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| 1 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 2 | One Step Preparation of Highly Dispersed TiO2 Nanoparticles显示文摘 | LIU Xu CHEN Yan JIAO Shihui PANG Guangsheng | 2015 | Chemical Research in Chinese Universities2015，31，5： | 2 |
| 3 | Heterostructure Ag@WO3-x Composites with High Selectivity for Breaking Azo-bond显示文摘 | FANG Zhenxing CHEN Yan WANG Boran JIAO Shihui PANG Guangsheng | 2018 | Chemical Research in Chinese Universities2018，34，4： | 1 |
| 4 | Two New Supramolecular Hybrids Based on Bi-capped Keggin {PMo12V2O42} Clusters and Transition Metal Mixed-organic-ligand Complexes显示文摘 | DUAN Weijie JIAO Shihui LIU Xu CHEN Jinlei CAO Xuan CHEN Yan XU Wei CUI Xiaobing XU Jiqing PANG Guangsheng | 2015 | Chemical Research in Chinese Universities2015，31，2： | 1 |
| 5 | Efficient Pd-Catalyzed C-H Oxidative Bromination of Arenes with Dimethyl Sulfoxide and Hydrobromic Acid显示文摘of main observation and conclusion We have developed an efficient Pd-catalyzed directed C-H bromination protocol,in which dimethyl sulfoxide(DMSO)is employed as oxidant with hydrobromic add aqueous solution(HBr(aq))as bromide source.The DMSO/HBr(aq)system,which is novelly and efficiently utilized in transition-metal catalyzed C-H activation,illustrates its practicability by the operational simplicity,inexpensive and readily available starting materials,and high bromide-atom economy. | Yizhi Yuan Yujie Liang Shihui Shi Yu-Feng Liang Ning Jiao | 2020 | Chinese Journal of Chemistry2020，38，11： | 0 |
| 6 | Interface engineering of Fe-Sn-Co sulfide/oxyhydroxide heterostructural electrocatalyst for synergistic water splitting显示文摘To realize large-scale hydrogen production by electrolysis of water,it is essential to develop non-precious metal catalysts for oxygen evolution reaction(OER)and hydrogen evolution reaction(HER).Here,we fabricate Sn-,Fe-,and Co-based sulfide/oxyhydroxide heterostructural catalyst on nickel foam(FeSnCo_(0.2)S_(x)O_(y)/NF)by solvothermal method.The FeSnCo_(0.2)S_(x)O_(y)/NF requires low overpotentials of 48 and 186 mV at 10 mA·cm^(-2),respectively,for HER and OER.When it is assembled into an electrolytic cell as a bifunctional electrocatalyst,it only needs 1.54 V to reach 10 mA·cm^(-2),far better than IrO_(2)||Pt/C electrolyzer.The formation of sulfide/hydroxide heterostructural interfaces improves the electron transfer and reduces the reaction energy barrier,thus promoting the electrocatalytic processes. | Siyu Chen Ting Zhang Jingyi Han Hui Qi Shihui Jiao Changmin Hou Jingqi Guan | 2024 | Nano Research Energy2024，3，2： | 0 |
| 7 | Changes in the mammary gland during aging and its links with breast diseases显示文摘The functional capacity of organisms declines in the process of aging.In the case of breast tissue,abnormal mammary gland development can lead to dysfunction in milk secretion,a primary function,as well as the onset of various diseases,such as breast cancer.In the process of aging,the terminal duct lobular units(TDLUs)within the breast undergo gradual degeneration,while the proportion of adipose tissue in the breast continues to increase and hormonal levels in the breast change accordingly.Here,we review changes in morphology,internal structure,and cellular composition that occur in the mammary gland during aging.We also explore the emerging mechanisms of breast aging and the relationship between changes during aging and breast-related diseases,as well as potential interventions for delaying mammary gland aging and preventing breast disease. | Junqiang Lin Shihui Ye Hao Ke Liang Lin Xia Wu Mengfei Guo Baowei Jiao Ceshi Chen Limin Zhao | 2023 | Acta Biochimica et Biophysica Sinica2023，55，6： | 0 |
| 8 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping ZhuZhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，1： | 0 |
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