，50，3： | 4 |
| 13 | Tojapride Reverses Esophageal Epithelial Inflammatory Responses on Reflux Esophagitis Model Rats显示文摘Objective To investigate the mechanism of Tojapride,a Chinese herbal formula extract,on strengthening the barrier function of esophageal epithelium in rats with reflux esophagitis(RE).Methods Ten out of 85 SD rats were randomly selected as the sham group(n10),and 75 rats were developed a reflux esophagitis model(RE)by the esophageal and duodenal side-to-side anastomosis.Fifty successful modeling rats were divided into different medicated groups through a random number table including the model,low-,medium-,and high-dose of Tojapride as well as omeprazole groups(n10).Three doses of Tojapride[5.73,11.46,22.92 g/(kg•d)]and omeprazole[4.17 mg/(kg•d)]were administrated intragastrically twice daily for 3 weeks.And the rats in the sham and model groups were administered 10 mL/kg distilled water.Gastric fluid was collected and the supernatant was kept to measure for volume,pH value and acidity.Esophageal tissues were isolated to monitor the morphological changes through hematoxylin-eosin(HE)staining,and esophageal epithelial ultrastructure was observed by transmission electron microscopy.The expressions of nuclear factor kappa-light-chain-enhancer of activated B cells p65(NF-KBp65),κB kinase beta(IKKß),occludin,and zonula occludens-1(ZO-1)in the esophageal tissues were measured by immunohistochemistry and Western blot,respectively.Results The gastric pH value in the model group was significantly lower than the sham group(P<0.05).Compared with the model group,gastric pH value in the omeprazole and medium-dose of Tojapride groups were significantly higher(P<0.05).A large area of ulceration was found on the esophageal mucosa from the model rats,while varying degrees of congestion and partially visible erosion was observed in the remaining groups.Remarkable increase in cell gap width and decrease in desmosome count was seen in RE rats and the effect was reversed by Tojapride treatment.Compared with the sham group,the IKKßlevels were significantly higher in the model group(P<0.05).However,the IKKßlevels were down-regulated after treatment by all doses of Tojapride(P<0.01 or P<0.05).The occluding and ZO-1 levels decreased in the model group compared with the sham group(Ps0.01 or Ps0.05),while both indices were significantly up-regulated in the Tojapride-treated groups(P<0.01 or P<0.05).Conclusions Tojapride could improve the pathological conditions of esophageal epithelium in RE rats.The underlying mechanisms may involve in down-regulating the IKKßexpression and elevating ZO-1 and occludin expression,thereby alleviating the inflammation of the esophagus and strengthening the barrier function of the esophageal epithelium. | YIN Xiao-lan ZHONG Linda LIN Cheng-yuan SHI Xiao-shuang ZHANG Jiao CHEN Zheng-yi CHE Hui MA Xiang-xue TIAN Ya-xin DUAN Yuan-zhi LU Lin Jl Hai-jie ZHAO Ying-pan TANG Xu-dong WANG Feng-yun | 2021 | Chinese Journal of Integrative Medicine2021，27，8： | 4 |
| 14 | Influence of As_2O_3 combined with ginsenosides Rg3 on inhibition of lung cancer NCI-H1299 cells and on subsistence of nude mice bearing hepatoma显示文摘Objective:To study the effect of arsenic trioxide(As_2O_3)combined with ginsenosides Rg3 on inhibiting the NCI-H1299 lung cancer cells and subsistence in nude mice bearing hepatoma.Methods:MTT method was used to measure the inhibition effect of(As_2O_3)combined Rg3 on NC1-H1299 cells,and the proliferation inhibiting effect was observed via establishing the transplanted tumor model in vitro.A total of 40 tumor-bearing nude mice were randomly divided into normal saline group,(As_2O_3),Rg3 and As_2O_3+Rg3 group.Transplantation tumor model of lung cancer in nude mice was constructed,followed by injection of certain concentrations of normal saline,As_2O_3,ginseng saponin Rg3 and As_2O_3+Rg3 every day.The survival duration and the tumors size of the mice were recorded and the Kaplan-Meier curve was made;microscopic observation of apoptosis of tumor cells in vivo was done using TUNEL staining.Results:After 72 h of injection.inhibition rate of tumor cell in normal saline group,As_2O_3 group.Rg3 group and As_2O_3+Rg3 group was(5.66±0.31)%,(65.58±4.75)%,(44.69±3.32)%and(82.67±5.43)%,respectively.Inhibition rate of tumor cell in As_2O_3 group.Rg3 groap and As_2O_3+Rg3 group was significantly higher than that of normal saline group(P<0.01);inhibition rate of tumor cells of As_2O_3+Rg3 group was significantly higher than that of the two groups given As_2O_3 or Rg3 alone(P<0.01).The tumor volume of As_2O_3 group,Rg3 group and As_2O_3+Rg3 group shrank to(65.38±3.25)%,(77.68±3.43)%and(42.65±3.55)%of the original,tumor volume of saline group was 1.21 times of the original size(P<0.01);Median survival of saline group,Rg3 group,As_2O_3 group were significantly shorter than that of As_2O_3+Rg3 group(P<0.01);co-ordinated intervention ability of As_2O_3+Rg3 on NCI-H1299 cell was significantly higher than that of As_2O_3 or Rg3,separately.Conclusions:As_2O_3 combined with Rg3 can significantly inhibit prolifaration of NCI-H1299 cells in lung cancer,prolong survival fo tumor-bearing nude mice,and promote tumor cell apoptosis,and have significant effect on lung cancer treatment. | Jian-Bo Che Zhong-Hua Liu Hong-Bing Ma Yong Li Hui Zhao Xiao-Hui Li Wei-Chao Liu Gong-Ning Shi | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，10： | 3 |
| 15 | A novel magnetic silica supported spinel ferrites NiFe2O4 catalyst for heterogeneous Fenton-like oxidation of rhodamine B显示文摘A series of spinel fe rrites magnetic nanopa rticles NiFe2 O4 we re synthesized as the heterogeneous Fentonlike catalyst by hydrothermal method and then NiFe2 O4@SiO2 catalysts were obtained by the modification of NiFe2 O4 via micro emulsion method.XRD,VSM,FTIR,SEM,TEM,BET and XPS were carried to analyze the difference between the above two catalysts.NiFe2 O4@SiO2 catalyst exhibited the higher catalytic activity than NiFe2 O4 for the degradation of Rhodamine B owe to the outer Si02 layers surface,the more important is both of them showed the better catalytic performance when at neutral pH environment. | Jifeng Qu Tinghua Che Libin Shi Qinghua Lu Suitao Qi | 2019 | Chinese Chemical Letters2019，30，6： | 3 |
| 16 | Optimization of dewatering schemes for a deep foundation pit near the Yangtze River, China显示文摘A deep foundation pit constructed for an underground transportation hub was excavated near the Yangtze River. Among the strata, there are two confined aquifers, between which lies an aquiclude that is partially missing. To guarantee the safety of pit excavation, the piezometric head of the upper confined aquifer, where the pit bottom is located, should be 1 m below the pit bottom, while that of the lower confined aquifer should be dewatered down to a safe water level to avoid uplift problem. The Yangtze River levee is notably close to the pit, and its deformation caused by dewatering should be controlled. A pumping test was performed to obtain the hydraulic conductivity of the upper confined aquifer. The average value of the hydraulic conductivity obtained from analytical calculation is 20.45 m/d, which is larger than the values from numerical simulation(horizontal hydraulic conductivity K_H = 16 m/d and vertical hydraulic conductivity K_V = S m/d). The difference between K_H and K_V indicates the anisotropy of the aquifer. Two dewatering schemes were designed for the construction and simulated by the numerical models for comparison purposes. The results show that though the first scheme could meet the dewatering requirements, the largest accumulated settlement and differential settlement would be94.64 mm and 3.3‰, respectively, greatly exceeding the limited values. Meanwhile, the second scheme,in which the bottoms of the waterproof curtains in ramp B and the river side of ramp A are installed at a deeper elevation of-28 m above sea level, and 27 recharge wells are set along the levee, can control the deformation of the levee significantly. | Yang You Changhong Yan Baotian Xu Shi Liu Canhui Che | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，3： | 3 |
| 17 | Polarization-enhanced AlGaN solar-blind ultraviolet detectors显示文摘AlGaN solar-blind ultraviolet detectors have great potential in many fields,although their performance has not fully meet the requirements until now.Here,we proposed an approach to utilize the inherent polarization effect of AlGaN to improve the detector performance.AlGaN heterostructures were designed to enhance the polarization field in the absorption layer,and a high built-in field and a high electron mobility conduction channel were formed.As a result,a high-performance solar-blind ultraviolet detector with a peak responsivity of 1.42 A/W at 10 V was achieved,being 50 times higher than that of the nonpolarization-enhanced one.Moreover,an electron reservoir structure was proposed to further improve the performance.A higher peak responsivity of 3.1 A/W at30 V was achieved because the electron reservoir structure could modulate the electron concentration in the conduction channel.The investigation presented here provided feasible approaches to improve the performance of the AlGaN detector by taking advantage of its inherent property. | Ke Jiang Xiaojuan Sun Zi-Hui Zhang Jianwei Ben Jiamang Che Zhiming Shi Yuping Jia Yang Chen Shanli Zhang Wei Lv Dabing Li | 2020 | Photonics Research2020，8，7： | 3 |
| 18 | Radiomics signature:A potential biomarker forβ-arrestin1 phosphorylation prediction in hepatocellular carcinoma显示文摘BACKGROUND The phosphorylation status ofβ-arrestin1 influences its function as a signal strongly related to sorafenib resistance.This retrospective study aimed to develop and validate radiomics-based models for predictingβ-arrestin1 phosphorylation in hepatocellular carcinoma(HCC)using whole-lesion radiomics and visual imaging features on preoperative contrast-enhanced computed tomography(CT)images.AIM To develop and validate radiomics-based models for predictingβ-arrestin1 phosphorylation in HCC using radiomics with contrast-enhanced CT.METHODS Ninety-nine HCC patients(training cohort:n=69;validation cohort:n=30)receiving systemic sorafenib treatment after surgery were enrolled in this retrospective study.Three-dimensional whole-lesion regions of interest were manually delineated along the tumor margins on portal venous CT images.Radiomics features were generated and selected to build a radiomics score using logistic regression analysis.Imaging features were evaluated by two radiologists independently.All these features were combined to establish clinico-radiological(CR)and clinico-radiological-radiomics(CRR)models by using multivariable logistic regression analysis.The diagnostic performance and clinical usefulness of the models were measured by receiver operating characteristic and decision curves,and the area under the curve(AUC)was determined.Their association with prognosis was evaluated using the Kaplan-Meier method.RESULTS Four radiomics features were selected to construct the radiomics score.In the multivariate analysis,alanine aminotransferase level,tumor size and tumor margin on portal venous phase images were found to be significant independent factors for predictingβ-arrestin1 phosphorylation-positive HCC and were included in the CR model.The CRR model integrating the radiomics score with clinico-radiological risk factors showed better discriminative performance(AUC=0.898,95%CI,0.820 to 0.977)than the CR model(AUC=0.794,95%CI,0.686 to 0.901;P=0.011),with increased clinical usefulness confirmed in both the training and validation cohorts using decision curve analysis.The risk ofβ-arrestin1 phosphorylation predicted by the CRR model was significantly associated with overall survival in the training and validation cohorts(log-rank test,P<0.05).CONCLUSION The radiomics signature is a reliable tool for evaluatingβ-arrestin1 phosphorylation which has prognostic significance for HCC patients,providing the potential to better identify patients who would benefit from sorafenib treatment. | Feng Che Qing Xu Qian Li Zi-Xing Huang Cai-Wei Yang Li Ye Wang Yi Wei Yu-Jun Shi Bin Song | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 19 | Effects of salt-alkali stress on active oxygen metabolism in roots of Spiraea × bumalda 'Gold Mound' and Spiraea × bumalda 'Gold Flame'显示文摘Under artificially-simulated complex salt-alkali stress, the levels of active oxygen metabolism in roots were studied using three-year-old cutting seedlings of Spiraea × bumalda 'Gold Mound' and Spiraea × bumalda 'Gold Flame'. The present study aimed at exploring the antioxidant capacity in roots of spiraeas and revealing their adaptability to salt-alkali stress. Results indicate that the oxygen free radicals contents, electrolyte leakage rates and MDA contents in roots of Spiraea × bumalda 'Gold Mound' and Spiraea × bumalda 'Gold Flame' show an increasing tendency with the increases of the salinity and pH value, whereas the activities of superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) all increased firstly and then decreased. With the increase in intensity of salt-alkali stress, the CAT activity in roots of Spiraea × bumalda 'Gold Flame' is higher and the increasing extents in the oxygen free radicals contents, electrolyte leakage rates as well as MDA contents are lower compared with Spiraea × bumalda 'Gold Mound', indicating that Spiraea × bumalda 'Gold Flame' has a stronger antioxidant capacity. | YAN Yong-qing CHE Dai-di SHI Xi-chan LIU Xing-liang | 2011 | Journal of Forestry Research2011，22，1： | 2 |
| 20 | A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells显示文摘Natural compound valepotriate exhibits inhibitory activity against a number of cancers,but the effect of valepotdriate against pancreatic cancer is unclear,and the structure-activity relationship of valepotriate has not been characterized:In this study,we performed a structure-based similarity search and found 16 hit compounds.Among the 16 hits,(1S,6S,7R)-6-(acetyloxy)-1-[(3-methylbutanoyl)oxy]-4a,5,6,7a-tetrahydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxiran]-4-ylmethyl 3-methylbutanoate(denoted as Amcp)exhibited superior anticancer activity against human pancreatic cancer BxPC-3 and SW1990 cells.The anti-proliferation activity of Amcp was validated in human pancreatic cancer BxPC-3 and SW1990 cells in vitro.Amcp more effectively induced apoptosis in BxPC-3 and SW1990 cells than gemcitabine.At a concentration of 15μM,Amcp Significantly suppressed the PI3K/AKT pathway and disrupted the mitochondrial membrane equilibrium through modulation of Noxa and Mcl-1 balance in both cell lines.Meanwhile,knockdown of Noxa substantially attenuated Amcp-induced reduction of cell viability and anti-apoptotic protein Mcl-1 level in BxPC-3 cells.In addition,Amcp showed synergistic anticancer effects when combined with gemcitabine in BxPC-3 cells.To conclude,this work not only suggests that Amcp possesses a dual-inhibitory activity towards PI3K/AKT pathway and Mcl-1,but also enlightens further development of bioactive valepotriate derivatives. | You-you Yan Ke-yu Shi Fei Teng Jing Chen Jin-xin Che Xiao-wu Dong Neng-ming Lin Bo Zhang | 2020 | Acta Pharmacologica Sinica2020，41，6： | 2 |
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