|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Vision-Related Quality of Life and Visual Function Following Vitrectomy for Proliferative Diabetic Retinopathy显示文摘 | Fumiki Okamoto Yoshifumi Okamoto Shinichi Fukuda Takahiro Hiraoka Tetsuro Oshika | 2008 | American Journal of Ophthalmology2008，，6： | 1 |
| 2 | Gamma-ray irradiation effect on corrosion rates of stainless steel, Ti and Ti -5Ta in boiling 9N nitric acid 显示文摘 | Yamamot Takao Tsukui Shigeki Okamoto Shinichi | 1996 | Journal of Nuclear Materials1996，228，： | 1 |
| 3 | Low?dose paclitaxel inhibits the induction of epidermal?mesenchymaltransition in the human cholangiocarcinoma CCKS?1 cell line显示文摘 | Atsushi Hirose Hidehiro Tajima Tetsuo Ohta Tomoya Tsukada Koichi Okamoto Shinichi Nakanuma Seisho Sakai Jun Kinoshita Isamu Makino Hiroyuki Furukawa Hironori Hayashi Keishi Nakamura Katsunobu Oyama Masafumi Inokuchi Hisatoshi Nakagawara Tomoharu Miyashita | 2013 | Oncology Letters2013，，4： | 1 |
| 4 | A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease显示文摘AIM: To study a more accurate quantification of hepatic fibrosis which would provide clinically useful information for monitoring the progression of chronic liver disease. METHODS: Using a cDNA microarray containing over 22 000 clones, we analyzed the gene-expression profiles of non-cancerous liver in 74 patients who underwent hepatic resection. We calculated the ratio of azan- stained: total area, and determined the morphologic fibrosis index (MFI), as a mean of 9 section-images. We used the MFI as a reference standard to evaluate our method for assessing liver fibrosis. RESULTS: We identified 39 genes that collectively showed a good correlation (r > 0.50) between gene-expression and the severity of liver fibrosis. Many of the identified genes were involved in immune responses and cell signaling. To quantify the extent of liver fibrosis, we developed a new genetic fibrosis index (GFI) based on gene-expression profiling of 4 clones using a linear support vector regression analysis. This technique, based on a supervised learning analysis, correctly quantified the various degrees of fibrosis in both 74 training samples (r = 0.76, 2.2% vs 2.8%, P < 0.0001) and 12 independent additional test samples (r = 0.75, 9.8% vs 8.6%, P < 0.005). It was far better in assessing liver fibrosis than blood markers such as prothrombin time (r = -0.53), type Ⅳ collagen 7s (r = 0.48), hyaluronic acid (r = 0.41), and aspartate aminotransferase to platelets ratio index (APRI) (r = 0.38). CONCLUSION: Our cDNA microarray-based strategy may help clinicians to precisely and objectively monitor the severity of liver fibrosis. | Tohru Utsunomiya Masahiro Okamoto Shigeki Wakiyama Masaji Hashimoto Kengo Fukuzawa Takahiro Ezaki Shinichi Aishima Yasuji Yoshikawa Taizo Hanai Hiroshi Inoue Graham F Barnard Masaki Mori | 2007 | World Journal of Gastroenterology2007，13，3： | 1 |
| 5 | Prophylactic Use of Intra‐Aortic Balloon Pumps in Open Heart Surgery显示文摘 | Shinichi Taguchi Koji Tsutsumi Masahiko Okamoto Ichiro Kashima | 2012 | Artificial Organs2012，，12： | 1 |
| 6 | A factor analysis-multiple regression model for source apportionment of suspended particulate matter显示文摘 | Shinichi Okamoto Masayuki Hayashi Masaomi Nakaji- ma etal | 1990 | Atmospheric Environment1990，24，8： | 1 |
| 7 | Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin显示文摘 | Yoshihiro Kamada Shinji Tamura Shinichi Kiso Hitoshi Matsumoto Yukiko Saji Yuichi Yoshida Koji Fukui Norikazu Maeda Hitoshi Nishizawa Hiroyuki Nagaretani Yoshihisa Okamoto Shinji Kihara Jun-ichiro Miyagawa Yasuhisa Shinomura Tohru Funahashi Yuji Matsuzawa | 2003 | Gastroenterology2003，，6： | 1 |
| 8 | Hepatocellular carcinoma infiltrated with non-Hodgkin’s lymphoma: Report of a case显示文摘 | Tohru Utsunomiya Masahiro Okamoto Eiji Tsujita Manabu Yamamoto Shinichi Tsutsui Megumu Fujihara Teruyoshi Ishida | 2009 | Surgery Today2009，，11： | 1 |
| 9 | Prognostic Factors and Treatment Outcomes for Anaplastic Thyroid Carcinoma: ATC Research Consortium of Japan Cohort Study of 677 Patients显示文摘 | Iwao Sugitani Akira Miyauchi Kiminori Sugino Takahiro Okamoto Akira Yoshida Shinichi Suzuki | 2012 | World Journal of Surgery2012，，： | 1 |
| 10 | Preliminary study of photodynamic diagnosis using 5-aminolevulinic acid in gastric and colorectal tumors显示文摘AIM:To investigate the utility of photodynamic diagnosis(PDD) using 5-aminolevulinic acid(5-ALA) to detect gastric/colorectal tumors.METHODS:This prospective single-center study investigated inter-subject variability in patients with early-stage gastric/colorectal tumor indicated for endoscopic resection.Subjects were patients with gastric or colorectal tumors who had undergone endoscopic resection between November 2012 and November 2013.Selection criteria included age 20-80 years,either sex,and provision of informed consent.Patients were orally administered 20 mg/kg of 5-ALA enteric-coated capsules(SBI ALApromo Co.,Tokyo,Japan).Administration of5-ALA was followed by endoscopic resection of gastric or colorectal tumors,and the resected specimens were examined using a video autofluorescence processor and a fluorescence endoscope(SAFE-3000 and EB-1970 AK,respectively;Pentax,Tokyo,Japan).The primary endpoint was the presence of fluorescence in tumors.Endoscopic,macroscopic,and histopathologic findings of tumors were assessed.We also evaluated adverse events of the present procedure as a secondary endpoint and examined each patient for the presence of known adverse effects of 5-ALA,namely,hematocytopenia,liver dysfunction,hypotension,nausea,and photosensitivity.RESULTS:We enrolled 10 patients(7 men,3 women)(n = 13 lesions:10 gastric/3 colorectal tumors).Fluorescence was detected in 7/13(53.8%) lesions.No significant differences in sex(male:55.6%vs female:50.5%,P = 1.00),age(67.1 ± 1.9 years vs 65.0 ±2.0 years,P= 0.45),tumor color(reddish:60.0%vs discolored:33.3%,P = 0.56),tumor diameter(15.0± 2.1 mm vs 14.2 ± 2.3 mm,P= 0.80),macroscopic type(protruded:70.0%vs depressed 0%,P = 0.07),histologic type(differentiated type:58.3%vs 0%,P = 0.46),invasion depth(mucosal layer:55.6%vs submucosal layer:33.3%,P = 1.00),lymphatic invasion(present:33.3%vs absent:50.0%,P= 1.00),venous invasion(present:0%vs absent:54.5%,P= 1.00) or procedure time of endoscopic resection(36.3 ± 8.3 min vs 36.7 ± 9.0 min,P = 0.98) were observed between the patients with and without fluorescence.Fluorescence detection rate tended to be high for elevated lesions.Liver dysfunction developed in 4/10(40.0%) patients.The extent of the liver dysfunction was a slight increase in transaminases and total bilirubin levels,which spontaneously improved in the patients.None of the patients developed photosensitivity.CONCLUSION:Results of this preliminary study suggest the utility of PDD using 5-ALA for screening of gastric and colorectal cancers. | Munetaka Nakamura Jun Nishikawa Kouichi Hamabe Atsushi Goto Junichi Nishimura Hiroaki Shibata Misato Nagao Sho Sasaki Shinichi Hashimoto Takeshi Okamoto Isao Sakaida | 2015 | World Journal of Gastroenterology2015，21，21： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员