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| 1 | NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens显示文摘像点头的受体(NLR ) 是对微生物引起的感染在天生的免疫起关键作用的细胞内部的蛋白质的一个家庭。NLRC5, NLR 家庭的最大的成员,最近吸引了许多注意。然而,在 vitro,研究在主人防卫并且在调整有免疫力的发信号的小径关于 NLRC5 的角色报导了不一致的结果。在里面 NLRC5 的 vivo 功能仍然保持未知。这里,我们报导 NLRC5 是对在 vivo 的细胞内部的病原体的主人防卫的一个批评管理者。NLRC5 明确地为涉及 MHC 一级抗原表示的基因的表示被要求。NLRC5 缺乏的老鼠显示了在 MHC 一级基因和伴随物失败的表示的一个深刻缺点激活 L。monocytogenes 特定的 CD8 + T 房间回答,包括的激活,增长和 cytotoxicity,和变异的老鼠更产生病原体感染。调停 NLRP3 的 inflammasome 激活部分也在 NLRC5 缺乏的老鼠被损害。然而, NLRC5 为 NF-κ 的导致病原体的表示是非必需的; B 依赖的支持 inflammatory 基因以及类型我干扰素基因。因此, NLRC5 极其调整 MHC 一级抗原表示控制细胞内部的病原体感染。 | Yikun Yao Yalong Wang Fuxiang Chen Yin Huang Shu Zhu Qibin Leng Hongyan Wang Yufang Shi Youcun Qian | 2012 | Cell Research2012，22，5： | 13 |
| 2 | Organic-inorganic bismuth (lll)-based material: A lead- free, air-stable and solution-processable light-absorber beyond organolead perovskites显示文摘 | Miaoqiang Lyu Jung-Ho Yun Molang Cai Yalong Jiao Paul V. Bernhardt Meng Zhang Qiong Wang Aijun Du Hongxia Wang Gang Liu Lianzhou Wang | 2016 | Nano Research2016，9，3： | 8 |
| 3 | Oxygen vacancy-engineered BaTiO_(3)nanoparticles for synergistic cancer photothermal,photodynamic,and catalytic therapy显示文摘With the rapid development of photo-responsive nanomaterials,photo-triggered therapeutic strategies such as photothermal therapy(PTT)and photodynamic therapy(PDT)have been new alternatives to current cancer therapeutic methods.Herein,we have fabricated oxygen vacancy-engineered BaTiO_(3)(BTO-Ov)nanoparticles(NPs)for near-infrared(NIR)light-triggered PTT,PDT,and catalytic therapy cooperatively for significantly improving cancer therapy.Compared to pristine BaTiO_(3)nanoparticles,BTO-Ov has stronger NIR light absorption and narrower band gap structure,which results in superior photothermal conversion and superoxide radical generation capabilities through PTT and PDT.Meanwhile,due to the existence of Ti^(3+),BTO-Ov also exhibits peroxidase(POD)-like activity to produce hydroxyl radical under tumor environment,which can be further improved under 808 nm light irradiation.Both in vitro and in vivo results demonstrate that such a multifunctional therapeutic nanoplatform can achieve a high therapeutic efficacy triggered by a single NIR light irradiation.The defect engineering strategy can be used as a general approach to fabricate multifunctional cancer therapeutic nanoplatform. | Yiming Ding Zhuo Wang Zeyu Zhang Yunchao Zhao Shangyu Yang Yalong Zhang Shuncheng Yao Shaobo Wang Tian Huang Yang Zhang Linlin Li | 2022 | Nano Research2022，15，8： | 3 |
| 4 | Cross-species single-cell transcriptomic analysis reveals divergence of cell composition and functions in mammalian ileum epithelium显示文摘Animal models are widely used for biomedical studies and drug evaluation.The small intestine plays key roles in nutrient absorption,hormone secretion,microbiota defense and drug absorption and metabolism.Although the intestinal structure of mammals is conserved,the differences on epithelial cell composition,functional assignments and drug absorption among mammals are largely unknown.Here,cross-species analysis of single-cell transcriptomic atlas of the ileum epithelium from mouse,rat,pig,macaque and human reveals the conserved and differential cell types and functions among species,identifies a new CA7+cell type in pig,macaque and human ileum,uncovers the distinct expression pattern in enterocytes,enteroendocrine cells and Paneth cells,and defines the conserved and species-specific intestinal stem cell signature genes.The examination of drug absorption across species suggests that drug metabolism in mouse ileum is closer to human while drug transport in macaque ileum is more similar to human.Together,our data provide the comprehensive information about cell composition and functional assignments in five species,and offer the valuable guidance for animal model selection and drug testing. | Haonan Li Xiaodan Wang Yalong Wang Mengxian Zhang Fan Hong Hong Wang Along Cui Jianguo Zhao Weizhi Ji Ye-Guang Chen | 2022 | Cell Regeneration2022，11，1： | 2 |
| 5 | Intestinal cellular heterogeneity and disease development revealed by single-cell technology显示文摘The intestinal epithelium is responsible for food digestion and nutrient absorption and plays a critical role in hormone secretion,microorganism defense,and immune response.These functions depend on the integral single-layered intestinal epithelium,which shows diversified cell constitution and rapid self-renewal and presents powerful regen-eration plasticity after injury.Derailment of homeostasis of the intestine epithelium leads to the development of dis-eases,most commonly including enteritis and colorectal cancer.Therefore,it is important to understand the cellular characterization of the intestinal epithelium at the molecular level and the mechanisms underlying its homeostatic maintenance.Single-cell technologies allow us to gain molecular insights at the single-cell level.In this review,we summarize the single-cell RNA sequencing applications to understand intestinal cell characteristics,spatiotemporal evolution,and intestinal disease development. | Yalong Wang Wanlu Song Shicheng Yu Yuan Liu Ye-Guang Chen | 2022 | Cell Regeneration2022，11，1： | 2 |
| 6 | A review of in situ upgrading technology for heavy crude oil显示文摘With the growing demand of oil worldwide,heavy oil has increasingly become vital in the world energy market.However,further development of heavy oil reservoirs are limited by regular enhanced oil recovery(EOR)methods.In situ upgrading technology provides potential for the development of heavy oil and bitumen reservoirs.This study reviews three categories of in situ upgrading methods:solvent-based,in situ combustion(ISC),and catalytic.Solvent-based methods,including cyclic solvent injection,vapor extraction,and hybrid processes,have recently received attention and have been progressed in both laboratory and field applications.However,high solvent costs in relation to the low price of heavy oil have continued to limit the field applications of these techniques.ISC,which may have the potential to develop particularly harsh reservoirs with extremely viscous crude oil,involves complex reaction mechanisms and consists of three main steps:oxidation,combustion,and gas flooding.Yet,complex operating conditions and a low success rate have restricted its application.Catalytic methods,which have demonstrated the potential to refine and upgrade crude oil in a more economic and environmentally friendly way,are often accompanied by conventional thermal EOR methods,such as steam flooding and ISC,and involve a series of hydroprocessing or hydrotreating reactions,such as hydrocracking,hydrodesulfurization,hydrodenitrogenation,hydrodeoxygenation,and hydrodemetallization.However,the high cost and complexity of the reaction mechanisms have limited their applications. | Yibo Li Zhiqiang Wang Zhiming Hu Yalong Li Wanfen Pu Jinzhou Zhao | 2021 | Petroleum2021，7，2： | 2 |
| 7 | Modeling and optimizing parabolic trough solar collector systems using the least squares support vector machine method显示文摘 | Qibin Liu Minlin Yang Jing Lei Hongguang Jin Zhichao Gao Yalong Wang | 2012 | Solar Energy2012，，7： | 2 |
| 8 | Serrated lithium fluoride nanofibers-woven interlayer enables uniform lithium deposition for lithium-metal batteries显示文摘The uncontrollable formation of Li dendrites has become the biggest obstacle to the practical application of Li-metal anodes in high-energy rechargeable Li batteries.Herein,a unique LiF interlayer woven by millimeter-level,single-crystal and serrated LiF nanofibers(NFs)was designed to enable dendrite-free and highly efficient Li-metal deposition.This high-conductivity Li F interlayer can increase the Li^(+)transference number and induce the formation of’Li F–NFs-rich’solid–electrolyte interface(SEI).In the’Li F–NFs-rich’SEI,the ultra-long Li F nanofibers provide a continuously interfacial Li^(+)transport path.Moreover,the formed Li–LiF interface between Li-metal and SEI film renders low Li nucleation and high Li^(+)migration energy barriers,leading to uniform Li plating and stripping processes.As a result,steady charge–discharge in a Li//Li symmetrical cell for 1600 h under 4 m Ah cm^(-2)and 400 stable cycles under a high area capacity of 5.65 mAh cm^(-2)in a high-loading Li//rGO–S cell at 17.9 mA cm^(-2)could be achieved.The free-standing LiF–NFs interlayer exhibits superior advantages for commercial Li batteries and displays significant potential for expanding the applications in solid Li batteries. | Shuangshuang Tan Yalong Jiang Shuyan Ni Hao Wang Fangyu Xiong Lianmeng Cui Xuelei Pan Chen Tang Yaoguang Rong Qinyou An Liqiang Mai | 2022 | National Science Review2022，9，11： | 2 |
| 9 | Establishment of porcine and monkey colonic organoids for drug toxicity study显示文摘Pig and monkey are widely used models for exploration of human diseases and evaluation of drug efficiency and toxicity,but high cost limits their uses.Organoids have been shown to be promising models for drug test as they reasonably preserve tissue structure and functions.However,colonic organoids of pig and monkey are not yet established.Here,we report a culture medium to support the growth of porcine and monkey colonic organoids.Wnt signaling and PGE2 are important for long-term expansion of the organoids,and their withdrawal results in lineage differentiation to mature cells.Furthermore,we observe that porcine colonic organoids are closer to human colonic organoids in terms of drug toxicity response.Successful establishment of porcine and monkey colonic organoids would facilitate the mechanistic investigation of the homeostatic regulation of the intestine of these animals and is useful for drug development and toxicity studies. | Haonan Li Yalong Wang Mengxian Zhang Hong Wang Along Cui Jianguo Zhao Weizhi Ji Ye-Guang Chen | 2021 | Cell Regeneration2021，10，1： | 1 |
| 10 | Molecular mechanisms of adaptive evolution in wild animals and plants显示文摘Wild animals and plants have developed a variety of adaptive traits driven by adaptive evolution,an important strategy for species survival and persistence.Uncovering the molecular mechanisms of adaptive evolution is the key to understanding species diversification,phenotypic convergence,and inter-species interaction.As the genome sequences of more and more non-model organisms are becoming available,the focus of studies on molecular mechanisms of adaptive evolution has shifted from the candidate gene method to genetic mapping based on genome-wide scanning.In this study,we reviewed the latest research advances in wild animals and plants,focusing on adaptive traits,convergent evolution,and coevolution.Firstly,we focused on the adaptive evolution of morphological,behavioral,and physiological traits.Secondly,we reviewed the phenotypic convergences of life history traits and responding to environmental pressures,and the underlying molecular convergence mechanisms.Thirdly,we summarized the advances of coevolution,including the four main types:mutualism,parasitism,predation and competition.Overall,these latest advances greatly increase our understanding of the underlying molecular mechanisms for diverse adaptive traits and species interaction,demonstrating that the development of evolutionary biology has been greatly accelerated by multi-omics technologies.Finally,we highlighted the emerging trends and future prospects around the above three aspects of adaptive evolution. | Yibo Hu Xiaoping Wang Yongchao Xu Hui Yang Zeyu Tong Ran Tian Shaohua Xu Li Yu Yalong Guo Peng Shi Shuangquan Huang Guang Yang Suhua Shi Fuwen Wei | 2023 | Science China(Life Sciences)2023，66，3： | 1 |
| 11 | Genome-wide signatures of the geographic expansion and breeding of soybean显示文摘Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding. | Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing Jun Wang Yongzhe Gu Xingpeng Gao Delin Li Hongyu Li Zhangxiong Liu Xin Jing Beibei Feng Tao Zhao Rongxia Guan Yong Guo Jun Liu Zhe Yan Lijuan Zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai Zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin Liu Shilin Tian Li-juan Qiu | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 12 | Highly compact and uniform CH3NH3Sn0.5Pb0.5I3 films for efficient panchromatic planar perovskite solar cells显示文摘An efficient panchromatic planar perovskite solar cell is developed based on highly uniform,lead-reduced CH3NH3Sn0.5Pb0.5I3 perovskite films with full film-coverage on the substrates.We demonstrate here that full-coverage of the CH3NH3Sn0.5Pb0.5I3 films can be developed by a facile chlorobenzene-assisted spin-coating method.A power conversion efficiency of 7 % is achieved using low-temperature processes,which is among the best-reported performance for panchromatic planar perovskite solar cells with a light-absorption over 1,000 nm. | Miaoqiang Lyu Meng Zhang Nathan A. Cooling Yalong Jiao Qiong Wang Jung-Ho Yun Ben Vaughan Gerry Triani Peter Evans Xiaojing Zhou Krishna Feron Aijun Du Paul Dastoor Lianzhou Wang | 2016 | Science Bulletin2016，61，20： | 1 |
| 13 | Coordinated regulation of BACH1 and mitochondrial metabolism through tumor-targeted self-assembled nanoparticles for effective triple negative breast cancer combination therapy显示文摘The poor prognosis of triple negative breast cancer(TNBC)results from a lack of approved targeted therapies coupled with aggressive proliferation and metastasis,which is associated with high recurrence and short overall survival.Here we developed a strategy by employing tumor-targeted selfassembled nanoparticles to coordinately regulate BACH1(BTB domain and CNC homology 1)and mitochondrial metabolism.The BACH1 inhibitor hemin and mitochondria function inhibitor berberine derivative(BD)were used to prepare nanoparticles(BH NPs)followed by the modification of chondroitin sulfate(CS)on the surface of BH NPs to achieve tumor targeting(CS/BH NPs).CS/BH NPs were found to be able to inhibit tumor migration and invasion by significantly decreasing the amounts of tumor cell metabolites,glycolysis and metastasis-associated proteins,which were related to the inhibition of BACH1 function.Meanwhile,decreased mitochondrial membrane potential,activated caspase 3/9 and increased ROS production demonstrated coordinated regulation of BACH1 and mitochondrial metabolism.In a xenograft mice model of breast cancer,CS/BH NPs significantly inhibited tumor growth and metastasis due to the synergetic effect of hemin and BD without showing obvious toxicities for major organs.In sum,the results of efficacy and safety experiments suggest potential clinical significance of the prepared self-assembled CS/BH nanoparticles for the treatment of TNBC. | Xuan Yang Yalong Wang Junke Zhao Hehui Rong Yujun Chen Mengting Xiong Xiaoxing Ye Shihui Yu Haiyan Hu | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 1 |
| 14 | Assessment of reprocessed sea surface height measurements derived from HY-2A radar altimeter and its application to the observation of 2015–2016 El Nino显示文摘Haiyang-2A(HY-2A) is China's first ocean dynamic environment satellite and the radar altimeter is one of its main payloads. One of the main purposes of the radar altimeter is to measure the sea surface height(SSH). The SSH determined from the altimeter range measurements includes some range and geophysical corrections. These corrections largely affect the accuracy of the SSH measurements. The range and the geophysical corrections are reprocessed and the altimeter waveforms in HY-2A sensor interim geophysical data set records(S-IGDR) are retracked from June 1, 2014 to June 14, 2014, and the accuracy of the reprocessed SSH measurements is evaluated.The methods of the range and geophysical corrections used to reprocess HY-2A altimeter data are validated by using these methods to reprocess the Jason-2 range and geophysical corrections and comparing the results with the range and geophysical corrections in Jason-2 geophysical dataset records(GDR) product. A crossover analysis is used to evaluate the accuracy of the reprocessed HY-2A SSH measurements. The standard deviation(STD) of the crossover SSH differences for HY-2A is around 4.53 cm while the STD of the SSH differences between HY-2A and Jason-2 is around 5.22 cm. The performance of the reprocessed HY-2A SSH measurements is significantly improved with respect to the SSH measurements derived from HY-2A interim geophysical dataset records(IGDR)product. The 2015–2016 El Ni?o has been the strongest El Ni?o event since 1997–1998. The range and the geophysical corrections in HY-2A IGDR are reprocessed and sea level anomalies are used to monitor the2015–2016 El Ni?o. The results show that the HY-2A altimeter can well observe the 2015–2016 El Ni?o. | JIANG Maofei XU Ke LIU Yalong ZHAO Jin WANG Lei | 2018 | Acta Oceanologica Sinica2018，37，1： | 1 |
| 15 | Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy显示文摘Objective:This study aimed to evaluate the effects of mitochondrial pyruvate carrier(MPC)blockade on the sensitivity of detection and radiotherapy of prostate cancer(PCa).Methods:We investigated glycolysis reprogramming and MPC changes in patients with PCa by using metabolic profiling,RNASeq,and tissue microarrays.Transient blockade of pyruvate influx into mitochondria was observed in cellular studies to detect its different effects on prostate carcinoma cells and benign prostate cells.Xenograft mouse models were injected with an MPC inhibitor to evaluate the sensitivity of 18F-fluorodeoxyglucose positron emission tomography with computed tomography and radiotherapy of PCa.Furthermore,the molecular mechanism of this different effect of transient blockage towards benign prostate cells and prostate cancer cells was studied in vitro.Results:MPC was elevated in PCa tissue compared with benign prostate tissue,but decreased during cancer progression.The transient blockade increased PCa cell proliferation while decreasing benign prostate cell proliferation,thus increasing the sensitivity of PCa cells to 18F-PET/CT(SUVavg,P=0.016;SUVmax,P=0.03)and radiotherapy(P<0.01).This differential effect of MPC on PCa and benign prostate cells was dependent on regulation by a VDAC1-MPC-mitochondrial homeostasis-glycolysis pathway.Conclusions:Blockade of pyruvate influx into mitochondria increased glycolysis levels in PCa but not in non-carcinoma prostate tissue.This transient blockage sensitized PCa to both detection and radiotherapy,thus indicating that glycolytic potential is a novel mechanism underlying PCa progression.The change in the mitochondrial pyruvate influx caused by transient MPC blockade provides a critical target for PCa diagnosis and treatment. | Huan Xu Junyi Chen Zhi Cao Xi Chen Caihong Huang Jin Ji Yalong Xu Junfeng Jiang Yue Wang Guowang Xu Lina Zhou Jingyi He Xuedong Wei Jason Boyang Wu Zhong Wang Shancheng Ren Fubo Wang | 2022 | Cancer Biology & Medicine2022，19，9： | 1 |
| 16 | A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization against SARS-CoV-2 Omicron subvariants and other variants显示文摘Multivalent vaccines combining crucial mutations from phylogenetically divergent variants could be an effective approach to defend against existing and future SARS-Co V-2 variants.In this study,we developed a tetravalent COVID-19 vaccine SCTV01E,based on the trimeric Spike protein of SARS-Co V-2 variants Alpha,Beta,Delta,and Omicron BA.1,with a squalenebased oil-in-water adjuvant SCT-VA02B.In the immunogenicity studies in na?ve BALB/c and C57BL/6J mice,SCTV01E exhibited the most favorable immunogenic characteristics to induce balanced and broad-spectrum neutralizing potencies against pre-Omicron variants(D614G,Alpha,Beta,and Delta)and newly emerging Omicron subvariants(BA.1,BA.1.1,BA.2,BA.3,and BA.4/5).Booster studies in C57BL/6J mice previously immunized with D614G monovalent vaccine demonstrated superior neutralizing capacities of SCTV01E against Omicron subvariants,compared with the D614G booster regimen.Furthermore,SCTV01E vaccination elicited na?ve and central memory T cell responses to SARS-Co V-2 ancestral strain and Omicron spike peptides.Together,our comprehensive immunogenicity evaluation results indicate that SCTV01E could become an important COVID-19 vaccine platform to combat surging infections caused by the highly immune evasive BA.4/5 variants.SCTV01E is currently being studied in a head-to-head immunogenicity comparison phase 3 clinical study with inactivated and m RNA vaccines(NCT05323461). | Rui Wang Hongpeng Huang Chulin Yu Chunyun Sun Juan Ma Desheng Kong Yalong Lin Dandan Zhao Shaozheng Zhou Jianbo Lu Sai Cao Yanjing Zhang Chunxia Luo Xuefeng Li Yang Wang Liangzhi Xie | 2023 | Science China(Life Sciences)2023，66，8： | 1 |
| 17 | Analysis of coast-by noise of heavy truck tires显示文摘Heavy truck tires are one of the main sources of road traffic noise.However,the mechanism and propagation of the noise generated by these tires have not been systematically investigated.To determine the noise of heavy truck tires with different structures and patterns,and to analyze the correlation between the indoor tire noise and coast-by tire noise,an integrated tire indoor noise test and a coast-by noise test were designed and successfully implemented.The indoor test was conducted on a drum inside a semianechoic chamber to simultaneously measure the near field and far field noise of the tires.The outdoor measurements were carried out using a coast-by test on the new ISO 10844 surface.A formula for quantitative analysis with appropriate corrections was developed to analyze the data with reasonable errors,which can be used to predict the coast-by noise through the indoor tire noise test accurately and effectively.The analysis shows that when trying to build the relationship between indoor and outdoor heavy truck tire noise,care should be taken to differentiate the tires with a load capacity index in excess of 121 and without any dual fitting indication from ordinary tires,due to the specified test procedure. | Yintao Wei Yongbao Yang Yalong Chen Hao Wang Dabing Xiang zhichao Li | 2016 | Journal of Traffic and Transportation Engineering(English Edition)2016，3，2： | 1 |
| 18 | A rapid method for the detection of foodborne pathogens by extraction of a trace amount of DNA from raw milk based on amino-modified silica-coated magnetic nanoparticles and polymerase chain reaction显示文摘 | Yalong Bai Minghui Song Yan Cui Chunlei Shi Dapeng Wang George C. Paoli Xianming Shi | 2013 | Analytica Chimica Acta2013，，： | 1 |
| 19 | Ground response of circular tunnel in poorly consolidated rock 显示文摘 | WANG Yalong | 1996 | Journal of Geotechnical Engineering ASCE1996，122，9： | 1 |
| 20 | Microbial sensing in the intestine显示文摘The gut microbiota plays a key role in host health and disease,particularly through their interactions with the immune system.Intestinal homeostasis is dependent on the symbiotic relationships between the host and the diverse gut microbiota,which is influenced by the highly co-evolved immune-microbiota interactions.The first step of the interaction between the host and the gut microbiota is the sensing of the gut microbes by the host immune system.In this review,we describe the cells of the host immune system and the proteins that sense the components and metabolites of the gut microbes.We further highlight the essential roles of pattern recognition receptors(PRRs),the G protein-coupled receptors(GPCRs),aryl hydrocarbon receptor(AHR)and the nuclear receptors expressed in the intestinal epithelial cells(IECs)and the intestine-resident immune cells.We also discuss the mechanisms by which the disruption of microbial sensing because of genetic or environmental factors causes human diseases such as the inflammatory bowel disease(IBD). | Tingting Wan Yalong Wang Kaixin He Shu Zhu | 2023 | Protein & Cell2023，14，11： | 1 |
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