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| 1 | Vegetation-environment relationships in the forests of Chitral district Hindukush range of Pakistan显示文摘We investigated the composition of plant communities to quantify their relationships with environmental parameters in the Chitral Hindukush range of Pakistan. We sampled tree vegetation using the Point Centered Quarter (PCQ) method while understory vegetation was sampled in 1.5-m circular quadrats. Cedrus deodara is the national symbol of Pakistan and was dominant in the sampled communities. Because environmental variables determine vegetation types, we analyzed and evaluated edaphic and topographic factors. DCA-Ordination showed the major gradient as an amalgam of elevation (p<0.05) and slope (p<0.01) as the topographic factors correlated with species distribution. Soil variables were the factors of environmental significance along DCA axes. However, among these factors, Mg2+ , K + and N2+ contributed not more than 0.054% 0.20% and 0.073%, respectively, to variation along the first ordination axis. We conclude that the principal reason for weak or no correlation with many edaphic variables was the anthropogenic disturbance of vegetation. The understory vegetation was composed of perennial herbs in most communities and was most dense under the tree canopy. The understory vegetation strongly regulates tree seedling growth and regeneration patterns. We recommend further study of the understory vegetation using permanent plots to aid development of forest regeneration strategies. | Nasrullah Khan Syed Shahid Shaukat Moinuddin Ahmed Muhammad Faheem Siddiqui | 2013 | Journal of Forestry Research2013，24，2： | 8 |
| 2 | Investigation on the process parameters of TIG-welded aluminum alloy through mechanical and microstructural characterization显示文摘Multi-pass TIG welding was conducted on plates(15×300×180 mm^(3))of aluminum alloy Al-5083 that usually serves as the component material in structural applications such as cryogenics and chemical processing industries.Porosity formation and solidification cracking are the most common defects when TIG welding Al-5083 alloy,which is sensitive to the welding heat input.In the experiment,the heat input was varied from 0.89 kJ/mm to 5 kJ/mm designed by the combination of welding torch travel speed and welding current.Tensile,micro-Vicker hardness and Charpy impact tests were executed to witness the impetus response of heat input on the mechanical properties of the joints.Radiographic inspection was performed to assess the joint’s quality and welding defects.The results show that all the specimens displayed inferior mechanical properties as compared to the base alloy.It was established that porosity was progressively abridged by the increase of heat input.The results also clinched that the use of medium heat input(1-2 kJ/mm)offered the best mechanical properties by eradicating welding defects,in which only about 18.26% of strength was lost.The yield strength of all the welded specimens remained unaffected indica ted no influence of heat input.Partially melted zone(PMZ)width also affected by heat input,which became widened with the increase of heat input.The grain size of PMZ was found to be coarser than the respective grain size in the fusion zone.Charpy impact testing revealed that the absorbed energy by low heat input specimen(welded at high speed)was greater than that of high heat input(welded at low speed)because of low porosity and the formation of equiaxed grains which induce better impact toughness.Cryogenic(-196℃)impact testing was also performed and the results corroborate that impact properties under the cryogenic environment revealed no appreciable change after welding at designated heat input.Finally,Macro and micro fractured surfaces of tensile and impact specimens were analyzed using Stereo and Scanning Electron Microscopy(SEM),which have supported the experimental findings. | Muhammad Samiuddin Jing-long Li Muhammad Taimoor Mohammad Nouman Siddiqui Sumair Uddin Siddiqui Jiang-tao Xiong | 2021 | Defence Technology(防务技术)2021，17，4： | 5 |
| 3 | Cancer models in preclinical research:A chronicle review of advancement in effective cancer research显示文摘Cancer is a major stress for public well-being and is the most dreadful disease.The models used in the discovery of cancer treatment are continuously changing and extending toward advanced preclinical studies.Cancer models are either naturally existing or artificially prepared experimental systems that show similar features with human tumors though the heterogeneous nature of the tumor is very familiar.The choice of the most fitting model to best reflect the given tumor system is one of the real difficulties for cancer examination.Therefore,vast studies have been conducted on the cancer models for developing a better understanding of cancer invasion,progression,and early detection.These models give an insight into cancer etiology,molecular basis,host tumor interaction,the role of microenvironment,and tumor heterogeneity in tumor metastasis.These models are also used to predict novel can-cer markers,targeted therapies,and are extremely helpful in drug development.In this review,the potential of cancer models to be used as a platform for drug screening and therapeutic discoveries are highlighted.Although none of the cancer models is regarded as ideal because each is associated with essential caveats that restraint its application yet by bridging the gap between preliminary cancer research and transla-tional medicine.However,they promise a brighter future for cancer treatment. | Humna Sajjad Saiqa Imtiaz Tayyaba Noor Yusra Hasan Siddiqui Anila Sajjad Muhammad Zia | 2021 | Animal Models and Experimental Medicine2021，4，2： | 5 |
| 4 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 5 | Gene-gene,gene-environment,gene-nutrient interactions and single nucleotide polymorphisms of inflammatory cytokines显示文摘Inflammation plays a significant role in the etiology of type 2 diabetes mellitus(T2DM).The rise in the pro-inflammatory cytokines is the essential step in glucotoxicity and lipotoxicity induced mitochondrial injury,oxidative stress and beta cell apoptosis in T2 DM.Among the recognized markers are interleukin(IL)-6,IL-1,IL-10,IL-18,tissue necrosis factor-alpha(TNF-α),C-reactive protein,resistin,adiponectin,tissue plasminogen activator,fibrinogen and heptoglobins.Diabetes mellitus has firm genetic and very strong environmental influence; exhibiting a polygenic mode of inheritance.Many single nucleotide polymorphisms(SNPs) in various genes including those of pro and antiinflammatory cytokines have been reported as a risk for T2 DM.Not all the SNPs have been confirmed by unifying results in different studies and wide variations have been reported in various ethnic groups.The inter-ethnic variations can be explained by the fact that gene expression may be regulated by gene-gene,gene-environment and gene-nutrient interactions.This review highlights the impact of these interactions on determining the role of single nucleotide polymorphism of IL-6,TNF-α,resistin and adiponectin in pathogenesis of T2 DM. | Amina Nadeem Sadaf Mumtaz Abdul Khaliq Naveed Muhammad Aslam Arif Siddiqui Ghulam Mustafa Lodhi Tausif Ahmad | 2015 | World Journal of Diabetes2015，6，4： | 4 |
| 6 | Antibiotic susceptibility profiling and virulence potential of Campylobacter jejuni isolates from different sources in Pakistan显示文摘Objective:To determine antibiotic resistance patterns and virulence potential of Campylobacter jejuni(C.jejuni) isolates from clinical human diarrheal infections,cattle and healthy broilers.Methods:Antibiotic sensitivity patterns of C.jejuni isolates were determined by Kirby Bauer Disc Diffusion assay.These isolates were then subjected to virulence profiling for the detection of map A(membrane-associated protein).cadF(fibronectin binding protein).wlaN(beta-1.3-galaclosyltransferase) and neu AB(sialic acid biosynthesis gene).Further C.jejuni isolates were grouped by random amplification of polymorphic DNA(RAPD) profiling.Results:A total of436 samples from poultry(n=88).cattle(n=216) and humans(n=132) from different locations were collected.Results revealed percentage of C.jejuni isolates were 35.2%(31/88).25.0%(54/216) and 11.3%(15/132) among poultry,cattle and clinical human samples respectively.Antibiotic susceptibility results showed that similar resistance patterns to cephalothin was ie.87.0%,87.1%and 89%among humans,poultry and cattle respectively,followed by sulfamethoxazolc+trimcthoprim 40.0%,38.7%and 31.0%in humans,poultry and cattle and Ampicillin 40%,32%and 20%in humans,poultry and cattle respectively.Beta-lactamase activity was detected in 40.00%humans.20.37%cattle and 32.25%in poultry C.jejuni isolates.CadF and mapA were present in all poultry,cattle and human C jejuni isolates.wlauN was not detected in any isolate and neu AB was found in 9/31(36%) poultry isolates.RAPD profiling results suggested high diversity of C.jejuni isolates.Conclusions:Detection of multidrug resistant C.jejuni strains from poultry and cattle is alarming as they can be potential hazard to humans.Moreover,predominant association of virulence factors,cadF and map A(100%each) in C.jejuni isolates from all sources and neuAB(36%) with poultry isolates suggest the potential source of transmission of diverse types of C.jejuni to humans. | Fariha Masood Siddiqui Muhammad Akram Nighat Nourccn Zobia Noreen Habib Bokhari | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，3： | 2 |
| 7 | Simulation, Modeling, and Optimization of Intelligent Kidney Disease Predication Empowered with Computational Intelligence Approaches显示文摘Artificial intelligence(AI)is expanding its roots in medical diagnostics.Various acute and chronic diseases can be identified accurately at the initial level by using AI methods to prevent the progression of health complications.Kidney diseases are producing a high impact on global health and medical practitioners are suggested that the diagnosis at earlier stages is one of the foremost approaches to avert chronic kidney disease and renal failure.High blood pressure,diabetes mellitus,and glomerulonephritis are the root causes of kidney disease.Therefore,the present study is proposed a set of multiple techniques such as simulation,modeling,and optimization of intelligent kidney disease prediction(SMOIKD)which is based on computational intelligence approaches.Initially,seven parameters were used for the fuzzy logic system(FLS),and then twenty-five different attributes of the kidney dataset were used for the artificial neural network(ANN)and deep extreme machine learning(DEML).The expert system was proposed with the assistance of medical experts.For the quick and accurate evaluation of the proposed system,Matlab version 2019 was used.The proposed SMOIKD-FLSANN-DEML expert system has shown 94.16%accuracy.Hence this study concluded that SMOIKD-FLS-ANN-DEML system is effective to accurately diagnose kidney disease at initial levels. | Abdul Hannan Khan Muhammad Adnan Khan Sagheer Abbas Shahan Yamin Siddiqui Muhammad Aanwar Saeed Majed Alfayad Nouh Sabri Elmitwally | 2021 | Computers, Materials & Continua2021，，5： | 2 |
| 8 | Preliminary study of microstructure, mechanical properties and corrosion resistance of antibacterial Ti-15Zr-xCu alloy for dental application显示文摘Ti-15 Zr-xCu(3≤x≤7,wt.%) novel antibacterial and antibiofilm alloys with competitive mechanical properties,biological responses and corrosion resistance were designed and fabricated.Annealing heat treatment on Ti-15 Zr-7 Cu(TZC-7 A),after holding for 2 h at slightly above their beta transus temperature(BTT) ensured their tensile strength(UTS),yield strength(YS) and hardness(HRV) were improved by31.2%,20% and 12.3% respectively compared to the control without Cu,Ti-15 Zr(T-15 ZA).Although the3 wt.% Cu alloy displayed the highest elongation(26%),the TZC-7 A alloy also possessed a good ductility.Presence of evenly dispersed Ti2 Cu and Zr2 Cu Cu-rich intermetallic phases formed as interwoven and alternating lamellae within the α+β matrix as a result of Cu addition,as revealed by X-ray diffraction(XRD),scanning electron microscopy(SEM) and transmission electron microscopy(TEM).These greatly contributed to their strengthening and bactericidal properties.Over 98% antibacterial effect against E.coli and S.aureus have been imparted,coupled with excellent biofilm inhibition.Potentiodynamic polarization curves showed that the TZC-7 A alloy possessed higher corrosion resistance than commercially pure titanium,cp-Ti;contact angle test revealed enhanced hydrophilicity;while confocal laser scanning microscopy(CLSM) and cell counting kit(CCK-8) assays also displayed drastically lowered bacterial adhesion rate with comparatively no cytotoxicity.Cell attachment on all alloys was similar but the best spread was obtained on TZC-7 A after 24 h.The developed alloy has good potential as an antibacterial implant material with combination of optimized properties. | Sharafadeen Kunle Kolawole Wang Hai Shuyuan Zhang Ziqing Sun Muhammad Ali Siddiqui Ihsan Ullah Wei Song Frank Witte Ke Yang | 2020 | Journal of Materials Science & Technology2020，47，15： | 2 |
| 9 | Recent Insights into Signaling Responses to Cope Drought Stress in Rice显示文摘Drought is one of the hot topics needing urgent attention in the current era of climate change.It massively disturbs the rice growth and productivity and is becoming a serious threat.The drought avoidance strategies in rice include stomatal closure,cellular adaptation and changes in root development.Moreover,the endogenous plant hormones(abscisic acid and jasmonic acid)and reactive oxygen species have paramount importance in drought tolerance in rice.The drought tolerance induces modification in biochemical,molecular and physiological properties of plants.At the molecular level,expression of several transcription-factors is modulated which further determine the activation of drought responsive gene families.Mitogen activated protein kinases and Ca signaling pathways initiate an array of signaling cascade for mediating the gene expression in rice.Approaches,conventional breeding methods combined with modern emerging techniques such as genetic engineering,to improve rice drought tolerance were discussed.This review provided recent insights into major regulatory factors against drought stress,signaling mechanisms and molecular engineering strategies(including conventional transgenic and recent genome editing approaches)to induce drought tolerance in rice. | Muhammad Mahran ASLAM Muhammad Abdul Rehman RASHID Mohammad Aquil SIDDIQUI Muhammad Tahir KHAN Fozia FARHAT Shafquat YASMEEN Imtiaz Ahmad KHAN Shameem RAJA Fatima RASOOL Mahboob Ali SIAL ZHAO Yan | 2022 | Rice science2022，29，2： | 2 |
| 10 | Anti-nociceptive, anti-inflammatory and sedative activities of the extracts and chemical constituents of Diospyros lotus L.显示文摘 | Ghias Uddin Abdur Rauf Bina S. Siddiqui Naveed Muhammad Ajmal Khan Syed Uzair Ali Shah | 2014 | Phytomedicine2014，，： | 1 |
| 11 | A benzil and isoflavone from Iris tenuifolia显示文摘 | Muhammad Iqbal Choudharya Sumaira Hareem Hina Siddiqui | | 0，，： | 1 |
| 12 | Support-Vector-Machine-based Adaptive Scheduling in Mode 4 Communication显示文摘Vehicular ad-hoc networks(VANETs)are mobile networks that use and transfer data with vehicles as the network nodes.Thus,VANETs are essentially mobile ad-hoc networks(MANETs).They allow all the nodes to communicate and connect with one another.One of the main requirements in a VANET is to provide self-decision capability to the vehicles.Cognitive memory,which stores all the previous routes,is used by the vehicles to choose the optimal route.In networks,communication is crucial.In cellular-based vehicle-to-everything(CV2X)communication,vital information is shared using the cooperative awareness message(CAM)that is broadcast by each vehicle.Resources are allocated in a distributed manner,which is known as Mode 4 communication.The support vector machine(SVM)algorithm is used in the SVM-CV2X-M4 system proposed in this study.The k-fold model with different values of k is used to evaluate the accuracy of the SVM-CV2XM4 system.The results show that the proposed system achieves an accuracy of 99.6%.Thus,the proposed system allows vehicles to choose the optimal route and is highly convenient for users. | Muhammad Adnan Khan Ahmed Abu-Khadrah Shahan Yamin Siddiqui Taher M.Ghazal Tauqeer Faiz Munir Ahmad Sang-Woong Lee | 2022 | Computers, Materials & Continua2022，，11： | 1 |
| 13 | Privacy and security federated reference architecture for Internet of Things显示文摘Physical objects are getting connected to the Internet at an exceptional rate,making the idea of the Internet of Things(IoT)a reality.The IoT ecosystem is evident everywhere in the form of smart homes,health care systems,wearables,connected vehicles,and industries.This has given rise to risks associated with the privacy and security of systems.Security issues and cyber attacks on IoT devices may potentially hinder the growth of IoT products due to deficiencies in the architecture.To counter these issues,we need to implement privacy and security right from the building blocks of IoT.The IoT architecture has evolved over the years,improving the stack of architecture with new solutions such as scalability,management,interoperability,and extensibility.This emphasizes the need to standardize and organize the IoT reference architecture in federation with privacy and security concerns.In this study,we examine and analyze 12 existing IoT reference architectures to identify their shortcomings on the basis of the requirements addressed in the standards.We propose an architecture,the privacy-federated IoT security reference architecture(PF-IoT-SRA),which interprets all the involved privacy metrics and counters major threats and attacks in the IoT communication environment.It is a step toward the standardization of the domain architecture.We effectively validate our proposed reference architecture using the architecture trade-off analysis method(ATAM),an industry-recognized scenario-based approach. | Musab KAMAL Imran RASHID Waseem IQBAL Muhammad Haroon SIDDIQUI Sohaib KHAN Ijaz AHMAD | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，4： | 1 |
| 14 | Border tax adjustments in the climate policy context:CO2 versus broad-based GHG emission targeting显示文摘 | Madanmohan Ghosh Deming Luo Muhammad Shahid Siddiqui Yunfa Zhu | | 0，，： | 1 |
| 15 | Extracorporeal Shock Wave Therapy Is Effective In Treating Chronic Plantar Fasciitis: A Meta-analysis of RCTs显示文摘 | Adeel Aqil Muhammad R. S. Siddiqui Matthew Solan David J. Redfern Vivek Gulati Justin P. Cobb | 2013 | Clinical Orthopaedics and Related Research?2013，，11： | 1 |
| 16 | Burning Regression Analysis for 3D Grain Configurations显示文摘Grain design is essentially filling a prescribed volume (chamber case) with a certain shape of propellant so as to ensure mission requirements. An infinite number of possibilities exist, covering from two dimensional to three dimensional grain designs. Accurate calculation of grain geometrical properties plays a vital role in performance prediction. In this paper a methodology has been presented for designing 3D grain configuration for Solid Rocket Motors (SRMs). The design process involves parametric modeling of the geometry in CAD software through dynamic variables that define the complex configuration. Initial geometry is defined in the form of a surface which defines the grain configuration. Grain burn back is achieved by making new surfaces at each web increment and calculating geometrical properties at each step. Geometrical calculations are based on volume and change in volume calculations. Models for Axisymetric and Finocyl grain configuration have been developed. Equilibrium pressure method is used to calculate the internal ballistics. The procedure adopted can be applied to any complex geometry in a relatively simple way for preliminary designing of grain configuration. | ALI Kamran LIANG Guozhu MUHAMMAD Zeeshan Siddiqui | 2010 | Computer Aided Drafting,Design and Manufacturing2010，20，1： | 1 |
| 17 | Application of polyethylene glycol immobilized Clostridium sp . LS2 for continuous hydrogen production from palm oil mill effluent in upflow anaerobic sludge blanket reactor显示文摘 | Lakhveer Singh Muhammad Faisal Siddiqui Anwar Ahmad Mohd Hasbi Ab. Rahim Mimi Sakinah Zularisam A. Wahid | 2013 | Biochemical Engineering Journal2013，，： | 1 |
| 18 | Preliminary study of adsorption behavior of bovine serum albumin(BSA) protein and its effect on antibacterial and corrosion property of Ti-3Cu alloy显示文摘The adsorption behavior, antibacterial, and corrosion properties of a Ti-3 Cu alloy were studied in a phosphate-buffered saline solution containing 0, 1, 3, and 6 gL^(-1) bovine serum albumin protein at 37℃ and pH = 7.4(±0.2). The protein adsorption behavior was examined via cyclic voltammetry, secondary ions mass spectroscopy(SIMS), and angle-resolved X-ray photoelectron spectroscopy(ARXPS). The corrosion property was analyzed by the open circuit potential(OCP), potentiodynamic polarization(PD),and electrochemical impedance spectroscopy(EIS) examinations. The antibacterial test was conducted according to the GB/T 21510 China Standard. It was observed that the surface charge density(QA DS) was directly proportional to the amount of the adsorbed BSA protein, signifying that the protein adsorption was accompanied by the charge transfer, pointing to chemisorptions phenomena. BSA amino groups and other organic species were observed in the surface analysis examinations. It was shown that the formation of barrier complexes between the TiO_(2) oxide-layer and PBS solution resulted in decreasing the release of Cu-ions, which consequently reduced the antibacterial activity. On the other hand, these barrier complexes improved the corrosion resistance by increasing the charge transfer resistance and double-layer capacitance of the Ti-3 Cu alloy. | Muhammad Ali Siddiqui Ihsan Ullah Hui Liu Shuyuan Zhang Ling Ren Ke Yang | 2021 | Journal of Materials Science & Technology2021，，21： | 1 |
| 19 | The anti-biofouling effect of Piper betle extract against Pseudomonas aeruginosa and bacterial consortium显示文摘 | Muhammad Faisal Siddiqui Mimi Sakinah A.F. Ismail T. Matsuura A.W. Zularisam | 2011 | Desalination2011，，： | 1 |
| 20 | Biomass production and nutritional quality of Moringa oleifera as a field crop 显示文摘 | Nouman Wasif Siddiqui Muhammad Basra Shahzad | 2013 | Turkish Journal of Agriculture and Forestry''2013，37，： | 1 |
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