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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens显示文摘像点头的受体(NLR ) 是对微生物引起的感染在天生的免疫起关键作用的细胞内部的蛋白质的一个家庭。NLRC5, NLR 家庭的最大的成员,最近吸引了许多注意。然而,在 vitro,研究在主人防卫并且在调整有免疫力的发信号的小径关于 NLRC5 的角色报导了不一致的结果。在里面 NLRC5 的 vivo 功能仍然保持未知。这里,我们报导 NLRC5 是对在 vivo 的细胞内部的病原体的主人防卫的一个批评管理者。NLRC5 明确地为涉及 MHC 一级抗原表示的基因的表示被要求。NLRC5 缺乏的老鼠显示了在 MHC 一级基因和伴随物失败的表示的一个深刻缺点激活 L。monocytogenes 特定的 CD8 + T 房间回答,包括的激活,增长和 cytotoxicity,和变异的老鼠更产生病原体感染。调停 NLRP3 的 inflammasome 激活部分也在 NLRC5 缺乏的老鼠被损害。然而, NLRC5 为 NF-κ 的导致病原体的表示是非必需的; B 依赖的支持 inflammatory 基因以及类型我干扰素基因。因此, NLRC5 极其调整 MHC 一级抗原表示控制细胞内部的病原体感染。 | Yikun Yao Yalong Wang Fuxiang Chen Yin Huang Shu Zhu Qibin Leng Hongyan Wang Yufang Shi Youcun Qian | 2012 | Cell Research2012，22，5： | 13 |
| 3 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 4 | FY-3 satellite Ultraviolet Total Ozone Unit显示文摘FY-3 satellites are Chinese second-generation polar orbit meteorological satellite series. Ultraviolet Total Ozone Unit (TOU) is one of the main payloads on FY-3 satellite and the first instrument for daily global coverage of total ozone monitoring in China. The main purpose of TOU is to measure the Earth backscatter ultraviolet radiation for retrieving daily global map of atmospheric ozone. TOU will provide the important parameters for environmental monitoring, climate forecasting and global climate changing research. At present, the in-orbit testing of TOU has accomplished and won a consummation, and it will be delivered to National Satellite Meteorological Center for the operational phase of the project. In this paper we introduce the instrument of TOU and its measuring principle, in general. We also analyze the recent working status of the instrument, including the sensitivity, measuring precision of solar irradiance, diffuser degradation and wavelength drift. The inversion results show that TOU can provide good global ozone maps, and a comparison with the OMI total ozone product shows that their RMS deviation is about 5%. It is indicated that the satisfied global distribution of total ozone can be obtained through TOU observational data and self-developed inversion method. | WANG YongMei WANG YingJian WANG WeiHe ZHANG ZhongMou LU JianGong FU LiPing JIANG Fang CHEN Ji WANG JiHong GUAN FengJun HUANG FuXiang ZHANG XingYing | 2010 | Chinese Science Bulletin2010，55，1： | 9 |
| 5 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 6 | Borehole stability in naturally fractured reservoirs luring production tests显示文摘基于软弱理论的飞机,为在不同压力国家下面在折断的水库预言地上凿穿稳定性的一个模型是 estiblisted,为解决地上凿穿稳定性的方程被开发。要求在不同自然破裂出现下面维持地上凿穿稳定性的最小的 downhole 压力被在 Tazhong (中央 Tarim ) 从一口井使用数据计算区域, Tarim 盆,西方中国。几个结论从不到 10 | Zhang Fuxiang Zhang Shaoli Jiang Xuehai Lu Rende Chen Mian | 2008 | Petroleum Science2008，5，3： | 5 |
| 7 | Wear Behavior of In-situ TiC Particles Reinforced Aluminum Matrix Composite显示文摘The microstructure, tensile property and wear resistance of 7075 aluminum matrix composite reinforced with TiC particles prepared by in-situ reaction casting were investigated. The effect of TiC reinforcement on wear behavior was analyzed. The wear mechanism was also discussed. A micro-mechanism model of reaction kinetics for synthesis of TiC was acquired. Results show that TiC could increase the tensile and yield strength, but decrease the elongation. Besides, TiC particles improve the property of wear resistance of 7075 aluminum alloy. The wear mechanisms include abrasive wear and adhesive wear in wear test process. | 隋艳伟 CHEN Xiao WANG Rui QI Jiqiu WEI Fuxiang HE Yezeng MENG Qingkun 孙智 | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，3： | 3 |
| 8 | Timing of mineralization at the Shihu gold deposit in the middle segment of the Taihang Mountain, China显示文摘The Shihu gold deposit, located in the middlesouth section of the core of the Fuping mantle branch structure, is hosted in the Archean Fuping Group and adjacent to the quartz diorite porphyrite. The gold deposit is the only large gold deposit with reserves of more than 30 tons gold discovered in western Hebei Province so far. In order to constrain the timing of mineralization of this ore deposit, this paper focuses on the isotopic dating of zircon and pyrite. Zircons in gold-bearing quartz veins are magmatic in origin and no hydrothermal zircon has been found in such quartz veins, indicating that zircons were derived from the wall rocks. U–Pb ages of zircons fall mainly in the two domains: 2492 ± 82 and 136 ± 4 Ma, respectively,indicative of the contribution of the Fuping-Group TTG gneiss and Yanshanian igneous rocks, respectively. The Re–Os isotopic compositions of pyrites in the gold-bearing quartz veins yield an isochron age of 127 ± 31 Ma. Combined with other dating results, we suggest that the main metallogenic age of the Shihu gold deposit is 120–127 Ma. | Chao Chen Shuyin Niu Fang Wang Fuxiang Zhang Qinglian Zhang Baojun Ma Aiqun Sun Jianzhen Zhang Yaqi Cao Xiaoqing Zhang | 2018 | Acta Geochimica2018，37，1： | 3 |
| 9 | Analysis of the ore-controlling role of Guojiadian mantle branch structure,Northwest Shandong Peninsula,China显示文摘Metallogenesis in the gold ore-concentrated zone of Northwest Shandong Peninsula is closely related to deep processes.The region in the eastern part of North China entered into the stage of mantle plume evolution during the Yanshanian movement,following the long-time stage of stable platform evolution during Paleozoic time.At that time,the ore-concentrated zone of Northwest Shandong Peninsula just entered into the development-evolution stage of the Laiyang sub-mantle plume and the Guojiadian mantle branch structure in its periphery.The core-mantle-source gold was present in the gas-liquid form,and it migrated through mantle plume→sub-mantle plume→mantle branch structure→favorable tectonic expansion zone to the favorable loci of the mantle branch structure,where gold was deposited as ores,thereafter constituting a series of large-to medium-sized gold deposits distributed around the Guojiadian mantle branch structure.This study also dealt with the Jiaojia fault as the main detachment(fault altered rock) belt on the northwestern margin of the mantle branch structure and also presented a basic cognition about the fact that the Sanshandao fault as the listric fault on the hanging wall of the detachment belt.Furthermore,on this basis,this study also pointed out the orientation for further ore prospecting in this region. | NIU Shuyin Sun Aiqun ZHANG Jianzhen MA Baojun WANG Baode CHEN Chao ZHANG Fuxiang LIU Cheng ZHANG Xiaofei | 2012 | Chinese Journal Of Geochemistry2012，31，4： | 2 |
| 10 | Latest Advances in High-Voltage and High-Energy-Density Aqueous Rechargeable Batteries显示文摘Aqueous rechargeable batteries(ARBs)have become a lively research theme due to their advantages of low cost,safety,environmental friendliness,and easy manufacturing.However,since its inception,the aqueous solution energy storage sys-tem has always faced some problems,which hinders its development,such as the narrow electrochemical stability window of water,poor percolation of electrode materials,and low energy density.In recent years,to overcome the shortcomings of the aqueous solution-based energy storage system,some very pioneering work has been done,which also provides a great inspiration for further research and development of future high-performance aqueous energy storage systems.In this paper,the latest advances in various ARBs with high voltage and high energy density are reviewed.These include aqueous rechargeable lithium,sodium,potassium,ammonium,zinc,magnesium,calcium,and aluminum batteries.Further chal-lenges are pointed out. | Xinhai Yuan Fuxiang Ma Linqing Zuo Jing Wang Nengfei Yu Yuhui Chen Yusong Zhu Qinghong Huang Rudolf Holze Yuping Wu Teunis van Ree | 2021 | Electrochemical Energy Reviews2021，4，1： | 2 |
| 11 | Synthesis and biological activities of 2-oxocycloalkylsulfonamides显示文摘 | XINGHAI LI XINLING YANG XIAOMEI LIANG ZHENPENG KAI HUIZU YUAN DEKAIYUAN JIANJUN ZHANG RUIQING WANG FUXIANG RAN SHUHUA QI YUN LING FUHENG CHEN DAOQUAN WANG | | 0，，08： | 1 |
| 12 | Recent progress on photocatalysts with wide visible light range absorption for heterogeneous water splitting显示文摘 | Shanshan Chen Fuxiang Zhang | 2014 | 催化学报2014，35，9： | 1 |
| 13 | Synthesis of titania-supported platinum catalyst:the effect of pH on morphology control and valence state during photodeposition 显示文摘 | ZHANG Fuxiang CHEN Jixin ZHANG Xiu | 2004 | Langmuir2004，20，21： | 1 |
| 14 | Simple and low-cost preparation method for highly dispersed Pd/ TiO2 catalysts 显示文摘 | Zhang Fuxiang Chen Jixin Zhang Xiu | 2004 | Catal Today2004，，： | 1 |
| 15 | Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells显示文摘 | Yanwen Peng Zhenguang Chen Weihua Yu Qifeng Zhou Lin Xu Frank Fuxiang Mao Gang Huang Xiuming Zhang Shunong Li Bruce T. Lahn Andy Peng Xiang | 2008 | Cell Biology International2008，，10： | 1 |
| 16 | Intermetallic IrGa-IrO_(x) core-shell electrocatalysts for oxygen evolution Hide Author's Information显示文摘The development of high-performance Ir-based catalyst for electrocatalysis of oxygen evolution reaction(OER)in acidic media plays a critical role in realizing the commercialization of polymer electrolyte membrane-based water electrolyzer technology.Here we report a low-Ir core–shell OER electrocatalyst consisting of an intermetallic IrGa(IrGa-IMC)core and a partially oxidized Ir(IrOx)shell.In acidic electrolytes,the IrGa-IMC@IrOx core–shell catalysts exhibit a low overpotential of 272 mV at 10 mA·cm^(−2) with Ir loading of~20µg·cm^(−2) and a mass activity of 841 A·gIr^(−1) at 1.52 V,which is 3.6 times greater than that of commercial Ir/C(232 A·gIr^(−1))catalyst.We understand by the density functional theory(DFT)calculations that the enhanced OER activity of the IrGa-IMC@IrO_(x) catalysts is ascribed to the lifted degeneracy of Ir 5d electron of surface IrO_(x) sites induced by the intermetallic IrGa core,which increases the adsorption capacity of IrO_(x) layer for O and OH binding and eventually lowers the energy barrier of the OER rate-determining steps. | Lin-Wei Chen Fuxiang He Ru-Yang Shao Qiang-Qiang Yan Peng Yin Wei-Jie Zeng Ming Zuo Lixin He Hai-Wei Liang | 2022 | Nano Research2022，15，3： | 0 |
| 17 | Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release显示文摘Hydrogel capsules show attractive prospects in drug delivery recently because of high drug loading and sustained release behavior. In this study we reported a simple and convenient route to fabricate poly(acrylic acid)-poly(N-isopropylacrylamide)(PAA-PNIPAm) hydrogel capsules by using hydroxypropylcellulose-poly(acrylic acid)(HPC-PAA) complexes as the templates. The capsules showed a high drug loading(~280% to the weight of capsules) for Doxorubicin hydrochloride. The release of drug from the capsules was responsive to the temperature and p H of the surroundings, showing a low-rate but sustained release behavior favorable for low-toxic and long-term therapy. Together with the convenient preparation, high drug loading, dual responsivity as well as the sustained release feature, it is implied that this polymeric hydrogel capsule might be a promising candidate for new drug carriers. | Jingya Nan Ying Chen Rutian Li Jifu Wang Meihong Liu Chunpeng Wang Fuxiang Chu | 2014 | Nano-Micro Letters2014，6，3： | 0 |
| 18 | Accurate prediction of pan-cancer types using machine learning with minimal number of DNA methylation sites显示文摘DNA methylation analysis has been applied to determine the primary site of cancer;however, robust and accurate prediction of cancer types with a minimum number of sites is still a significant scientific challenge. To build an accurate and robust cancer type prediction tool with a minimum number of DNA methylation sites, we internally benchmarked different DNA methylation site selection and ranking procedures, as well as different classification models. We used The Cancer Genome Atlas dataset (26 cancer types with 8296 samples) to train and test models and used an independent dataset (17 cancer types with 2738 samples) for model validation. A deep neural network model using a combined feature selection procedure (named MethyDeep) can predict 26 cancer types using 30 methylation sites with superior performance compared with the known methods for both primary and metastatic cancers in independent validation datasets. In conclusion, MethyDeep is an accurate and robust cancer type predictor with the minimum number of DNA methylation sites;it could help the cost-effective clarification of cancer of unknown primary patients and the liquid biopsy-based early screening of cancers. | Wei Ning Tao Wu Chenxu Wu Shixiang Wang Ziyu Tao Guangshuai Wang Xiangyu Zhao Kaixuan Diao Jinyu Wang Jing Chen Fuxiang Chen Xue-Song Liu | 2023 | Journal of Molecular Cell Biology2023，15，4： | 0 |
| 19 | Effects of Pouring Temperature on Interfacial Reaction between Ti-47-5Al-2-5V-1Cr Alloy and Mold during Centrifugal Casting显示文摘Pouring temperature and time are the most important influencing factors on interfacial reaction during the centrifugal casting. When cast at high temperatures, the crucible becomes brittle and prone to cracking, and shows a low stability. In this paper, we studied the centrifugal casting of Ti-47.5-Al-2.5V-1Cr alloy, and explored the effects of pouring temperature on the interfacial reaction. Castings at 1 600, 1 650, and 1 700 ℃ were obtained by controlling the other parameters constant in the experiments. The microstructure, elemental distribution, thickness of the reaction layer and phase composition of the castings at the interface were studied. The results show that the thickness at the interfacial reaction layer is increased by raising the pouring temperature. The elements in the mold and the matrix were double-diffused and reacted at the interface during the casting process, and formed solid solutions with the precipitation of many new phases such as Al_2O_3 and TiO_2. The roughness of interface structure and layer thickness of reaction increase with the rise of temperature, and the interfacial reaction is more intense. There is a minimum layer thickness of the reaction layer that is 80 μm when the temperature is 1 600 ℃. | 隋艳伟 FENG Kun CHENG Cheng CHEN Xiao 戚继球 HE Yezeng MENG Qingkun WEI Fuxiang SUN Zhi | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，5： | 0 |
| 20 | Tip-induced directional charge separation on one-dimensional BiVO4 nanocones for asymmetric light absorption显示文摘One dimensional(1D)semiconductor is a class of extensively attractive materials for many emerging solar energy conversion technologies.However,it is still of shortage to assess the impact of 1D structural symmetry on spatial charge separation and understand its underlying mechanism.Here we take controllably-synthesized 1D BiVO_(4)nanocones and nanorods as prototypes to study the influence of 1D symmetry on charge separation.It is found that the asymmetric BiVO_(4)nanocones enable more effective charge separation compared with the symmetric nanorods.The unexpected spatial charge separation on the nanocones is mainly ascribed to uneven light absorption induced diffusion-controllable charge separation due to symmetry breaking of 1D nanostructure,as evidenced by spatial and temporal resolved spectroscopy.Moreover,the promotion effect of charge separation on the nanocones was quantitatively evaluated to be over 20 times higher than that in BiVO_(4)nanorods.This work gives the first demonstration of the influence of 1D structural symmetry on the charge separation behavior,providing new insights to design and fabricate semiconductor materials for efficient solar energy conversion. | Nengcong Yang Ruotian Chen Chenwei Ni Dongfeng Li Qi Sun Lifang Liu Yu Qi Shengye Jin Xiuli Wang Fengtao Fan Can Li Fuxiang Zhang | 2022 | Journal of Energy Chemistry2022，31，9： | 0 |
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