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| 1 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 2 | Upregulation of GLT25D1 in Hepatic Stellate Cells Promotes Liver Fibrosis via the TGF-β1/SMAD3 Pathway In Vivo and In vitro显示文摘Background and Aims:Collagenβ(1-O)galactosyltransferase 25 domain 1(GLT25D1)is associated with collagen production and glycosylation,and its knockout in mice results in embryonic death.However,its role in liver fibrosis remains elusive,particularly in hepatic stellate cells(HSCs),the primary collagen-producing cells associated with liver fibrogenesis.Herein,we aimed to elucidate the role of GLT25D1 in HSCs.Methods:Bile duct ligation(BDL)-induced mouse liver fibrosis models,primary mouse HSCs(mHSCs),and transforming growth factor beta 1(TGF-β1)-stimulated LX-2 human hepatic stellate cells were used in in vivo and in vitro studies.Stable LX-2 cell lines with either GLT25D1 overexpression or knockdown were established using lentiviral transfection.RNA-seq was performed to investigate the genomic differences.HPLCMS/MS were used to identify glycosylation sites.Scanning electronic microscopy(SEM)and second-harmonic generation/two-photon excited fluorescence(SHG/TPEF)were used to image collagen fibril morphology.Results:GLT25D1 expression was upregulated in nonparenchymal cells in human cirrhotic liver tissues.Meanwhile,its knockdown attenuated collagen deposition in BDL-induced mouse liver fibrosis and inhibited mHSC activation.GLT25D1 was overexpressed in activated versus quiescence LX-2 cells and regulated in vitro LX-2 cell activation,including proliferation,contraction,and migration.GLT25D1 also significantly increased liver fibrogenic gene and protein expression.GLT25D1 upregulation promoted HSC activation and enhanced collagen expression through the TGF-β1/SMAD signaling pathway.Mass spectrometry showed that GLT25D1 regulated the glycosylation of collagen in HSCs,affecting the diameter of collagen fibers.Conclusions:Collectively,the upregulation of GLT25D1 in HSCs promoted the progression of liver fibrosis by affecting HSCs activation and collagen stability. | Shiwei Wang Lingling He Fan Xiao Meixin Gao Herui Wei Junru Yang Yang Shu Fuyang Zhang Xiaohui Ye Ping Li Xiaohua Hao Xingang Zhou Hongshan Wei | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 1 |
| 3 | Association between TLR2 , MTR , MTRR , XPC , TP73 , TP53 genetic polymorphisms and gastric cancer: A meta-analysis显示文摘 | Chen Cheng Wang Lingyan Huang Yi Zhang Cheng Ye Huadan Xu Xuting Xu Leiting Ye Meng Duan Shiwei | 2014 | Clinics and Research in Hepatology and Gastroenterology2014，，： | 1 |
| 4 | An error-based micro-sensor capture system for real-time motion estimation显示文摘A wearable micro-sensor motion capture system with 16 IMUs and an error-compensatory complementary filter algorithm for real-time motion estimation has been developed to acquire accurate 3D orientation and displacement in real life activities.In the proposed filter algorithm,the gyroscope bias error,orientation error and magnetic disturbance error are estimated and compensated,significantly reducing the orientation estimation error due to sensor noise and drift.Displacement estimation,especially for activities such as jumping,has been the challenge in micro-sensor motion capture.An adaptive gait phase detection algorithm has been developed to accommodate accurate displacement estimation in different types of activities.The performance of this system is benchmarked with respect to the results of VICON optical capture system.The experimental results have demonstrated effectiveness of the system in daily activities tracking,with estimation error 0.16 ± 0.06m for normal walking and 0.13 ± 0.11m for jumping motions. | Lin Yang Shiwei Ye Zhibo Wang Zhipei Huang Jiankang Wu Yongmei Kong Li Zhang | 2017 | Journal of Semiconductors2017，38，10： | 0 |
| 5 | 2 - 30 Progress in Analyzing RIBLL1 17F+p Experimental Data显示文摘 | He Jianjun Hu Jun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Zhang Xueheng Su Jun Li Ertao Hu Zhengguo Guo Zhongyan Xu Xing Yuan Xiaohua Lu Wan Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2010 | IMP & HIRFL Annual Report2010，，1： | 0 |
| 6 | Self-supervised deep-learning two-photon microscopy显示文摘Artificial neural networks have shown great proficiency in transforming low-resolution microscopic images into high-resolution images.However,training data remains a challenge,as large-scale open-source databases of microscopic images are rare,particularly 3D data.Moreover,the long training times and the need for expensive computational resources have become a burden to the research community.We introduced a deep-learning-based self-supervised volumetric imaging approach,which we termed“Self-Vision.”The self-supervised approach requires no training data,apart from the input image itself.The lightweight network takes just minutes to train and has demonstrated resolution-enhancing power on par with or better than that of a number of recent microscopybased models.Moreover,the high throughput power of the network enables large image inference with less postprocessing,facilitating a large field-of-view(2.45 mm×2.45 mm)using a home-built two-photon microscopy system.Self-Vision can recover images from fourfold undersampled inputs in the lateral and axial dimensions,dramatically reducing the acquisition time.Self-Vision facilitates the use of a deep neural network for 3D microscopy imaging,easing the demanding process of image acquisition and network training for current resolutionenhancing networks. | YUEZHI HE JING YAO LINA LIU YUFENG GAO JIA YU SHIWEI YE HUI LI WEI ZHENG | 2023 | Photonics Research2023，11，1： | 0 |
| 7 | The Construction of an Intrauterine Diagnosis and Treatment System and Comprehensive Lifecycle Health Service of Congenital Heart Disease:Xinhua Hospital Model显示文摘With the growing influence of slow population growth and population aging,China has established the birth policy and issued a series of documents to promote maternal and fetal health and improve the birth rate.With the increase in prevalence of birth defects,timely diagnosis and intervention in utero provide possibilities to reduce unnecessary abortions and offer better prognosis.Congenital heart disease(CHD),as one of the most common congenital birth defects,is the leading cause of mortality in patients aged<5 years,and brings a heavy burden to both the affected families and society.Fetuses with CHD are associated with an increased risk of pregnancy-related complications and premature birth,and children with CHD typically face growth and developmental problems even after the correction of malformation.Therefore,management including diagnosis,treatment,and rehabilitation throughout the fetal period into childhood and even adulthood is essential for children with CHD.Based on the rapid advances in intrauterine and perinatal medicine and an in-depth collaboration among obstetrics and pediatrics,a novel diagnosis and treatment system has been established for the management of CHD in the past 2 decades in Shanghai Xinhua Hospital.This Intrauterine Diagnosis and Treatment System and Comprehensive Lifecycle Health Service of Congenital Heart Disease model provides prenatal diagnosis,intrauterine intervention,delivery room service and neonatal therapies,and postintrauterine rehabilitation for children with CHD.We have developed a four-dimensional spatiotemporal image correlation echocardiography and a three-dimensional cardiac virtual endoscopy system for the intrauterine diagnosis of CHD,dramatically raising the diagnostic utility.Our innovative and independent newborn-intervention technique has effectively reduced the re-intervention rate in patients with pulmonary atresia with intact ventricular septum and critical pulmonary stenosis.In 2018,Xinhua Hospital independently performed the case of fetal aortic valvuloplasty in Asia through a multidepartment collaborative effort.All children treated in this system achieved biventricular circulation and a better long-term postoperative outcome.We also have conducted postoperative rehabilitation therapy to promote the development and health of children with CHD.The practice of Xinhua model has reduced unnecessary abortion of CHD fetuses,reduced the mortality rate associated with critical CHD,and improved the mid-and long-term prognosis in CHD,which is essential to promote the fertility level and children’s health.Furthermore,translational medicine platform and the birth cohort Early Life Plan was constructed to explore the origins of major developmental diseases and establish an early intervention model in CHD.This practice of assessment of the intrauterine system has been expanded to other congenital defects in Xinhua Hospital,and sequential treatment of more than 2,000 cases has been completed to date.Based on practice in intrauterine management of CHD and other diseases,the concept of Intrauterine Pediatrics was proposed as a first to emphasize early prevention and intervention of childhood diseases and promote a comprehensive lifecycle service for children.The development and evolution of this system requires further attention not only from researchers but also from the government and global medical communities. | Shiwei Jiang Jiajun Ye Hualin Wang Jian Wang Sun Cheni Yongjun Zhang Qing Du Ling Yang Lei Wang Kun Sun | 2023 | Cardiology Discovery2023，3，3： | 0 |
| 8 | Enhanced monopole transition strength from the cluster decay of ^(13)C显示文摘The inelastic excitations and cluster decay of ^(13)C have been measured using the reaction,9Be(^(13)C, ^(13)C* →~9Be + α)~9Be. We observe strong excitation to the 14.3-MeV(1/2-) resonant state from the cluster-decay channel, leading to an enhanced monopole matrix element of(6.3 ± 0.6) fm^2. This large cluster-related monopole strength is a clear indication of the cluster-structure domination of this state and is consistent with the recent prediction of the orthogonality condition model(OCM). It would be interesting to further explore the three-center molecular rotational band that is initiated from the observed band-head. | Jun Feng YanLin Ye Biao Yang ChengJian Lin HuiMin Jia DanYang Pang ZhiHuan Li JianLing Lou QiTe Li XiaoFei Yang Jing Li HongLiang Zang Qiang Liu Wei Jiang ChenGuang Li Yang Liu ZhiQiang Chen HongYi Wu ChunGuang Wang Wei Liu Xiang Wang JingJing Li DiWen Luo Ying Jiang ShiWei Bai JinYan Xu NanRu Ma LiJie Sun DongXi Wang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 0 |
| 9 | Interactions between ShPP2-1, an F-box family gene, and ACR11A regulate cold toleranee of tomato显示文摘There is a critical need to identify germplasm resources and genes that promote cold tolerance of tomato because global tomato production is threatened by cold stress.We found that the expression of an F-box gene family member named ShPP2-1 from Solanum habrochaites is cold inducible and studied its contribution to cold tolerance.Overexpression of ShPP2-1 in cultivated tomato(AC)reduced cold tolerance by intensifying damage to cell membranes.To explore the underlying molecular mechanism,we conducted a yeast two-hybrid library screen and found that a protein containing ACT domain repeats named ACR11A interacts with PP2-1.Overexpression of SIACR11A in AC enhanced the cold tolerance of seedlings and germinating seeds.Cold tolerance decreased in tomato plants that overexpressed both of these genes.Additionally,we performed seed germination experiments in the cold with 177 tomato accessions and identified two alleles of SlACR11A that differ in one single-nucleotide polymorphism.We found that one of these alleles,SlACR11A G,is significantly enriched in cold-tolerant tomato plants.Taken together,our fi ndings indicate that the combination of low expression levels of PP2-1 and high expression levels of ACR11A can promote cold tolerance.These genes may therefore serve as direct targets for both genetic engineering and improvement projects that aim to enhance the cold tolerance of tomato. | Jianwen Song Lele Shang Shiwei Chen Yongen Lu Yuyang Zhang Bo Ouyang Zhibiao Ye Junhong Zhang | 2021 | Horticulture Research2021，8，1： | 0 |
| 10 | A Discussion on the Policy of R&D Stock for China’s Energy Technology显示文摘The constraints of energy supply have been a long-term threat to the sustainable development of China. Technological progress and innovation are essential to helping solve this problem. Research and development (R&D) stock plays a key role in technological progress and innovation. Through comparisons with some other countries, it is found that China has fallen behind in the R&D stock for energy technology. The R&D stock can be improved by two means: one is putting capital and human resources in those strategically key fields; the other is taking advantage of the R&D resources from abroad. The strategically key fields include energy saving techniques, energy materials, the manufacture of key equipment and new energy resources. | Tao Ye Su Shiwei Qi Zhongying | 2006 | Petroleum Science2006，3，4： | 0 |
| 11 | AlphaMat: a material informatics hub connecting data, features, models and applications显示文摘The development of modern civil industry,energy and information technology is inseparable from the rapid explorations of new materials.However,only a small fraction of materials being experimentally/computationally studied in a vast chemical space.Artificial intelligence(AI)is promising to address this gap,but faces many challenges,such as data scarcity and inaccurate material descriptors.Here,we develop an AI platform,AlphaMat,that can complete data preprocessing and downstream AI models.With high efficiency and accuracy,AlphaMat exhibits strong powers to model typical 12 material attributes(formation energy,band gap,ionic conductivity,magnetism,bulk modulus,etc.).AlphaMat’s capabilities are further demonstrated to discover thousands of new materials for use in specific domains.AlphaMat does not require users to have strong programming experience,and its effective use will facilitate the development of materials informatics,which is of great significance for the implementation of AI for Science(AI4S). | Zhilong Wang An Chen Kehao Tao Junfei Cai Yanqiang Han Jing Gao Simin Ye Shiwei Wang Imran Ali Jinjin Li | 2023 | npj Computational Materials2023，，1： | 0 |
| 12 | Genesis of Mafic Microgranular Enclaves in the Shaocunwu Granodiorite,Southern China,and their Implications:Evidence from Zircon and Whole-rock Geochemistry显示文摘Magmatic microgranular enclaves(MMEs)are widely developed in the Shaocunwu granodiorite at the northeast margin of the eastern Jiangnan orogenic belt.Field geology showed that the MMEs occur as irregular ellipsoids near the edge of the intrusion,and consist of diorite,dominantly composed of amphibole,biotite,and plagioclase grains,with minor acicular apatite.Zircon U-Pb dating showed the ages of the host granodiorites and MMEs are 145.9±1.1 Ma and 145.6±2.5 Ma,respectively,indicating both originated during coeval late Jurassic magmatism.Whole-rock geochemical results show that the host granodiorite and MMEs have similar rare earth and trace element partition curves in spider grams,and similar 87Sr/86Sr,and 147Nd/144Nd isotope ratios,and their zircon 177Hf/176Hf isotopic ratios are similar.Geochemical studies indicate that both the host granodiorite and MMEs formed by mixing of coeval magma.Zircon Ti thermometers and oxygen fugacity of the host granodiorite and the MMEs show high oxygen fugacity,similar to that of W-Cu(Mo)mineralized granitoids in the eastern Jiangnan orogenic belt.A similar magma mixing process was probably one of the mechanisms that generated the W-Cu(Mo)fertile melts. | JIANG Hua ZHANG Dayu WANG Shiwei FU Xiang YE Longxiang Noel C.WHITE ZHOU Taofa | 2021 | Acta Geologica Sinica(English Edition)2021，95，3： | 0 |
| 13 | Preparation of waterborne polyurethane/β-cyclodextrin composite nanosponge by ion condensation method and its application in removing of dyes from wastewater显示文摘Currently,polymer nanosponges have received extensive attention.However,developing new synthetic techniques for novel nanosponges remains a challenge.Furthermore,to date,composite nanosponge adsorbents based on waterborne polyurethane(WPU)andβ-cyclodextrin(β-CD)have not been reported.Herein,a novel green method,ion condensation method,was developed in this study for the preparation of polymer nanosponge adsorbents for efficient removal of dyes from wastewater.Based on the principle of charge repulsion between nanoparticles to maintain emulsion stability,waterborne polyurethane/β-cyclodextrin composite nanosponges(WPU-x,y)were prepared by coagulating the emulsions synthesized from 2,2-dimethylolpropionic acid,polypropylene glycol and hexamethylene diisocyanate as raw materials in a mixture of hydrochloric acid and anhydrous ethanol.The structure and appearance of WPU-x,y were characterized by attenuated total reflectance Fourier transform infrared spectroscopy,thermal gravimetric analyzer,scanning electron microscope and mercury intrusion porosimetry.The adsorption capacity of WPU-x,y was tested by parameters such as cross-linking degree,β-CD dosage,contact time,initial dye concentration and p H value.The study found that WPU-4,4.62 had the best adsorption effect on methylene blue(MB),the maximum removal rate was 93.42%,and the maximum adsorption capacity was 136.03 mg·g^(-1).Moreover,the Sips isotherm and pseudo-second-order-model were suitable for MB adsorption.Therefore,this study provides some perspectives for the fabrication of nanosponge adsorbents. | Shanghong Ma Haitao Zhang Jianbo Qu Xiuzhong Zhu Qingfei Hu Jianyong Wang Peng Ye Futao Sai Shiwei Chen | 2023 | Chinese Journal of Chemical Engineering2023，58，6： | 0 |
| 14 | Investigation of Proton Resonant Properties in laNe via 17F+p and Its Astrophysical Implications for 14O(α,p)17F Stellar Reaction显示文摘 | Hu Jun He Jianjun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Yuan Xiaohua Lu Wan Zhang Xueheng SuJun Li Ertao Hu Zhengguo Guo Zhongya n Xu Xing Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
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