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| 1 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(http://gffzze7c39cdc9e894ca6snq9boxoou90v69q6.ffgz.tsg.suse.edu.cn).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 2 | NK cells play a significant role in immunosurveillance at the early stage of MLL-AF9 acute myeloid leukemia via CD226/CD155 interactions显示文摘Acute myeloid leukemia(AML) is an aggressive hematological malignancy, and the mechanism underlying immune system involvement in leukemia development is unclear. In the present study, we utilized a myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3(MLLT3/MLL-AF9)-induced AML mouse model with or without exposure to irradiation. We found that the leukemia cells could survive and expand in hosts with intact immune systems, whereas leukemia progression was accelerated in mice with impaired immune systems. Moreover, the leukemia cells escaped from host immunosurveillance via editing their immunogenicity, including the up-regulation of an inhibitory antigen(i.e., CD47) and the down-regulation of active antigens(i.e., CD86, CD54, retinoic acid early transcript(RAE), histocompatibility 2, D region locus b(H2-Db) and H2-Dd). Natural killer(NK) cells were activated in the early phase of AML progression, whereas T cells were stimulated in the late phase. Furthermore, NK cell depletion showed that NK cells were necessary for the elimination of leukemia cells in our AML mouse model. Notably, CD155/CD226 primarily mediated the interaction between NK cells and leukemia cells and contributed to the antitumor effects of NK cells during the early phase of AML. Clinical data from patients with diverse hematological malignancies showed that CD155 expression was decreased in hematological malignancies. Taken together, our results demonstrate that NK cells play a pivotal role in immunosurveillance against leukemia cells during the early stage of AML primarily through the CD226/CD155 interaction; however, NK cells are not sufficient to eliminate leukemia cells. | WANG YaJie CHEN Chen DONG Fang MA ShiHui XU Jing GONG YueMin CHENG Hui ZHOU Yuan CHENG Tao HAO Sha | 2015 | Science China(Life Sciences)2015，58，12： | 3 |
| 3 | Heterostructure Ag@WO3-x Composites with High Selectivity for Breaking Azo-bond显示文摘 | FANG Zhenxing CHEN Yan WANG Boran JIAO Shihui PANG Guangsheng | 2018 | Chemical Research in Chinese Universities2018，34，4： | 1 |
| 4 | A self-crosslinking,double-functional group modified bacterial cellulose gel used for antibacterial and healing of infected wound显示文摘Cellulose/chitosan composite,as a mature commercial antibacterial dressing,is an important type of wound repair material.However,how to achieve the perfect compound of two components and improve antibacterial activity is a major,lingering issue.In this study,a bifunctional group modified bacterial cellulose(DCBC)was prepared by carboxymethylation and selective oxidation.Further,the chitosan(CS)was compounded in the network of DCBC by self-crosslinking to form dialdehyde carboxymethyl bacterial cellulose/chitosan composites(S-DCBC/CS).The aldehyde group can react with amino of CS by Schiff base reaction.The carboxyl group of DCBC and the amorphous distribution of CS molecular chains increase the antimicrobial properties of com-posites.The bacteriostatic rate of composites could be higher than 95%.Bacteria can be attracted onto the surface of composites,what we call it“directional adhesion antibacterial effects”.In particular,a kind of large animal wound model,deep II degree infected scald of Bama miniature pig,was used to research the antimicrobial and healing properties of materials.The S-DCBC/CS can effectively inhibit bacterial proliferation of wound and kill the bacteria.The wound healing rate of S-DCBC/CS was up to 80%after three weeks.The composites show better antibacterial and promoting concrescence effects than traditional chitosan dressings. | Yajie Xie Kun Qiao Lina Yue Tao Tang Yudong Zheng Shihui Zhu Huiyi Yang Ziyuan Fang | 2022 | Bioactive Materials2022，7，11： | 1 |
| 5 | Interleukin-12 supports in vitro self-renewal of long-term hematopoietic stem cells显示文摘Hematopoietic stem cells(HSCs)self-renew or differentiate through division.Cytokines are essential for inducing HSC division,but the optimal cytokine combination to control self-renewal of HSC in vitro remains unclear.In this study,we compared the effects of interleukin-12(IL-12)and thrombopoietin(TPO)in combination with stem cell factor(SCF)on in vitro self-renewal of HSCs.Single-cell assays were used to overcome the heterogeneity issue of HSCs,and serum-free conditions were newly established to permit reproduction of data.In single-cell cultures,CD150^(+)CD48^(-)CD41^(-)CD34^(-)c-Kit^(+)Sca-1^(+)lineage^(-)SCs divided significantly more slowly in the presence of SCF+IL-12 compared with cells in the presence of SCF+TPO.Serial transplantation of cells from bulk and clonal cultures revealed that TPO was more effective than IL-12 at supporting in vitro self-renewal of short-term(<6 months)HSCs,resulting in a monophasic reconstitution wave formation,whereas IL-12 was more effective than TPO at supporting the in vitro selfrenewal of long-term(>6 months)HSCs,resulting in a biphasic reconstitution wave formation.The control of division rate in HSCs appeared to be crucial for preventing the loss of self-renewal potential from their in vitro culture. | Shanshan Zhang Maiko Morita Zhao Wang Jun Ooehara Sen Zhang Miner Xie Haitao Bai Wenying Yu Xiaofang Wang Fang Dong Jinhong Wang Shihui Ma Satoshi Yamazaki Hideo Ema | 2019 | Blood Science2019，1，1： | 0 |
| 6 | A Novel Approach for Image Encryption with Chaos-RNA显示文摘In today’s information society,image encryption technology is crucial to protecting Internet security.However,traditional image encryption algorithms have problems such as insufficient chaotic characteristics,insufficient randomness of keys,and insecure Ribonucleic Acid(RNA)encoding.To address these issues,a chaos-RNA encryption scheme that combines chaotic maps and RNA encoding was proposed in this research.The initial values and parameters of the chaotic system are first generated using the Secure Hash Algorithm 384(SHA-384)function and the plaintext image.Next,the Lühyperchaotic system sequence was introduced to change the image’s pixel values to realize block scrambling,and further disturbance is achieved through spiral index sequence to enhance encryption effectiveness.Subsequently,to obtain the final encrypted image,the diffusion is accomplished through different RNA encoding rules and operation rules corresponding to the chaotic sequence generated by an improved one-dimensional chaotic map(1DCM).Here innovatively propose four new RNA operation rules,increasing the difficulty of decryption.Simulation results demonstrate that the normalized pixel change rate(NPCR)and the unified average changed intensity(UACI)values of the tested encrypted images were 99.61%and 33.46%,respectively.The average ciphertext entropy value in the Red Green Blue(RGB)channels were 7.9986,7.991,and 7.991.Furthermore,this algorithm exhibits a low correlation coefficient and enhanced robustness.This encryption method effectively improves the security and reliability of image encryption compared to other similar techniques. | Yan Hong Shihui Fang Jingming Su Wanqiu Xu Yuhao Wei Juan Wu Zhen Yang | 2023 | Computers, Materials & Continua2023，77，10： | 0 |
| 7 | Neuroprotective effect of Eleutheroside B on 1-methyl-4-phenylpyridinium ion-induced apoptosis in PC12 cells显示文摘Apoptosis and viability of PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+)-induced injury were monitored by flow cytometry, following Annexin V-propidium iodide double labeling, and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, respectively. The release of lactate dehydrogenase, superoxide dismutase activity and levels of malondialdehyde were determined by UV spectrophotometry. The changes in mitochondrial membrane potential and the intracellular concentration of calcium were determined by flow cytometry, and the activity of caspase-3 was monitored by western blot. According to cell viability and apoptosis studies, MPP+-induced apoptosis in PC12 cells was inhibited in the presence of 10 μg/mL of Eleutheroside B. Our results indicate that the neuroprotective effect of Eleutheroside B, following MPP+-induced apoptosis in PC12 cells, involves increasing the anti-oxidative stress capacity of cells, maintaining the high-energy state of mitochondrial membrane potential, reducing intracellular calcium concentration and inhibiting caspase-3 activity. | Fang Lu Yang Dong Laijun Deng Shumin Liu Shihui Zhou Lifeng An Bo Tang | 2011 | Neural Regeneration Research2011，6，18： | 0 |
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