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| 1 | Machine learning in materials genome initiative:A review显示文摘Discovering new materials with excellent performance is a hot issue in the materials genome initiative.Traditional experiments and calculations often waste large amounts of time and money and are also limited by various conditions. Therefore, it is imperative to develop a new method to accelerate the discovery and design of new materials. In recent years, material discovery and design methods using machine learning have attracted much attention from material experts and have made some progress. This review first outlines available materials database and material data analytics tools and then elaborates on the machine learning algorithms used in materials science. Next, the field of application of machine learning in materials science is summarized, focusing on the aspects of structure determination, performance prediction, fingerprint prediction, and new material discovery. Finally, the review points out the problems of data and machine learning in materials science and points to future research. Using machine learning algorithms, the authors hope to achieve amazing results in material discovery and design. | Yingli Liu Chen Niu Zhuo Wang Yong Gan Yan Zhu Shuhong Sun Tao Shen | 2020 | Journal of Materials Science & Technology2020，54，22： | 15 |
| 2 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 3 | Using borehole core analysis to reveal Late Quaternary paleoearthquakes along the Nankou-Sunhe Fault,Beijing显示文摘The Nankou-Sunhe Fault is a buried active normal fault that traverses the urban area of Beijing.Its seismic risks have caused considerable concerns.This paper studies paleoearthquakes along this fault by analyzing and correlating bore-hole cores obtained from triple-tube coring,incorporating experience acquired from trenching.As a result,a model for identifying earthquake-derived colluvium by sediment-core analysis is proposed.Triple-tube coring technique is useful to collect continuous undis-turbed soil core near the Nankou-Sunhe Fault.By identifying fault-scarp colluviums,determining cumulative displacement,and analysing stratum thickening on the hanging wall,we are able to establish a preliminary paleoearthquake sequence consisting of 13 surface-rupturing events since 60 ka.The seismic history can be divided into three periods based on different recurrence intervals.Between 60 and 40 ka,three earthquakes occurred with recurrence interval of ~10 ka.From 40 to 25 ka,there were six earthquakes with the recurrence interval of about 2.5 ka.In the last 25 ka,four earthquakes have taken place with the recurrence interval varying considerably.The recurrence interval between the last three events is ~5 ka.Smaller recurrence intervals correspond to stages of faster fault slip.The coseismic displacement of a single event is 0.8 to 2.2 m,average 1.4 m,largely equivalent to moment magnitudes 6.7-7.1.This study demonstrates the feasibility of bore-hole drilling in investigating paleoearthquakes along normal faults.It also suggests that closely spaced boreholes with continuous undisturbed cores are essential for reconstructing the complete paleoearthquake sequence. | ZHANG ShiMin WANG DanDan LIU XuDong ZHANG GuoHong ZHAO JunXiang LUO MingHui REN JunJie WANG Rui ZHANG YingLi | 2008 | Science China Earth Sciences2008，51，8： | 11 |
| 4 | Microvascular protective role of pericytes in melatonin-treated spinal cord injury in the C57BL/6 mice显示文摘 | Jing Yingli Wu Qingbin Yuan Xiaochen Li Bingwei Liu Mingming Zhang Xiaoyan Liu Shuying Li Hongwei Xiu Ruijuan | 2014 | Chinese Medical Journal2014，，15： | 9 |
| 5 | Synthesis of Fe_3O_4@SiO_2@polymer nanoparticles for controlled drug release显示文摘Novel multifunctional nanoparticles containing a magnetic Fe3O4@SiO2 sphere and a biocompatible block copolymer poly(ethylene glycol)-b-poly(aspartate)(PEG-b-PAsp) were prepared.The silica coated on the superparamagnetic core was able to achieve a magnetic dispersivity,as well as to protect Fe3O4 against oxidation and acid corrosion.The PAsp block was grafted to the surface of Fe3O4@SiO2 nanoparticles by amido bonds,and the PEG block formed the outermost shell.The anticancer agent doxorubicin(DOX) was loaded into the hybrid nanoparticles via an electrostatic interaction between DOX and PAsp.The release rate of DOX could be adjusted by the pH value. | WU ChengLin,HE Huan,GAO HongJun,LIU Gan,MA RuJiang,AN YingLi & SHI LinQi Key Laboratory of Functional Polymer Materials,Ministry of Education Institute of Polymer Chemistry,Nankai University,Tianjin 300071,China | 2010 | Science China Chemistry2010，53，3： | 9 |
| 6 | Rb-Sr and Sm-Nd Isochron Ages of the Dongmozhazhua and Mohailaheng Pb-Zn Ore Deposits in the Yushu area, southern Qinghai and Their Geological Implications显示文摘Located on the northeast margin of the Qiangtang terrane between the Jinshajiang suture zone and Bangonghu-Nujiang suture zone, the Dongmozhazhua and Mohailaheng Pb-Zn deposits in the Yushu area of Qinghai Province are representative Pb-Zn deposits of the Pb-Zn-Cu polymetallic mineralization belt in the northern part of the Nujiang-Lancangjiang-Jinshajiang area, which are in the front belt of the Yushu thrust nappe system. The formed environments of these two deposits are different from those of sediment-hosted base metal deposits elsewhere in the world. The authors hold that they were formed during the Indian-Asian continental collision and developed within the foldthrust belt combined with thrust and strike-slip-related Cenozoic basins in the interior of the collisional zone. Studying on the metallogenic epochs of these two deposits is helpful to the understanding of ore-forming regularity of the regional Pb-Zn-Cu mineralization belt and also to the search for new deposits in this region. The age of the Dongmozhazhua deposit has been determined by the Rb-Sr isochron method for sphalerite residues, whereas the age of the Mohailaheng deposit has been determined by the Rb-Sr isochron method for sphalerite residues and the Sm-Nd isochron method for fluorite. The age of the Dongmozhazhua deposit is 35.0±0.0 Ma((87Sr/86Sr)0=0.708807) for sphalerite residues. The age of the Mohailaheng deposit is 32.2±0.4 Ma((87Sr/86Sr)0=0.708514) for sphalerite residues and 31.8±0.3 Ma((143Nd/144Nd)0=0.512362) for fluorite with an average of 32.0 Ma. Together with the regional geological setting during mineralization, a possible tectonic model for metallogeny of the Dongmozhazhua and Mohailaheng Pb-Zn deposits has been established. These two ages are close to the ages of the Pb-Zn deposits in the Lanping and Tuotuohe basins, indicating that it is possible that the narrow 1000-kilometer-long belt controlled by a thrust nappe system on the eastern and northern margins of the Tibetan plateau could be a giant Pb-Zn mineralized belt. | TIAN Shihong GONG Yingli YANG Zhusen HOU Zengqian LIU Yingchao SONG Yucai XUE Wanwen LU Haifeng WANG Fuchun ZHANG Yubao ZHU Tian YU Changjie | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 8 |
| 7 | Effects of biochar amendment in two soils on greenhouse gas emissions and crop production显示文摘 | Jinyang Wang Xiaojian Pan Yinglie Liu Xiaolin Zhang Zhengqin Xiong | 2012 | Plant and Soil2012，，1： | 5 |
| 8 | Injectable dual glucose-responsive hydrogel-micelle composite for mimicking physiological basal and prandial insulin delivery显示文摘For type 1 and advanced type 2 diabetic patients, insulin replacement therapy with simulating on-demand prandial and basal insulin secretion is the best option for optimal glycemic control. However, there is no insulin delivery system yet could mimic both controlled basal insulin release and rapid prandial insulin release in response to real-time blood glucose changes. Here we reported an artificial insulin delivery system, mimicking physiological basal and prandial insulin secretion, to achieve real-time glycemic control and reduce risk of hypoglycemia. A phenylboronic acid(PBA)/galactosyl-based glucose-responsive insulin delivery system was prepared with insulin-loaded micelles embedded in hydrogel matrix. At the hyperglycemic state, both the hydrogel and micelles could swell and achieve rapid glucose-responsive release of insulin, mimicking prandial insulin secretion.When the glucose level returned to the normal state, only the micelles partially responded to glucose and still released insulin gradually. The hydrogel with increased crosslinking density could slow down the diffusion speed of insulin inside, resulting in controlled release of insulin and simulating physiological basal insulin secretion. This hydrogel-micelle composite insulin delivery system could quickly reduce the blood glucose level in a mouse model of type 1 diabetes, and maintain normal blood glucose level without hypoglycemia for about 24 h. This kind of glucose-responsive hydrogel-micelle composite may be a promising candidate for delivery of insulin in the treatment of diabetes. | Juan Lv Gang Wu Ying Liu Chang Li Fan Huang Yumin Zhang Jinjian Liu Yingli An Rujiang Ma Linqi Shi | 2019 | Science China Chemistry2019，62，5： | 5 |
| 9 | Gas chromatography-mass spectrometry analysis on compounds in volatile oils extracted from Yuan Zhi(Radix Polygalae) and Shi Chang Pu(Acorus Tatarinowii) by supercritical CO_2显示文摘OBJECTIVE:To analyze the constituents of volatile oils extracted from Yuan Zhi(Radix Polygalae),Shi Chang Pu(Acorus Tatarinowii),and a mixture of the two herbs.METHODS:The volatile oils were extracted using supercritical fluid extraction(SFE) with CO 2,and the constituents of the volatile oil extracts were analyzed by gas chromatography-mass spectrometry(GC-MS).The relative content of each component was calculated using peak area normalization.RESULTS:The optimized SFE conditions were 45 MPa at 35℃ for 2 h.Twenty-four compounds were identified in the extract from the Yuan Zhi(Radix Polygalae) and Shi Chang Pu(Acorus Tatarinowii) mixture,and six of these had relative contents >1.These compounds were 1,2-dimethoxy-4-(2-propenyl)-benzene;1,2,3-trimethoxy-5-(2-propenyl)-benzene;β-asarone;(Z,Z) 9,12-octadecadienoic acid;(Z) 6-octadecenoic acid;and ethyl oleate.Combination of the herbs increased the number of pharmacologically active substances in the extract and decreased the number of compounds with one benzene ring compared with the extracts from the individual herbs.CONCLUSION:These results indicate there is a synergistic relationship among the compounds in these herbs. | Yingli Wang Liping Chang Xiaoguang Zhao Xianbin Meng Yaming Liu | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 4 |
| 10 | Time-stepping finite element analysis on the influence of skewed rotors and different skew angles on the losses of squirrel cage asynchronous motors显示文摘To study the influence of skewed rotors and different skew angles on the losses of squirrel cage asynchronous motors,a 5.5-kW motor was taken as an example and the multi-sliced field-circuit coupled time stepping finite element method(T-S FEM)was used to analyze the axially non-uniform fundamental and harmonic field distribution characteristics at typical locations in the stator and rotor cores.The major conclusions are:firstly the skewed rotor exhibits a decrease in the harmonic copper losses caused by slot harmonic currents in the stator winding and rotor bars.Secondly,the skewed rotor shifts the non-uniform distribution of field in the axial direction,which leads to more severe saturation and an increase in iron losses.The heavier the load,the more pronounced the increase in iron losses.Furthermore,the influences of different skew angles on motor losses are studied systematically,with skew angles from 0.5 to 1.5 stator tooth pitch.It is found that the lowest total loss occurs at 0.8 stator tooth pitch,and the slot harmonics can be decreased effectively. | ZHAO HaiSen LIU XiaoFang LUO YingLi CHEN WeiHua Peter BALDASSARI | 2011 | Science China(Technological Sciences)2011，54，9： | 4 |
| 11 | Preparation and characterization of ultrafine Fe-Cu-based catalysts for CO hydrogenation显示文摘新风格 Fe-Cu-based 的极其细小的粒子为公司加氢的催化剂被使 Fe 的器官的大音阶的第五音妊娠准备(哦)3和 Cu (哦)2到激活的艾尔 2 O 3,在它 Fe 的器官的大音阶的第五音(哦)3和 Cu (哦)2与 V (A) /V (O)=在 dodecylbenzenesulfonic 酸钠 /n-butanol (A) /toluene (O) /water 的微乳液被准备 0.25 并且 W (A) /W (S)= 1.50 。这催化剂被粒子尺寸分析, XRD 和 TG 描绘。粒子尺寸分析的结果显示出那 Fe (哦) 有 17.1 nm 和 Cu 的一种吝啬的尺寸的 3 粒子(哦) 有 6.65 μm 的一种平均尺寸的 2 粒子被获得。TG 分析和 XRD 模式建议 673 K 是最佳的锻烧温度。当催化剂,和全部的白酒 0.250 g · m l −1 · h−1 让步,公司加氢由使用极其细小的粒子在 58 wt% 上面与一种高选择生产了 C +2OH 当时,被获得艾尔的内容 2 O 3 和 K 是 88.61 wt% 和 1.60 wt% 分别地。 | Yunlai Su Yingli Wang Zhongmin Liu | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 4 |
| 12 | PagGRF12a interacts with PagGIF1b to regulate secondary xylem development through modulating PagXND1a expression in Populus alba×P.glandulosa显示文摘Growth-regulating factors(GRFs)are important regulators of plant development and growth,but their possible roles in xylem development in woody plants remain unclear.Here,we report that Populus alba×Papulus glandulosa PagGRF12a negatively regulates xylem development in poplar.PagGRF12a is expressed in vascular tissues.Compared to non-transgenic control plants,transgenic poplar plants overexpressing PagGRF12a exhibited reduced xylem width and plants with repressed expression of PagGRF12a exhibited increased xylem width.Xylem NAC domain 1(XND1)encodes a NAC domain transcription factor that regulates xylem development and transcriptional analyses revealed that PagXND1a is highly upregulated in PagGRF12a-overexpressing plants and downregulated in PagGRF12a-suppressed plants,indicating that PagGRF12a may regulate xylem development through PagXND1a.Transient transcriptional assays and chromatin immunoprecipitation-polymerase chain reaction assays confirmed that PagGRF12a directly upregulates PagXND1a.In addition,PagGRF12a interacts with the GRF-Interacting Factor(GIF)PagGIF1b,and this interaction enhances the effects of PagGRF12a on PagXND1a.Our results indicate that PagGRF12a inhibits xylem development by upregulating the expression of PagXND1a. | Jinnan Wang Houjun Zhou Yanqiu Zhao Cheng Jiang Jihong Li Fang Tang Yingli Liu Shutang Zhao Jianjun Hu Xueqin Song MengZhu Lu | 2021 | Journal of Integrative Plant Biology2021，63，10： | 3 |
| 13 | Discovery and study of silver sulfate mineral in S_5 from the eastern suburb of Xi'an显示文摘The paleosol samples from the fifth layer of the loess profile at Renjiapo in the eastern suburb of Xi'an are observed and analyzed using electron microscope and energy spectrum. Minerals such as AgSO4 and molybdenum, which are rare to find and can indicate typical dry climate environment, are found in this layer of paleosol. Secondary mineral is usually granular form of ellipsoidal and crystallization, and has the characteristics of chemical precipitating crystallization of apertures and fracture. Molybdenum minerals have the characteristics of colloidal substances. There are two kinds of secondary minerals. One is silver sulfate mineral and the other is silver oxide mineral. The movement of secondary silver, molybdenum and cobalt minerals, new clay mineral, Fe2O3 and Al2O3 indicates that S5 has experienced strong chemical weathering and mineral dissolution during its development. Silver, molybdenum, and cobalt can be released from primary minerals. During that period, the precipitation was abundant in Xi'an where soil reached an acidity stage of chemical weathering. At the later development stage of paleosol in the lowest part of S5, warm and wet monsoon climate had changed to dry and non-monsoon climate. In the period of the formation of AgSO4, which is easier to dissolve than CaSO4, a dry and non-monsoon climate was present in the Guanzhong Plain. Strong evaporation resulted in the accumulation of SO42-in the soil water solution and the formation of AgSO4. At that time, summer monsoon of East Asia was weak and did not cross Qinling Mountains to reach Guanzhong Plain. And at that time, the precipitation in Xi'an was less than 300 mm, and it was drier then in Xi'an than at present in Lanzhou. | ZHAO JingBo CAO JunJi SHAO TianJie LIU Rui YUE YingLi DU Juan | 2012 | Science China Earth Sciences2012，55，3： | 2 |
| 14 | Natural products against hematological malignancies and identification of their targets显示文摘Naturally occurring molecules derived from higher plants, animals, microorganisms and minerals play an important role in the discovery and development of novel therapeutic agents. The identification of molecular targets is of interest to elucidate the mode of action of these compounds, and it may be employed to set up target-based assays and allow structure-activity relationship studies to guide medicinal chemistry efforts toward lead optimization. In recent years, plant-derived natural compounds possessing potential anti-tumor activities have been garnering much interest and efforts are underway to identify their molecular targets. Here, we attempt to summarize the discoveries of several natural compounds with activities against hematological malignancies, such as adenanthin, oridonin, gambogic acid and wogonoside, the identification of their targets, and their modes of actions. | XU Ying LIU JinBao WU YingLi GUO QingLong SUN HanDong CHEN GuoQiang | 2015 | Science China(Life Sciences)2015，58，12： | 2 |
| 15 | Gradient high performance liquid chromatography method for simultaneous determination of ilaprazole and its related impurities in commercial tablets显示文摘A methodology(HPLC)proposed in this paper for simultaneously quantitative determination of ilaprazole and its related impurities in commercial tablets was developed and validated.The chromatographic separation was carried out by gradient elution using an Agilent C8 column(4.6 mm×250 mm,5 mm)which was maintained at 25℃.The mobile phase composed of solvent A(methanol)and solvent B(solution consisting 0.02 mmol/l monopotassium phosphate and 0.025 mmol/l sodium hydroxide)was at a flow rate of 1.0 ml/min.The samples were detected and quantified at 237 nm using an ultraviolet absorbance detector.Calibration curves of all analytes from 0.5 to 3.5 mg/ml were good linearity(r≥0.9990)and recovery was greater than 99.5% for each analyte.The lower limit of detection(LLOD)and quantification(LOQ)of this analytical method were 10 ng/ml and 25 ng/ml for all impurities,respectively.The stress studies indicated that the degradation products could not interfere with the detection of ilaprazole and its related impurities and the assay can thus be considered stability-indicating.The method precisions were in the range of 0.41-1.21 while the instrument precisions were in the range of 0.38-0.95 in terms of peak area RSD% for all impurities,respectively.This method is considered stabilityindicating and is applicable for accurate and simultaneous measuring of the ilaprazole and its related impurities in commercial enteric-coated tablets. | Shang Wang Dong Zhang Yingli Wang Xiaohong Liu Yan Liu Lu Xu | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 2 |
| 16 | Effects of sleep deprivation on polysomnography and executive function in patients with depression显示文摘 | Lu Yingzhi Ren Qingtao Zong Li Wu Yingli Zhang Qinfeng Ma Xiuqing Pu Jinyu Dong Hanzhen Liu Qingqing Tang Yunxiang Song Lisheng Chen Xingshi Pan Xiao Cui Yi | 2014 | Chinese Medical Journal2014，，18： | 2 |
| 17 | Multiscale analysis of the contents of palmatine in the Nature populations of Phellodendron amurense in Northeast China显示文摘Palmatine is a valuable ingredient in Chinese medicine that is produced by Phellodendron amurense Rupr.The contents of palmatine content in root bark, trunk bark,perennial branch bark, annual branches, and leaves of the trees with different ages and geographies in Northeast China were measured by high-performance liquid chromatography.The contents of palmatine in the barks of root, trunk, and perennial branch were significantly higher than those in annual branches and leaves. The contents of palmatine in trunk bark and root bark from Lesser Khingan Mountains increased with age, which is significantly opposite to other three vegetation types. The contents of palmatine in perennial branch bark, annual bark and leaves had no significant regularity. Moreover, the contents of palmatine in samples of root bark, trunk bark, perennial branch bark and annual bark varied significantly with latitude. The nature populations of P. amurense growing at low latitude contained significantly more palmatine than those growing at high latitude. These results provide a scientific basis for the reasonable cultivation and efficient utilization of P. amurense. | Minglong Sun Lijiao Xu Yingli Peng Tong Liu Yuhong Zhang Zhiqiang Zhou | 2016 | Journal of Forestry Research2016，27，2： | 2 |
| 18 | Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs显示文摘 | Wei Jiang Jilong Wang Jinbin Yang Zhiwei He Zhenhui Hou Yingli Luo Li Wang Jing Liu Houbing Zhang Yangyang Zhao Guoqing Zhang Fang Huang Xuechang Zhou Lifeng Yan Xianzhu Yang Yucai Wang Jun Wang | 2018 | Nano Research2018，11，10： | 2 |
| 19 | Study of magnetic and magneto-optical properties of heavily doped bismuth substitute yttrium iron garnet (Bi∶YIG) film显示文摘The magnetic and magneto-optical properties of heavily doped Bi∶YIG film were studied. The film was deposited by radio frequency magnetron sputtering method and crystallized by rapid recurrent thermal annealing (RRTA). The results show that the RRTA treated film has good properties both in microwave and optical wave band. The saturation magnetization of the film on different substrates varies from 135.7 to 138.6 kA·m-1. The coercive field of the film on GGG substrate is about 0.32 kA·m-1, while about 0.8-1.43 kA·m-1 on YAG substrate and 1.75 kA·m-1 on Al2O3 substrate. The Faraday angle is about 3-5 (°)·μm-1 when optical wavelength ranges at 450-600 nm. The transmission spectra of the Bi∶YIG films on three substrates has similar change as annealing temperature below 800 ℃. Specially, when annealing temperature is above 800 ℃ a step is observed between 550 and 650 nm wavelength for the film deposited on Al2O3 substrate.Three results are very useful in magneto-optical recording application and integrated microwave devices. | YANG Qinghui ZHANG Huaiwu LIU Yingli | 2006 | Rare Metals2006，25，z1： | 2 |
| 20 | Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure显示文摘 | Tianyan Chen Yingli He Xiaojing Liu Zhi Yan Ke Wang Hongli Liu Shuling Zhang Yingren Zhao | 2012 | Clinical and Experimental Medicine2012，，3： | 2 |
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