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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | Geological Characteristics and Zircon U-Pb Dating of Volcanic Rocks from the Beizhan Iron Deposit in Western Tianshan Mountains, Xinjiang, NW China显示文摘The Beizhan large iron deposit located in the east part of the Awulale metallogenic belt in the western Tianshan Mountains is hosted in the Unit 2 of the Dahalajunshan Formation as lens, veinlets and stratoid, and both of the hanging wall and footwall are quartz-monzonite; the dip is to the north with thick and high-grade ore bodies downwards. Ore minerals are mainly magnetite with minor sulfides, such as pyrite, pyrrhotite, chalcopyrite and sphalerite. Skarnization is widespread around the ore bodies, and garnet, diopside, wollastonite, actinolite, epidote, uralite, tourmaline sericite and calcite are ubiquitous as gangues. Radiating outwards from the center of the ore body the deposit can be classified into skarn, calcite, serpentinite and marble zones. LA-ICP-MS zircon U-Pb dating of the rhyolite and dacite from the Dahalajunshan Formation indicates that they were formed at 301.3±0.8 Ma and 303.7±0.9 Ma, respectively, which might have been related to the continental arc magmatism during the late stage of subduction in the western Tianshan Mountains. Iron formation is genetically related with volcanic eruption during this interval. The Dahalajunshan Formation and the quartz-monzonite intrusion jointly control the distribution of ore bodies. Both ore textures and wall rock alteration indicate that the Beizhan iron deposit is probably skarn type. | ZHANG Zuoheng HONG Wei JIANG Zongsheng DUAN Shigang XU Lingang LI Fengming GUO Xincheng ZHAO Zhengang | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 29 |
| 3 | Two-and three-electrode impedance spectroscopic studies of graphite electrode in the first lithiation显示文摘The first lithiation of graphite electrode was investigated by electrochemical impedance spectroscopy (EIS) and scanning electron microscope (SEM) in a two-electrode button cell and a three-electrode glass cell. The results demonstrate that the study of the variation of EIS feature of the graphite electrode in the two-electrode button cell with electrode polarization potential decreasing in the first lithiation cannot be used to investigate the formation mechanism of the solid electrolyte interphase (SEI) film. However, the formation and growth process of the SEI film can be acquired by investigating the variation of EIS features of the graphite electrode in the three-electrode glass cell with the decrease of electrode po-larization potential in the first lithiation. Moreover, the results also point out that the SEI film on graph-ite electrode is mainly formed between 1.0 and 0.6 V in the first lithiation. | ZHUANG QuanChao TIAN LeiLei WEI GuoZhen DONG QuanFeng SUN ShiGang | 2009 | Chinese Science Bulletin2009，54，15： | 4 |
| 4 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 5 | STUDY ON IMAGE EDGE PROPERTY LOCATION BASED ON FRACTAL THEORY显示文摘A novel approach of printed circuit board(PCB)image locating is presented Based on the rectangle mark image edge of PCB,the featur es is used to describe the image edge and the fractal properby of image edge is analyzed It is proved that the rectangle mark image edge of PCB has some fractal features A method of deleting unordinary curve noise and compensating the length of the fractal curve is put forward,which can get the fractal dimension value from one complex edge fractal property curve The relation between the dim ension of the fractal curve and the turning angle of image can be acquired from an equation,as a result,the angle value of the PCB image is got exactly A real image edge analysis result confirms that the method based on the fractal theory is a new powerful tool for angle locating on PCB and related image area. | Wang Hong, Wang Shigang, Xu Wei, Yu Xinrui (Institute of Robots,Shanghai Jiaotong University) | 2001 | Chinese Journal of Mechanical Engineering2001，14，4： | 2 |
| 6 | Overpotential-dependent shape evolution of gold nanocrystals grown in a deep eutectic solvent显示文摘这份报纸报导在胆碱氯化物脲(ChCl 脲) 的金 nanocrystals (Au NC ) 的过电位依赖者形状进化基于深最容易溶解的溶剂(DES ) 。生长过电位在调节 Au NC 的形状起一个关键作用,这被发现。Au NC 的形状进化连续地从凹面菱形的 dodecahedra (RD ) 到凹面立方体,八足类动物, cuboctahedral 盒子,并且最后,到空 octahedra (哦) 被小心地从 -0.50 在范围控制生长过电位到 -0.95 V 完成(对磅伪参考电极) 。另外,脲的存在在 Au NC 的形状进化是重要的。同样准备的 Au NC 的表面结构被扫描电子显微镜学(SEM ) 包括地描绘,传播电子显微镜学(TEM ) 和电气化学的研究。为 D 葡萄糖 electrooxidation 的同样准备的 Au NC 的 electrocatalytic 活动易感知地依赖于他们的形态学,这被表明。说明的结果使脱氢的葡萄糖在凹面 RD 和凹面上吸附了立方的 Au NC,这优先地在低电极潜力被转变到 gluconolactone。随后的 gluconolactone 氧化在八足类动物上有利地发生了与 { 111 } 截断的手臂并且空在高电极潜力的 OH。这研究开创一条新途径由把 DES 与电气化学的技术相结合开发 Au NC 的 surface-structurecontrolled 生长。另外,它为调节 NC 的 electrocatalytic 性质是重要的。 | Lu Wei Bangan Lu Mingjun Sun Na Tian Zhiyou Zhou Binbin Xu Xinsheng Zhao Shigang Sun | 2016 | Nano Research2016，9，11： | 2 |
| 7 | Interaction between indomethacin and human serum albumin by fluorescebnce quenching method显示文摘 | Bi Shuyun Song Daqian Wei Shigang | 2006 | Journal of Jilin University (Science Edition)2006，44，3： | 1 |
| 8 | New fuzzy c-meansclustering model based on the data weighted approach显示文摘 | TANG Chenglong WANG Shigang XU Wei | 2010 | Data&Knowledge Engineering2010，69，9： | 1 |
| 9 | Ultrasonic nebulization extraction-heating gas flow transfer-headspace single drop microextraction of essential oil from pericarp of Zanthoxylum bungeanum Maxim显示文摘 | Wei Shigang Zhang Huihui Wang Yeqiang | | 0，，： | 1 |
| 10 | Ultrasonic nebulization extraction-heating gas flow transfer-headspace single drop microextraction of essential oil from pericarp of Zanthoxylum bungeanum Maxim 显示文摘 | Shigang Wei Huihui Zhang Yeqiang Wang | 2011 | Journal of Chromatography A2011，1218，： | 1 |
| 11 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 12 | IR optical properties of Pt nanoparticles and their agglomerates investigated by in situ FTIRS using CO as the probe molecule 显示文摘 | Chen Wei Sun Shigang Zhou Zhiyou Chen Shengpei | 2003 | Journal of Physical Chemistry B2003，107，36： | 1 |
| 13 | Ultrasonic nebulization extraction-heating gas flow transfer-headspace single drop microextraction of essential oil from pericarp of Zanthoxylum bungeanum Maxim显示文摘 | Wei Shigang Zhang Huihui Wang Yeqiang | | 0，，29： | 1 |
| 14 | Ultrasonic nebulization extraction-heating gas flow transfer-headspace singledrop microextraction of essential oil from pericarp of Zanthoxylum bungeanum Maxim显示文摘 | WEI Shigang HANG Huihui WANG Yeqiang | 2011 | Chromatography A2011，1218，79： | 1 |
| 15 | Efficient oxygen electrocatalysts with highly-exposed Co-N4 active sites on N-doped graphene-like hierarchically porous carbon nanosheets enhancing the performance of rechargeable Zn-air batteries显示文摘Designing bifunctional oxygen electrocatalysts with high activity,lasting stability,and low-cost for rechargeable zinc-air batteries(RZABs)is a tough challenge.Herein,an advanced electrocatalyst is prepared by anchoring atomically dispersed Co atoms on Ndoped graphene-like hierarchically porous carbon nanosheets(SA-Co-N4-GCs)and thereby forming Co-N4-C architecture.Its unique structure with excellent conductivity,large surface area,and three dimensional(3D)interconnected hierarchically porous architecture exposes not only more Co-N4 active sites to accelerate the kinetics of both oxygen reduction reaction(ORR)and oxygen evolution reaction(OER),but also provides an efficient charge/mass transport environment to reduce diffusion barrier.Consequently,SA-Co-N4-GCs exhibits excellent ORR/OER bifunctional activities and durability,surpassing noble-metal catalysts.Liquid RZABs using SA-Co-N4-GCs cathodes display a high open-circuit voltage of 1.51 V,a remarkable power density of 149.3 mW·cm−2,as well as excellent stability and rechargeability with faint increase in polarization even at a large depth of charge–discharge cycle with 16 h per cycle over an entire 600 h long-term test.Moreover,flexible quasi-solid-state RZABs with SA-Co-N4-GCs cathodes also deliver a considerable power density of 124.5 mW·cm−2,which is even higher than that of liquid batteries using noble-metal catalysts.This work has thrown new insight into development of high-performance and low-cost electrocatalysts for energy conversion and storage. | Nengfei Yu Hui Chen Jingbiao Kuang Kailin Bao Wei Yan Jilei Ye Zhongtang Yang Qinghong Huang Yuping Wu Shigang Sun | 2022 | Nano Research2022，15，8： | 0 |
| 16 | Process Modeling of Ferrofluids Flow for Magnetic Targeting Drug Delivery显示文摘Among the proposed techniques for delivering drugs to specific sites within the human body, magnetic targeting drug delivery surpasses due to its non-invasive character and its high targeting efficiency. Although there have been some analyses theoretically for magnetic drug targeting, very few researchers have addressed the hydrodynamic models of magnetic fluids in the blood vessel of human body. This paper presents a mathematical model to describe the hydrodynamics of ferrofluids as drug carriers flowing in a blood vessel under the applied magnetic field. A 3D flow field of magnetic particles in a blood vessel model is numerically simulated in order to further understand clinical application of magnetic targeting drug delivery. Simulation results show that magnetic nanoparticles can be enriched in a target region depending on the applied magnetic field intensity. Magnetic resonance imaging confirms the enrichment of ferrofluids in a desired body tissue of Sprague-Dawley rats. The simulation results coincide with those animal experiments. Results of the analysis provide the important information and can suggest strategies for improving delivery in favor of the clinical application. | LIU Handan WANG Shigang XU Wei | 2009 | Chinese Journal of Mechanical Engineering2009，22，3： | 0 |
| 17 | COVID-19 pharmacological research trends:a bibliometric analysis显示文摘Background:The coronavirus disease 2019(COVID-19)pandemic is ravaging the world.Many therapies have been explored to treat COVID-19.This report aimed to assess the global research trends for the development of COVID-19 therapies.Methods:We searched the relevant articles on COVID-19 therapies published from January 1,2020,to May 25,2022,in the Web of Science Core Collection Database(WOSCC).VOSviewer 1.6.18 software was used to assess data on the countries,institutions,authors,collaborations,keywords,and journals that were most implicated in COVID-19 pharmacological research.The latest research and changing trends in COVID-19-relevant pharmacological research were analyzed.Results:After manually eliminating articles that do not meet the requirements,a total of 5,289 studies authored by 32,932 researchers were eventually included in the analyses,which comprised 95 randomized controlled trials.3,044(57.6%)studies were published in 2021.The USA conducted the greatest number of studies,followed by China and India.The primary USA collaborators were China and England.The topics covered in the publications included:the general characteristics,the impact on pharmacists’work,the pharmacological research,broad-spectrum antiviral drug therapy and research,and promising targets or preventive measures,such as vaccine.The temporal diagram revealed that the current research hotspots focused on the vaccine,molecular docking,Mpro,and drug delivery keywords.Conclusion:Comprehensive bibliometric analysis could aid the rapid identification of the principal research topics,potential collaborators,and the direction of future research.Pharmacological research is critical for the development of therapeutic and preventive COVID-19-associated measures.This study may therefore provide valuable information for eradicating COVID-19. | Yanyan Shi Yahan Song Zhijun Guo Wei Yu Huiling Zheng Shigang Ding Siyan Zhan | 2023 | Intelligent Medicine2023，3，1： | 0 |
| 18 | Molecular engineering on all ortho-linked carbazole/oxadiazole hybrids toward highly-efficient thermally activated delayed fluorescence materials in OLEDs显示文摘The highest efficiency thermally activated delayed fluorescence(TADF)emitters in OLEDs are mostly based on twisted donor/acceptor(D/A)type organic molecules.Herein,we report the rational molecular design on twisted all ortho-linked carbazole/oxadiazole(Cz/OXD)hybrids with tunable D-A interactions by adjusting the numbers of donor/acceptor units and electron-donating abilities.Singlet-triplet energy bandgaps(ΔEST)are facilely tuned from^0.4,0.15 to^0 eV in D-A,D-A-D to A-D-A type compounds.This variation correlates well with triplet-excited-state frontier orbital spatial separation efficiency.NonTADF feature with solid state photoluminescence quantum yield(PLQY)<10%is observed in D-A type 2CzOXD and D-A-D type 4CzOXD.Owing to the extremely lowΔEST for efficient reverse intersystem crossing,strong TADF with PLQY of 71%-92%is achieved in A-D-A type 4CzDOXD and 4tCzDOXD.High external quantum efficiency from 19.4%to 22.6%is achieved in A-D-A typed 4CzDOXD and 4tCzDOXD. | Wenbo Yuan Hannan Yang Mucan Zhang Die Hu Shigang Wan Zijing Li Changsheng Shi Ning Sun Youtian Tao Wei Huang | 2019 | Chinese Chemical Letters2019，30，11： | 0 |
| 19 | Construction risks of Huaying mount tunnel and countermeasures显示文摘 | Haibo YAO Feng GAO Shigang YU Wei DANG | 2017 | Frontiers of Structural and Civil Engineering2017，11，3： | 0 |
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