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| 1 | Ripple-effect analysis for operational architecture of air defense systems with supernetwork modeling显示文摘In order to solve the problem that the ripple-effect analysis for the operational architecture of air defense systems(OAADS)is hardly described in quantity with previous modeling approaches,a supernetwork modeling approach for the OAADS is put forward by extending granular computing. Based on that operational units and links are equal to different information granularities, the supernetwork framework of the OAADS is constructed as a 'fournetwork within two-layer' structure by forming dynamic operating coalitions, and measuring indexes of the ripple-effect analysis for the OAADS are given combining with Laplace spectral radius. In this framework, via analyzing multidimensional attributes which inherit relations between operational units in different granular scales, an extended granular computing is put forward integrating with a topological structure. Then the operation process within the supernetwork framework, including transformation relations between two layers in the vertical view and mapping relations among functional networks in the horizontal view, is studied in quantity. As the application case shows, comparing with previous modeling approaches, the supernetwork model can validate and analyze the operation mechanism in the air defense architecture, and the ripple-effect analysis can be used to confirm the key operational unit with micro and macro viewpoints. | Zhigang Zou Fuxian Liu Shiman Sun Lu Xia Chengli Fan | 2014 | Journal of Systems Engineering and Electronics2014，25，2： | 5 |
| 2 | Novel cross-linked anion exchange membranes with diamines as ionic exchange functional groups and crosslinking groups显示文摘 | Shiman Zhang Cunpu Li Xiaofeng Xie Fushi Zhang | 2014 | International Journal of Hydrogen Energy2014，，： | 2 |
| 3 | EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer显示文摘Tyrosine kinase inhibitors for epidermal growth factor receptor(EGFR TKIs)greatly improved clinical outcomes of patients with non-small cell lung cancer(NSCLC).Unfortunately,primary and acquired resistance limits their clinical benefits.To overcome such resistance,new generations of EGFR TKIs have been developed by targeting newly identified mutations in EGFR.However,much less effort has been put into alternative strategies,such as targeting the intrinsic protective responses to EGFR TKIs.In this study,we found that EGFR TKIs,including gefitinib and AZD9291,impaired lysosome-dependent degradation of SQSTM1,thus compromising their anti-cancer efficiency.By accumulating in the lysosome lumen,gefitinib and AZD9291 attenuated lysosomal acidification and impaired autolysosomal degradation of SQSTM1 owing to their intrinsic alkalinity.As a result,SQSTM1 protein was stabilized in response to gefitinib and AZD9291 treatment and conferred EGFR TKI resistance.Depleting SQSTM1 significantly increased the sensitivity of NSCLC cells to gefitinib and AZD9291 both in vitro and in vivo.Furthermore,a chemically modified gefitinib analog lacking alkalinity displayed stronger inhibitory effects on NSCLC cells.Therefore,targeting accumulated SQSTM1 or chemically modified EGFR TKIs may represent new strategies to increase the effectiveness of EGFR targeted therapy. | Lixian Yang Shilong Ying Shiman Hu Xiangtong Zhao Muchun Li Miaoqin Chen Yiran Zhu Ping Song Liyuan Zhu Tingting Jiang Huimin An Neelum Aziz Yousafzai Wenxia Xu Zhiguo Zhang Xian Wang Lifeng Feng Hongchuan Jin | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 4 | Effects of myrloid cell groath factors on alkakine phosphatase, myrloperixidase, defensin and granuloeyte cotonystimulating factor receptor mRNA expression in haemopoietic cells of normal individuals and myeloid disorders显示文摘 | Tsuruta T Tani K Shimane M | 1996 | Br J Haematol1996，92，： | 1 |
| 5 | Associations of physical activity and inactivity before and during pregnancy with glucose tolerance 显示文摘 | Oken E Ning Y Rifas - Shiman SL | 2006 | Obstet Gynecol2006，108，5： | 1 |
| 6 | The Effect of Liquid Additives on Dry Ultrafine Grinding of Quartz显示文摘 | Hasegawa W Shimane M | 2001 | Powder Technology2001，6，： | 1 |
| 7 | Pea- nut allergy prevalence among school age children in a US co hort not selected for any disease显示文摘 | Bunyavanich S Rifas Shiman S L Plat ts Mills T A | 2014 | J Allergy Clin Immunol2014，134，3： | 1 |
| 8 | Effects of concurrent S-1,nedaplatin/radiation therapy for 5 cases of head and neck cancer with esophageal carcinoma显示文摘 | Shimane T Mori T Ono T | 2010 | Cancer Chemotherapy2010，37，7： | 1 |
| 9 | Molecular cloning of a novel vascular endothelial growth factor, VEGF - D显示文摘 | YAMADA Y NEZU J SHIMANE M | 1997 | Genomics1997，42，3： | 1 |
| 10 | Risk of overweight among adolescents who were breasted as infants显示文摘 | Gillman MW Rifsa - Shiman SL Camargo CA | 2002 | JAMA2002，285，19： | 1 |
| 11 | The effect of liquid additives on dry ultrafine grinding of quartz 显示文摘 | Hasegawa M Kimata M Shimane M | 2001 | Powder Technology2001，114，13： | 1 |
| 12 | Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillinBRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin显示文摘 | Appelbaum PC Spangler SK Shiman R | 1992 | Antimicrob Agents Chemother1992，36，5： | 1 |
| 13 | Changes in dietary intake from the first to the second trimester of pregnancy显示文摘 | Rifas Shiman SL Rich Edwards JW Willett WC | 2006 | Paediatric and Perinatal Epidemiology2006，20，1： | 1 |
| 14 | On environmental effects of emulsion explosives with products of processing of solid propellants in blasting works显示文摘 | Ustimenko E V Shiman L N Kholodenko T F | 2010 | Nauch Vestn Nats Gorn Univ Ukrainy2010，4，： | 1 |
| 15 | Adhesion-induced drug resistance in leukemia stem cells显示文摘 | Funayama K Murai F Shimane M | 2010 | Pharmacology2010，86，2： | 1 |
| 16 | Solubilization and partial purification of tyrosine hydroxylase from bovine adrenal medulla显示文摘 | Shiman R Akino M Kaufman S | 1971 | J Biol Chem1971，246，5： | 1 |
| 17 | Venous ulcers : A re- appraisal analyzing the effects of neuropathy, muscle involve- ment, and range of motion upon gait and calf muscle function显示文摘 | Shiman MI Pieper B Templin TN | 2009 | Wound Repair Regen2009，17，2： | 1 |
| 18 | The effect of liquid additives on dry uhrafine grinding of quartz显示文摘 | Hasegawa M Kimata M Shimane M | 2001 | Powder Technology2001，114，13： | 1 |
| 19 | An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population:effects of * 09:01 allele on disease phenotypes 显示文摘 | Shimane K Kochi Y Suzuki A | 2013 | Rheumatology (Oxford)2013，52，7： | 1 |
| 20 | High-speed gyroscopic instability and cross-feedback compensation of a digitally controlled magnetic bearing显示文摘 | Shimane T Nagai B | 1990 | Transactions of the Japan Society of Mechanical Engineers1990，56，528： | 1 |
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