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| 1 | A novel advanced oxidation process to degrade organic pollutants in wastewater:Microwave-activated persulfate oxidation显示文摘This article,for the first time,provides a novel advanced oxidation process based on sulfate radical(SO4. -) to degrade organic pollutants in wastewater:microwave(MW)-activated persulfate oxidation(APO)with or without active carbon(AC).Azo dye acid Orange 7(AO7)is used as a model compound to investigate the high reactivity of MW-APO.It is found that AO7(up to 1000 mg/L)is completely decolorized within 5-7 min under an 800 W MW furnace assisted-APO.In the presence of chloride ion(up to 0.50 mol/L),the decolorization is still 100%completed,though delayed for about 1-2 min.Experiments are made to examine the enhancement by AC.It is exciting to find that the 100%decolorization of AO7(500 mg/L)is achieved within 3 min by MW-APO using 1.0 g/L AC as catalyst,while the degradation effciency maintains at 50%by MW energy without persulfate after about 5 min.Besides the destruction of visible light chromophore band of AO7(484 nm),during MW-APO,two bands in the ultraviolet region(228 nm and 310 nm)are rapidly broken down.The removal of COD is about 83%-95%for 500 mg/L AO7.SO4. -is identified with quenching studies using specific alcohols.Both SO4. -and.OH could degrade AO7,but SO 4 .-plays the dominant role.In a word,MW-APO AC is a new catalytic combustion technology for destruction of organic contamination even for high concentration. | YANG Shiying WANG Ping YANG Xin WEI Guang ZHANG Wenyi SHAN Liang | 2009 | Journal of Environmental Sciences2009，21，9： | 41 |
| 2 | Nitrate in shallow groundwater in typical agricultural and forest ecosystems in China,2004-2010显示文摘The nitrate-nitrogen(NO 3-N) concentrations from shallow groundwater wells situated in 29 of the Chinese Ecosystem Research Network field stations,representing typical agroand forest ecosystems,were assessed using monitoring data collected between 2004 and 2010.Results from this assessment permit a national scale assessment of nitrate concentrations in shallow groundwater,and allow linkages between nitrate concentrations in groundwater and broad land use categories to be made.Results indicated that most of the NO 3--N concentrations in groundwater from the agroand forest ecosystems were below the Class 3 drinking water standard stated in the Chinese National Standard:Quality Standard for Ground Water(≤ 20 mg/L).Over the study period,the average NO 3--N concentrations were significantly higher in agro-ecosystems(4.1 ± 0.33 mg/L) than in forest ecosystems(0.5 ± 0.04 mg/L).NO 3-N concentrations were relatively higher(> 10 mg N /L) in 10 of the 43 wells sampled in the agricultural ecosystems.These elevated concentrations occurred mainly in the Ansai,Yucheng,Linze,Fukang,Akesu,and Cele field sites,which were located in arid and semiarid areas where irrigation rates are high.We suggest that improvements in N fertilizer application and irrigation management practices in the arid and semi-arid agricultural ecosystems of China are the key to managing groundwater nitrate concentrations. | Xinyu Zhang Zhiwei Xu Xiaomin Sun Wenyi Dong Deborah Ballantine | 2013 | Journal of Environmental Sciences2013，25，5： | 10 |
| 3 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 4 | Effects of Extrusion Speed on the Microstructure and Mechanical Properties of Mg-9Gd-3Y-1.5Zn-0.8Zr alloy显示文摘The effects of the extrusion speed on the microstructures,mechanical properties and aging hardening behaviors of Mg—9Gd—3Y—1.5Zn—0.8Zr alloy have been investigated.The microstructure evolution during hot extrusion has also been discussed.The microstructures of the extruded alloys mainly consist of the equiaxed dynamically recrystallized grains and fiber-like long period stacking ordered(LPSO)phase.The increasing extrusion speed results in grain coarsening and the mechanical properties deterioration.Meanwhile,it could also retard the aging hardening response.The extrudability of the investigated alloy is limited.Cracks nucleate and grow up rapidly when the extrusion speed is over 0.3 m/min.It should be closely related to the large amount of LPSO phase and the unique microstructure evolution.The rapidly precipitating fine lamella during extrusion could pin the dislocations and grain boundaries effectively.It could strengthen the alloy but also limit the extrudability of the investigated alloy. | Xuan Liu Zhiqiang Zhang Wenyi Hu Qichi Le Lei Bao Jianzhong Cui | 2016 | Journal of Materials Science & Technology2016，32，4： | 7 |
| 5 | Characterization and mapping of a novel mutant sms1 (senescence and male sterility 1) in rice显示文摘Plant senescence plays diverse important roles in development and environmental responses.However,the molecular basis of plant senescence is remained largely unknown.A rice spontaneous mutant with the character of early senescence and male sterility (sms) was found in the breeding line NT10-748.In order to identify the gene SMS1 and the underlying mechanism,we preliminarily analyzed physiological and biochemical phenotypes of the mutant.The mutant contained lower chlorophyll content compared with the wild type control and was severe male sterile with lower pollen viability.Genetic analysis showed that the mutant was controlled by a single recessive gene.By the map-based cloning approach,we fine-mapped SMS1 to a 67 kb region between the markers Z3-4 and Z1-1 on chromosome 8 using 1,074 F2 recessive plants derived from the cross between the mutant sms1 (japonica) × Zhenshan 97 (indica),where no known gene involved in senescence or male sterility has been identified.Therefore the SMS1 gene will be a novel gene that regulates the two developmental processes.The further cloning and functional analysis of the SMS1 gene is under way. | Wenyi Yan Shenghai Ye Qingsheng Jin Longjun Zeng Yu Peng Dawei Yan Weibing Yang Donglei Yang Zuhua He Yanjun Dong Xiaoming Zhang | 2010 | Journal of Genetics and Genomics2010，37，1： | 6 |
| 6 | Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method显示文摘This study was designed to elucidate the immunoregulation of Ganoderma lucidum.HPLC fingerprint and spectrum-effect relationship of G.lucidum were established to predict the active compounds and BP neural network model was established to predict the efficacy.Then the target compounds were identified by high resolution mass spectrometry.The results indicated that there are both enhanced immunity and immunosuppressive components in G.lucidum.BP neural network was trained with the common peak area and immune effi cacy index of G.lucidum fi ngerprint as samples,and a combined evaluation system of G.lucidum fi ngerprint effi cacy was established.The correlation coeffi cient R of BP network model was 0.98643,and the error of pharmacodynamic prediction results was in the ideal range.Eight compounds were identifi ed by high resolution mass spectrometry.The compounds related to immune activity in G.lucidum were determined in this study. | Changqin Li Yiping Cui Jie Lu Lijun Meng Changyang Ma Zhenhua Liu Yan Zhang Wenyi Kang | 2021 | Food Science and Human Wellness2021，10，3： | 6 |
| 7 | COVID-19: Antiviral Agents, Antibody Development and Traditional Chinese Medicine显示文摘The World Health Organization(WHO) has declared coronavirus disease 2019(COVID-19) is the first pandemic caused by coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). Currently, there is no effective anti-SARS-CoV-2 drug approved worldwide for treatment of patients with COVID-19. Therapeutic options in response to the COVID-19 outbreak are urgently needed. To facilitate the better and faster development of therapeutic COVID-19 drugs, we present an overview of the global promising therapeutic drugs, including repurposing existing antiviral agents,network-based pharmacology research, antibody development and traditional Chinese medicine. Among all these drugs,we focus on the most promising drugs(such as favipiravir, tocilizumab, SARS-CoV-2 convalescent plasma, hydroxychloroquine, Lianhua Qingwen, interferon beta-1 a, remdesivir, etc.) that have or will enter the final stage of human testing—phase Ⅲ–Ⅳ clinical trials. | Wenyi Guan Wendong Lan Jing Zhang Shan Zhao Junxian Ou Xiaowei Wu Yuqian Yan Jianguo Wu Qiwei Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 8 | Induction of fibroblasts to neurons through adenoviral gene delivery显示文摘 | Fengxi Meng Siye Chen Qinglong Miao Kechun Zhou Qicheng Lao Xiaohui Zhang Wenyi Guo Jianwei Jiao | 2012 | Cell Research2012，22，2： | 4 |
| 9 | Antrodia Cinnamomea ameliorates neointimal formation by inhibiting infl ammatory cell infi ltration through downregulation of adhesion molecule expression in vitro and in vivo显示文摘The increased vascular infl ammation is a key event in the development of atherosclerotic lesions.Antrodia cinnamomea has been shown to promote anticancerogenic activity through decreasing infl ammation.However,the potential role of A.cinnamomea in cardiovascular diseases remains unexplored.Herein,using carotid arterial ligation models,we found that ethanol extract from A.cinnamomea(EEAC)signifi cantly inhibited neointimal hyperplasia in a dose-dependent manner,accompanied with the reduced expression of activated p65 and infl ammatory cytokines.We also show that EEAC ameliorated TNF-α-induced phosphorylation of p65 and pro-infl ammatory cytokine expression in both vascular smooth muscle cells(VSMCs)and macrophages in vitro.Mechanistically,EEAC suppressed expression levels of intercellular adhesion molecule-1(ICAM-1)and vascular cell adhesion molecule(VCAM-1)in VSMCs,which attenuates the ability of monocytes/macrophages adhesion to VSMCs.Furthermore,the expression level of these adhesion molecules and infi ltration of monocytes/macrophages were also decreased in neointimal VSMCs of arteries pretreated with EEAC.Altogether,our results reveal a novel function of A.cinnamomea in suppressing vascular infl ammation upon ligation injury during neointimal formation,likely through inhibition of infl ammatory cell infi ltration via downregulating the adhesion molecules in VSMCs.Thus,A.cinnamomea may offer a pharmacological therapy to slow down disease progression in patients with vascular injury. | Yan Zhang Aijin Ma Hao Xi Ning Chen Rong Wang Chenhui Yang Jinbang Chen Pin Lü Fuping Zheng Wenyi Kang | 2021 | Food Science and Human Wellness2021，10，4： | 4 |
| 10 | Numerical simulation of DC casting of AZ31 magnesium slab at different casting speeds显示文摘A mathematical model of the direct chill(DC)casting process for AZ31magnesium slab has been developed to predict the temperature evolution in the slab.The temperature fields at different casting speeds were compared and the optimum casting speed of 300 mm×800 mm magnesium slab in the certain pouring temperature and cooling-water flow rate was obtained.The casting speed during the plant trial was consistent with the calculation. | Wenyi Hu Qichi Le Zhiqiang Zhang Lei Bao Jianzhong Cui | 2013 | Journal of Magnesium and Alloys2013，1，1： | 4 |
| 11 | Oxygen sensing and adaptability won the 2019 Nobel Prize in Physiology or medicine显示文摘The 2019 Nobel Prize in Physiology or Medicine was awarded to three physician scientists,Drs.William G.Kaelin,Jr.,Peter Ratcliffe and Gregg Semenza,for their groundbreaking work revealing how cells sense and adapt to oxygen availability.Here,we summarize the history of their discoveries. | Qing Zhang Qin Yan Haifeng Yang Wenyi Wei | 2019 | Genes & Diseases2019，6，4： | 4 |
| 12 | Composite denitrification reagent for high concentration ammonia removal by air stripping显示文摘Based on the traditional method of high concentration ammonia removal from wastewater,a mixture mainly consisting of ethyl lactate and acetic acid is used as an aid for ammonia removal by air stripping.The effect of dosage,the depth of air nozzle in water and other conditions for ammonia removal were investigated.The results show that under the conditions that denitrification reagent is in the dosage of 30 mg/L,pH value is 9-11,blowing depth is 400 mm,stripping time is greater than 2.5 h,and the temperature is normal(25°C),the concentration of ammonia nitrogen in wastewater can be reduced from 21006.0 mg/L to 10.6 mg/L. The ammonia nitrogen removal rate is up to 99.95%.At the temperature of 45°C,the concentration of ammonia nitrogen in wastewater can be decreased from 21006 mg/L to 0.2 mg/L.The ammonia nitrogen removal rate is up to 99.999%.When the wastewater ammonia concentration is between 800-30000 mg/L,the ammonia is air stripped under the above mentioned conditions,the residual concentration can be below 15 mg/L.The stripped ammonia can be absorbed without secondary pollution. | LEI ChunSheng MA JianFeng LI DingLong ZHANG WenYi GUANG XiaoHong MA Jun | 2010 | Chinese Science Bulletin2010，55，24： | 4 |
| 13 | Desmoglein 2(DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia显示文摘Human adenovirus type 55(HAdV-B55) is a re-emergent acute respiratory disease pathogen that causes adult communityacquired pneumonia(CAP). Previous studies have shown that the receptor of HAdV-B14, which genome is highly similar with HAdV-B55, is human Desmoglein 2(DSG2). However, whether the receptor of HAdV-B55 is DSG2 is undetermined because there are three amino acid mutations in the fiber gene between HAdV-B14 and HAdV-B55. Here, firstly we found the 3T3 cells, a mouse embryo fibroblast rodent cell line which does not express human DSG2, were able to be infected by HAdV-B55 after transfected with pcDNA3.1-DSG2, while normal 3T3 cells were still unsusceptible to HAdV-B55 infection. Next, A549 cells with h DSG2 knock-down by siRNA were hard to be infected by HAdV-B3/-B14/-B55, while the control siRNA group was still able to be infected by all these types of HAdVs. Finally, immunofluorescence confocal microscopy indicated visually that Cy3-conjugated HAdV-B55 viruses entered A549 cells by binding to DSG2 protein.Therefore, DSG2 is a major receptor of HAdV-B55 causing adult CAP. Our finding is important for better understanding of interactions between adenoviruses and host cells and may shed light on the development of new drugs that can interfere with these processes as well as for the development of potent prophylactic vaccines. | Jing Zhang Kui Ma Xiangyu Wang Yinbo Jiang Shan Zhao Junxian Ou Wendong Lan Wenyi Guan Xiaowei Wu Heping Zheng Bin Yang Chengsong Wan Wei Zhao Jianguo Wu Qiwei Zhang | 2021 | Virologica Sinica2021，36，6： | 4 |
| 14 | Deeply learned broadband encoding stochastic hyperspectral imaging显示文摘Many applications requiring both spectral and spatial information at high resolution benefit from spectral imaging.Although different technical methods have been developed and commercially available,computational spectral cameras represent a compact,lightweight,and inexpensive solution.However,the tradeoff between spatial and spectral resolutions,dominated by the limited data volume and environmental noise,limits the potential of these cameras.In this study,we developed a deeply learned broadband encoding stochastic hyperspectral camera.In particular,using advanced artificial intelligenee in filter design and spectrum reconstruction,we achieved 7000-11,000 times faster signal processing and〜10 times improvement regarding noise toleranee.These improvements enabled us to precisely and dynamically reconstruct the spectra of the entire field of view,previously unreachable with compact computational spectral cameras. | Wenyi Zhang Hongya Song Xin He Longqian Huang Xiyue Zhang Junyan Zheng Weidong Shen Xiang Hao Xu Liu | 2021 | Light(Science & Applications)2021，10，6： | 4 |
| 15 | Thermo-Mechanically Coupled Thermo-Elasto-Visco-Plastic Modeling of Thermo-Induced Shape Memory Polyurethane at Finite Deformation显示文摘A series of mono tonic tensile experiments of thermo-induced shape memory polyurethane(TSMPU) at different loading rates were carried out to investigate the interaction between the internal heat production and the mechanical deformation. It is shown that the temperature variation on the surfaces of the specimens due to the internal heat production affects the mechanical properties of TSMPU remarkably. Then, based on irreversible thermodynamics, the Helmholtz free energy was decomposed into three parts, i.e., the instantaneous elastic free energy,visco-plastic free energy and heat free energy. The total deformation gradient was decomposed into the mechanical and thermal parts, and the mechanical deformation gradient was further divided into the elastic and visco-plastic components. The Hencky's logarithmic strain was used in the current configuration. The heat equilibrium equation of internal heat production and heat exchange was derived in accordance with the first and second thermodynamics laws. The temperature of specimens was contributed by the internal heat, production and the ambient temperature simultaneously, and a thermo-mechanic ally coupled thermo-elas to-visco-plastic model was established. The effect of temperature variation of specimens on the mechanical properties of the material was considered in this work. Finally, the capability of the proposed model was validated by comparing the simulated results with the corresponding experimental data of TSMPU. | Jian Li Qian-hua Kan Ze-bin Zhang Guo-zheng Kang Wenyi Yan | 2018 | Acta Mechanica Solida Sinica2018，31，2： | 3 |
| 16 | Effects of acute cold exposure on oxidative balance and total antioxidant capacity in juvenile Chinese soft-shelled turtle,Pelodiscus sinensis显示文摘Acute cold exposure may disturb the physiological homeostasis of the body in ectotherms.To date,there has been no information on the effects of cold exposure on homeostasis of reactive oxygen species(ROS)or antioxidant defense response in the Chinese soft-shelled turtle,Pelodiscus sinensis.In this study,P.sinensis juveniles were acclimated at 28℃,transferred to 8℃ as cold exposure for 12 h,then moved back to 28℃ rewarming for 24 h.We measured the ROS level and total antioxidant capacity(TAC)in the brain,liver,kidney and spleen at 2 and 12 h cold exposure,and at the end of the rewarming period.Malonaldehyde(MDA)and carbonyl protein were used as markers of oxidative damage.Turtles being maintained simultaneously at 28℃ were used as the control group.Cold exposure did not disturb the ROS balance in all 4 tissues,while rewarming raised the ROS level in the brain and kidney of P.sinensis.Cold exposure and rewarming decreased the TAC in the brain,liver and spleen but did not change the TAC in the kidney.MDA and carbonyl protein levels did not increase during the treatment,indicating no oxidative damage in all 4 tissues of P.sinensis.Our results indicated that extreme cold exposure did not impact the inner oxidative balance of P.sinensis,but more ROS was produced during rewarming.P.sinensis showed good tolerance to the harsh temperature change through effective protection of its antioxidant defense system to oxidative damage.This study provides basic data on the stress biology of P.sinensis. | Wenyi ZHANG Cuijuan NIU Hui JIA Xutong CHEN | 2017 | Integrative Zoology2017，12，5： | 3 |
| 17 | NLRP3 Deficiency Attenuates Secondary Degeneration of Visual Cortical Neurons Following Optic Nerve Injury显示文摘In the visual pathway, optic nerve(ON) injury may cause secondary degeneration of neurons in distal regions, such as the visual cortex. However, the role of the neuroinflammatory response in regulating secondary impairment in the visual cortex after ON injury remains unclear. The NOD-like receptor family pyrin domain containing 3(NLRP3) is an important regulator of neuroinflammation. In this study, we established a mouse model of unilateral ON crush(ONC) and showed that the expression of NLRP3 was significantly increased in the primary visual cortex(V1) as a response to ONC and that the NLRP3 inflammasome was activated in the contralateral V1 1 days–14 days after ONC. Ablation of the NLRP3 gene significantly decreased the trans-neuronal degeneration within 14 days. Visual electrophysiological function was improved in NLRP3-/- mice. Taken together, these findings suggest that NLRP3 is a potential therapeutic target for protecting visual cortical neurons against degeneration after ON injury. | Zhou Zhang Wenyi Liu Yubin Huang Linlin Luo Xiaofeng Cai Yunjia Liu Liqianyu Ai Jun Yan Sen Lin Jian Ye | 2020 | Neuroscience Bulletin2020，36，3： | 3 |
| 18 | Antioxidant andα-glucosidase inhibitiory activity of Cercis chinensis flowers显示文摘Antioxidant andα-glucosidase inhibitiory active compounds of Cercis chinensis flowers were investigated with bio-assay guiding method.Ethyl acetate fraction(CLEa)and n-butanol fraction(CLBu)exhibited antioxidant andα-glucosidase inhibitiory activity in vitro,and the corresponding active fractions,EaFr.3,EaFr.5 and BuFr.1,exhibited higher antioxidant andα-glucosidase inhibitiory activity than those of other fractions.Eight compounds,ethyl gallate(1),stearic acid(2),docosanoic acid(3),5α-stigmast-9(11)-en-3β-ol(4),kaempferol-3-O-α-rhamnopyranoside(5),vanillic acid(6),fisetin(7),andβ-sitosterol(8),were isolated and identified from CLEa and CLBu.Ethyl gallate shown the highest antioxidant activity by scavenging DPPH radical and reducing ferric compared.Docosanoic acid and vanillic acid shown strongerα-glucosidase inhibitory activity than that of acarbose. | Juanjuan Zhang Li Zhou Lili Cui Zhenhua Liu Jinfeng Wei Wenyi Kang | 2020 | Food Science and Human Wellness2020，9，4： | 3 |
| 19 | The origin of Mosuo people as revealed by mtDNA and Y chromosome variation显示文摘The Mosuo, living in the Lugu Lake area in northwest Yunnan Province, China, is the only matriarchal population in China. The Mosuo was officially identified as Naxi nationality although its relationship with Naxi remains controversial. We studied the genetic relationship between the Mosuo and five other ethnic groups currently residing in northwest Yunnan, i.e. Naxi, Tibetan, Bai, Yi and Pumi, by typing the genetic variations in mtDNA HVS1 and 21 Y chromosome markers (13 SNPs & 8 STR markers). We showed that the maternal lineages of the Mosuo bear the strongest resemblance with those found in Naxi while its paternal lineages are more similar to those that are prevalent in Yunnan Tibetan. The marked difference between paternal and maternal lineages may be attributable to the genetic history, matriarchal structure, and visiting marriage. | WEN Bo, SHI Hong, REN Ling, XI Huifeng, LI Kaiyuan, ZHANG Wenyi, SU Bing, SI Shiheng, JIN Li & XIAO ChunjieJoined Laboratory of Human Population Genetics of Yunnan University and Fudan University, Kunming 650091, China Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center of Yunnan University, Kunming 650091, China National Key Laboratory of Genetic Engineering & Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai 200433, China Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650031, China Center for Genome Information, Department of Environmental Health, University of Cincinnati, Cincinnati 45267, USA The Central Hospital of Ninglang County, Ninglang 674300, China | 2004 | Science China(Life Sciences)2004，47，1： | 3 |
| 20 | α-Glucosidase inhibitors isolated from medicinal plants显示文摘Objective:α-Glucosidase inhibitors can be used as a new class of antidiabetic drug.By competitively inhibiting glycosidase activity,these inhibitors help to prevent the fast breakdown of sugars and thereby control the blood sugar level.This study provides a wealth of information aboutα-glucosidase inhibitors isolated from medicinal plants;this knowledge will be useful in finding more potent antidiabetic candidates from the natural resources for the clinical development of antidiabetic therapeutics.Results:411 compounds exhibitingα-glucosidase inhibitory activity were summarized and isolated them from medicinal plants.The compound classes isolated include:terpenes(61)from 14 genus,alkaloids(37)from 11 genus,quinines(49)from 4 genus,flavonoids(103)from 24 genus,phenols(37)from 9 genus,phenylpropanoids(73)from 20 genus,sterides(8)from 5 genus,and other types of compounds(43).Conclusion:Compounds withα-glucosidase inhibitory activity are abundant in nature and can be obtained from several sources.They have highα-glucosidase inhibitory potential,and can be clinically developed for treating diabetes mellitus. | Zhenhua Yin Wei Zhang Fajin Feng Yong Zhang Wenyi Kang | 2014 | Food Science and Human Wellness2014，3，3： | 3 |
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