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| 1 | Changes in China’s lakes: climate and human impacts显示文摘Lakes have played a critical role in providing water and ecosystem services for people and other organisms in China for millennia.However,accelerating climate change and economic boom have resulted in unprecedented changes in these valuable lakes.Using Landsat images covering the entity of the country,we explored the changes in China’s lakes and the associated driving forces over the last 30 years(i.e.mid-1980 s to 2015).We discovered that China’s lakes have changed with divergent regional trends:in the sparsely populated Tibetan Plateau,lakes are abundant and the lake area has increased dramatically from 38596 to46831 km^2(i.e.increased by 8235 km^2,or 21.3%),whereas,in the densely populated northern and eastern regions,lakes are relatively scarce and the lake area has decreased from 36659 to 33657 km^2(i.e.decreased by 3002 km^2,or 8.2%).In particular,severe lake decreases occurred in the Mongolia-Xinjiang Plateau and the Eastern Plain(-2151 km^2).Statistical analyses indicated that climate was the most important factor controlling lake changes in the Tibetan Plateau,the Yun-Gui Plateau and the Northeast Plain.However,the strength of climatic control on lake changes was low in the Eastern Plain and the Mongolia-Xinjiang Plateau,where human activities,e.g.impoldering,irrigation and mining,have caused serious impacts on lakes.Further lake changes will exacerbate regional imbalances between lake resources and population distribution,and thus may increase the risk of water-resource crises in China. | Shengli Tao Jingyun Fang Suhui Ma Qiong Cai Xinyu Xiong Di Tian Xia Zhao Leqi Fang Heng Zhang Jiangling Zhu Shuqing Zhao | 2020 | National Science Review2020，7，1： | 14 |
| 2 | Effects of Pseudoalteromonas sp. BC228 on Digestive Enzyme Activity and Immune Response of Juvenile Sea Cucumber(Apostichopus japonicus)显示文摘A marine bacterium, Pseudoalteromonas sp. BC228 was supplemented to feed in a feeding experiment aiming to determine its ability of enhancing the digestive enzyme activity and immune response of juvenile Apostichopus japonicus. Sea cucumber individuals were fed with the diets containing 0(control), 105, 107 and 109 CFU g-1 diet of BC228 for 45 days. Results showed that intestinal trypsin and lipase activities were significantly enhanced by 107 and 109 CFU g-1 diet of BC228 in comparison with control(P < 0.01). The phagocytic activity in the coelomocytes of sea cucumber fed the diet supplemented with 107 CFU g-1 diet of BC228 was significantly higher than that of those fed control diet(P < 0.05). In addition, 105 and 107 CFU g-1 diet of BC228 significantly enhanced lysozyme and phenoloxidase activities in the coelomic fluid of sea cucumber, respectively, in comparison with other diets(P < 0.01). Sea cucumbers, 10 each diet, were challenged with Vibrio splendidus NB13 after 45 days of feeding. It was found that the cumulative incidence and mortality of sea cucumber fed with BC228 containing diets were lower than those of animals fed control diet. Our findings evidenced that BC228 supplemented in diets improved the digestive enzyme activity of juvenile sea cucumber, stimulated its immune response and enhanced its resistance to the infection of V. splendidus. | MA Yuexin SUN Feixue ZHANG Congyao BAO Pengyun CAO Shuqing ZHANG Meiyan | 2014 | Journal of Ocean University of China2014，13，6： | 4 |
| 3 | High-resolution azimuth estimation algorithm based on data fusion method for the vector hydrophone vertical array显示文摘To aim at the problem that the horizontal directivity index of the vector hydrophone vertical array is not higher than that of a vector hydrophone,the high-resolution azimuth estimation algorithm based on the data fusion method was presented.The proposed algorithm first employs MUSIC algorithm to estimate the azimuth of each divided sub-band signal,and then the estimated azimuths of multiple hydrophones are processed by using the data fusion technique.The high-resolution estimated result is achieved finally by adopting the weighted histogram statistics method.The results of the simulation and sea trials indicated that the proposed algorithm has better azimuth estimation performance than MUSIC algorithm of a single vector hydrophone and the data fusion technique based on the acoustic energy flux method.The better performance is reflected in the aspects of the estimation precision,the probability of correct estimation,the capability to distinguish multi-objects and the inhibition of the noise sub-bands. | CHEN Yu MENG Zhou MA Shuqing BAO Changchun | 2015 | Chinese Journal of Acoustics2015，34，3： | 3 |
| 4 | IAP's Solar-Powered Unmanned Surface Vehicle Actively Passes through the Center of typhoon Sinlaku(2020)显示文摘The solar-powered marine unmanned surface vehicle(USV) developed by the USV team of the Institute of Atmospheric Physics is a rugged, long-duration, and autonomous navigation vessel designed for the collection of longrange, continuous, real-time, meteorological and oceanographic measurements, especially under extreme sea conditions(sea state 6–7). These solar-powered USVs completed a long-term continuous navigation observation test over 26 days.During this time, they coordinated double-USV observations and actively navigated into the path of Typhoon Sinlaku(2020) before collecting data very close to its center during the 2020 USV South China Sea Typhoon Observation Experiment. Detailed high temporal resolution(1 min) real-time observations collected by the USV on the typhoon were used for operational typhoon forecasting and warning for the first time. As a mobile meteorological and oceanographic observation station capable of reliable, automated deployment, data collection, and transmission, such solar-powered USVs can replace traditional observation platforms to provide valuable real-time data for research, forecasting, and early warnings for potential marine meteorological disasters. | Hongbin CHEN Jun LI Wenying HE Shuqing MA Yingzhi WEI Jidong PAN Yu ZHAO Xuefen ZHANG Shuzhen HU | 2021 | Advances in Atmospheric Sciences2021，38，4： | 2 |
| 5 | An analytical method for wind measurement using miniature aircraft 显示文摘 | Ma Shuqing Wang Gai Pan Yi | 1999 | Chinese Journal of Atmospheric Science1999，23，2： | 1 |
| 6 | Arsenic trioxide elicits prophylactic and therapeutic immune responses against solid tumors by inducing necroptosis and ferroptosis显示文摘Boosting tumor immunosurveillance with vaccines has been proven to be a feasible and cost-effective strategy to fight cancer. Although major breakthroughs have been achieved in preventative tumor vaccines targeting oncogenic viruses, limited advances have been made in curative vaccines for virus-irrelevant malignancies. Accumulating evidence suggests that preconditioning tumor cells with certain cytotoxic drugs can generate whole-cell tumor vaccines with strong prophylactic activities. However, the immunogenicity of these vaccines is not sufficient to restrain the outgrowth of existing tumors. In this study, we identified arsenic trioxide (ATO) as a wide-spectrum cytotoxic and highly immunogenic drug through multiparameter screening. ATO preconditioning could generate whole-cell tumor vaccines with potent antineoplastic effects in both prophylactic and therapeutic settings. The tumor-preventive or tumor-suppressive benefits of these vaccines relied on CD8^(+) T cells and type I and II interferon signaling and could be linked to the release of immunostimulatory danger molecules. Unexpectedly, following ATO-induced oxidative stress, multiple cell death pathways were activated, including autophagy, apoptosis, necroptosis, and ferroptosis. CRISPR‒Cas9-mediated knockout of cell death executors revealed that the absence of Rip3, Mlkl, or Acsl4 largely abolished the efficacy of ATO-based prophylactic and therapeutic cancer vaccines. This therapeutic failure could be rescued by coadministration of danger molecule analogs. In addition, PD-1 blockade synergistically improved the therapeutic efficacy of ATO-based cancer vaccines by augmenting local IFN-γ production. | Jinfeng Chen Ziqi Jin Shuqing Zhang Xiao Zhang Peipei Li Heng Yang Yuting Ma | 2023 | Cellular & Molecular Immunology2023，20，1： | 1 |
| 7 | A novel synthesis of spherical LiFePO 4 nanoparticles显示文摘 | XingYao Wang Cui Miao Jia Zhou Cong Ma HuanFeng Wang ShuQing Sun | 2011 | Materials Letters2011，，14： | 1 |
| 8 | Fully Developed Turbulence of Power⁃Law Fluids in Circular Pipe Based on Large Eddy Simulation显示文摘In this study,Large eddy simulation(LES)of the fully developed turbulence of power⁃law fluids in a circular pipe was performed using the dynamic subgrid⁃scale model.Under a specific Reynolds number,the flow information of three fluids with a range of power⁃law indexes was obtained.The trends of the mean axial velocity and the normalized apparent viscosity were analyzed.Simulation results show that shearing⁃thinning fluid displayed more noticeable non⁃Newtonian characteristics than shear⁃thickening fluid.The predicted friction factors were approximately equal to the Dodge and Metzner correlation and Gomes correlation.The peak values of root mean squares(RMS)and Reynolds stress increased as the power⁃law index increased.The turbulence statistics(skewness and flatness)from the wall to the pipe center were calculated.From the calculated results,the velocity fluctuation near the wall had strong intermittent and asymmetry.As demonstrated by the contours of the normalized instantaneous axial velocity and viscosity,the turbulence was more developed as the power⁃law index increased.It is concluded that the LES is feasible to predict the turbulence of pipe flow under higher Reynolds numbers. | Shuyan Wang Miao Li Shuqing Wang Haoting Li Yujia Chen Yimei Ma Qiji Sun | 2021 | Journal of Harbin Institute of Technology(New Series)2021，28，4： | 0 |
| 9 | Variation microstructure and properties of X80 pipeline steel in the rapid induction tempering process显示文摘A self-developed electromagnetic induction-heating device was used to investigate the variation in the microstructure and properties of X80 pipeline steel in the rapid induction tempering process at different process parameters. The effects of the tempering condition on toughness,microstructure,size and distribution of precipitates of X80 pipeline steel were observed using a metallographic microscopy and scanning electron microscopy.Compared with the samples prepared via traditional tempering techniques,results showthat the samples prepared via rapid induction tempering had improved performances. When the heating temperature is 590 ℃,at a holding time of90 s,it was found that acicular ferrite was refined,carbonite precipitation was small,and precipitates were evenly distributed in the matrix. The low-temperature impact energy,also known as the impact absorption energy,at- 40 ℃ was found to be 430. 5 J for the rapid induction tempering samples and 323. 2 J for the traditionally tempered sample. The low-temperature impact energy at- 60 ℃ was found to be 351. 3 J for the rapid induction tempered sample and 312. 1 J for the tradition tempering sample. | FAN Yujing MA Yonglin ZHANG Yunlong XING Shuqing | 2016 | Baosteel Technical Research2016，10，1： | 0 |
| 10 | A BIOSENSOR USING COUPLED PLASMON WAVEGUIDE RESONANCE COMBINED WITH HYPERSPECTRAL FLUORESCENCE ANALYSIS显示文摘We developed a biosensor that is capable for simultaneous surface plasmon resonance(SPR)sensing and hyperspectral fuores cence analysis in this paper.A symmetrical metal-dielectric slabscheme is employed for the excitation of coupled plasnon waveguide resonance(CPWR)in thepresent work.Resonance bet ween surface plasmon mode and the guided waveguide mode gen-erates narrower full width half-maximum of the refective curves which leads to increased pre.cision for the determination of refractive index over conventional SPR sensors.In addition,CPWR also fers longer surface propagation depths and higher surface electric field strengthsthat enable the excitation of fluorescence with hyperspectral technique to maintain an appreci-able signal-to-noise ratio.The refractive index information obtained from SPR sensing and thechemical properties obt ained through hyperspectral fluorescence analysis confirm each other toexclude false-positive or false-negative cases.The sensor provides a comprehensive understandingof the biological events on the sensor chips. | CHAN DU LE LIU JUN GUO YONGHONG HE JIHUA GUO SHUQING SUN HUI MA | 2014 | Journal of Innovative Optical Health Sciences2014，7，1： | 0 |
| 11 | Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state显示文摘During homeostasis and after injury,adult muscle stem cells(MuSCs)activate to mediate muscle regeneration.However,much remains unclear regarding the heterogeneous capacity of MuSCs for self-renewal and regeneration.Here,we show that Lin28a is expressed in embryonic limb bud muscle progenitors,and that a rare reserve subset of Lin28a^(+)Pax7^(-)skeletal MuSCs can respond to injury at adult stage by replenishing the Pax7^(+)MuSC pool to drive muscle regeneration.Compared with adult Pax7^(+)MuSCs,Lin28a^(+)MuSCs displayed enhanced myogenic potency in vitro and in vivo upon transplantation.The epigenome of adult Lin28a^(+)MuSCs showed resemblance to embryonic muscle progenitors.In addition,RNA-sequencing revealed that Lin28a^(+)MuSCs co-expressed higher levels of certain embryonic limb bud transcription factors,telomerase components and the p53 inhibitor Mdm4,and lower levels of myogenic differentiation markers compared to adult Pax7^(+)MuSCs,resulting in enhanced self-renewal and stress-response signatures.Functionally,conditional ablation and induction of Lin28a^(+)MuSCs in adult mice revealed that these cells are necessary and sufficient for efficient muscle regeneration.Together,our findings connect the embryonic factor Lin28a to adult stem cell self-renewal and juvenile regeneration. | Peng Wang Xupeng Liu Ziyue Yao Yu Chen Lanfang Luo Kun Liang Jun-Hao Elwin Tan Min-Wen Jason Chua Yan-Jiang Benjamin Chua Shilin Ma Liping Zhang Wenwu Ma Shuqing Liu Wenhua Cao Luyao Guo Lu Guang Yuefan Wang He Zhao Na Ai Yun Li Chunwei Li Ruiqi Rachel Wang Bin Tean Teh Lan Jiang Kang Yu Ng Shyh-Chang | 2023 | Cell Research2023，33，9： | 0 |
| 12 | A New X-band Weather Radar System with Distributed Phased-Array Front-ends: Development and Preliminary Observation Results显示文摘A novel weather radar system with distributed phased-array front-ends was developed. The specifications and preliminary data synthesis of this system are presented, which comprises one back-end and three or more front-ends. Each front-end, which utilizes a phased-array digital beamforming technology, sequentially transmits four 22.5°-width beams to cover the 0°–90° elevational scan within about 0.05 s. The azimuthal detection is completed by one mechanical scan of0°–360° azimuths within about 12 s volume-scan update time. In the case of three front-ends, they are deployed according to an acute triangle to form a fine detection area(FDA). Because of the triangular deployment of multiple phased-array front-ends and a unique synchronized azimuthal scanning(SAS) rule, this new radar system is named Array Weather Radar(AWR). The back-end controls the front-ends to scan strictly in accordance with the SAS rule that assures the data time differences(DTD) among the three front-ends are less than 2 s for the same detection point in the FDA. The SAS can maintain DTD < 2 s for an expanded seven-front-end AWR. With the smallest DTD, gridded wind fields are derived from AWR data, by sampling of the interpolated grid, onto a rectangular grid of 100 m ×100 m ×100 m at a 12 s temporal resolution in the FDA. The first X-band single-polarized three-front-end AWR was deployed in field experiments in 2018 at Huanghua International Airport, China. Having completed the data synthesis and processing, the preliminary observation results of the first AWR are described herein. | Xiaoqiong ZHEN Shuqing MA Hongbin CHEN Guorong WANG Xiaoping XU Siteng LI | 2022 | Advances in Atmospheric Sciences2022，39，3： | 0 |
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