|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | RTRA differentially regulates interleukin-1β and interleukin-1 receptor antagonist production by human alveolar macrophages 显示文摘 | Shu Hashimoto Shinichi Hayashi Sachiko Yoshida | 1998 | Leukemia Research1998，22，： | 1 |
| 2 | Efficacy and safety of tacrolimus for lupus nephritis: a placebo-controlled double-blind multicenter study显示文摘 | Nobuyuki Miyasaka Shinichi Kawai Hiroshi Hashimoto | 2009 | Modern Rheumatology2009，，6： | 1 |
| 3 | Hepatocellular carcinoma: Efficacy of transcatheter oily chemoembolization in relation to macroscopic and microscopic patterns of tumor growth among 100 patients with partial hepatectomy显示文摘 | Tohru Hashimoto M.D. Hironobu Nakamura Shinichi Hori Kaname Tomoda Katsuyuki Nakanishi Takamichi Murakami Takahiro Kozuka Morito Monden Mitsukazu Gotoh Chikazumi Kuroda Kenichi Wakasa Masami Sakurai | 1995 | Cardiovascular and Interventional Radiology1995，，2： | 1 |
| 4 | Efficacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study显示文摘 | Masako Hara Tohru Abe Sachiko Sugawara Yutaka Mizushima Keiko Hoshi Shoichiro Irimajiri Hiroshi Hashimoto Shinichi Yoshino Nobuo Matsui Masashi Nobunaga Shigeyuki Nakano | 2007 | Modern Rheumatology2007，，1： | 1 |
| 5 | Development of target protein-selective degradation inducer for protein knockdown显示文摘 | Yukihiro Itoh Minoru Ishikawa Risa Kitaguchi Shinichi Sato Mikihiko Naito Yuichi Hashimoto | 2011 | Bioorganic & Medicinal Chemistry2011，，10： | 1 |
| 6 | A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease显示文摘AIM: To study a more accurate quantification of hepatic fibrosis which would provide clinically useful information for monitoring the progression of chronic liver disease. METHODS: Using a cDNA microarray containing over 22 000 clones, we analyzed the gene-expression profiles of non-cancerous liver in 74 patients who underwent hepatic resection. We calculated the ratio of azan- stained: total area, and determined the morphologic fibrosis index (MFI), as a mean of 9 section-images. We used the MFI as a reference standard to evaluate our method for assessing liver fibrosis. RESULTS: We identified 39 genes that collectively showed a good correlation (r > 0.50) between gene-expression and the severity of liver fibrosis. Many of the identified genes were involved in immune responses and cell signaling. To quantify the extent of liver fibrosis, we developed a new genetic fibrosis index (GFI) based on gene-expression profiling of 4 clones using a linear support vector regression analysis. This technique, based on a supervised learning analysis, correctly quantified the various degrees of fibrosis in both 74 training samples (r = 0.76, 2.2% vs 2.8%, P < 0.0001) and 12 independent additional test samples (r = 0.75, 9.8% vs 8.6%, P < 0.005). It was far better in assessing liver fibrosis than blood markers such as prothrombin time (r = -0.53), type Ⅳ collagen 7s (r = 0.48), hyaluronic acid (r = 0.41), and aspartate aminotransferase to platelets ratio index (APRI) (r = 0.38). CONCLUSION: Our cDNA microarray-based strategy may help clinicians to precisely and objectively monitor the severity of liver fibrosis. | Tohru Utsunomiya Masahiro Okamoto Shigeki Wakiyama Masaji Hashimoto Kengo Fukuzawa Takahiro Ezaki Shinichi Aishima Yasuji Yoshikawa Taizo Hanai Hiroshi Inoue Graham F Barnard Masaki Mori | 2007 | World Journal of Gastroenterology2007，13，3： | 1 |
| 7 | Therapeutic endoscopic retrograde cholangiography using a single‐balloon enteroscope in patients with R oux‐en‐ Y anastomosis显示文摘 | Takashi Obana Naotaka Fujita Kei Ito Yutaka Noda Go Kobayashi Jun Horaguchi Shinsuke Koshita Yoshihide Kanno Takahisa Ogawa Shinichi Hashimoto Kaori Masu | 2013 | Digestive Endoscopy2013，，6： | 1 |
| 8 | Impact of respiratory movement on the computed tomographic images of small lung tumors in three-dimensional (3D) radiotherapy显示文摘 | Shinichi Shimizu Hiroki Shirato Kenji Kagei Takeshi Nishioka Xo Bo Hirotoshi Dosaka-Akita Seiko Hashimoto Hidefumi Aoyama Kazuhiko Tsuchiya Kazuo Miyasaka | 2000 | International Journal of Radiation Oncology Biology Physics2000，，5： | 1 |
| 9 | Prevalence and Avoidance of Patient-Prosthesis Mismatch in Aortic Valve Replacement in Small Adults显示文摘 | Yoshimasa Sakamoto Kazuhiro Hashimoto Hiroshi Okuyama Hiromitsu Takakura Shinichi Ishii Shingo Taguchi Hiroshi Kagawa | 2006 | The Annals of Thoracic Surgery2006，，4： | 1 |
| 10 | Steroid‐free living donor liver transplantation for HCV – a multicenter prospective cohort study in Japan显示文摘 | Shigeru Marubashi Koji Umeshita Toshimasa Asahara Kenji Fujiwara Hironori Haga Takashi Hashimoto Katsuyoshi Hatakeyama Takafumi Ichida Takashi Kanematsu Masaki Kitajima Kendo Kiyosawa Masatoshi Makuuchi Shinichi Miyagawa Susumu Satomi Yuji Soejima Yasutsu | 2012 | Clin Transplant2012，，6： | 1 |
| 11 | Prevalence and Clinicoepidemiological Features of Moyamoya Disease in Japan: Findings From a Nationwide Epidemiological Survey显示文摘 | Shinichi Kuriyama Yasuko Kusaka Miki Fujimura Kenji Wakai Akiko Tamakoshi Shuji Hashimoto Ichiro Tsuji Yutaka Inaba Takashi Yoshimoto | 2008 | Stroke2008，，1： | 1 |
| 12 | LGR5‐Positive Colon Cancer Stem Cells Interconvert with Drug‐Resistant LGR5‐Negative cells and are Capable of Tumor Reconstitution显示文摘 | Shinta Kobayashi Hisafumi Yamada‐Okabe Masami Suzuki Osamu Natori Atsuhiko Kato Koichi Matsubara Yu Jau Chen Masaki Yamazaki Shinichi Funahashi Kenji Yoshida Eri Hashimoto Yoshinori Watanabe Hironori Mutoh Motooki Ashihara Chie Kato Takeshi Watanabe Takas | 2012 | STEM CELLS2012，，12： | 1 |
| 13 | Three-dimensional movement of a liver tumor detected by high-speed magnetic resonance imaging显示文摘 | Shinichi Shimizu Hiroki Shirato Bo Xo Kenji Kagei Takeshi Nishioka Seiko Hashimoto Kazuhiko Tsuchiya Hidefumi Aoyama Kazuo Miyasaka | 1999 | Radiotherapy and Oncology1999，，： | 1 |
| 14 | Prevalence and Clinicoepidemiological Features of Moyamoya Disease in Japan: Findings From a Nationwide Epidemiological Survey显示文摘 | Shinichi Kuriyama Yasuko Kusaka Miki Fujimura Kenji Wakai Akiko Tamakoshi Shuji Hashimoto Ichiro Tsuji Yutaka Inaba Takashi Yoshimoto | 2008 | Stroke2008，，1： | 1 |
| 15 | Real-time monitoring of a digestive tract marker to reduce adverse effects of moving organs at risk (OAR) in radiotherapy for thoracic and abdominal tumors显示文摘 | Takayuki Hashimoto Hiroki Shirato Mototsugu Kato Koichi Yamazaki Nobuaki Kurauchi Toshiaki Morikawa Shinichi Shimizu Yong Chan Ahn Yasuyuki Akine Kazuo Miyasaka | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 16 | Immunohistochemically Detected Expression of p27Kip1 and Skp2 Predicts Survival in Patients with Intrahepatic Cholangiocarcinomas显示文摘 | Nozomi Hashimoto MD Shinichi Yachida MD Keiichi Okano MD Hisao Wakabayashi MD Katsumi Imaida MD Kazutaka Kurokohchi MD Tsutomu Masaki MD Hisoka Kinoshita MD Masahiro Tominaga MD Tetsuo Ajiki MD Yonson Ku MD Takehiro Okabayashi MD Kazuhiro Hanazaki MD Mako | 2009 | Annals of Surgical Oncology2009，，2： | 1 |
| 17 | The osteoblastic differentiation ability of human dedifferentiated fat cells is higher than that of adipose stem cells from the buccal fat pad显示文摘 | Naotaka Kishimoto Yoshihiro Momota Yoshiya Hashimoto Shinichi Tatsumi Kayoko Ando Takeshi Omasa Junichiro Kotani | 2014 | Clinical Oral Investigations2014，，8： | 1 |
| 18 | Preliminary study of photodynamic diagnosis using 5-aminolevulinic acid in gastric and colorectal tumors显示文摘AIM:To investigate the utility of photodynamic diagnosis(PDD) using 5-aminolevulinic acid(5-ALA) to detect gastric/colorectal tumors.METHODS:This prospective single-center study investigated inter-subject variability in patients with early-stage gastric/colorectal tumor indicated for endoscopic resection.Subjects were patients with gastric or colorectal tumors who had undergone endoscopic resection between November 2012 and November 2013.Selection criteria included age 20-80 years,either sex,and provision of informed consent.Patients were orally administered 20 mg/kg of 5-ALA enteric-coated capsules(SBI ALApromo Co.,Tokyo,Japan).Administration of5-ALA was followed by endoscopic resection of gastric or colorectal tumors,and the resected specimens were examined using a video autofluorescence processor and a fluorescence endoscope(SAFE-3000 and EB-1970 AK,respectively;Pentax,Tokyo,Japan).The primary endpoint was the presence of fluorescence in tumors.Endoscopic,macroscopic,and histopathologic findings of tumors were assessed.We also evaluated adverse events of the present procedure as a secondary endpoint and examined each patient for the presence of known adverse effects of 5-ALA,namely,hematocytopenia,liver dysfunction,hypotension,nausea,and photosensitivity.RESULTS:We enrolled 10 patients(7 men,3 women)(n = 13 lesions:10 gastric/3 colorectal tumors).Fluorescence was detected in 7/13(53.8%) lesions.No significant differences in sex(male:55.6%vs female:50.5%,P = 1.00),age(67.1 ± 1.9 years vs 65.0 ±2.0 years,P= 0.45),tumor color(reddish:60.0%vs discolored:33.3%,P = 0.56),tumor diameter(15.0± 2.1 mm vs 14.2 ± 2.3 mm,P= 0.80),macroscopic type(protruded:70.0%vs depressed 0%,P = 0.07),histologic type(differentiated type:58.3%vs 0%,P = 0.46),invasion depth(mucosal layer:55.6%vs submucosal layer:33.3%,P = 1.00),lymphatic invasion(present:33.3%vs absent:50.0%,P= 1.00),venous invasion(present:0%vs absent:54.5%,P= 1.00) or procedure time of endoscopic resection(36.3 ± 8.3 min vs 36.7 ± 9.0 min,P = 0.98) were observed between the patients with and without fluorescence.Fluorescence detection rate tended to be high for elevated lesions.Liver dysfunction developed in 4/10(40.0%) patients.The extent of the liver dysfunction was a slight increase in transaminases and total bilirubin levels,which spontaneously improved in the patients.None of the patients developed photosensitivity.CONCLUSION:Results of this preliminary study suggest the utility of PDD using 5-ALA for screening of gastric and colorectal cancers. | Munetaka Nakamura Jun Nishikawa Kouichi Hamabe Atsushi Goto Junichi Nishimura Hiroaki Shibata Misato Nagao Sho Sasaki Shinichi Hashimoto Takeshi Okamoto Isao Sakaida | 2015 | World Journal of Gastroenterology2015，21，21： | 0 |
| 19 | Efficacy of hybrid endoscopic submucosal dissection with SOUTEN in gastric lesions:An ex vivo porcine model basic study显示文摘BACKGROUND Hybrid endoscopic submucosal dissection(ESD)that comprises mucosal incision and partial submucosal dissection followed by snaring in a planned manner,has been developed for endoscopic resection of gastrointestinal neoplasms to overcome the technical barrier of ESD.Although the superiority of hybrid ESD with SOUTEN,a single multifunctional device,over conventional ESD has been indicated,the actual effect of snaring itself remains unclear since SOUTEN could be applied to hybrid ESD group,but not to the conventional ESD group,due to ethical issue in clinical practice.AIM To determine whether and how hybrid ESD was superior to conventional ESD in the endoscopic treatment of gastric lesions in an ex vivo porcine model basic study.METHODS Sixteen endoscopists participated in this basic study in August 2020 at Kyushu University,performing 32 procedures each for hybrid ESD and conventional ESD.Mock lesions(10-15 mm,diameter)were created in the porcine stomach.The primary outcome was total procedure time and secondary outcomes were en bloc or complete resection,perforation,procedure time/speed for both,mucosal incision,and submucosal dissection.Factors associated with difficulty in ESD including longer procedure time,incomplete resection,and perforation,were also investigated.Categorical and continuous data were analyzed using the chi-square test or Fisher’s exact test and the Mann-Whitney U test,respectively.RESULTS The median total procedure time of hybrid ESD was significantly shorter than that of conventional ESD(median:8.3 min vs 16.2 min,P<0.001).Time,speed,and the amount of hyaluronic acid during submucosal dissection were more favorable in hybrid ESD than conventional ESD(time,5.2 min vs 10.4 min,P<0.001;speed,43.7 mm^(2)/min vs 23.8 mm^(2)/min,P<0.00;injection volume,1.5 mL vs 3.0 mL,P<0.001),although no significant differences in those factors were observed between both groups during mucosal incision.There was also no significant difference between both groups in the en bloc/complete resection rate and perforation rate(complete resection,93.8%vs 87.5%,P=0.67;perforation,0% vs 3.1%,P=1).Selection of conventional ESD as the treatment method was significantly associated with difficulties during ESD(odds ratio=10.2;highest among factors).CONCLUSION Hybrid ESD with SOUTEN improves the treatment outcomes of gastric lesions.It also has the potential to reduce medical costs since SOUTEN is a single multifunctional device that is inexpensive. | Mitsuru Esaki Eikichi Ihara Norikazu Hashimoto Shuichi Abe Chihoko Aratono Noriko Shiga Yorinobu Sumida Hiroyuki Fujii Kazuhiro Haraguchi Shunsuke Takahashi Tsutomu Iwasa Kayoko Nakano Masafumi Wada Shinichi Somada Kei Nishioka Yosuke Minoda Haruei Ogino Yoshihiro Ogawa | 2021 | World Journal of Gastrointestinal Surgery2021，13，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员