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24篇 您的检索式:作者名="Yuhao Wei"
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1Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development.Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang 2019Science China(Life Sciences)2019,62,3:14
2Few-layer Tellurium:one-dimensional-like layered elementary semiconductor with striking physical properties显示文摘Few-layer Tellurium, an elementary semiconductor, succeeds most of striking physical properties that black phosphorus(BP) offers and could be feasibly synthesized by simple solution-based methods. It is comprised of non-covalently bound parallel Te chains, among which covalent-like feature appears.This feature is, we believe, another demonstration of the previously found covalent-like quasi-bonding(CLQB) where wavefunction hybridization does occur. The strength of this inter-chain CLQB is comparable with that of intra-chain covalent bonding, leading to closed stability of several Te allotropes. It also introduces a tunable bandgap varying from nearly direct 0.31 eV(bulk) to indirect 1.17 eV(2L) and four(two) complex, highly anisotropic and layer-dependent hole(electron) pockets in the first Brillouin zone.It also exhibits an extraordinarily high hole mobility(~10~5 cm^2/Vs) and strong optical absorption along the non-covalently bound direction, nearly isotropic and layer-dependent optical properties, large ideal strength over 20%, better environmental stability than BP and unusual crossover of force constants for interlayer shear and breathing modes. All these results manifest that the few-layer Te is an extraordinary-high-mobility, high optical absorption, intrinsic-anisotropy, low-cost-fabrication, tunable bandgap, better environmental stability and nearly direct bandgap semiconductor. This ‘‘one-dimen sion-like' few-layer Te, together with other geometrically similar layered materials, may promote the emergence of a new family of layered materials.Jingsi Qiao Yuhao Pan Feng Yang Cong Wang Yang Chai Wei Ji 2018Science Bulletin2018,63,3:12
3High-quality genome assembly of 'Cuiguan' pear (Pyrus pyrifolia) as a reference genome for identifying regulatory genes and epigenetic modifications responsible for bud dormancy显示文摘Dormancy-associated MADS-box(DAM)genes serve as crucial regulators of the endodormancy cycle in rosaceous plants.Although pear DAM genes have been identified previously,the lack of a high-quality reference genome and techniques to study gene function have prevented accurate genome-wide analysis and functional verification of such genes.Additionally,the contribution of other genes to the regulation of endodormancy release remains poorly understood.In this study,a high-quality genome assembly for'Cuiguan'pear(Pyrus pyrifolia),which is a leading cultivar with a low chilling requirement cultivated in China,was constructed using PacBio and Hi-C technologies.Using this genome sequence,we revealed that pear DAM genes were tandemly clustered on Chr8 and Chr15 and were differentially expressed in the buds between'Cuiguan'and the high-chilling-requirement cultivar'Suli'during the dormancy cycle.Using a virus-induced gene silencing system,we determined the repressive effects of DAM genes on bud break.Several novel genes potentially involved in the regulation of endodormancy release were identified by RNA sequencing and H3K4me3 chromatin immunoprecipitation sequencing analyses of‘Suli'buds during artificial chilling using the new reference genome.Our findings enrich the knowledge of the regulatory mechanism underlying endodormancy release and chilling requirements and provide a foundation for the practical regulation of dormancy release in fruit trees as an adaptation to climate change.Yuhao Gao Qinsong Yang Xinhui Yan Xinyue Wu Feng Yang Jianzhao Li Jia Wei Junbei Ni Mudassar Ahmad Songling Bai Yuanwen Teng 2021Horticulture Research2021,8,1:5
4Measurement of γ detector backgrounds in the energy range of 3-8 MeV at Jinping underground laboratory for nuclear astrophysics显示文摘The astrophysical reaction rate of the charged-particleinduced reaction is dominated by the cross section within the Gamow window.The total cross section σ(E)of a chargedparticle-induced reaction is known to drops steeply with decreasing energy owing to the Coulomb barrier in the entrance channel:YangPing Shen Jun Su WeiPing Liu Gang Lian Lin Gan LvHua Qiao ShengQuan Yan Yong Zhou Qian Yue Zhi Zeng QingDong Hu YuHao Mi Wei Zhao 2017Science China(Physics,Mechanics & Astronomy)2017,60,10:5
5Signaling pathways and therapeutic interventions in gastric cancer显示文摘Gastric cancer(GC)ranks fifth in global cancer diagnosis and fourth in cancer-related death.Despite tremendous progress in diagnosis and therapeutic strategies and significant improvements in patient survival,the low malignancy stage is relatively asymptomatic and many GC cases are diagnosed at advanced stages,which leads to unsatisfactory prognosis and high recurrence rates.With the recent advances in genome analysis,biomarkers have been identified that have clinical importance for GC diagnosis,treatment,and prognosis.Modern molecular classifications have uncovered the vital roles that signaling pathways,including EGFR/HER2,p53,PI3K,immune checkpoint pathways,and cell adhesion signaling molecules,play in GC tumorigenesis,progression,metastasis,and therapeutic responsiveness.These biomarkers and molecular classifications open the way for more precise diagnoses and treatments for GC patients.Nevertheless,the relative significance,temporal activation,interaction with GC risk factors,and crosstalk between these signaling pathways in GC are not well understood.Here,we review the regulatory roles of signaling pathways in GC potential biomarkers,and therapeutic targets with an emphasis on recent discoveries.Current therapies,including signaling-based and immunotherapies exploited in the past decade,and the development of treatment for GC,particularly the challenges in developing precision medications,are discussed.These advances provide a direction for the integration of clinical,molecular,and genomic profiles to improve GC diagnosis and treatments.Zi-Ning Lei Qiu-Xu Teng Qin Tian Wei Chen Yuhao Xie Kaiming Wu Qianlin Zeng Leli Zeng Yihang Pan Zhe-Sheng Chen Yulong He 2022Signal Transduction and Targeted Therapy2022,7,11:4
6Blue light-emitting polyfluorenes containing dibenzothiophene-S,S-dioxide unit in alkyl side chain显示文摘Blue light-emitting polyfluorenes containing dibenzothiophene-S,S-dioxide(SO) unit in alkyl side chain(PF-FSOs and PF-CzSOs) were synthesized. All the polymers show high thermal stability with the decomposition temperatures over400 °C. The highest occupied molecular orbital(HOMO) and the lowest unoccupied molecular orbital(LUMO) energy levels of the copolymer slightly decrease with the increase of SO content in side chain. PL spectra of the polymers show slightly red shift and broadening with the increase of solvent polarities, indicating unremarkable intramolecular charge transfer(ICT) effect in the polymers containing SO unit in alkyl side chain. EL spectra of the polymers are almost unchanged in the current densities from 100 to 400 mA cm.2, indicating the superb EL stability of the resulted polymers. The EL spectra of the copolymers exhibit obvious blue-shift and narrowing with the CIE of(0.18, 0.11) for PF-FSO10 and(0.17, 0.11) for PF-CzSO10, respectively,compared with PF-SO10 containing SO unit in main chain with the CIE of(0.16, 0.17) and PFO with the CIE of(0.18, 0.18).The superior device performances were obtained with the luminous efficiency(LEmax) of 1.17 and 0.68 cd A.1 for PF-FSO15 and PF-CzSO20, respectively, compared with the LEmax of 0.37 cd A.1 for PFO. The results indicate that linking SO unit to alkyl side chain of the polyfluorene is a promising strategy for efficient blue light-emitting polymers.Yiwen Fang Jie Liu Yuhao Zhang Ting Guo Fei Huang Wei Yang Yong Cao 2017Science China Chemistry2017,60,10:2
7Osteopontin inhibits osteoarthritis progression via the OPN/CD44/PI3K signal axis显示文摘Chondrocyte degeneration and extracellular matrix component loss are the primary causes of osteoarthritis(OA).OA can be treated by inhibiting chondrocyte degeneration and increasing extracellular matrix component secretion.Osteopontin(OPN),a multifunctional protein,has gained immense attention with regard to its involvement in OA.This study aimed to explore the therapeutic value and mechanism of action of OPN in OA treatment.Results of the histomorphological analysis revealed a worn-off OA cartilage tissue surface,cartilage matrix layer deterioration,and calcium salt deposition.Compared to that in normal chondrocytes,in OA chondrocytes,the OPN,CD44,and PI3K protein and mRNA expression was upregulated.Further,siOPN,rhOPN,and rhOPN plus LS-C179404 interfered with OA chondrocytes.As verified in mice,OPN directly inhibited the expression level of PI3K in OA chondrocytes by binding with CD44.Morphological analysis of the knee joints demonstrated that OPN effectively inhibited OA progression via the OPN/CD44/PI3K signal axis.In conclusion,OPN activates intracellular PI3K signaling molecules by binding to CD44 on the cell surface to cause downstream cascading effects,thereby delaying chondrocyte degeneration and reducing cartilage matrix component loss;therefore,OPN is a potential therapeutic agent for OA.Qing Liu Hao Zeng Yuhao Yuan Zhiwei Wang Ziyi Wu Wei Luo 2022Genes & Diseases2022,9,1:2
8Sapphirine-Bearing Pelitic Granulite from Ailaoshan Orogen,West Yunnan,China: Metamorphic Conditions and Tectonic Setting显示文摘To reveal the petrological characteristics, metamorphic evolution histon and tectonic setting of the pelitic granulites from Ailaoshan Orogen, Uest Yunnan, China, a comprehensive study in mineral chemistry, petrogeochemistry and geochronology studies is presented in this paper. Two metamorphic stages of the granulites can be established:(1) the peak metamorphism recorded by the mineral assemblage of garnet, kyanite, K-feidspar and rutile, and the initial retrograde metamorphism shown by the mineral assemblage of garnet, sillimanite, sapphirine, spinel, K-feldspar, plagioclase and biotite;(2) the superim-posed metamorphism recorded by the mineral assemblage of biotite, muscovite, plagioclase, quartz and ilmenite. Zircon LA-ICP-MS U-Pb dating indicates that the protolith of the granulite was deposited after 337 Ma. The initial retrograde metamorphism occurred at P-T conditions of 8.6-12 kbar at 850-920℃ estimated by mineral assemblages, the low pressure limit of kyanite stability and GBPQ geothermobarometer in Indosinian (about 235 Ma), and the late superimposed metamorphism occurred at the P-T condition of 3.5-3.9 kbar at 572-576℃ estimated by GBPQ geothermobarometer since 33Ma. The first stage was related to the amalgamation of the South China and Indochina blocks during the Triassic, and the second stage was possibly related with the large scale sinistral slip-shearing since the Oligocene. It is inferred that the upper continental crust was suhducted/underthrusted to the lower continental crust (deeper than 30 km) and underwent granulite-facies metamorphism and then quickly exhumed to the middle-upper crust (10-12 km) and initial retrograde metamorphism occurred due to the collision of the Indochina and South China blocks during Indosinian, which was followed by superimposition of the second stage of metamorphism since the Oligocene.Cheng Wei Yuhao Zhao Luhua Zhu Xuexiang Qi Zhihui Cai Xufeng Liu Guangfei Ma 2019Journal of Earth Science2019,30,3:1
9Bipolar Blue Light-emitting Polyfluorenes Containing Dibenzothiophene-S,S-dioxide/Carbazole Units显示文摘LIANG Li LIU Jie ZHANG Yuhao HU Liwen GUO Ting YANG Wei CAO Yong 2018Chemical Research in Chinese Universities2018,34,3:1
10Recent Progress on Hydrogeodesy in China显示文摘Modern geodetic technologies,including high-precision ground-based gravity measurements,satellite gravimetry,satellite altimetry,Global Navigation Satellite Systems(GNSS),and Interferometric Synthetic Aperture Radar(InSAR),offer a wealth of observations for monitoring global hydrological processes with exceptional accuracy and spatio-temporal resolutions.Mass redistribution and Earth’s surface deformation over land related to global and regional water cycling can be inferred from modern gravimetry,altimetry,GNSS,and InSAR techniques.Hydrogeodesy becomes an emerging field of geodesy aiming to analyze the changes of water in the Earth system.The paper introduces the China’s advances in hydrogeodesy in recent years.It brings together multiple geodetic teams’work from China,showcasing the application of modern geodetic technologies in the field of hydrology,including research on terrestrial water storage,groundwater storage,glaciers/ice sheets,and reservoir water storage.Wei FENG Yuhao XIONG Shuang YI Bo ZHONG Xiaodong CHEN Yulong ZHONG Yuanjin PAN Lin LIU Wei WANG Min ZHONG 2023Journal of Geodesy and Geoinformation Science2023,6,3:0
11Defects inducing anomalous exciton kinetics in monolayer WS_(2)显示文摘Two-dimensional(2D)transition metal dichalcogenide(TMD)has emerged as an effective optoelectronics material due to its novel optical properties.Understanding the role of defects in exciton kinetics is crucial for achieving high-efficiency TMD devices.Here,we observe defects induced anomalous power dependence exciton dynamics and spatial distribution in hexagonal heterogeneous WS_(2).With transient absorption microscopy study,we illustrate that these phenomena originate from the competition between radiative and defect-related non-radiative decays.To understand the physics behind this,a decay model is introduced with two defect-related channels,which demonstrates that more excitons decay through non-radiative channels in the dark region than the bright region.Our work reveals the mechanisms of anomalous exciton kinetics by defects and is instrumental for understanding and exploiting excitonic states in emerging 2D semiconductors.Zhe Li Yan Zeng Zhenwei Ou Tianzhu Zhang Rongguang Du Ke Wu Quanbing Guo Wei Jiang Yuhao Xu Tao Li Tai Min Ti Wang Hongxing Xu 2022Nano Research2022,15,2:0
12Sulfur-doped CMK-5 with expanded lattice for high-performance lithium ion batteries显示文摘Heteroatom-doped porous carbon materials are very attractive for lithium ion batteries(LIBs) owing to their high specific surface areas, open pore structures, and abundant active sites. However, heteroatomdoped porous carbon with very high surface area and large pore volume are highly desirable but still remain a big challenge. Herein, we reported a sulfur-doped mesoporous carbon(CMK-5-S) with nanotubes array structure, ultrahigh specific surface area(1390 m^(2)/g), large pore volume(1.8 cm^(3)/g), bimodal pore size distribution(2.9 and 4.6 nm), and high sulfur content(2.5 at%). The CMK-5-S used as an anode material for LIBs displays high specific capacity, excellent rate capability and highly cycling stability. The initial reversible specific capacity at 0.1 A/g is as high as 1580 mAh/g and simultaneously up to 701 mAh/g at 1A/g even after 500 cycles. Further analysis reveals that the excellent electrochemical storage performances is attributed to its unique structures as well as the expanded lattice by sulfur-doping.Zhenjin Liang Yuhao Peng Xing Zhang Kewei Cao Wei Xiao Dong Gu 2023Chinese Chemical Letters2023,34,7:0
13Photocatalytic nonoxidative coupling of methane to ethylene over carbon-doped ZnO/Au catalysts显示文摘A photocatalytic nonoxidative coupling of methane to multi-carbon compounds remains a huge challenge due to its high dissociation energy of C–H bonds and sluggish charge carrier dynamics.Au-modified carbon-doped ZnO(C-ZnO/Au)photocatalyst is constructed by an interfacial modification-assisted self-assembly approach for efficient photocatalytic nonoxidative coupling of methane to ethylene and hydrogen(2CH_4=C_2H_4+2H_2).Benefitting from the presence of C-ZnO/Au interfaces,the catalyst not only weakens the excitonic confinement to improve the photogenerated charge carrier separation,but also enhances the stability of lattice oxygen to suppress C_2H_4 overoxidation.Moreover,this hybrid catalyst also accelerates the generation of Zn~+–O~–pairs to activate C–H bonds,stabilizes the important reaction intermediate(*OCH_3)to achieve the C–C coupling,and promotes the generation of low-valence Zn to accelerate the dehydrogenation of the*OC_2H_5 into C_2H_4.Therefore,a stable photocatalytic methane conversion performance can be achieved over C-ZnO/Au heterojunctions with a stoichiometric generation of the oxidation product(C_2H_4,45.85μmol g~(-1)h~(-1))and reduction product(H_2,88.07μmol g~(-1)h~(-1)).This work provides deep insights into the elemental doping and oxide/Au interfaces for the enhanced photocatalytic activity and product selectivity under mild conditions in the absence of extra oxidants.Jing Wang Yuhao Peng Wei Xiao 2023Science China Chemistry2023,66,11:0
14Preface to Special Issue on Towards High Performance Ga_(2)O_(3) Electronics: Epitaxial Growth and Power Devices(Ⅰ)显示文摘There is currently great optimism within the electronics community that gallium oxide(Ga_(2)O_(3)) ultra-wide bandgap semiconductors have unprecedented prospects for eventually revolutionizing a rich variety of power electronic applications. Specially, benefiting from its ultra-high bandgap of around 4.8 eV, it is expected that the emerging Ga_(2)O_(3) technology would offer an exciting platform to deliver massively enhanced device performance for power electronics and even completely new applications.Genquan Han Shibing Long Yuhao Zhang Yibo Wang Zhongming Wei 2023Journal of Semiconductors2023,44,6:0
15Osteopontin(OPN)alleviates the progression of osteoarthritis by promoting the anabolism of chondrocytes显示文摘Osteoarthritis(OA)is a chronic debilitating joint disease,characterized by degen-eration of the cartilage and loss of the cartilage matrix,and it is clinically manifested as joint pain.Osteopontin(OPN)is a glycoprotein that is abnormally expressed in the bone and carti-lage tissues and plays a vital role in various pathological processes such as the osteoarthritic inflammatory response and endochondral ossification.The focus of our study is to investigate the therapeutic potential and specific role of OPN in OA.Using morphological comparisons,we found that the cartilage was severely worn-out and there was a significant loss of the cartilage matrix in OA.OPN,CD44,and hyaluronic acid(HA)synthase 1(HAS1)were highly expressed,and the anabolism of HA was significantly higher in the OA chondrocytes than in the control chondrocytes.Additionally,we treated the OA chondrocytes with small interfering RNA(siRNA)targeting OPN,recombinant human OPN(rhOPN),and a combination of rhOPN and anti-CD44 antibodies.Furthermore,in vivo experiments were performed in mice.We found that OPN up-regulated the expression of downstream HAS1 and increased the anabolism of HA through CD44 protein expression in OA mice compared with those in control mice.Moreover,intra-articular injection of OPN in mice with OA significantly inhibited OA progression.In summary,OPN ini-tiates an intracellular cascade via CD44 which results in an anabolic increase in HA levels,thereby inhibiting OA progression.Therefore,OPN is a promising therapeutic agent in precision treatment of OA.Wei Luo Zili Lin Yuhao Yuan Ziyi Wu Wei Zhong Qing Liu 2023Genes & Diseases2023,10,4:0
16A Novel Approach for Image Encryption with Chaos-RNA显示文摘In today’s information society,image encryption technology is crucial to protecting Internet security.However,traditional image encryption algorithms have problems such as insufficient chaotic characteristics,insufficient randomness of keys,and insecure Ribonucleic Acid(RNA)encoding.To address these issues,a chaos-RNA encryption scheme that combines chaotic maps and RNA encoding was proposed in this research.The initial values and parameters of the chaotic system are first generated using the Secure Hash Algorithm 384(SHA-384)function and the plaintext image.Next,the Lühyperchaotic system sequence was introduced to change the image’s pixel values to realize block scrambling,and further disturbance is achieved through spiral index sequence to enhance encryption effectiveness.Subsequently,to obtain the final encrypted image,the diffusion is accomplished through different RNA encoding rules and operation rules corresponding to the chaotic sequence generated by an improved one-dimensional chaotic map(1DCM).Here innovatively propose four new RNA operation rules,increasing the difficulty of decryption.Simulation results demonstrate that the normalized pixel change rate(NPCR)and the unified average changed intensity(UACI)values of the tested encrypted images were 99.61%and 33.46%,respectively.The average ciphertext entropy value in the Red Green Blue(RGB)channels were 7.9986,7.991,and 7.991.Furthermore,this algorithm exhibits a low correlation coefficient and enhanced robustness.This encryption method effectively improves the security and reliability of image encryption compared to other similar techniques.Yan Hong Shihui Fang Jingming Su Wanqiu Xu Yuhao Wei Juan Wu Zhen Yang 2023Computers, Materials & Continua2023,77,10:0
17Mechanical properties,thermal conductivity and defect formation energies of samarium immobilization in Gd_(2)Zr_(2)O_(7):First-principles study and irradiation experiment显示文摘A density functional theory(DFT)study was employed to investigate the mechanical property,thermal conductivity,Debye temperature,electronic structure and defect chemistry of(Gd_(1-x)Sm_(x))_(2)Zr_(2)O_(7).All the(Gd_(1-x)Sm_(x))_(2)Zr_(2)O_(7) compounds exhibit an excellent structural and mechanical stability(Gd_(0.25)Sm_(0.75))_(2)Zr_(2)O_(7) has the lowest Young’s modulus of 213.7 GPa,the largest Possion’s ratio of 0.292,the lowest Debye temperature of 491.8 K and the lowest thermal conductivity.The calculated thermal conductivities of(Gd_(1-x)Sm_(x))_(2)Zr_(2)O_(7) are 1.17-1.21 W/(m·K)by the Clark’s model and 1.32-1.36 W/(m·K)by the Cahall’s model,respectively.The formation energies of O vacancies at 48f site are negative,which increase with the Sm content,however,the formation energies of O vacancies at 8b site are almost invariable.In addition,Sm partly occupying the Gd-site reduces distinctly the formation energies of defects such as A-site vacancies,cation antisite defects,anion Frenkel pairs of oxygen at 8b site and cation interstitials,which suggests that Sm-doped Gd_(2)Zr_(2)O_(7),especially equimolar GdSmZr_(2)O_(7),has a better irradiation tolerance.After the 16 MeVTa-ion irradiation at a fluence of 1×10^(14) or 2×10^(14) ions/cm^(2),the crystal structure of GdSmZr_(2)O_(7) transforms from pyrochlore to a defect fluorite without obvious amorphous phase.Yuhao Wang Jiahu Ouyang Tao Wei Gui Cao Zhanguo Liu Zhaoying Ding Yujin Wang Yaming Wang 2023Journal of Rare Earths2023,41,3:0
18Modulation of Excitonic Confinement of TiO_(2)in Molten Salts for Overall CO_(2)Photoreduction显示文摘Excitonic confinement greatly determines the charge carrier transport of photocatalysts.A molten salt modulation of excitonic con-finement is herein demonstrated as formation of ultrafine carbon-doped anatase TiO_(2)with grafted graphitic carbon nitride,which is rationalized as an excellent catalyst for overall CO_(2)photoreduction.Compared with bulk TiO_(2),the carbon-doped TiO_(2)(M-TiO_(2))pos-sesses a weaker excitonic confinement to decrease exciton binding energy from 99 to 58 meV,consequently enhancing free-charge-carrier generation and transportation.Effective Z-scheme electron transfer from M-TiO_(2)to C_(3)N_(4) is built,enhancing the CO_(2)conversion via the synchronous optimization of redox ability,CO_(2)activation,and^(*)COOH generation.This work highlights the unique chemistry of excitonic dissociation on facilitating separation of electron and hole,and also extends the scope of molten salt-mediated modulation of photocatalysis materials.Jing Wang Ren Sheng Dong Gu Yuhao Peng Juanxiu Xiao Yijun Shen Wei Xiao 2023Chinese Journal of Chemistry2023,41,10:0
19The link between genetic variation and variability in vaccine responses:a narrative review显示文摘Vaccines are one of the biggest successes in modern history and are particularly important in light of the multiple ongoing epidemics.Recently,vaccines have protected peoples’health and lives around the world during the coronavirus disease 2019 pandemic.Different types of vaccines have their own characteristics and advantages and are used in the context of different epidemics.Responses to vaccination are also different,and can include adverse reactions and absent responses.These individual differences are thought to be influenced by host genes.In this review,we first discuss vaccine types and characteristics.Second,we discuss different responses to vaccination,primarily focusing on the association between genetic variation and inter-individual differences.Yingtian Zhang Mingzhe Zhao Wei Zhou Luan Chen Mo Li Bixuan Jiang Xianglong Zhao Hao Wu Lu Shen Na Zhang Hengwei Qin Yuhao Tang Chenhan Jiad Lin He Shengying Qin 2022Journal of Bio-X Research2022,5,2:0
20Experimental Investigation of Material Removal in Elliptical Vibration Cutting of Cortical Bone显示文摘To benefit tissue removal and postoperative rehabilitation,increased efficiency and accuracy and reduced operating force are strongly required in the osteotomy.A novel elliptical vibration cutting(EVC)has been introduced for bone cutting compared with conventional cutting(CC)in this paper.With the assistance of high-speed microscope imaging and the dynamometer,the material removals of cortical bone and their cutting forces from two cutting regimes were recorded and analysed comprehensively,which clearly demonstrated the chip morphology improvement and the average cutting force reduction in the EVC process.It also revealed that the elliptical vibration of the cutting tool could promote fracture propagation along the shear direction.These new findings will be of important theoretical and practical values to apply the innovative EVC process to the surgical procedures of the osteotomy.Wei Bai Yuhao Zhai Jiaqi Zhao Guangchao Han Linzheng Ye Xijing Zhu Liming Shu Dong Wang 2023Chinese Journal of Mechanical Engineering2023,36,2:0
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