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| 1 | siRNA targeting stathmin inhibits invasion and enhances chemotherapy sensitivity of stem cells derived from glioma cell lines显示文摘Glioma 高度是大多数之一 angiogenic 肿瘤,和 glioma 干细胞(GSC ) 为到化疗和放射疗法的抵抗负责,以及在操作以后的复发。Stathmin 为有丝分裂是实质的并且在导出 glioma 的 endothelial 房间的增长和移植起一个重要作用。然而,在 stathmin 和 GSC 之间的关系不完全地被理解。这里,我们从 glioma 房间线 U87MG 和 U251 孤立 GSC,然后使用了为 silencing 指向 stathmin 的 siRNA。我们证明 stathmin 的 silencing 压制了增长,增加了 apoptosis 率,并且逮捕了在在 GSC 的 G2/M 阶段的房间周期。在 GSC 的 stathmin 的 Silencing 也导致了禁止了迁居 / 侵略以及 vasculogenic 的能力模仿。到 temozolomide 的 GSC 的危险性被 stathmin silencing 也提高。我们的调查结果为 glioma 处理在 GSC 作为一个潜在的目标建议 stathmin。 | Yuwen Song Luyan Mu Xuezhe Han Xiaoqian Liu Songbin Fu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 4 |
| 2 | MDM2 SNP309 contributes to tumor susceptibility:A meta-analysis显示文摘潜在地功能的多型性, SNP309,在 MDM2 的倡导者区域,基因在出版研究看了不确定的结果的癌症风险,而是个人被含有。获得在 MDM2 SNP309 和癌症的风险之间的协会的更精确的估计,我们在与肿瘤和 33,046 控制的不同类型包括了 26,160 个盒子的 59 份出版物执行了 70 单个研究的元分析。概括机会比率(或) 并且相应当适当时, 95% 信心间隔(CI ) 用改正效果和随机效果的模型被估计。总的来说,变体遗传型在不同基因模型为所有癌症类型与显著地增加的癌症风险被联系(GG 对 TT:或, 1.123;95% CI, 1.0561.193;GG/GT 对 TT:或, 1.028;95% CI, 1.0061.050 ) 。在成层的分析,为大多数的研究仍然是的增加的风险癌症,亚洲人口,和医院打字 -- 在不同基因模型的 /population-based 研究,而显著地减少了,风险在前列腺癌症被发现(GG 对 TT:或, 0.606;95% CI, 0.4070.903;GG/GT 对 TT:或, 0.748;95% CI, 0.5790.968 ) 。在结论,元分析的数据建议 MDM2 SNP309 是为癌症风险的潜在的 biomarker。 | Xiaoman Wo Dong Han Haiming Sun Yang Liu Xiangning Meng Jing Bai Feng Chen Yang Yu Yan Jin Songbin Fu | 2011 | Journal of Genetics and Genomics2011，38，8： | 3 |
| 3 | Enhancing upconversion of Nd3+ through Yb^(3+)-mediated energy cycling towards temperature sensing显示文摘Photon upconversion of lanthanides has been a powerful means to convert low-energy photons into high-energy ones.However,in contrast to the mostly investigated lanthanide ions,it has remained a challenge for the efficient upconversion of Nd^(3+)due to the deleterious concentration quenching effect.Here we report an efficient strategy to enhance the upconversion of Nd^(3+)through the Yb^(3+)-mediated energy cycling in a core-shell-shell nanostructure.Both Nd^(3+)and Yb^(3+)are confined in the interlayer,and the presence of Yb^(3+)in the Nd-sublattice provides a more matched energy for the upconversion transitions occurring at the intermediate state of Nd^(3+)towards much better population at its emissive levels.Moreover,this design also minimizes the possible cross-relaxation processes at both intermediate level and the emissive levels of Nd^(3+)which are the primary factors limiting the upconversion performance for the Nd^(3+)-doped materials.Such energy cycling-enhanced upconversion shows promise in temperature sensing. | Nan Song Songbin Liu Peng Zhang Junshan He Qinyuan Zhang Feng Wang Bo Zhou | 2021 | Journal of Rare Earths2021，39，12： | 3 |
| 4 | Flight Safety System Evaluation and Optimal Linear Prediction显示文摘The complexity of flight safety system is usually affected by a variety of uncertainties.The uncertainty of overall security situation of flight safety system are hardly determined.In this work,flight safety assessment index system is firstly established based on software hardware environment liveware management(SHELM)model.And flight safety assessment is also carried out with matter-element theory algorithm to obtain safety state.According to correlation degree values of each evaluation index,key indexes affected flight safety are obtained.Under the assumption that the flight safety system is a linear dynamic system and combining the above evaluation analysis,Kalman filter algorithm is used to carry out prediction analysis on security situation.A simulation analysis is carried out based on an actual flight safety situation of an airline.The results show that the security state of airline flight safety system in a short period of time can be obtained,and main factors affecting flight safety are found out.This provides a viable way for airlines to further strengthen flight safety management. | DING Songbin GU Qianqian LIU Jiayu | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，2： | 1 |
| 5 | TSG101, identified by screening a cancer cDNA library and soft agar assay, promotes cell proliferation in human lung cancer显示文摘 | Fangli Liu Yang Yu Yan Jin Songbin Fu | 2010 | Molecular Biology Reports2010，，6： | 1 |
| 6 | S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis byactivating the TGF-β signaling pathway in cancer cells显示文摘 | Dandan Tong Hui Qu Xiangning Meng Yang Jiang Duanyang Liu Shengqian Ye He Chen Yan Jin Songbin Fu Jingshu Geng | 2014 | Oncology Reports2014，，3： | 1 |
| 7 | microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C显示文摘 | Jing Hu Yongxia Cheng Yuezhen Li Zaishun Jin Yanming Pan Guibo Liu Songbin Fu Yafang Zhang Kejian Feng Yukuan Feng | 2014 | European Journal of Cancer2014，，13： | 1 |
| 8 | TSG101, identified by screening a cancer cDNA library and soft agar assay, promotes cell proliferation in human lung cancer显示文摘 | Fangli Liu Yang Yu Yan Jin Songbin Fu | 2010 | Molecular Biology Reports2010，，6： | 1 |
| 9 | A novel locus of coralliform cataract mapped to chromosome 2p24-pter显示文摘 | Linghan Gao Wei Qin Hao Cui Guoyin Feng Ping Liu Weiqi Gao Lin Ma Pu Li Lin He Songbin Fu | 2005 | Journal of Human Genetics2005，，6： | 1 |
| 10 | Based on the embedded system agricultural short message switching control device显示文摘 | Cheng Taobo Liu Guixiong Zhou Songbin | 2007 | Science and Engineering2007，，4： | 1 |
| 11 | Enabling efficient NIR-II luminescence in lithium-sublattice core–shell nanocrystals towards Stark sublevel based nanothermometry显示文摘The luminescence in the second near-infrared(NIR-II)spectral region(1,000–1,700 nm)has recently attracted great attention for emerging biological applications owing to its merit of deep tissue bioimaging and high spatiotemporal resolution.However,it still remains a challenge to achieve the highly efficient NIR-II emissions of lanthanides in nanomaterials.Herein,we report an ideal design of sensitizing lithium sublattice core–shell nanocrystals for efficient NIR-II emission properties from a set of lanthanide emitters including Er3+,Tm3+,Ho3+,Pr3+,and Nd3+.In particular,the typical NIR-II emission of Er3+at 1.5μm was greatly enhanced by further manipulating the energy transfer via Er3+–Ce3+cross-relaxation,and the quantum yield can reach up to 35.74%under 980 nm excitation(12.5 W·cm−2),which is the highest value to the best of our knowledge.The 808 nm responsive efficient NIR-II emission was also enabled at the single-particle level through rational core–shell–shell structure design.Moreover,the lithium-sublattice provides an obvious spectral Stark-splitting feature,which can be used in the ultrasensitive NIR-II nanothermometer with relative sensitivity of 0.248%K−1 and excellent thermal cycling stability.These results open a door to the research of new kinds of efficient NIR-II luminescent materials,showing great promise in various frontier fields such as deep tissue nanothermometry and in vivo bioimaging. | Songbin Liu Zhengce An Jinshu Huang Bo Zhou | 2023 | Nano Research2023，16，1： | 0 |
| 12 | Optimized Deep Learning Model for Fire Semantic Segmentation显示文摘Recent convolutional neural networks(CNNs)based deep learning has significantly promoted fire detection.Existing fire detection methods can efficiently recognize and locate the fire.However,the accurate flame boundary and shape information is hard to obtain by them,which makes it difficult to conduct automated fire region analysis,prediction,and early warning.To this end,we propose a fire semantic segmentation method based on Global Position Guidance(GPG)and Multi-path explicit Edge information Interaction(MEI).Specifically,to solve the problem of local segmentation errors in low-level feature space,a top-down global position guidance module is used to restrain the offset of low-level features.Besides,an MEI module is proposed to explicitly extract and utilize the edge information to refine the coarse fire segmentation results.We compare the proposed method with existing advanced semantic segmentation and salient object detection methods.Experimental results demonstrate that the proposed method achieves 94.1%,93.6%,94.6%,95.3%,and 95.9%Intersection over Union(IoU)on five test sets respectively which outperforms the suboptimal method by a large margin.In addition,in terms of accuracy,our approach also achieves the best score. | Songbin Li Peng Liu Qiandong Yan Ruiling Qian | 2022 | Computers, Materials & Continua2022，，9： | 0 |
| 13 | General Steganalysis Method of Compressed Speech Under Different Standards显示文摘Analysis-by-synthesis linear predictive coding(AbS-LPC)is widely used in a variety of low-bit-rate speech codecs.Most of the current steganalysis methods for AbS-LPC low-bit-rate compressed speech steganography are specifically designed for a specific coding standard or category of steganography methods,and thus lack generalization capability.In this paper,a general steganalysis method for detecting steganographies in low-bit-rate compressed speech under different standards is proposed.First,the code-element matrices corresponding to different coding standards are concatenated to obtain a synthetic code-element matrix,which will be mapped into an intermediate feature representation by utilizing the pre-trained dictionaries.Then,bidirectional long short-term memory is employed to capture long-term contextual correlations.Finally,a code-element affinity attention mechanism is used to capture the global inter-frame context,and a full connection structure is used to generate the prediction result.Experimental results show that the proposed method is effective and better than the comparison methods for detecting steganographies in cross-standard low-bit-rate compressed speech. | Peng Liu Songbin Li Qiandong Yan Jingang Wang Cheng Zhang | 2021 | Computers, Materials & Continua2021，，8： | 0 |
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