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| 1 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540edsfqxxcbo0cvc660kb.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540edsfqxxcbo0cvc660kb.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540edsfqxxcbo0cvc660kb.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 2 | Petroleum hydrocarbons and their effects on fishery species in the Bohai Sea, North China显示文摘Systematic studies on the changes in concentrations of petroleum hydrocarbons (PHs) and their effects on fishery species in the Bohai Sea during 1974-2004 are presented. Changes in PHs concentrations were closely related to Yellow River runoff. Concentrations of PHs accumulated in fish and shrimp increased by about 0.712 mg/kg dry weight when trophic level of fish and shrimps increased by 1. Attention should also be paid to the high PHs concentrations in mollusks along the coastal waters of the Bohai Sea. Average concentration of PHs in the adjacent coastal waters of Tianjin City during 1996-2005 decreased the population growth rates of fish, crustaceans and mollusks in the Bohai Sea by 2.58%, 6.59% and 2.33%, respectively. Therefore, PHs have significantly contributed to the decline in fisheries in the Bohai Sea, and they must be reduced to realize the sustainable fisheries. | Sisi Xu Jinming Song Huamao Yuan Xuegang Li Ning Li Liqin Duan Yu Yu | 2011 | Journal of Environmental Sciences2011，23，4： | 15 |
| 3 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://gffzzdbc7b6aaae734bddhfqxxcbo0cvc660kb.ffgz.tsg.suse.edu.cn/gsa or http://gffzz4eaf941a184140e3hfqxxcbo0cvc660kb.ffgz.tsg.suse.edu.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 4 | Urban Expansion in China Based on Remote Sensing Technology:A Review显示文摘Urban areas and its evolution are important anthropogenic indicators and human ecological footprints, and play decisive roles in environmental change analysis, global geo-conditional monitoring, and sustainable development. China has the highest rate of urban expansion and has emerged as an urban expansion hotspot worldwide. In this paper, the progress of studies on Chinese urban expansion based on remote sensing technology are summarized and analyzed from the aspects of urban area definition, remotely sensed imagery applied in urban expansion, monitoring methods of urban expansion, and urban expansion applications. Existing issues and future directions of Chinese urban expansion are discussed and proposed. Results indicate that: 1) The fusion of multi-source remotely sensed imagery is imperative to meet the needs of urban expansion with various monitoring terms and frequencies on different scales and dimensions. 2) To guarantee the classification accuracy and efficiency and describe urban expansion and its influences on local land use simultaneously, the combination of visual interpretation and automatic classification is the tendency of future monitoring methods of urban areas. 3) Urban expansion data have become the prerequisite for recognizing the urban development process, excavating its driving forces, simulating and predicting the future development directions, and also is conducive to revealing and explaining urban ecological and environmental issues. 4) In the past decades, Chinese scholars have promoted the application of remote sensing technology in the urban expansion field, with data construction, methods and models developing from the quotation stage to improvement and innovation stage; however, an independent and consistent urban expansion data on the national scale with long-term and high-frequency(such as annual monitoring) monitoring is still lacking. | ZHANG Zengxiang LIU Fang ZHAO Xiaoli WANG Xiao SHI Lifeng XU Jinyong YU Sisi WEN Qingke ZUO Lijun YI Ling HU Shunguang LIU Bin | 2018 | Chinese Geographical Science2018，28，5： | 6 |
| 5 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 6 | Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity显示文摘定期聚类短 palindromic 重复的 interspaced (CRISPR ) 在细菌和 archaea 的 -CRISPR-associated (Cas ) 系统对入侵外国 nucleic 酸提供适应免疫。以前的研究建议某些细菌采用他们的类型 II CRISPR-Cas 系统指向他们的自己的基因,因此躲避主人免疫。然而,另外的 CRISPR-Cas 系统是否在主机房间的细菌的侵略期间有类似的函数,仍然保持未知。这里,我们为类型识别一个新奇角色我在在 Pseudomonas aeruginosa 躲避主人防卫的 CRISPR-Cas 系统拉紧 UCBPP-PA14。类型我 PA14 的 CRISPR-Cas 系统指向细菌的察觉到治安法官的管理者 LasR 的 mRNA 阻抑由像使用费的受体的识别 4,因此减少在房间和鼠标模型的主机的支持 inflammatory 回答。机械学地,这调停核酸酶的 RNA 降级在类型的 Cas3 在目标 mRNA,和 HD 和 DExD/H 领域要求一个 5-GGN-3 识别主题我 CRISPR-Cas 系统。作为 LasR 和类型我 CRISPR-Cas 系统在细菌是无所不在地在场的,我们的调查结果阐明重要普通机制内在的细菌的毒力。 | Rongpeng Li Lizhu Fang Shirui Tan Min Yu Xuefeng Li Sisi He Yuquan Wei Guoping Li Jianxin Jiang Min Wu | 2016 | Cell Research2016，26，12： | 4 |
| 7 | ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals显示文摘The ZNF804 A variant rs1344706 has consistently been associated with schizophrenia and plays a role in hippocampal-prefrontal functional connectivity during working memory. Whether the effect exists in the resting state and in patients with schizophrenia remains unclear. In this study, we investigated the ZNF804 A polymorphism at rs1344706 in 92 schizophrenic patients and 99 healthy controls of Han Chinese descent, and used resting-state functional magnetic resonance imaging to explore the functional connectivity in the participants. We found a significant main effect of genotype on the resting-state functional connectivity(RSFC) between the hippocampus and the dorsolateral prefrontal cortex(DLPFC) in both schizophrenic patients and healthy controls. The homozygous ZNF804 A rs1344706 genotype(AA) conferred a high risk of schizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC(F(2,165) = 13.43,P \ 0.001). The RSFC strength was also correlated with cognitive performance and the severity of psychosis in schizophrenia. The current findings identified the neural impact of the ZNF804 A rs1344706 on hippocampalprefrontal RSFC associated with schizophrenia. | Yuyanan Zhang Hao Yan Jinmin Liao Hao Yu Sisi Jiang Qi Liu Dai Zhang Weihua Yue | 2018 | Neuroscience Bulletin2018，34，3： | 3 |
| 8 | Self-Assembled Al Nanostructure/ZnO Quantum Dot Heterostructures for High Responsivity and Fast UV Photodetector显示文摘Light confinement induced by spontaneous near-surface resonance is inherently determined by the location and geometry of metallic nanostructures(NSs),offering a facile and effective approach to break through the limitation of the light-mater interaction within the photoactive layers.Here,we demonstrate high-performance Al NS/ZnO quantum dots(Al/ZnO) heterostructure UV photodetectors with controllable morphologies of the self-assembled Al NSs.The Al/ZnO heterostructures exhibit a superior light utilization than the ZnO/Al heterostructures,and a strong morphological dependence of the Al NSs on the optical properties of the heterostructures.The inter-diffusion of Al atoms into ZnO matrixes is of a great benefit for the carrier transportation.Consequently,the optimal photocurrent of the Al/ZnO heterostructure photodetectors is significantly increased by 275 times to ~1.065 mA compared to that of the pristine ZnO device,and an outstanding photoresponsivity of 11.98 A W-1 is correspondingly achieved under 6.9 MW cm-2 UV light illumination at 10 V bias.In addition,a relatively fast response is similarly witnessed with the Al/ZnO devices,paving a path to fabricate the high-performance UV photodetectors for applications. | Sisi Liu Ming‑Yu Li Jianbing Zhang Dong Su Zhen Huang Sundar Kunwar Jihoon Lee | 2020 | Nano-Micro Letters2020，12，9： | 3 |
| 9 | Investigation and experimental validation of curcumin-related mechanisms against hepatocellular carcinoma based on network pharmacology显示文摘Objective:To determine the potential molecular mechanisms underlying the therapeutic effect of curcumin on hepatocellular carcinoma(HCC)by network pharmacology and experimental in vitro validation.Methods:The predictive targets of curcumin or HCC were collected from several databases.the identified overlapping targets were crossed with Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses using the Database for Annotation,Visualization,and Integrated Discovery(DAVID)platform.Two of the candidate pathways were selected to conduct an experimental verification.The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium(MTT)assay was used to determine the effect of curcumin on the viability of Hep G2 and LO2 cells.The apoptosis and autophagy of Hep G2 cells were respectively detected by flow cytometry and transmission electron microscopy.Besides,western blot and real-time polymerase chain reaction(PCR)were employed to verify the p53 apoptotic pathway and adenosine 5’-monophosphate(AMP)-activated protein kinase(AMPK)autophagy pathway.Hep G2 cells were pretreated with pifithrin-α(PFT-α)and GSK690693 for further investigation.Results:The 167 pathways analyzed by KEGG included apoptosis,autophagy,p53,and AMPK pathways.The GO enrichment analysis demonstrated that curcumin was involved in cellular response to drug,regulation of apoptotic pathway,and so on.The in vitro experiments also confirmed that curcumin can inhibit the growth of Hep G2 cells by promoting the apoptosis of p53 pathway and autophagy through the AMPK pathway.Furthermore,the protein and messenger RNA(m RNA)of the two pathways were downregulated in the inhibitor-pretreated group compared with the experimental group.The damage-regulated autophagy modulator(DRAM)in the PFT-α-pretreated group was downregulated,and p62 in the GSK690693-pretreated group was upregulated.Conclusions:Curcumin can treat HCC through the p53 apoptotic pathway and the AMPK/Unc-51-like kinase 1(ULK1)autophagy pathway,in which the mutual transformation of autophagy and apoptosis may occur through DRAM and p62. | Yang CHEN Qian LI Sisi REN Ting CHEN Bingtao ZHAI Jiangxue CHENG Xiaoyan SHI Liang SONG Yu FAN Dongyan GUO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，8： | 3 |
| 10 | Piezo1 regulates migration and invasion of breast cancer cells via modulating cell mechanobiological properties显示文摘Cell migration and invasion are two essential processes during cancer metastasis. Increasing evidence has shown that the Piezo1 channel is involved in mediating cell migration and invasion in some types of cancers. However, the role of Piezo1 in the breast cancer and its underlying mechanisms have not been clarified yet. Here, we show that Piezo1 is high-expressed in breast cancer cell (BCC) lines, despite its complex expression in clinical patient database. Piezo1 knockdown (Piezo1-KD) promotes unconfined BCC migration, but impedes confined cell migration. Piezo1 may mediate BCC migration through the balances of cell adhesion, cell stiffness, and contractility. Furthermore, Piezo1-KD inhibits BCC invasion by impairing the invadopodium formation and suppressing the expression of metalloproteinases (MMPs) as well. However, the proliferation and cell cycle of BCCs are not significantly affected by Piezo1. Our study highlights a crucial role of Piezo1 in regulating migration and invasion of BCCs, indicating Piezo1 channel might be a new prognostic and therapeutic target in BCCs. | Yang Yu Xiao’an Wu Sisi Liu Hongping Zhao Bo Li Hucheng Zhao Xiqiao Feng | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 2 |
| 11 | Components of complex interventions for healthcare: A narrative synthesis of qualitative studies显示文摘Objective:Qualitative research on therapeutic components is necessary to evaluate the efficacy of complex interventions in healthcare.As few qualitative syntheses have been conducted,this study aimed to derive a new conceptual framework for understanding the components of complex interventions and provide evidence for the implementation and evaluation of complex healthcare interventions.Methods:A systematic search of seven databases was conducted to identify qualitative studies that explored components of complex healthcare interventions.Meta-ethnography was used to analyze the data and thematic analysis was used to build the conceptual framework.Results:Of the 35 included studies,most complex interventions were non-pharmacological,with cancer accounting for 22%,mental health for 14%,and stroke for 8%.Half of the studies were conducted in the United Kingdom.Three main categories emerged:what should healthcare workers do?what qualifications should they have?and what should patients do?Five main themes were identified:psychological,biological,cognitive and behavioral,environmental,and social support.Conclusion:This analysis provides a reference for designing components of complex interventions in further studies. | Sisi Ma He Yu Ning Liang Sijia Zhu Xun Li Nicola Robinson Jianping Liu | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 2 |
| 12 | Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia显示文摘Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia(SCAP).We prospectively enrolled consecutive SCAP patients admitted to ICU.Bronchoscopy was performed at bedside within 48 h of ICU admission,and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage fluid.The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following bronchoscopy.Sixty-seven patients were included.Multivariable permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota(R2=0.033;P=0.018),followed by acute kidney injury(AKI;R2=0.032;P=0.011)and plasma MIP-1βlevel(R2=0.027;P=0.044).Random forest identified that the families Prevotellaceae,Moraxellaceae,and Staphylococcaceae were the biomarkers related to the positive bacteria lab test results.Multivariable Cox regression showed that the increase inα-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical improvements.The positive bacteria lab test results,AKI,and plasma MIP-1βlevel were associated with patients’lung microbiota composition on ICU admission.The families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements. | Sisi Du Xiaojing Wu Binbin Li Yimin Wang Lianhan Shang Xu Huang Yudi Xia Donghao Yu Naicong Lu Zhibo Liu Chunlei Wang Xinmeng Liu Zhujia Xiong Xiaohui Zou Binghuai Lu Yingmei Liu Qingyuan Zhan Bin Cao | 2022 | Frontiers of Medicine2022，16，3： | 2 |
| 13 | Microstructure and electrical properties of (Pb 0.87 Ba 0.1 La 0.02 )(Zr 0.68 Sn 0.24 Ti 0.08 )O 3 anti-ferroelectric ceramics fabricated by the hot-press sintering method显示文摘 | Guangzu Zhang Sisi Liu Yan Yu Yike Zeng Yangyang Zhang Xu Hu Shenglin Jiang | 2013 | Journal of the European Ceramic Society2013，，1： | 1 |
| 14 | Establishing Standardized Biomedical Laboratory Technician Education for the Development of Biotech no logy Research in China显示文摘Chinese scientists have been actively engaged in biotechnology research since the mid-2Oth century.However,biotechnology education,especially biomedical laboratory technology education,is relatively scarce in China.More and more cutting-edge equipment and techniques have been introduced into biomedical laboratories in China,but there is a lack of high-quality techni&ans to apply these advancements to scientific research.In addition,the traditional education and apprenticeship systems have been demonstrated little progress.To address this gap,West China Hospital of Sichuan University established a 2-year educational program for laboratory technology in 2006 based on the residency training program.The project integrates scientific methods into the research laboratory technician training in relevant disciplines,and has developed a systematic,scientific,and effective standardized training system to cultivate high-level and stable experimental technician team for the need of advanced laboratories,which has been demonstrated gready improve the efficiency of biomedical researchers and laboratory facilities.In this article,we introduce the practical experience in establishment and development of a standardized training system for biomedical laboratory technicians to ensure the sustainable development of medical researches. | Guonian Zhu Qiang Huang Yu Ding Jinkui Pi Lan Zhan Sisi Wu | 2020 | Chinese Medical Sciences Journal2020，35，2： | 1 |
| 15 | Assessing 40 years of spatial dynamics and patterns in megacities along the Belt and Road region using satellite imagery显示文摘The Belt and Road(B&R)region,a vital area with historical,economic,cultural and political significance,has undergone rapid urbanization in the past several decades,especially in the form of urban expansion.In this study,20 megacities in the B&R region were selected to explore different spatiotemporal patterns of urban expansion.Object-oriented support vector machines(SVM),annual growth rate(AGR)models,and landscape metrics were employed to delineate the urban areas and characterize spatiotemporal characteristics and landscape patterns of these megacities during 1975–2015.All urban maps presented high overall accuracies(80.70%–95.90%)and overall Kappa coefficients(0.76–0.95).The study revealed that megacities in the B&R region have undergone different types of urban sprawl,mainly adopting a‘concentric circle’pattern in inland areas and a‘sector’pattern in coastal areas.Besides,six expansion modes were summarized according to the AGRs of individual megacities.Differences existed in megacities of the developing and developed countries and among five sub-regions.Moreover,‘dispersion,gathering,and re-dispersion’and‘coalescence’were two major landscape patterns of megacities in developing and developed countries.Results of this study can provide a scientific reference for urban planning and aid in sustainable development of local areas. | Zhongchang Sun Sisi Yu Huadong Guo Cuizhen Wang ZengXiang Zhang Ru Xu | 2021 | International Journal of Digital Earth2021，14，1： | 1 |
| 16 | Validation and correction of sea surface salinity retrieval from SMAP显示文摘In this study, sea surface salinity(SSS) Level 3(L3) daily product derived from soil moisture active passive(SMAP)during the year 2016, was validated and compared with SSS daily products derived from soil Moisture and ocean salinity(SMOS) and in-situ measurements. Generally, the root mean square error(RMSE) of the daily SSS products is larger along the coastal areas and at high latitudes and is smaller in the tropical regions and open oceans. Comparisons between the two types of daily satellite SSS product revealed that the RMSE was higher in the daily SMOS product than in the SMAP, whereas the bias of the daily SMOS was observed to be less than that of the SMAP when compared with Argo floats data. In addition, the latitude-dependent bias and RMSE of the SMAP SSS were found to be primarily influenced by the precipitation and the sea surface temperature(SST). Then, a regression analysis method which has adopted the precipitation and SST data was used to correct the larger bias of the daily SMAP product. It was confirmed that the corrected daily SMAP product could be used for assimilation in high-resolution forecast models, due to the fact that it was demonstrated to be unbiased and much closer to the in-situ measurements than the original uncorrected SMAP product. | Sisi Qin Hui Wang Jiang Zhu Liying Wan Yu Zhang Haoyun Wang | 2020 | Acta Oceanologica Sinica2020，39，3： | 1 |
| 17 | Oral Chinese herbal medicine (CHM) as an adjuvant treatment during chemotherapy for non-small cell lung cancer: A systematic review显示文摘 | Sisi Chen Andrew Flower Andrew Ritchie Jianping Liu Alex Molassiotis He Yu George Lewith | 2009 | Lung Cancer2009，，2： | 1 |
| 18 | Cloth simulation-based construction of pitfree canopy height models from airborne LiDAR data显示文摘Background:The universal occurrence of randomly distributed dark holes(i.e.,data pits appearing within the tree crown)in LiDAR-derived canopy height models(CHMs)negatively affects the accuracy of extracted forest inventory parameters.Methods:We develop an algorithm based on cloth simulation for constructing a pit-free CHM.Results:The proposed algorithm effectively fills data pits of various sizes whilst preserving canopy details.Our pitfree CHMs derived from point clouds at different proportions of data pits are remarkably better than those constructed using other algorithms,as evidenced by the lowest average root mean square error(0.4981 m)between the reference CHMs and the constructed pit-free CHMs.Moreover,our pit-free CHMs show the best performance overall in terms of maximum tree height estimation(average bias=0.9674 m).Conclusion:The proposed algorithm can be adopted when working with different quality LiDAR data and shows high potential in forestry applications. | Wuming Zhang Shangshu Cai Xinlian Liang Jie Shao Ronghai Hu Sisi Yu Guangjian Yan | 2020 | Forest Ecosystems2020，7，1： | 1 |
| 19 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 20 | Oral Chinese herbal medicine (CHM) as an adjuvant treatment during chemotherapy for non-small cell lung cancer: A systematic review显示文摘 | Sisi Chen Andrew Flower Andrew Ritchie Jianping Liu Alex Molassiotis He Yu George Lewith | 2009 | Lung Cancer2009，，： | 1 |
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