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| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | Separation and Purification of Thrombin-like Enzymes by Affinity Adsorbents显示文摘An affinity adsorbent, benzamidine Sepharose 4B, was used to separate and purify thrombin like enzymes. The p aminobenzamidine as a specific ligand was coupled to the matrix-Sepharose 4B. The recombinant thrombin like enzyme-defibrase was used as a model in order to evaluate the efficiency of this biospecific affinity adsorbent. The homogeneity of the enzyme preparation was comfirmed as one band on sodium dodecyl sulfate polyacrylamide gel electrophoresis. | 杨青 Xu Xiaoming Hu Xuejun Gao Xiaorong Dong Xinyan Su Zhiguo An Lijia | 2001 | High Technology Letters2001，7，4： | 2 |
| 3 | Stilbene-containing polyactylenes:Molecular design,synthesis,and relationship between molecular structure and NLO properties显示文摘 | Xinyan Su Hongyao Xu Quanzhen Guo | 2008 | Journal of Polymer Science:Part A:Polymer Chemistry2008，46，： | 1 |
| 4 | Cosolvent effects on the diffusions of 1,3-dichlorobenzene, L-carvone, geraniol and 3-fluorophenol in supercriticai carbon dioxide显示文摘 | DONG Xinyan SU Baogen XING Huabin | 2011 | J of Supercritical Fluids2011，58，2： | 1 |
| 5 | Optica-limiting and nonlinear optical polyacetylenes:Synthesis azobenzene-containing poly(1-alkynes) with different spacer and tail lengths显示文摘 | Shouchun Yin Hongyao Xu Xinyan Su | 2006 | J Polymer Science:Part A Polymer Chemistry2006，44，： | 1 |
| 6 | 显示文摘 | Yin Shouchun Su Xinyan Xu Hongyao | 2004 | Journal of Functional Materials2004，35，： | 1 |
| 7 | Cosolvent effects on the diffusions of 1,3 dichlorobenzene, L-carvone, geraniol and 3-{luorophenol in supereritical carbon dioxide 显示文摘 | Dong Xinyan Su Baogen Xing Huabin | 2011 | Journal of SupercriticalFluides2011，58，21： | 1 |
| 8 | Preparation and optical limiting properties of polyurethane containing long conjugated chromophores 显示文摘 | SU Xinyan WU Lei YIN Shouchun | 2007 | Journal of Maeromoleeular Science : Part A2007，44，7： | 1 |
| 9 | Photovoltaic Properties of Titanium Dioxide Nanowires with Different Crystal Structures显示文摘 | WANG Xinyan WANG Huan YANG Xiaotian SU Xingguang | 2016 | Chemical Research in Chinese Universities2016，32，4： | 1 |
| 10 | Optical-limiting and nonlinear optical polyacetylenes:Synthesis azobenzene-containing poly(1-alkynes) with different spacer and tail lengths显示文摘 | Shouchun Yin Hongyao Xu Xinyan Su | 2006 | J Polymer Science:Part A Polymer Chemistry2006，44，： | 1 |
| 11 | Topological Disk Mesh Morphing Based on Area-Preserving Parameterization显示文摘 | CHEN Cailing SU Kehua ZHU Xinyan | 2018 | Wuhan University Journal of Natural Sciences2018，23，3： | 0 |
| 12 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 13 | Cationic ordering transition in oxygen-redox layered oxide cathodes显示文摘Understanding the structural origin of the competition between oxygen 2p and transition-metal 3d orbitals in oxygen-redox(OR)layered oxides is eminently desirable for exploring reversible and high-energy-density Li/Na-ion cathodes.Here,we reveal the correlation between cationic ordering transition and OR degradation in ribbon-ordered P3-Na_(0.6)Li_(0.2)Mn_(0.8)O_(2) via in situ structural analysis.Comparing two different voltage windows,the OR capacity can be improved approximately twofold when suppressing the in-plane cationic ordering transition.We find that the intralayer cationic migration is promoted by electrochemical reduction from Mn^(4+)to Jahn–Teller Mn^(3+)and the concomitant NaO_(6) stacking transformation from triangular prisms to octahedra,resulting in the loss of ribbon ordering and electrochemical decay.First-principles calculations reveal that Mn^(4+)/Mn^(3+)charge ordering and alignment of the degenerate eg orbital induce lattice-level collective Jahn–Teller distortion,which favors intralayer Mn-ion migration and thereby accelerates OR degradation.These findings unravel the relationship between in-plane cationic ordering and OR reversibility and highlight the importance of superstructure protection for the rational design of reversible OR-active layered oxide cathodes. | Xinyan Li Ang Gao Qinghua Zhang Hao Yu Pengxiang Ji Dongdong Xiao Xuefeng Wang Dong Su Xiaohui Rong Xiqian Yu Hong Li Yong-Sheng Hu Lin Gu | 2024 | Carbon Energy2024，6，1： | 0 |
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