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| 1 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 2 | Shape of Barrett's epithelium is associated with prevalence of erosive esophagitis显示文摘AIM:To test the hypothesis that the shape and length of Barrett's epithelium are associated with prevalence of erosive esophagitis.METHODS:A total study population comprised 869 patients who underwent endoscopy during a health checkup at our hospital.The presence and extent of Barrett's epithelium were diagnosed based on the Prague C & M Criteria.We originally classified cases of Barrett's epithelium into two types based on its shape,namely,flamelike and lotus-like Barrett's epithelium,and into two groups based on its length,its C extent < 2 cm,and ≥ 2 cm.Correlation of shape and length of Barrett's epithelium with erosive esophagitis was examined.RESULTS:Barrett's epithelium was diagnosed in 374 cases(43%).Most of these were diagnosed as shortsegment Barrett's epithelium.The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium,and in those with a C extent of ≥ 2 cm than < 2 cm.CONCLUSION:Flame-like rather than lotus-like Barrett's epithelium,and Barrett's epithelium with a longer segment were more strongly associated with erosive esophagitis. | Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hiroki Endo Kunihiro Hosono Yasunari Sakamoto Koji Fujita Masato Yoneda Hirokazu Takahashi Tomoko Koide Chikako Tokoro Ayumu Goto Yasunobu Abe Takeshi Shimamura Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 3 | Solid predominant histology predicts EGFR tyrosine kinase inhibitor response in patients with EGFR mutation-positive lung adenocarcinoma显示文摘 | Tatsuya Yoshida Genichiro Ishii Koichi Goto Kiyotaka Yoh Seiji Niho Shigeki Umemura Shingo Matsumoto Hironobu Ohmatsu Kanji Nagai Yuichiro Ohe Atsushi Ochiai | 2013 | Journal of Cancer Research and Clinical Oncology2013，，10： | 3 |
| 4 | Risk Factors for Lymph Node Metastasis from Gastric Cancers with Submucosal Invasion显示文摘 | Yusuke Tajima Masahiko Murakami Kimiyasu Yamazaki Yuki Masuda Shigeo Aoki Masanori Kato Atsushi Sato Satoru Goto Koji Otsuka Takashi Kato | 2010 | Annals of Surgical Oncology2010，，6： | 2 |
| 5 | Mechanism and kinetics of RAFT- based living radical polymerizations of styrene and methyl methacrylate 显示文摘 | Atsushi Goto Koichi Sato Yoshinobu Tsujii | 2001 | Macromolecules2001，34，： | 1 |
| 6 | Interactive effects of carbon footprint information and its accessibility on value and subjective qualities of food products 显示文摘 | Atsushi Kimura Yuji Wada Akiko Kamada Tomohiro Ma- suda Masako Okamoto Sho - ichi Goto Daisuke Tsuzuki Dongsheng Cai Takashi Oka Ippeita Dan | 2010 | Appetite2010，55，： | 1 |
| 7 | Electrophoretic fabrication of LiCoO2 positive electrodes for rechargeable lithimn batteries显示文摘 | Kiyoshi Kanamura Atsushi Goto Young Ho Rho | 2001 | J Power Sources2001，9798，： | 1 |
| 8 | Visualizing cell-cycle kinetics after hypoxia/reoxygenation in HeLa cells expressing fluorescent ubiquitination-based cell cycle indicator (Fucci)显示文摘 | Tatsuaki Goto Atsushi Kaida Masahiko Miura | 2015 | Experimental Cell Research2015，，： | 1 |
| 9 | Haplotype analysis of UDP-glucuronocyltransferase 2B7 gene ( UGT2B7 ) polymorphisms in healthy Japanese subjects显示文摘 | Katsuhiko Saito Hiroyuki Moriya Takeru Sawaguchi Takako Hayakawa Seiya Nakahara Akira Goto Yoshiaki Arimura Kohzoh Imai Nahoko Kurosawa Eiji Owada Atsushi Miyamoto | 2006 | Clinical Biochemistry2006，，： | 1 |
| 10 | Adjuvant mitomycin and fluorouracil followed by oral uracil plus tegafur in serosa-negative gastric cancer: a randomised trial显示文摘 | Toshifusa Nakajima Atsushi Nashimoto Masatsugu Kitamura Tsuyoshi Kito Takeshi Iwanaga Kenzo Okabayashi M Sasaki Masashi Goto | 1999 | The Lancet . 1999 (9175)1999，，： | 1 |
| 11 | Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts显示文摘Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adverse effects(AEs)with poorly understood mechanisms.We previously demonstrated that dronedarone inactivates CYP2J2 potently and irreversibly,disrupts AA-EET pathway leading to cardiac mitochondrial toxicity rescuable via EET enrichment.In this study,we investigated if mitigation of CYP2J2 inhibition prevents dronedarone-induced cardiac AEs.We first synthesized a deuterated analogue of dronedarone(termed poyendarone)and demonstrated that it neither inactivates CYP2J2,disrupts AA-EETs metabolism nor causes cardiac mitochondrial toxicity in vitro.Our patch-clamp experiments demonstrated that pharmacoelectrophysiology of dronedarone is unaffected by deuteration.Next,we show that dronedarone treatment or CYP2J2 knockdown in spontaneously beating cardiomyocytes indicative of depleted CYP2J2 activity exacerbates beat-to-beat(BTB)variability reflective of proarrhythmic phenotype.In contrast,poyendarone treatment yields significantly lower BTB variability compared to dronedarone in cardiomyocytes indicative of preserved CYP2J2 activity.Importantly,poyendarone and dronedarone display similar antiarrhythmic properties in the canine model of persistent AF,while poyendarone substantially reduces beat-to-beat variability of repolarization duration suggestive of diminished proarrhythmic risk.Our findings prove that deuteration of dronedarone prevents CYP2J2 inactivation and mitigates dronedarone-induced cardiac AEs. | Aneesh V.Karkhanis Gopalakrishnan Venkatesan Ryuichi Kambayashi Jacqueline Wen Hui Leow Marcus Qingrui Han Hiroko Izumi-Nakaseko Ai Goto Jeremy Kah Sheng Pang Boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong Chan | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 1 |
| 12 | Erythropoietin Receptor Signaling Mitigates Renal Dysfunction-Associated Heart Failure by Mechanisms Unrelated to Relief of Anemia显示文摘 | Atsushi Ogino Genzou Takemura Masanori Kawasaki Akiko Tsujimoto Hiromitsu Kanamori Longhu Li Kazuko Goto Rumi Maruyama Itta Kawamura Toshiaki Takeyama Tomonori Kawaguchi Takatomo Watanabe Yoshiyuki Moriguchi Hideki Saito Takako Fujiwara Hisayoshi Fujiwara | 2010 | Journal of the American College of Cardiology2010，，23： | 1 |
| 13 | 上地幔中绿泥石的稳定性显示文摘在上地幔条件下有斜方辉石存在时,绿泥石的稳定性已用模拟相系MgO-Al_2O_3-SiO_2-H_2O(MASH)进行了热力学研究.假定MASH相系中的所有矿物都是纯的,反应曲线的计算考虑了热容(C_p)、热膨胀(αV)和等温压缩(βV)等因素.如果假定△αV=△βV=0,那么上地幔中绿泥石的稳定性与压力有轻微的依赖关系,其上部稳定曲线分别位于800℃、2.9GPa,650℃、4.2GPa以及500℃、5.0GPa处.另一方面,如果假定△αV≠0、△βV≠0,那么绿泥石的稳定性与温度有较大的依赖关系,其稳定曲线分别位于800℃、3.9GPa和700℃、5.5GPa处.目前的计算结果表明,在地幔楔状体底部俯冲的含水橄榄岩中的绿泥石在3.0~3.5GPa压力下发生分解,因此,绿泥石中H_2O的释放,对于位于俯冲板块以上约110km的火山前锋之下岩浆的产生,可能起部分的控制作用. | Atsushi Goto Yoshiyuki Tatsumi 倪志耀 | 1991 | 地质科学译丛1991，8，1： | 1 |
| 14 | Hypopitu- itarism caused by bilateral internal carotid artery aneurysms with a carotid cavernous fistula显示文摘 | Atsushi Goto Yoshihiko Takahashi Miyako Kishimto | 2008 | Intermedicine2008，47，11： | 1 |
| 15 | Randomized Phase III Study of 5-Fluorouracil Continuous Infusion vs. Sequential Methotrexate and 5-Fluorouracil Therapy in Far Advanced Gastric Cancer with Peritoneal Metastasis (JCOG0106)显示文摘 | Kuniaki Shirao Narikazu Boku Yasuhide Yamada Kensei Yamaguchi Toshihiko Doi Masahiro Goto Junichiro Nasu Tadamichi Denda Yasuo Hamamoto Atsuo Takashima Haruhiko Fukuda Atsushi Ohtsu Akira Sawaki Hogara Nishisaki Kenji Amagai Yasuyuki Suzuki | 2013 | Japanese Journal of Clinical Oncology2013，，10： | 1 |
| 16 | Aberrant Methylation of the Netrin-1 Receptor Genes UNC5C and DCC Detected in Advanced Colorectal Cancer显示文摘 | Kenji Hibi Hiroki Mizukami Atsushi Shirahata Tetsuhiro Goto Makiko Sakata Yutaka Sanada | 2009 | World Journal of Surgery2009，，5： | 1 |
| 17 | Seismic proof test of a reinforced concrete containment vessel (RCCV)显示文摘 | Toshihiko Hirama Masashi Goto Hitoshi Kumagai Yukio Naito Atsushi Suzuki Hiroshi Abe Katsuki Takiguchi Hiroshi Akiyama | 2007 | Nuclear Engineering and Design2007，，11： | 1 |
| 18 | Sentinel Node Mapping Guided by Indocyanine Green Fluorescence Imaging During Laparoscopic Surgery in Gastric Cancer显示文摘 | Yusuke Tajima Masahiko Murakami Kimiyasu Yamazaki Yuki Masuda Masanori Kato Atsushi Sato Satoru Goto Koji Otsuka Takashi Kato Mitsuo Kusano | 2010 | Annals of Surgical Oncology2010，，7： | 1 |
| 19 | Steam gasification characteristics of coal with rapid heating 显示文摘 | Chihiro Fushim Mitsuhiro Goto Atsushi Tsutsumia | 2003 | J Anal Appl Pyrolysis2003，70，： | 1 |
| 20 | A phase I study of autologous dendritic cell-based immunotherapy for patients with unresectable primary liver cancer显示文摘 | Yukio Iwashita Kouichirou Tahara Shigeru Goto Atsushi Sasaki Seiichiro Kai Masataka Seike Chao-Long Chen Katsunori Kawano Seigo Kitano | 2003 | Cancer Immunology Immunotherapy2003，，3： | 1 |
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