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| 1 | Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer显示文摘AIM:To investigate M2 isoform of pyruvate kinase(PKM2) expression in gastric cancers and evaluate its potential as a prognostic biomarker and an anticancer target.METHODS:All tissue samples were derived from gastric cancer patients underwent curative gastrectomy as a primary treatment.Clinical and pathological information were obtained from the medical records.Gene expression microarray data from 60 cancer and 19 noncancer gastric tissues were analyzed to evaluate the expression level of PKM2 mRNA.Tissue microarrays were constructed from 368 gastric cancer patients.Immunohistochemistry was used to measure PKM2 expression and PKM2 positivity of cancer was determined by proportion of PKM2-positive tumor cells and staining intensity.Association between PKM2 expression and the clinicopathological factors was evaluated and the correlation between PKM2 and cancer prognosis was evaluated.RESULTS:PKM2 mRNA levels were increased more than 2-fold in primary gastric cancers compared to adjacent normal tissues from the same patients(log transformed expression level:7.6 ± 0.65 vs 6.3 ± 0.51,P < 0.001).Moreover,differentiated type cancers had significantly higher PKM2 mRNA compared to undifferentiated type cancers(log transformed expression level:7.8 ± 0.70 vs 6.7 ± 0.71,P < 0.001).PKM2 protein was mainly localized in the cytoplasm of primary cancer cells and detected in 144 of 368(39.1%) human gastric cancer cases.PKM2 expression was not related with stage(P = 0.811),but strongly correlated with gastric cancer differentiation(P < 0.001).Differentiated type cancers expressed more PKM2 protein than did the undifferentiated ones.Well differentiated adenocarcinoma showed 63.6% PKM2-positive cells;in contrast,signet-ring cell cancers showed only 17.7% PKM2-positive cells.Importantly,PKM2 expression was correlated with shorter overall survival(P < 0.05) independent of stage only in signet-ring cell cancers.CONCLUSION:PKM2 expression might be an adverse prognostic factor for signet-ring cell carcinomas.Its function and potential as a prognostic marker should be further verified in gastric cancer. | Jae Yun Lim Sun Och Yoon So Young Seol Soon Won Hong Jong Won Kim Seung Ho Choi Jae Yong Cho | 2012 | World Journal of Gastroenterology2012，18，30： | 19 |
| 2 | Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype显示文摘AIM:To identify molecular biologic differences between two gastric adenocarcinoma subgroups presenting different prognoses through the analysis of microRNA and protein expression.METHODS:Array technologies were used to generate1146 microRNAs and 124 proteins expression profiles of samples from 60 patients with gastric cancer.For the integrative analysis,we used established mRNA expression data published in our previous study.Whole mRNA expression levels were acquired from microarray data for 60 identical gastric cancer patients.Two gastric adenocarcinoma subgroups with distinct mRNA expression profiles presented distinctly different prognoses.MicroRNA and protein expression patterns were compared between gastric cancer tissue and normal gastric tissue and between two different prognostic groups.Aberrantly expressed microRNA,associated mRNA,and protein in patients with poor-prognosis gastric cancer were validated by quantitative reverse transcription polymerase chain reaction and immunochemistry in independent patients.RESULTS:We obtained the expression data of 1146microRNAs and 124 cancer-related proteins.Four microRNAs were aberrantly expressed in the two prognostic groups and in cancer vs non-cancer tissues(P<0.05).In the poor-prognosis group,miR-196b,miR-135b,and miR-93 were up-regulated and miR-29c*was down-regulated.miR-196b expression positively correlated with Homeobox A10(HOXA10)expression(r=0.726,P<0.001),which was significantly increased in poor-prognosis patients(P<0.001).Comparing gastric cancer with non-cancer tissues,46/124 proteins showed differential expression(P<0.05);COX2(P<0.001)and cyclin B1(P=0.017)were clearly overexpressed in the poor-prognosis group.CONCLUSION:Co-activation of miR-196b and HOXA10characterized a poor-prognosis subgroup of patients with gastric cancer.Elucidation of the biologic function of miR-196b and HOXA10 is warranted. | Jae Yun Lim Sun Och Yoon So-Young Seol Soon Won Hong Jong Won Kim Seung Ho Choi Ju-Seog Lee Jae Yong Cho | 2013 | World Journal of Gastroenterology2013，19，41： | 10 |
| 3 | Thioredoxin and thioredoxin-interacting protein as prognostic markers for gastric cancer recurrence显示文摘AIM:To evaluate the potential of thioredoxin (TXN) and thioredoxin-interacting protein (TXNIP) expression as biomarkers for predicting gastric cancer recurrence. METHODS:TXN and TXNIP expression levels were acquired from gene expression microarray data for 65 human gastric cancer tissues. We determined whether each gene expression level was associated with cancer recurrence and investigated the relationship between the two genes. For validation, the expression levels of TXN and TXNIP were measured by quantitative real- time reverse transcription polymerase chain reaction in 68 independent stage Ⅲ gastric cancer patients. The correlation between gene expression and cancer prognosis was evaluated. Immunohistochemical staining was performed to investigate the protein expression levels of TXN and TXNIP and to characterize the expression patterns of each protein. RESULTS:TXN was a prognosis-related gene (P = 0.009), whereas TXNIP, a TXN inhibitor, demonstrated a negative correlation with TXN in the gene expression microarray data. In the 68 stage Ⅲ patients, the expression levels of both TXN and TXNIP had a statistically significant effect on recurrence-free survival (RFS, P = 0.008 and P = 0.036, respectively). The low TXN and high TXNIP expression group exhibited a better prognosis than the other groups, and the high TXN and low TXNIP expression group exhibited a poorer prognosis (P < 0.001 for RFS and P = 0.001 for overall survival). More than half of the patients in the simulta-neously high TXN and low TXNIP expression group ex- perienced a recurrence within 1 year after curative surgery, and the 5-year survival rate of the patients in this group was 29%, compared with 89% in the low TXN and high TXNIP expression group. The TXN protein was overexpressed in 65% of the gastric cancer tissues, whereas the TXNIP protein was underexpressed in 85% of the cancer cells. In a correlation analysis, TXN and TXNIP were highly correlated with many oncogenes and tumor suppressors as well as with genes related to energy, protein synthesis and autophagy. CONCLUSION:TXN and TXNIP are promising prognostic markers for gastric cancer, and performing personalized adjuvant treatment based on TXN and TXNIP expression levels would be an effective practice in the treatment of gastric cancer. | Jae Yun Lim Sun Och Yoo Soon Won Hong Jong Won Kim Seung Ho Choi Jae Yong Cho | 2012 | World Journal of Gastroenterology2012，18，39： | 4 |
| 4 | An improved stator flux estimation for speed sensorless stator flux orientation control of induction motors显示文摘 | Shin Myoung Ho Hyun Dong Seok Cho Soon Bond | 2000 | IEEE Transactions on Power Electronics2000，15，2： | 1 |
| 5 | Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study显示文摘 | Hyun Joo Jang Jung Han Kim Hun Ho Song Kyung Hee Woo Mi Kim Sea Hyub Kae Jin Lee Ji Wong Cho Jung Hun Kang Soon Il Lee Soo Jung Gong Jung Ae Lee Dae Young Zang | 2008 | Digestive Diseases and Sciences2008，，2： | 1 |
| 6 | 3-Dimensional Finite Element Analysis of the Residual Stress by Cold Expansion Method and Interference Fit显示文摘 | Jae Soon Jang Myoung Rae Cho Won Ho Yang | 2006 | Key Engineering Materials2006，，326328： | 1 |
| 7 | Upstream regulation of matrix metalloproteinase by EMMPRIN; extracellular matrix metalloproteinase inducer in advanced atherosclerotic plaque显示文摘 | Young Won Yoon Hyuck Moon Kwon Ki-Chul Hwang Eui-Young Choi Bum-kee Hong Dongsoo Kim Hyun-Seung Kim Sang Ho Cho Kyung Soon Song Giuseppe Sangiorgi | 2004 | Atherosclerosis2004，，1： | 1 |
| 8 | Focal Fibrocartilaginous Dysplasia of Long Bones: Report of Eight Additional Cases and Literature Review显示文摘 | In Ho Choi Chong Jai Kim Tae-Joon Cho Chin Youb Chung Kwang Soon Song Jai Kwang Hwang Young Jin Sohn | 2000 | Journal of Pediatric Orthopaedics2000，，4： | 1 |
| 9 | Comparison of Surface Roughness and Bacterial Adhesion Between Cosmetic Contact Lenses and Conventional Contact Lenses显示文摘 | Yong Woo Ji Young Joo Cho Chul Hee Lee Soon Ho Hong Dong Yong Chung Eung Kweon Kim Hyung Keun Lee | 2015 | Eye & Contact Lens: Science & Clinical Practice2015，，1： | 1 |
| 10 | Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma显示文摘 | Ji Hye Choi Young-Seok Cho Yoon Ho Ko Soon Uk Hong Jin Hee Park Myung Ah Lee Robert Odze | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 11 | An improved stator flux estimation for speed sensorless stator flux orientation control of induction motors显示文摘 | Myoung Ho Shin Dong Seok Hyun Cho Soon Bong | 2000 | IEEE Transaction on Power Electronics2000，5，2： | 1 |
| 12 | Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in Cow Milk Allergy显示文摘 | Joonyong Noh Jae Ho Lee Geunwoong Noh So Young Bang Hyuk Soon Kim Wahn Soo Choi Sunheui Cho Sang Sun Lee | 2010 | Cellular Immunology2010，，： | 1 |
| 13 | Mul- tideterctor computed tomography findings and correlations with proteinuria in nutcracker syndrome 显示文摘 | Byoung Soo Cho Jin Soon Suh Won Ho Hahn | 2009 | Pediatr Neph- rol2009，10，： | 1 |
| 14 | A randomized comparative study of high-dose and low-dose hepatic arterial infusion chemotherapy for intractable, advanced hepatocellular carcinoma显示文摘 | Hyun Young Woo Si Hyun Bae Jun Yong Park Kwang Hyub Han Ho Jong Chun Byung Gil Choi Hyeon U. Im Jong Young Choi Seung Kew Yoon Jae Youn Cheong Sung Won Cho Byoung Kuk Jang Jae Seok Hwang Sang Gyune Kim Young Seok Kim Yeon Seok Seo Hyung Joon Yim Soon Ho U | 2010 | Cancer Chemotherapy and Pharmacology2010，，2： | 1 |
| 15 | A randomized trial of nursing interventions supportln8 recovery of the postmastectomy patient显示文摘 | Ho Soon Miehelle Cho Gail C Davisjae Elm Paek | 2012 | Journal of Clinical Nursing2012，22，10： | 1 |
| 16 | Biochemical methane potential and solid state anaerobic digestion of Korean food wastes显示文摘 | Jae Kyong Cho Soon Chul Park Ho Nam Chang | 1995 | BioresourceTechnology1995，52，： | 1 |
| 17 | Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma显示文摘 | Choong-Kyun Noh Soon Sun Kim Dong-Kyu Kim Hyun-Young Lee Hyo Jung Cho So Young Yoon Gil Ho Lee Sun A Hyun Yu Jeong Kim Ho Joong Kim Joo An Hwang Seun Joo Ahn Sung Jae Shin Kee Myung Lee Byung Moo Yoo Sung Won Cho Jae Youn Cheong | 2014 | Clinical Biochemistry2014，，： | 1 |
| 18 | Design of steel and composite beams with web openings 显示文摘 | Richard Redwood Soon Ho Cho | 1993 | Journal of Constructional Steel Research1993，25，12： | 1 |
| 19 | Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model显示文摘 | Soo Lim Ji Won Yoon Sung Hee Choi Bong Jun Cho Jun Tae Kim Ha Soon Chang Ho Seon Park Kyong Soo Park Hong Kyu Lee Young-Bum Kim Hak Chul Jang | 2009 | Metabolism2009，，1： | 1 |
| 20 | An improved stator flux estimation for speed sensorless stator flux orientation control of induction motors显示文摘 | Shin Myoung Ho Hyun Dong Seok Cho Soon Bong | 2000 | IEEE Transactions of Power Electronics2000，15，2： | 1 |
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