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| 1 | miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer显示文摘Dear Editor,Non-small cell lung cancer(NSCLC),one of the most common lung cancers,is well known to have diverse pathological features.Cancer stem cells(CSCs)have been identified to play critical roles in tumor metastasis and drug resistance,while its potential clinical significance and molecular mechanism are still unclear.In addition,numerous findings have also shown that miRNAs play pivotal roles in CSCs during tumor progression. | Qiuxia Xiong Liping Jiang Kun Liu Xiulin Jiang Baiyang Liu Yulin Shi Dating Cheng Yong Duan Cuiping Yang Yongbin Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 2 | Rural E-commerce and County Economic Development in China显示文摘With the proliferation of information and communication technology in rural areas,rural e-commerce has gradually become a new economic phenomenon in China. Usingthe national rural e-commerce comprehensive demonstration policy as a quasi-naturalexperiment, this study examines the causal linkage between rural e-commerce andcounty-level economic development in China. Its findings, which draw on county-levelpanel data from 2011 to 2018, indicate that the policy had a positive effect on the countyleveleconomy in China, resulting in an overall increase in county GDP by 3.5 percent(0.7 percent annually). Our analysis further shows that the impact of the policy diferedalong the region and human capital dimensions. Further analysis reveals that industrialstructure and nonagricultural employment were the main channels for the policy toexert a county-level economic impact. Infrastructure improvement in China also playsan important role. The findings emphasize the importance of advancing e-commerce inrural areas to stimulate county-level economic development. | Qiuxia Qin Hongdong Guo Xinjie Shi Kevin Chen | 2023 | China & World Economy2023，31，5： | 1 |
| 3 | Relationship between heart rate and failure of biological valve: slowing the heart rate could delay the failure of biological valve?显示文摘For the patients with a relatively slow heart rate,the frequency of opening and closing of biological valves and the number of impact of mechanical stress upon biological valves were relatively less,so the mechanical wear was reduced.The question is whether this can slow the failure and calcification of the biological valve.A retrospective analysis of 92 biological mitral valve replacement (MVR) cases during the period of 1996-2003 was carried out. | Shi Qiuxia Hu Chuanxian Hou Xiaotong Jia Ming Xu Zhiwei Xie Jinsheng | 2014 | Chinese Medical Journal2014，，8： | 0 |
| 4 | Response of MaHMA2 gene expression and stress tolerance to zinc stress in mulberry(Morus alba L.)显示文摘HMA2(heavy metal ATPase 2)plays a crucial role in extracellular and intracellular Zn^(2+)transport across biomembranes,maintaining ion homeostasis,and playing an important role in the normal physiological metabolism,growth,and development of plants.In our study,a novel HMA2 gene,named MaHMA2,was isolated and cloned from white mulberry(Morus alba L.).The gene sequence obtained was 1,342 bp long,with an open reading frame of 1,194 bp,encoding a protein of 397 amino acids,with a predicted molecular mass of 42.852 kD and an isoelectric point of 7.53.This protein belonged to the PIB-type ATPase transport protein family.We analyzed the expression of the MaHMA2 gene by quantitative real-time PCR.The results showed that the level of MaHMA2 gene expression decreased to a Zn concentration of 800 mg/kg.Malondialdehyde and proline levels increased and responded to increasing Zn when the MaHMA2 gene was silenced,whereas the activities of peroxidase and superoxide dismutase tended to increase in response to increasing Zn^(2+)ion stress concentrations but were lower in the gene-silenced plants.These findings suggested that the MaHMA2 gene played an active role in the tolerance response of mulberry to Zn stress. | LEI WANG QIUXIA DU YISU SHI MICHAEL ACKAH PENG GUO DANYAN ZHENG MENGMENG WU XIN JIN PEILAN LI QIAONAN ZHANG RUIXUE LI ZHI YIN MENGDI ZHAO WEIGUO ZHAO | 2022 | BIOCELL2022，46，10： | 0 |
| 5 | A novel injectable fibroblasts-porous PDLLA microspheres/collagen gel composite for soft-tissue augmentation显示文摘This study designed a novel porous PDLLA microspheres/collagen gel composite combined with fibroblasts as the injectable dermal filler for soft-tissue augmentation. The low degradation rate of porous PDLLA microspheres and seed cells were introduced in the system to achieve the filling volume stability and stronger regeneration activity. Biodegradable PDLLA porous microspheres were prepared by an improved water-in-oil-in-water double emulsion solvent evaporation method. The combine of fibroblasts with porous microspheres was observed through co-culture of cells with microspheres, SEM(scanning electron microscope) and fluorescent staining technology. The MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the hemolysis test and histocompatibility experiment indicated that the composite had satisfactory biocompatibility in vitro and in vivo. In the animal studies, the composite was implanted into the subcutaneous part of the rats' back through sterile needles. The collagen was metabolized within 30 days, meanwhile, fibroblasts-porous PDLLA microspheres served as scaffold structure and seed cells which promote new connective tissue formation. The histopathological studies demonstrate that the fibroblasts-porous PDLLA microspheres/collagen gel composite group could create larger amount of supportive structure than PDLLA porous microspheres/collagen gel composite group. All the results indicate that fibroblasts-porous PDLLA microspheres/collagen gel composite may have great clinical application in soft-tissue augmentation with its excellent biocompatibility, regeneration activity and stable long-term filling ability. | Qiuxia Ding Ruoyu Zha Xinye He Ao Sun Kun Shi Ying Qu Zhiyong Qian | 2020 | Progress in Natural Science:Materials International2020，30，5： | 0 |
| 6 | Highly branched poly(β-amino ester)s with narrow molecular weight distribution: Fractionation and gene transfection activity显示文摘Highly branched poly(β-amino ester)s(HPAEs) have shown their great promise in gene delivery. However, their broad molecular weight distribution(MWD) poses an additional challenge to the mechanistic understanding of the influence of molecular weight(MW) on their gene transfection activity. Using a stepwise precipitation strategy, HPAEs were fractionated. It is shown that MW has a significant effect on the transfection activity and cytotoxicity of HPAEs. The intermediate MW mediates higher transfection efficiency while maintaining high cell viability. Mechanistic studies show that the intermediate MW confers stronger DNA binding affinity to HPAEs, leading to the formulation of polyplexes with a relatively smaller size and more positive zeta potential. This study not only suggests a simple strategy to fractionate HPAEs with narrow MWD but also provides new insights into understanding the structure-property relationship, which would facilitate the clinical translation of HPAEs in gene therapy. | Chenfei Wang Litao Sun Qiuxia Li Zhili Li Chengyuan Xu Xinyue Zhang Jianjun Shi Hao Zhou Wenxin Wang Dezhong Zhou | 2023 | Chinese Chemical Letters2023，34，3： | 0 |
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