|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 糖尿病视网膜病变患病率的流行病学调查:在中国6省13473名糖尿病患者中的横断面研究显示文摘目的本研究旨在探究中国糖尿病患者中糖尿病视网膜病变(DR)和视力威胁性糖尿病视网膜病变(STDR)的患病率和严重程度。研究设计、设置与参与者本研究为横断面流行病学调查,研究对象为中国内地地区的糖尿病患者(N=13473)。研究对象为被内科医师诊断为糖尿病,并转诊到筛查门诊的糖尿病患者(其中住院患者占1/3,城市居民占1/3,农村居民占1/3)。研究对象的每只眼睛应用彩色、免散瞳和非立体眼底照相机拍摄2张眼底照片,并根据英国DR分级指南进行分级。主要结果和测量指标DR与STDR的患病率和严重程度。结果在参与本研究的13473例糖尿病患者中,共发现4591例DR和1769例STDR患者,DR的总体患病率为34.08%[95%可信区间(凹)33.28%~34.88%],其中STDR的总体患病率为13.13%(95%C112.56%~13.70%)。在所有研究对象中,12780例参与了眼底照片分级(94.86%)。年龄大于65岁的研究对象患DR或STDR的可能性较低(P〈0.001)。性别对是否患病没有显著影响(P〉0.05)。STDR患者与非STDR患者相比,视力损伤更为严重(P〈0.001)。中国北方DR和STDR的患病率高于南方(P〈0.001)。DR的患病率与糖尿病患病时间f比值比(鲫)2.63;95%C12.42~2.86;P〈0.001]以及糖尿病发病年龄(OR 0.38;95%CI为0.35~0.41;P〈0.001)密切相关。结论DR和STDR在中国内地地区的患病率偏高,并且不同地区患病率存在差异。在DR中,非增殖性DR更常见,但STDR更需要及时的诊断和治疗,特别是在经济欠发达地区。本研究强调了中国内地地区DR筛查和治疗的重要性。 | Liu, Yan Song, Yifan Tao, Liyuan Qiu, Weiqiang Lv, Huibin Jiang, Xiaodan Zhang, Mingzhou Li, Xuemin | 2017 | 英国医学杂志中文版2017，20，11： | 23 |
| 2 | Encapsulation of selenium sulfide in double-layered hollow carbon spheres as advanced electrode material for lithium storage显示文摘硒 sulfide/double-layered 空碳范围(SeS 2/DLHC) composites 为新奇 Li-SeS 2 电池作为高效的阴极材料被设计了。在里面构造合成, SeS 2 主要在 DLHC 的夹层空间被包含,高度(重量百分比)75% 装载并且为锂用作活跃部件存储。Se 在的存在合成并且碳框架不仅减轻 polysulfide 的 shuttling,而且改进电极的传导性。到在骑车以后的 DLHC 的空洞的从夹层虚空的活跃材料的移植,进一步减轻活跃材料和梭效果的损失,被观察。作为结果, SeS 2/DLHC 合成交付一个高特定的能力(930 mAed nanoparticles,有 81.8% 的轻发射度和 118.62ichia coli 的一个水接触角度(E。coli ) ,肠球菌(ENT ) 和全部的大肠菌(TC ) 被分析。除了 EC 和没有 3, ,结果揭示了低 concentrati 吗?? | Hongwei Zhang Liang Zhou Xiaodan Huang Hao Song Chengzhong Yu | 2016 | Nano Research2016，9，12： | 5 |
| 3 | Could CMIP6 climate models reproduce the early-2000s global warming slowdown?显示文摘The unexpected global warming slowdown during 1998–2013 challenges the existing scientific understanding of global temperature change mechanisms,and thus the simulation and prediction ability of state-of-the-art climate models since most models participating in phase 5 of the Coupled Model Intercomparison Project(CMIP5)cannot simulate it.Here,we examine whether the new-generation climate models in CMIP6 can reproduce the recent global warming slowdown,and further evaluate their capacities for simulating key-scale natural variabilities which are the most likely causes of the slowdown.The results show that although the CMIP6 models present some encouraging improvements when compared with CMIP5,most of them still fail to reproduce the warming slowdown.They considerably overestimate the warming rate observed in 1998–2013,exhibiting an obvious warming acceleration rather than the observed deceleration.This is probably associated with their deficiencies in simulating the distinct temperature change signals from the human-induced long-term warming trend and/or the three crucial natural variabilities at interannual,interdecadal,and multidecadal scales.In contrast,the 4 models that can successfully reproduce the slowdown show relatively high skills in simulating the long-term warming trend and the three keyscale natural variabilities.Our work may provide important insight for the simulation and prediction of near-term climate changes. | Meng WEI Qi SHU Zhenya SONG Yajuan SONG Xiaodan YANG Yongqing GUO Xinfang LI Fangli QIAO | 2021 | Science China Earth Sciences2021，64，6： | 5 |
| 4 | Active loading liposomal irinotecan hydrochloride:Preparation,in vitro and in vivo evaluation显示文摘The aim of the present study was to investigate the effect of various transmembrane ammonium salt gradients and different lipid composition on the loading efficiency of liposomal formulations of irinotecan hydrochloride(CPT-11),their behavior in vivo and cytotoxicity.Among ammonium salts studied,ammonium sulfate was successfully used to load CPT-11 into liposomes with the highest encapsulation efficiency.Subsequently,liposomal CPT-11 with different lipid composition was prepared by ammonium sulfate gradient method.CPT-11 can be loaded to a level over 90%into liposomes composed of soybean phospholipids/cholesterol(SPC-L)or hydrogenated natural soybean phospholipids/cholesterol(HSPC-L).In vitro release profiles were also investigated,indicating that HSPC-L had a lower release than that in SPC-L.In vivo,encapsulation of CPT-11 in both liposomal formulations showed higher area under the curve(AUC),a lower rate of clearance(CL)and smaller volume of distribution for CPT-11 than those of irinotecan hydrochloride solution(CPT-11-S).However,CL and AUC of 7-ethyl-10-hydroxycamptothecin(SN-38)were moderately improved in HSPC-L group.Based on the results of comparative pharmacokinetics of liposomal CPT-11 with different lipid composition,the in vitro cytotoxicity of HSPC-L was evaluated with human tumor cell.The result indicated that liposomal CPT-11 showed a great enhancement in vitro cytotoxicity.The results suggested that entrapment of CPT-11 in liposomes especially in those with high phase-transition temperature lipid by ammonium sulfate gradient would be a promising formulation with a better in vivo behavior. | Hongyan Wei Juan Song Hao Li Yang Li Shanshan Zhu Xiaodan Zhou Xiwen Zhang Li Yang | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，5： | 3 |
| 5 | Tailoring mesoporous-silica nanoparticles for robust immobilization of lipase and biocatalysis显示文摘nano 搬运人的合理设计为为先进 biocatalysis 的现代的酶固定是批评的。此处,我们与一个高 C18 内容报导修改 octadecylalkyl 的 mesoporous 硅石 nanoparticles (C18-MSNs ) 的合成(~ 19 wt.%) 并且悦耳的毛孔尺寸(1.6-13 nm ) 。增加的恐水病的内容和一个定制的毛孔缩放,这被表明(比脂肪分解酵素的尺寸稍微大) 为使不能调动的脂肪分解酵素的高效负责。优化 C18-MSNs 展览 711 mg/g 和比免费的酶的高 5.23 倍的一项特定的活动的一个装载能力。另外, 93% 起始的活动在复用以后被保留五次,它比性能迄今为止报导了的最好好。我们的调查结果为 biocatalytic 应用为脂肪分解酵素的柔韧的固定铺平道路。 | Mohammad Kalantari Meihua Yu Yannan Yang Ekaterina Strounina Zhengying Gu Xiaodan Huang Jun Zhang Hao Song Chengzhong Yu | 2017 | Nano Research2017，10，2： | 3 |
| 6 | Ultrastructural characterization of avian influenza A(H7N9) virus infecting humans in China显示文摘Dear Editor,In March 2013,the first 3 cases of severe disease dueto a novel avian-origin influenza A(H7N9)virus weredetected in the Chinese provinces of Shanghai and Anhui(Gao R,et al.,2013).A total of 339 laboratory-confirmedcases with 100 deaths were reported until January 142014(WHO,2014).To the best of our knowledge,thisis the first time that human infection with the avian in-fluenza A H7N9 subtype has been detected.Prior to | Rongbao Gao Jingdong Song Ye Zhang Shumei Zou Tian Bai Xiaodan Li Jianguo Qu Jianfang Zhou Tao Hung Yuelong Shu | 2014 | Virologica Sinica2014，29，2： | 2 |
| 7 | An infrared thermographic analysis of the sensitization acupoints of women with primary dysmenorrhea显示文摘OBJECTIVE:To explore the sensitization acupoints of women with primary dysmenorrhea(PD)by comparing infrared radiation temperatures between acupoints and non-acupoints.METHODS:We tested 10 acupoints of every woman with PD and healthy subjects on premenstrual,menstrual,and postmenstrual days using an infrared imaging device.The primary outcome was the absolute value of body surface temperature difference(AVTD)between the left and right sides of the same testing point.RESULTS:A total of 58 PD patients and 57 healthy volunteers completed the test from May 2016 to May 2017.Compared with the healthy group,we observed a significant reduction and increase in the AVTD in Taichong(LR3)and Sanyinjiao(SP6),respectively,during menstrual days in the PD group(P=0.01;P=0.04);while during postmenstrual days,all AVTDs of Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)were diminished in the PD group(P=0.01;P=0.03;P=0.01,respectively).No significant differences in AVTD were detected at any other points or testing times.CONCLUSIONS:Compared with the healthy group,the AVTDs of Taichong(LR3),Sanyinjiao(SP6),Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)at menstruationrelevant points of PD patients were sensitized,providing a reference for the selection of acupoints in the treatment of PD. | FAN Xisheng DU Xiaoyi PAN Lijia SONG Xiaodan LIU Jun ZHANG Juncha CHEN Hao GAO Yayu ZHANG Mingjian SHI Xuliang SHE Yanfen | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 2 |
| 8 | Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression显示文摘 | Michael C. Schmid Christie J. Avraamides Holly C. Dippold Irene Franco Philippe Foubert Lesley G. Ellies Lissette M. Acevedo Joan R.E. Manglicmot Xiaodan Song Wolfgang Wrasidlo Sara L. Blair Mark H. Ginsberg David A. Cheresh Emilio Hirsch Seth J. Field Ju | 2011 | Cancer Cell2011，，6： | 1 |
| 9 | Research on the unbiased probability estimation of error-correcting output coding显示文摘 | Zhou Jindeng Wang Xiaodan Song Heng | 2011 | Pattern Recognition2011，44，： | 1 |
| 10 | Treatment of Irreducible Old Atlantoaxial Subluxation With Cable-Dragged Reduction and Cantilever Beam Internal Fixation显示文摘 | Xi Liu Hao Liu Tao Li Quan Gong Yueming Song Limin Liu Rui Shi Xiaodan Zhao Wenli Zhang Ganjun Feng Beiyu Wang | 2011 | Spine2011，，15： | 1 |
| 11 | Adaptive thresholding based on variational background 显示文摘 | Fei LIU Xiaodan SONG Yupin LUO | 2002 | Lectronics Letters2002，38，18： | 1 |
| 12 | On evolutionary spectral clustering显示文摘 | Chi Yun Song Xiaodan Zhou Dengyong | 2009 | ACM Trans on Knowledge Discovery from Data2009，3，4： | 1 |
| 13 | Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy显示文摘The clinical outcomes of cancer nanovaccine have been largely impeded owing to the low antigen-specific T cell response rate and acquired resistance caused by the immunosuppressive tumor microenvironment(TME).Here,we reported a tumor acidity-responsive nanovaccine to remodel the immunosuppressive TME and expand the recruitment of tumor infiltrating lymphocytes(TILs)using hybrid micelles(HM),which encapsulated colony stimulating factor 1 receptor(CSF1-R)inhibitor BLZ-945 and indoleamine 2,3-dioxygenase(IDO)inhibitor NLG-919 in its core and displayed a model antigen ovalbumin(OVA)on its surface(denoted as BN@HM-OVA).The bioactive nanovaccine is coated with a polyethylene glycol(PEG)shell for extending nanoparticle circulation.The shell can be shed in response to the weakly acidic tumor microenvironment.The decrease in size and the increase in positive charge may cause the deep tumor penetration of drugs.We demonstrated that the bioactive nanovaccine dramatically enhance antigen presentation by dendritic cells(DCs)and drugs transportation into M1-like tumor-associated macrophages(TAMs)and tumor cells via size reduction and increasing positive charge caused by the weakly acidic TME.Such bioactive nanovaccine could remodel the immunosuppressive TME into an effector T cells favorable environment,leading to tumor growth inhibition in prophylactic and therapeutic E.G7-OVA tumor models.Furthermore,combining the bioactive nanovaccine with simultaneous anti-PD-1 antibody treatment leads to a long-term tumor inhibition,based on the optimal timing and sequence of PD-1 blockade against T cell receptor.This research provides a new strategy for the development of efficient cancer immunotherapy. | Xiaoxue Xie Yi Feng Hanxi Zhang Qingqing Su Ting Song Geng Yang Ningxi Li Xiaodan Wei Tingting Li Xiang Qin Shun Li Chunhui Wu Xiaojuan Zhang Guixue Wang Yiyao Liu Hong Yang | 2022 | Bioactive Materials2022，7，10： | 1 |
| 14 | Research on the Unbiased Probability Estimation of Error-correcting Output Coding显示文摘 | ZHOU Jindeng WANG Xiaodan SONG Heng | 2011 | Pattern Recognition2011，，44： | 1 |
| 15 | On evolutionary spectral clustering显示文摘 | Chi Yun Song Xiaodan Zhou Dengyong | 2009 | ACM Transac- tions on Knowlege Discovery from Data2009，3，4： | 1 |
| 16 | The essential role of N6-methyladenosine RNA methylation in complex eye diseases显示文摘There are many complex eye diseases which are the leading causes of blindness,however,the pathogenesis of the complex eye diseases is not fully understood,especially the underlying molecular mechanisms of N6-methyladenosine(m6A)RNA methylation in the eye diseases have not been extensive clarified.Our review summarizes the latest advances in the studies of m6A modification in the pathogenesis of the complex eye diseases,including cornea disease,cataract,diabetic retinopathy,age-related macular degeneration,proliferative vitreoretinopathy,Graves’disease,uveal melanoma,retinoblastoma,and traumatic optic neuropathy.We further discuss the possibility of developing m6A modification signatures as biomarkers for the diagnosis of the eye diseases,as well as potential therapeutic approaches. | Xiaohua Li Binyun Ma Wenfang Zhang Zongming Song Xiaodan Zhang Mengyu Liao Xue Li Xueru Zhao Mei Du Jinguo Yu Shikun He Hua Yan | 2023 | Genes & Diseases2023，10，2： | 1 |
| 17 | Impact of Atmospheric and Oceanic Conditions on the Frequency and Genesis Location of Tropical Cyclones over the Western North Pacific in 2004 and 2010显示文摘This study examines the impact of atmospheric and oceanic conditions during May–August of 2004 and 2010 on the frequency and genesis location of tropical cyclones over the western North Pacific. Using the WRF model, four numerical experiments were carried out based on different atmospheric conditions and SST forcing. The numerical experiments indicated that changes in atmospheric and oceanic conditions greatly affect tropical cyclone activity, and the roles of atmospheric conditions are slightly greater than oceanic conditions. Specifically, the total number of tropical cyclones was found to be mostly affected by atmospheric conditions, while the distribution of tropical cyclone genesis locations was mainly related to oceanic conditions, especially the distribution of SST. In 2010, a warmer SST occurred west of 140°E, with a colder SST east of 140°E. On the one hand, the easterly flow was enhanced through the effect of the increase in the zonal SST gradient.The strengthened easterly flow led to an anomalous boundary layer divergence over the region to the east of 140°E, which suppressed the formation of tropical cyclones over this region. On the other hand, the colder SST over the region to the east of 140°E led to a colder low-level air temperature, which resulted in decreased CAPE and static instability energy. The decrease in thermodynamic energy restricted the generation of tropical cyclones over the same region. | Pan SONG Jiang ZHU Zhong ZHONG Linlin QI Xiaodan WANG | 2016 | Advances in Atmospheric Sciences2016，33，5： | 1 |
| 18 | Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity显示文摘STING,an endoplasmic reticulum(ER)transmembrane protein,mediates innate immune activation upon cGAMP stimulation and is degraded through autophagy.Here,we report that activated STING could be transferred between cells to promote antitumor immunity,a process triggered by RAB22A-mediated non-canonical autophagy.Mechanistically,RAB22A engages PI4K2A to generate PI4P that recruits the Atg12–Atg5–Atg16L1 complex,inducing the formation of ER-derived RAB22A-mediated non-canonical autophagosome,in which STING activated by agonists or chemoradiotherapy is packaged.This RAB22A-induced autophagosome fuses with RAB22A-positive early endosome,generating a new organelle that we name Rafeesome(RAB22A-mediated non-canonical autophagosome fused with early endosome).Meanwhile,RAB22A inactivates RAB7 to suppress the fusion of Rafeesome with lysosome,thereby enabling the secretion of the inner vesicle of the autophagosome bearing activated STING as a new type of extracellular vesicle that we define as R-EV(RAB22A-induced extracellular vesicle).Activated STING-containing R-EVs induce IFNβrelease from recipient cells to the tumor microenvironment,promoting antitumor immunity.Consistently,RAB22A enhances the antitumor effect of the STING agonist diABZI in mice,and a high RAB22A level predicts good survival in nasopharyngeal cancer patients treated with chemoradiotherapy.Our findings reveal that Rafeesome regulates the intercellular transfer of activated STING to trigger and spread antitumor immunity,and that the inner vesicle of non-canonical autophagosome originated from ER is secreted as R-EV,providing a new perspective for understanding the intercellular communication of organelle membrane proteins. | Ying Gao Xueping Zheng Boyang Chang Yujie Lin Xiaodan Huang Wen Wang Shirong Ding Weixiang Zhan Shang Wang Beibei Xiao Lanqing Huo Youhui Yu Yilin Chen Run Gong Yuanzhong Wu Ruhua Zhang Li Zhong Xin Wang Qiuyan Chen Song Gao Zhengfan Jiang Denghui Wei Tiebang Kang | 2022 | Cell Research2022，32，12： | 1 |
| 19 | Why we twitter: understanding microblogging usage and communities显示文摘 | AKSHAY J SONG Xiaodan TIM F | 2007 | ACM New York2007，47，11： | 1 |
| 20 | Geochemical processes controlling dissolved selenium in the Changjiang(Yangtze) Estuary and its adjacent waters显示文摘Dissolved selenium in the Changjiang(Yangtze) Estuary and its adjacent waters was determined by hydride generation atomic fluorescence spectrometry to elucidate the source, behavior in estuary, adsorption-desorption process and biological role. In surface water, Se(IV) concentration ranged 0.05–1.14 nmol/L and Se(VI) concentration varied 0.01–1.20 nmol/L, with the means of 0.76 and 0.49 nmol/L, respectively. In bottom water, Se(IV) content varied 0.03–0.27 nmol/L and Se(VI) content ranged 0.04–0.85 nmol/L, with the averages of 0.10 and 0.40 nmol/L, respectively. High level of Se(IV) was observed near the shore with a significant decrease towards the open sea, suggesting the continental input from the adjacent rivers. Large value of Se(VI) was found in bottom water, reflecting the release from suspended sediment. Besides, high value appeared in the same latitude of the Changjiang Estuary and Hangzhou Bay illustrated the effect of lateral mixing and the long-distance transport of selenium. Se(VI), more soluble, occupied higher percentage in aqueous environment. The presence of Se(IV) resulted from the degradation of residue and the reduction of Se(VI) under anaerobic condition. The positive relationship to suspended particulate material(SPM) and negative correlation to depth indicated that Se(IV) tended to be released from the high density particulate matter. Instead, Se(VI) content did not significantly relate to SPM since it generally formed inner-sphere complex to iron hydroxide. Se(IV) content negatively varied to salinity and largely depended on the freshwater dilution and physical mixing. While, Se(VI) level deviated from the dilution line due to the in situ biogeochemical process such as removal via phytoplankton uptake and inputs via organic matter regeneration. As the essential element, Se(IV) was confirmed more bioavailable to phytoplankton growth than Se(VI), and moreover, seemed to be more related to phosphorus than to nitrogen. | WU Xiaodan SONG Jinming WU Bin LI Tiegang LI Xuegang | 2014 | Acta Oceanologica Sinica2014，33，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员