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| 1 | Systematic review of anastomotic complications of esophagojejunostomy after laparoscopic total gastrectomy显示文摘AIM: To investigate the anastomotic complications ofesophagojejunostomy(EJS) after laparoscopic total gastrectomy(LTG), we reviewed retrospective studies.METHODS: A literature search was conducted in Pub Med for studies published from January 1, 1994 through January 31, 2015. The search terms included 'laparoscopic,' 'total gastrectomy,' and 'gastric cancer.' First, we selected 16 non-randomized controlled trials(RCTs) comparing LTG with open total gastrectomy(OTG) and conducted an updated meta-analysis of anastomotic complications after total gastrectomy. The Newcastle-Ottawa scoring system(NOS) was used to assess the quality of the non-RCTs included in this study. Next, we reviewed anastomotic complications in 46 case studies of LTG to compare the various procedures for EJS. RESULTS: The overall incidence of anastomotic leakage associated with EJS was 3.0%(30 of 984 patients) among LTG procedures and 2.1%(31 of 1500 patients) among OTG procedures in the 16 non-RCTs. The incidence of anastomotic leakage did not differ significantly between LTG and OTG(odds OR = 1.42, 95%CI: 0.86-2.33, P = 0.17, I2 = 0%). Anastomotic stenosis related to EJS was reported in 72(2.9%) of 2484 patients, and the incidence was 3.2% among LTG procedures and 2.7% among OTG procedures. The incidence of anastomotic stenosis related to EJS was slightly, but not significantly, higher in LTG than in OTG(OR = 1.55, 95%CI: 0.94-2.54, P = 0.08, I2 = 0%). The various procedures for LTG were classified into six categories in the review of case studies of LTG. The incidence of EJS leakage was similar(1.1% to 3.2%), although the incidence of EJS stenosis was relatively high when the Or VilTM device was used(8.8%) compared with other procedures(1.0% to 3.6%).CONCLUSION:The incidence of anastomotic complications associated with EJS was not different between LTG and OTG. Anastomotic stenosis was relatively common when the Or VilTM device was used. | Mikito Inokuchi Sho Otsuki Yoshitaka Fujimori Yuya Sato Masatoshi Nakagawa Kazuyuki Kojima | 2015 | World Journal of Gastroenterology2015，21，32： | 23 |
| 2 | Clinical significance of MET in gastric cancer显示文摘Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer(GC),although outcomes remain unfavorable.Many molecular-targeted therapies inhibiting signaling pathways of various tyrosine kinase receptors have been developed,and monoclonal antibodies targeting human epidermal growth factor receptor 2 or vascular endothelial growth factor receptor 2 have become standard therapy for GC.Hepatocyte growth factor and its receptor,c-MET(MET),play key roles in tumor growth through activated signaling pathways from receptor in GC cells.Genomic amplification of MET leads to the aberrant activation found in GC tumors and is related to survival in patients with GC.This review discusses the clinical significance of MET in GC and examines MET as a potential therapeutic target in patients with GC.Preclinical studies in animal models have shown that MET antibodies or smallmolecule MET inhibitors suppress tumor-cell proliferation and tumor progression in MET-amplified GC cells.These drugs are now being evaluated in clinical trials as treatments for metastatic or unresectable GC. | Mikito Inokuchi Sho Otsuki Yoshitaka Fujimori Yuya Sato Masatoshi Nakagawa Kazuyuki Kojima | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 5 |
| 3 | Clinical impact of endoscopy position detecting unit(UPD-3) for a non-sedated colonoscopy显示文摘AIM:To evaluate whether an endoscopy position detecting unit(UPD-3) can improve cecal intubation rates, cecal intubation times and visual analog scale(VAS) pain scores, regardless of the colonoscopist's level of experience.METHODS:A total of 260 patients(170 men and 90women)who underwent a colonoscopy were divided into the UPD-3-guided group or the conventional group(no UPD-3 guidance).Colonoscopies were performed by experts(experience of more than 1000colonoscopies)or trainees(experience of less than 100colonoscopies).Cecal intubation rates,cecal intubation times,insertion methods(straight insertion:shortening the colonic fold through the bending technique;roping insertion:right turn shortening technique)and patient discomfort were assessed.Patient discomfort during the endoscope insertion was scored by the VAS that was divided into 6 degrees of pain.RESULTS:The cecum intubation rates,cecal intubation times,number of cecal intubations that were performed in<15 min and insertion methods were not significantly different between the conventional group and the UPD-3-guided group.The number of patients who experienced pain during the insertion was markedly less in the UPD-3-guided group than in the conventional group.Univariate and multivariate analysis showed that the following factors were associated with lower VAS pain scores during endoscope insertion:insertion method(straight insertion)and UPD-3guidance in the trainee group.For the experts group,univariate analysis showed that only the insertion method(straight insertion)was associated with lower VAS pain scores.CONCLUSION:Although UPD-3 guidance did not shorten intubation times,it resulted in less patient painduring endoscope insertion compared with conventional endoscopy for the procedures performed by trainees. | Masakatsu Fukuzawa Junichi Uematsu Shin Kono Sho Suzuki Takemasa Sato Naoko Yagi Yuichiro Tsuji Kenji Yagi Chika Kusano Takuji Gotoda Takashi Kawai Fuminori Moriyasu | 2015 | World Journal of Gastroenterology2015，21，16： | 5 |
| 4 | Internal Microanatomy and Zoological Affinity of the Early Cambrian Olivooides显示文摘The early Cambrian pentamerous microfossil Olivooides/Punctatus in South China,which is characterized by a diagnostic stellate tubular apex,has been well-known for its almost complete development sequence that can be confidently traced from embryos and hatched juveniles,to conical adults.However,its zoological affinity remains highly controversial.Here we describe the internal microanatomic structures of the soft-body inside the peridermal theca of Olivooides multisulcatus Qian,1977,including interradial pairs of tentacles,adradial and perradial frenula,perradial oral marginal lappets and twins of perradial gastric saccule-like humps as well as a circular velarium with striated coronal muscles.Particularly,one specimen shows bifurcated velarial canals along the bell aperture.Both the components of the soft-body and the external theca(or cyst)are arranged in perfect pentaradial symmetry.These characteristics are more compatible with those of living cubomedusans and co-occurring Cambrian athecate embryonic cubozoans.Concerning the presence of peridermal theca,Olivooides most likely represents an extinct thecate stem-group cubomedusae but devoid of both perradial eyes and specialized pedalia.The well-grown soft body inside the peridermal tube displays a set of mixed features of both polyp and medusa. | Han Jian LI Guoxiang KUBOTA Shin OU Qiang TOSHINO Sho WANG Xing YANG Xiaoguang UESUGI Kentaro MASATO Hoshino SASAKI Osamu KANO Harumasa SATO Tomohiko KOMIYA Tsuyoshi | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 3 |
| 5 | Pretreatment AKR1B10 expression predicts the risk of hepatocellular carcinoma development after hepatitis C virus eradication显示文摘AIM To clarify the association between aldo-keto reductase family 1 member B10(AKR1B10) expression and hepatocarcinogenesis after hepatitis C virus eradication.METHODS In this study,we enrolled 303 chronic hepatitis C patients who had achieved sustained virological response(SVR) through interferon-based antiviral therapy. Pretreatment AKR1B10 expression in the liver was immunohistochemically assessed and quantified as a percentage of positive staining area by using image-analysis software. A multivariate Cox analysis was used to estimate the hazard ratios(HRs) of AKR1B10 expression for hepatocellular carcinoma(HCC) development after achieving SVR. The cumulative incidences of HCC development were evaluated using Kaplan-Meier analysis and the log-rank test.RESULTS Of the 303 chronic hepatitis C patients,153(50.5%) showed scarce hepatic AKR1B10 expression,quantified as 0%,which was similar to the expression in control normal liver tissues. However,the remaining 150 patients(49.5%) exhibited various degrees of AKR1B10 expression in the liver,with a maximal AKR1B10 expression of 73%. During the median follow-up time of 3.6 years(range 1.0-10.0 years),8/303 patients developed HCC. Multivariate analysis revealed that only high AKR1B10 expression(≥ 8%) was an independent risk factor for HCC development(HR = 15.4,95%CI: 1. 8- 1 3 2. 5,P = 0. 0 1 2). T h e 5- y e a r c u m u l a t i v e incidences of HCC development were 13.7% and 0.5% in patients with high and low AKR1B10 expression,respectively(P < 0.001). During the follow-up period after viral eradication,patients expressing high levels of AKR1B10 expressed markedly higher levels of alanine aminotransferase and α-fetoprotein than did patients exhibiting low AKR1B10 expression.CONCLUSION Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after SVR. | Ayato Murata Takuya Genda Takafumi Ichida Nozomi Amano Sho Sato Hironori Tsuzura Shunsuke Sato Yutaka Narita Yoshio Kanemitsu Yuji Shimada Katsuharu Hirano Katsuyori Iijima Ryo Wada Akihito Nagahara Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，33： | 2 |
| 6 | Novel uterine sarcoma preoperative diagnosis score predicts the need for surgery in patients presenting with a uterine mass显示文摘 | Tomonori Nagai Yasushi Takai Taichi Akahori Hiroaki Ishida Tatsuya Hanaoka Takahiro Uotani Sho Sato Shigetaka Matsunaga Kazunori Baba Hiroyuki Seki | 2014 | SpringerPlus2014，，： | 1 |
| 7 | TRIM29 negatively regulates p53 via inhibition of Tip60显示文摘 | Sho T Tsukiyama T Sato T | 2011 | Biochim Biophys Acta2011，1813，6： | 1 |
| 8 | TRIM29 negatively regulatesp53 via inhibition of Tip60显示文摘 | Sho T Tsukiyama T Sato T | 2011 | Biochimica et biophysica acta2011，1813，： | 1 |
| 9 | TRIM29 negatively regulates p53 via inhibition of Tip60 显示文摘 | Sho T Tsukiyama T Sato T | 2011 | Biochim Biophys Acta2011，1813，6： | 1 |
| 10 | Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C显示文摘 | Junji Kato Koji Miyanishi Masayoshi Kobune Tokiko Nakamura Kohichi Takada Rishu Takimoto Yutaka Kawano Sho Takahashi Minoru Takahashi Yasushi Sato Tetsuji Takayama Yoshiro Niitsu | 2007 | Journal of Gastroenterology2007，，10： | 1 |
| 11 | TRIM29 negatively regulates p53 via inhibition of Tip60显示文摘 | Sho T Tsukiyama T Sato T | 2011 | Biochim Biophys Acta2011，1813，6： | 1 |
| 12 | TRIM29 negatively regulates p53 via inhibition of Tip60显示文摘 | Takuya Sho Tadasuke Tsukiyama Tomonobu Sato Takeshi Kondo Jun Cheng Takashi Saku Masahiro Asaka Shigetsugu Hatakeyama | 2011 | BBA - Molecular Cell Research2011，，6： | 1 |
| 13 | Book Recommenda- tion Based on Library Loan Records and Bibliographic Informa- tion显示文摘 | Keita Tsuji Nobuya Takizawa Sho Sato | 2014 | Procedia of Social and Behavioral Sciences2014，147，8： | 1 |
| 14 | TRIM29 negatively regulates p53via inhibition of Tip60显示文摘 | Sho T Tsukiyama T Sato T | 2011 | Biochim Biophys Acta2011，1813，6： | 1 |
| 15 | The effect of granulocyte and monocyte adsorptive apheresis on serum cytokine levels in patients with ulcerative colitis显示文摘 | Yosuke Toya Toshimi Chiba Tomomi Mizutani Kunihiko Sato Satoshi Kasugai Nozomi Matsuda Shunsuke Orikasa Sho Shibata Yukito Abiko Risaburo Akasaka Naoki Yokoyama Shuhei Oana Shigeru Hirota Masaki Endo Kazuyuki Suzuki | 2013 | Cytokine2013，，： | 1 |
| 16 | TRIM29 negatively regulates p53 via inhibition of Tip60 显示文摘 | Sho T Tsukiyama T Sato T et at | 2011 | Biochim Biophys Acta2011，1813，6： | 1 |
| 17 | Rice Stomatal Closure Requires Guard Cell Plasma Membrane ATP-Binding Cassette Transporter RCN1/OsABCG5显示文摘水应力是影响世界范围的农业生产的主要环境压力之一。从植物的水损失首先通过有气孔的毛孔发生。这里,我们报导那一种 Oryza sativa 一半尺寸 ATP 有约束力的盒子(ABC ) 亚科 G 蛋白质, RCN1/OsABCG5,被植物激素 abscisic 酸(骆驼毛的织物) 涉及有气孔的 closuremediated 在警卫房间的累积。我们发现 GFP-RCN1/OsABCG5-fusion 蛋白质在在警卫房间的血浆膜是局部性的。警卫房间的百分比配对包含在外长的骆驼毛的织物处理以后增加的骆驼毛的织物和 GFP-RCN1/OsABCG5,而他们不管外长的骆驼毛的织物是否被使用在警卫房间对是 co 局部性的。骆驼毛的织物申请导致了比在野类型的植物在 rcn1 异种(A684P ) 和 RCN1-RNAi 包含骆驼毛的织物的警卫房间对的百分比的更小的增加。而且,聚乙烯乙二醇(干旱压力) 在警卫房间的可诱导的骆驼毛的织物累积没发生在 rcn1 异种。Stomata 闭合由外长的骆驼毛的织物申请调停了强烈在 rcn1 异种被减少。最后, rcn1 异种植物比野类型的植物从分开的叶子有更快速的水损失。这些结果显示响应干旱应力, RCN1/OsABCG5 在警卫房间涉及骆驼毛的织物的累积,它为有气孔的闭合是不可缺少的。 | Shuichi Matsuda Sho Takano Moeko Sato Kaoru Furukawa Hidetaka Nagasawa Shoko Yoshikawa Jun Kasuga Yoshihiko Tokuji Kazufumi Yazaki Mikio Nakazono Itsuro Takamure Kiyoaki Kato | 2016 | Molecular Plant2016，9，3： | 1 |
| 18 | Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling显示文摘BACKGROUND Sodium glucose cotransporter 2(SGLT2)inhibitors are newly developed oral antidiabetic drugs.SGLT2 is primarily expressed in the kidneys and reabsorbs approximately 90%of the glucose filtered by the renal glomeruli.SGLT2 inhibitors lower glucose levels independently of insulin action by facilitating urinary glucose excretion.The SGLT2 inhibitor ipragliflozin has reportedly improved liver steatosis in animal models and clinical studies.However,the mechanisms by which SGLT2 inhibitors improve liver steatosis are not fully understood.AIM To investigate the ameliorative effects of ipragliflozin on liver steatosis and the mechanisms of these effects in obese mice.METHODS We analyzed 8-wk-old male obese(ob/ob)mice that were randomly divided into a group receiving a normal chow diet and a group receiving a normal chow diet supplemented with ipragliflozin(3 mg/kg or 10 mg/kg)for 4 wk.We also analyzed their lean sex-matched littermates receiving a normal chow diet as another control group. Body weight and liver weight were evaluated, and liverhistology, immunoblotting, and reverse transcription-polymerase chain reactionanalyses were performed.RESULTSHepatic lipid accumulation was significantly ameliorated in ob/ob mice treatedwith 10 mg/kg ipragliflozin compared to untreated ob/ob mice irrespective ofbody weight changes. Ipragliflozin had no appreciable effects on hepatic oxidativestress-related gene expression levels or macrophage infiltration, but significantlyreduced hepatic interleukin-1β (IL-1β) mRNA expression levels. Ipragliflozinincreased both the mRNA and protein expression levels of sirtuin 1 (SIRT1) in theliver. The hepatic mRNA levels of peroxisome proliferator-activated receptor γcoactivator 1α (PGC-1α), peroxisome proliferator-activated receptor α (PPARα),and fibroblast growth factor-21 (FGF21) were also significantly higher inipragliflozin-treated ob/ob mice than in untreated ob/ob mice.CONCLUSIONOur study suggests that the liver steatosis-ameliorating effects of ipragliflozin inob/ob mice may be mediated partly by hepatic SIRT1 signaling, possibly throughthe PGC-1α/PPARα-FGF21 pathway. | Takayoshi Suga Ken Sato Tatsuya Ohyama Sho Matsui Takeshi Kobayashi Hiroki Tojima Norio Horiguchi Yuichi Yamazaki Satoru Kakizaki Ayaka Nishikido Takashi Okamura Masanobu Yamada TadahiroKitamura Toshio Uraoka | 2020 | World Journal of Hepatology2020，12，7： | 0 |
| 19 | Clinical differentiation of acute appendicitis and right colonic diverticulitis: A case-control study显示文摘BACKGROUND Acute right colonic diverticulitis (ARCD) is an important differential diagnosis of acute appendicitis (AA) in Asian countries because of the unusually high prevalence of right colonic diverticula. Due to qualitative improvement and the high penetration rate of computed tomography (CT) scanning in Japan, differentiation of ARCD and AA mainly depends on this modality. But cost, limited availability, and concern for radiation exposure make CT scanning problematic. Differential findings of ARCD from AA are based on several small studies that used univariate comparisons from Korea and Taiwan. Previous studies on clinical and laboratory differences between AA and ARCD are limited. AIM To determine clinical differences between AA and ARCD for differentiation of these two diagnoses by creating a logistic regression model. METHODS We performed an exploratory single-center retrospective case-control study evaluating 369 Japanese patients (age ≥ 16 years), 236 (64.0%) with AA and 133 (36.0%) with ARCD, who were hospitalized between 2012 and 2016. Diagnoses were confirmed by CT images. We compared age, sex, onset-to-visit interval, epigastric/periumbilical pain, right lower quadrant (RLQ) pain, nausea/vomiting, diarrhea, anorexia, medical history, body temperature, blood pressure, heart rate, RLQ tenderness, peritoneal signs, leukocyte count, and levels of serum creatinine, serum C-reactive protein (CRP), and serum alanine aminotrans-ferase. We subsequently performed logistic regression analysis for differentiating AA from ARCD based on the results of the univariate analyses.RESULTS In the AA and ARCD groups, median ages were 35.5 and 41.0 years, respectively (p=0.011);median onset-to-visit intervals were 1 [interquartile range (IQR): 0-1] and 2 (IQR: 1-3) days, respectively (P < 0.001);median leukocyte counts were 12600 and 11500/mm3, respectively (P = 0.002);and median CRP levels were 1.1 (IQR: 0.2-4.1) and 4.9 (IQR: 2.9-8.5) mg/dL, respectively (P < 0.001). In the logistic regression model, odds ratios (ORs) were significantly high in nausea/vomiting (OR: 3.89, 95%CI: 2.04-7.42) and anorexia (OR: 2.13, 95%CI: 1.06-4.28). ORs were significantly lower with a longer onset-to-visit interval (OR: 0.84, 95%CI: 0.72- 0.97), RLQ pain (OR: 0.28, 95%CI: 0.11-0.71), history of diverticulitis (OR: 0.034, 95%CI: 0.005-0.20), and CRP level > 3.0 mg/dL (OR: 0.25, 95%CI: 0.14-0.43). The regression model showed good calibration, discrimination, and optimism. CONCLUSION Clinical findings can differentiate AA and ARCD before imaging studies;nausea/vomiting and anorexia suggest AA, and longer onset-to-visit interval, RLQ pain, previous diverticulitis, and CRP level > 3.0 mg/dL suggest ARCD. | Yosuke Sasaki Fumiya Komatsu Naoyasu Kashima Takahiro Sato Ikutaka Takemoto Sho Kijima Tadashi Maeda Takamasa Ishii Taito Miyazaki Yoshiko Honda Nagato Shimada Yoshihisa Urita | 2019 | World Journal of Clinical Cases2019，7，12： | 0 |
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