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| 1 | Recent glacial retreat in High Asia in China and its impact on water resource in Northwest China显示文摘Under the impact of climatic warming, the glaciers in the High Asia in China have been retreating continuously with negative glacial mass balance in recent several decades. The retreat became more intensive in the past 10 years. The spatial pattern of the glacial retreat in the High Asia in China is that the smallest magnitude of retreat is in the inland of the Tibetan Plateau, the magnitude increases from the inland to the margin of the Tibetan Plateau, and the largest magnitude at the margin of the Tibetan Plateau. The glacial retreat in the High Asia in China has an important impact on the water resource of the arid regions in Northwest China. This study shows that the glacial retreat in the 1990s has caused an increase of 5.5% in river runoff in Northwest China. In the Tarim River basin, the increase of river runoff is higher than 5.5%. | YAO Tandong 1,2 ,WANG Youqing 2 ,LIU Shiying 2,1 ,PU Jianchen 2,1 ,SHEN Yongping 2 & LU Anxin 2,1 1.Institute of Tibetan Plateau Research,Chinese Academy of Sciences,Beijing 100029,China 2.Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou 730000,China | 2004 | Science China Earth Sciences2004，47，12： | 117 |
| 2 | A novel advanced oxidation process to degrade organic pollutants in wastewater:Microwave-activated persulfate oxidation显示文摘This article,for the first time,provides a novel advanced oxidation process based on sulfate radical(SO4. -) to degrade organic pollutants in wastewater:microwave(MW)-activated persulfate oxidation(APO)with or without active carbon(AC).Azo dye acid Orange 7(AO7)is used as a model compound to investigate the high reactivity of MW-APO.It is found that AO7(up to 1000 mg/L)is completely decolorized within 5-7 min under an 800 W MW furnace assisted-APO.In the presence of chloride ion(up to 0.50 mol/L),the decolorization is still 100%completed,though delayed for about 1-2 min.Experiments are made to examine the enhancement by AC.It is exciting to find that the 100%decolorization of AO7(500 mg/L)is achieved within 3 min by MW-APO using 1.0 g/L AC as catalyst,while the degradation effciency maintains at 50%by MW energy without persulfate after about 5 min.Besides the destruction of visible light chromophore band of AO7(484 nm),during MW-APO,two bands in the ultraviolet region(228 nm and 310 nm)are rapidly broken down.The removal of COD is about 83%-95%for 500 mg/L AO7.SO4. -is identified with quenching studies using specific alcohols.Both SO4. -and.OH could degrade AO7,but SO 4 .-plays the dominant role.In a word,MW-APO AC is a new catalytic combustion technology for destruction of organic contamination even for high concentration. | YANG Shiying WANG Ping YANG Xin WEI Guang ZHANG Wenyi SHAN Liang | 2009 | Journal of Environmental Sciences2009，21，9： | 41 |
| 3 | Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats显示文摘It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuronal injury in a rat model of vascular dementia. In model rats, hippocampal CA1 neurons were severely damaged, and expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3 was elevated compared with that in sham-operated animals. These responses were suppressed in animals that received a single intraperitoneal injection of wortmannin, an autophagy inhibitor, prior to model establishment. The present results confirm that autophagy and autophagy-related proteins are involved in the pathological changes of vascular dementia, and that inhibition of autophagy has neuroprotective effects. | Bin Liu Jing Tang Jinxia Zhang Shiying Li Min Yuan Ruimin Wang | 2014 | Neural Regeneration Research2014，9，13： | 25 |
| 4 | Investigation of quality of life in patients with lung cancer by the EORTC QLQ-C30(V3.0) Chinese version显示文摘Objective To explore quality of life(QOL) and its influencing factors in patients with lung cancer.Methods A QOL questionnaire(European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire-Core 30 [QLQ-C30] Chinese version) was used with 138 patients with lung cancer participating in the study. A statistical description of the general characteristics of the patients with lung cancer was performed. The patients' QLQ-C30 scores were compared with the reference value for each dimension. To analyze the influence of QOL in different genders, age groups, and cancer stages, ttests and rank sum tests were used to compare the differences in QOL using a 5% significance level. Results The QLQ-C30 function scores in PF(physical functioning), EF(emotional functioning), SF(social functioning), and GH(global functioning), and symptom scales in NV(nausea and vomiting), DY(dyspnea), SL(insomnia), and FI(financial difficulties) were significantly different(P < 0.05) in comparison to the reference values. Female patients were worse than males(P < 0.05) in EF, NV, and DI(diarrhea). The later the stage of lung cancer, the worse the quality of life became; the functional scales in RF(role functioning), EF, CF, SF, and GH, and symptom scales in PA(pain), AP(appetite), and SL differences were statistically significant(P < 0.05). Conclusion This study aids understanding of the status of the quality of life of Chinese patients with cancer and might be useful for clinical work, theory research, and health policymakers. | Jun Li Xiaoguang Xiao Yao Wei Yang Li Man Zou Shiying Yu Yuan Chen Qian Chu | 2015 | Oncology and Translational Medicine2015，1，3： | 18 |
| 5 | Identification and functional annotation of novel microRNAs in the proximal sciatic nerve after sciatic nerve transection显示文摘The peripheral nervous system is able to regenerate after injury, and regeneration is associated with the expression of many genes and proteins. MicroRNAs are evolutionarily conserved, small, non-coding RNA molecules that regulate gene expression at the level of translation. In this paper, we focus on the identification and functional annotation of novel microRNAs in the proximal sciatic nerve after rat sciatic nerve transection. Using Solexa sequencing, computational analysis, and quantitative reverse transcription PCR verification, we identified 98 novel microRNAs expressed on days 0, 1, 4, 7, and 14 after nerve transection. Furthermore, we predicted the target genes of these microRNAs and analyzed the biological processes in which they were involved. The identified biological processes were consistent with the known time-frame of peripheral nerve injury and repair. Our data provide an important resource for further study of the role and regulation of microRNAs in peripheral nerve injury and regeneration. | LI ShiYing YU Bin WANG YongJun YAO DengBing ZHANG ZhanHu GU XiaoSong | 2011 | Science China(Life Sciences)2011，54，9： | 16 |
| 6 | MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus显示文摘Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear.Here,we show that patients with systemic lupus erythematosus(SLE)display a unique miRNA signature in bone marrow-derived MSCs(BMSCs)compared with normal controls,among which miR-663 is closely associated with SLE disease activity.MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper(Tfh)cells and upregulation of regulatory T(Treg)cells by targeting transforming growth factorβ1(TGF-β1).MiR-663 overexpression weakens the therapeutic effect of BMSCs,while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice.Thus,miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus. | Linyu Geng Xiaojun Tang Kangxing Zhou Dandan Wang Shiying Wang Genhong Yao Weiwei Chen Xiang Gao Wanjun Chen Songtao Shi Nan Shen Xuebing Feng Lingyun Sun | 2019 | Cellular & Molecular Immunology2019，16，3： | 16 |
| 7 | 恶性肿瘤骨转移及骨相关疾病临床诊疗中国专家共识(英文)显示文摘Since 1980s, palliative medicine has been an independent educational project. The development of palliative care in China started in the early 1990s. During the last 18 years, we have seen an increasing allocation of resources to palliative care, the establishment of an academic chair in palliative medicine, and more focused interest and awareness of the need for palliative care in the society at large. So the doctors in China have established principles of treatment on clinical diagnosis and treatment of malignant tumor bone metastases and bone related complications. In order to share our experience with the world, after two years’ preparation, the top-level experts in palliative medicine have written the consensus statement on clinical diagnosis and treatment of malignant tumor bone metastases and bone related complications. The overview includes not only the achievements in the world, but the hands-on experience in clinic, especially the experience in combination of TCM and Western medicine. We hope that the publication of this consensus statement will contribute to the palliative medicine development in this field, thus bring benefits to the majority of patients. | Shiying Yu Zefei Jiang Li Zhang Xiaohui Niu Lvhua Wang Ning Wu Jianhui Ma | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，1： | 15 |
| 8 | Monitoring of frozen soil hydrology in macro-scale in the Qinghai-Xizang Plateau显示文摘Monitoring of frozen soil hydrology in macro-scale was performed by Chinese and Japanese scientists from 1997 to 1998. Quality measured data were obtained. Measured data on soil moisture and temperature are preliminarily analyzed. Based on profiles of soil temperature and moisture in individual measured sites, intra-annual freezing and melting process of soil is discussed. Maximum frozen and thawed depths and frozen days in various depths are estimated. The work emphasized the spatial distribution on soil temperature and moisture in macro-scale and the effect of topography on conditions of soil water and heat. | Yongjian Ding Baisheng Ye Shiying Liu Yongping Shen Shaoling Wang Meixie Yang | 2000 | Chinese Science Bulletin2000，45，12： | 13 |
| 9 | Microstructural evolution and FCC twinning behavior during hot deformation of high temperature titanium alloy Ti65显示文摘Although the development of titanium alloys with working temperatures above 600?C faces enormous difficulties and challenges,the related research has not stopped.In the present work,detailed analyses on microstructure evolution and hot deformation behavior of a new temperature resistant 650?C titanium alloy Ti65 were investigated from micrometer scale to nanometer scale.The results revealed that lamellarαgrains gradually fragmentized and spheroidized during theα+βphase region compression and the orientation of the c-axis ofαgrains gradually aligned to radial directions,forming two high Schmid factors(SFs)value texture eventually with the increase of strain to 0.7.Moreover,there were some strengthening characters in theα+βphase region such as lenticularαsand nano silicide(TiZr)6 Si3.In theβphase region,fine equiaxed dynamic recrystallized(DRX)βgrains were formed.Besides,the variant selection ofαm′artensite followed Burgers orientation relationship during the compression process.The main deformation mechanisms of theα+βphase region were dislocation slip and orientation dependent spheroidization.Whereas,the deformation process in theβphase region was controlled byβgrain DRX.Interestingly,many nano scale FCC twins were generated at the interface ofαl′ath during deforming in theβphase region,which was firstly observed in Ti65 alloy. | Zhixin Zhang Jiangkun Fan Bin Tang Hongchao Kou Jian Wang Xin Wang Shiying Wang Qingjiang Wang Zhiyong Chen Jinshan Li | 2020 | Journal of Materials Science & Technology2020，47，14： | 10 |
| 10 | Improvement of the security of quantum protocols for anonymous voting and surveying显示文摘Several quantum protocols were proposed in a recent paper by Vaccaro,Spring and Chefles for ensuring the anonymous voting in a number of different scenarios.However,it is shown that their protocols are very vulnerable in terms of security.Improved schemes are also presented to recover the security. | XU QingJun & ZHANG ShiYing Department of Physics and Electronic Engineering,Zaozhuang University,Zaozhuang 277160,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，11： | 8 |
| 11 | Threshold pressure gradient of fluid flow through multi-porous media in low and extra-low permeability reservoirs显示文摘After analyzing many studies of fluid flow theory of multi-porous media in low and extra-low permeability reservoirs and the numerical simulation of non-Darcy flow, we found that a negative flow rate occurs in the existing non-Darcy flow equation, which is unreasonable. We believe that the existing equation can only be considered as a discriminant to judging Darcy flow or non-Darcy flow, and cannot be taken as a fluid flow governing equation of multi-porous media. Our analysis of the experimental results shows that the threshold pressure gradient(TPG) of low and extra-low permeability reservoirs is excessively high, and does not conform to fluid flow through multi-porous media in the actual reservoir situation. Therefore, we present a reasonable TPG ranging from 0.006 to 0.04 MPa/m at the well depth of 1500 m and oil drainage distance of 500 m. The results of our study also indicate that the non-Darcy flow phenomenon will disappear when the TPG reaches a certain value. In addition, the TPG or non-Darcy flow in low and extra-low permeability reservoirs does not need to be considered in the productivity prediction and reservoir numerical simulation. At present, the black oil model or dual-porous media is suitable for simulating low and extra-low permeability reservoirs. | DOU HongEn MA ShiYing ZOU CunYou YAO ShangLin | 2014 | Science China Earth Sciences2014，57，11： | 8 |
| 12 | Non-Resonant Structure Design of Catenary Transformer in Ultrasonic Gear Honing显示文摘To solve the design problem of transformer composed of non-resonant structure in ultrasonic gear-honing, force coupling conditions for moderately thick annular plate (MTAP) and catenary horn are proposed, and the frequency equations of the transformer, which consist of an MTAP and a catenary horn, are derived based on Mindlin's theory. The design parameters of the transformer were obtained by solving the frequency equations with the help of MATLAB, and its mode and frequency were deduced by the modal analysis of finite element method (FEM), which are consistent with the theoretical design demands. The transformer design can be extended from system with thin annular plate to that with MTAP as the theoretical method by the simulation analysis of various ratios of the thickness to radius. | LI Xiangpeng ZHANG Chunhui WANG Shiying | 2012 | Wuhan University Journal of Natural Sciences2012，17，1： | 8 |
| 13 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 14 | Involvements of chloride ion in decolorization of Acid Orange 7 by activated peroxydisulfate or peroxymonosulfate oxidation显示文摘The effects of chloride anion (Cl-) (up to 1.0 mol/L) on the decolorization of a model compound,azo dye Acid Orange 7 (AO7),by sulfate radical (SO4-) based-peroxydisulfate (PS) or peroxymonosulfate (PMS) oxidation under various activated conditions (UV 254 nm /PS,Thermal (70°C/PS,UV 254 nm /PMS,Co 2+ /PMS) were investigated.Methanol and NH4 + were used as quenching reagents to determine the contributions of active chlorine species (dichloride radical (Cl2-.) and hypochlorous acid (HClO)).The results indicated that the effects of Cl- on the reaction mechanism were different under various activated conditions.For UV/PS and Thermal/PS,the inhibition tendency became more clear as the Cl- concentration increased,probably due to the reaction between Cl- and SO4-.and the generation of Cl2-.or HClO.For UV/PMS,Cl- did not exhibit inhibition when the concentration was below 0.1 mol/L.As Cl- concentration reached to 1.0 mol/L,the decolorization rate of AO7 was,however,accelerated,possibly because PMS directly reacts with Cl- to form HClO.For Co2+ /PMS,Cl- exhibited a significant inhibiting effect even at low concentration ( 0.01 mol/L).When Cl- concentration exceeded 0.1 mol/L,the activation of PMS by Co 2+ was almost completely inhibited.Under this condition,HClO maybe played a major role in decolorization of AO7.The results implicated that chloride ion is an important factor in SO4-.-based degradation of organic contamination in chloride-containing water. | Ping Wang Shiying Yang Liang Shan Rui Niu Xueting Shao | 2011 | Journal of Environmental Sciences2011，23，11： | 7 |
| 15 | Reliability analysis of Lan Chengyu corroded pipeline with associated defects显示文摘Traditional reliability evaluation method for corroded pipeline exists the problem of not considering the associated defects.We therefore propose a new calculation method considering the associated defects.In this paper,the traditional and new methods are respectively used to calculate and contrastively analyze the failure probability of corroded pipeline;we then perform the research of residual life prediction for the corroded pipeline,followed by the sensitivity calculation of all random evaluation parameters.And then the Monte Carlo method(MCS)is applied to verify the rationality of the new method.The research results show that:the method considering associated defect is more objective,and truly react corroded pipeline's dynamic reliability changes;obtain new method to predict residual life of corroded pipeline;corrosion depth,radial corrosion rate have a significant impact on reliability of corroded pipeline considering associated defects.The calculation results of the method are more accurate,more time-saving. | Qin Li Chunmei Sun Zhiqiang Huang Xiang Xiao Haiping Thang Shiying Zhao | 2015 | Petroleum2015，1，3： | 6 |
| 16 | DEGREE CONDITIONS OF INDUCED MATCHING EXTENDABLE GRAPHS显示文摘A simple graph G is induced matching extendable,shortly IM\|extendable,if every induced matching of G is included in a perfect matching of G .The degree conditions of IM\|extendable graphs are researched in this paper.The main results are as follows:\;(1) 2n/32n/32n/32n/3 is the minimum integer δ such that every graph with minimum degree at least δ is IM\|extendable,where n=|V(G)|≥6 is even.\;(2) is the minimum integer δ such that every graph with minimum degree at least δ is IM\|extendable,where n=|V(G)|≥6 is even.\;(2) (2n-2)/3 is the minimum integer k such that, for k′≥k ,every k ′ regular graph with vertex number n is IM\|extendable,where n=|V(G)| is even, n ≥8 and n ≠10. | Liu Yan\ Yuan Jinjiang\ Wang Shiying Dept.ofSystem Sci.and Math.,Zhengzhou Univ.,Zhengzhou 450052 | 2000 | Applied Mathematics(A Journal of Chinese Universities)2000，15，1： | 6 |
| 17 | Robust L_2-L_∞ control for uncertain singular systems with time-varying delay显示文摘We study the problem of L2-L1 control for a class of uncertain singular systems with time-delay and norm-bounded parameter uncertainties in this paper. A new delay-dependent robust stability criterion is obtained in terms of linear matrix inequalities (LMIs). Based on this criterion, a state feedback controller is designed to guarantee that the closed-loop system is regular, impulse free and stable with a prescribed L2-L1 performance satisfied for all admissible parameter uncertainties. A simulation example is included to illustrate the effectiveness of the proposed method. | Lin Li Yingmin Jia Junping Du Shiying Yuan | 2008 | Progress in Natural Science:Materials International2008，18，8： | 5 |
| 18 | ITS2 barcoding DNA region combined with high resolution melting(HRM) analysis of Hyoscyami Semen, the mature seed of Hyoscyamus niger显示文摘Hyoscyami Semen, the mature dried seed of Hyoscyamus niger L., has long been used as a traditional Chinese medicine to treat human diseases. Hyoscyami Semen is found in local markets in China. In markets, sellers and buyers commonly inadvertently mix the seeds of H. niger with the seeds of related species such as Hygrophila salicifolia(Vahl) Nees, Astragalus complanatus R. Br., Cuscuta australis R. Br., Cuscuta chinensis Lam., and Impatiens balsamina L. because of their similar morphologies or similar names. Thus, developing a reliable method for discriminating H. niger seeds from its adulterants is necessary to reduce confusion and ensure the safe use of Hyoscyami Semen. The present study was designed to evaluate the efficiency of high-resolution melting analysis combined with DNA barcoding(Bar-HRM) with internal transcribed spacer 2 to discriminate H. niger. Our results show that Bar-HRM successfully identified the adulterants and detected the proportion of H. niger DNA extract within an admixture. In particular, HRM detected H. niger DNA extract in A. complanatus DNA extract at concentrations as low as 1%. In conclusion, the Bar-HRM method developed in the present study for authenticating H. niger is rapid and cost-effective. It can be used in the future to guarantee the purity of Hyoscyami Semen for the clinical use. | XIONG Chao HU Zhi-Gang TU Yuan LIU He-Gang WANG Ping ZHAO Ming-Ming SHIi Yu-Hua WU Lan SUN Wei CHEN Shi-Lin | 2016 | Chinese Journal of Natural Medicines2016，14，12： | 5 |
| 19 | Microstructure and mechanical properties of CoCrNi-Mo medium entropy alloys:Experiments and first-principle calculations显示文摘The effect of Mo additions on the microstructures and mechanical properties of CoCrNi alloys was investigated,meanwhile,ab initio calculations are performed to quantitatively evaluate the lattice distortion and stacking fault energy(SFE).The yield strength,ultimate tensile strength,and elongation of(CoCrNi)_(97)Mo_(3)alloy are 475 MPa,983 MPa and 69%,respectively.The yield strength is increased by~30%and high ductility is maintained,in comparison with CoCrNi alloy.Besides the nano-twins and dislocations,the higher density of stacking faults is induced during the tensile deformation for(CoCrNi)_(97)Mo_(3)alloy.Ab initio calculation results indicate the mean square atomic displacement(MSAD)and SFE value of(CoCrNi)_(97)Mo_(3)alloy is 42.6 pm^(2)and-40.4 mJ/m^(2)at 0 K,respectively.The relationship between mechanical properties and MSAD,SFE for various multiple principal element alloys is discussed. | Ruobin Chang Wei Fang Jiaohui Yan Haoyang Yu Xi Bai Jia Li Shiying Wang Shijian Zheng Fuxing Yin | 2021 | Journal of Materials Science & Technology2021，，3： | 5 |
| 20 | Remimazolam besylate for sedation of postoperative patients in intensive care units: a phase I, open label, dose-finding study显示文摘To the Editor:Remimazolam besylate is a novel,ultrashort-acting benzodiazepine with a rapid and a predictable onset and offset profile,no accumulation and extended effect,and independence of organ elimination. | Yun Tang Xiaobo Yang Huaqing Shu Yuan Yu Jiqian Xu Shangwen Pan Xiaojing Zou Shiying Yuan You Shang | 2022 | Chinese Medical Journal2022，135，17： | 5 |
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