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| 1 | Influence of Al-Ti-B addition on the microstructure and mechanical properties of A356 alloys显示文摘The mechanical properties (σb,σ0.2,and δ) and fracture behavior of tensile specimens of the refined A356 alloys were investigated as a function of the addition level of Al-Ti-B master alloy under both as-cast and T6 heat-treated conditions. The results show that as the addition level of Al-5Ti-1B master alloy increases from 0.1 wt.% to 5.0 wt.%,the mechanical properties of refined A356 alloys improve steadily and then decrease slightly under both as-cast and T6 heat-treated conditions. Also,they display excellent mechanical properties with σb = 231.30-258.30 MPa,σ0.2 =134.00-155.50 MPa,and δ = 8.5%-11.75% at T6 heat-treated state. The excellent mechanical properties of refined A356 alloys are ascribed to the formation of α-Al equiaxed dendrites,the improvement of eutectic structure from needle/plate-like to short-lathy/block-shaped,and the Mg2Si aging precipitation phase after T6 heat treatment. The fracture surface examined by SEM exhibits a mixed fracture mode of refined A356 alloys at as-cast state,while it reveals a ductile fracture mode after T6 heat treatment. | Zhu Man Yang Gencang Yao Lijuan Cheng Suling Zhou Yaohe | 2009 | Rare Metals2009，28，2： | 11 |
| 2 | A seasonal hybrid procedure for electricity demand forecasting in China显示文摘 | Suling Zhu Jianzhou Wang Weigang Zhao Jujie Wang | 2011 | Applied Energy2011，，11： | 1 |
| 3 | Combined Modeling for Electric Load Forecasting with Adaptive Particle Swarm Optimization显示文摘 | Wang Jianzhou Zhu Suling Zhang Wenyu | | 0，，35： | 1 |
| 4 | Chiral metal-containing ionic liquid:Synthesis and applications in the enantioselective cycloaddition of carbon dioxide to epoxides显示文摘A series of novel chiral metal-containing ionic liquids(CMILs) consisting of the cation of crown ether-chelated potassium/sodium and the anion of chiral amino acids were designed and synthesized.These new CMILs were used to catalyze the enantioselective cycloaddition of epoxides and carbon dioxide incorporating with the salenCo(OOCCCl3) to generate corresponding chiral cyclic carbonates under mild conditions.These new catalysts can be recycled at least five times without significant loss of activity and enantioselectivity. | SONG YingYing JIN QianRu ZHANG SuLing JING HuanWang ZHU QianQian | 2011 | Science China Chemistry2011，54，7： | 1 |
| 5 | Microstructures and Morphology Evolution of Icosahedral Phase of As-cast Mg_(67.4)Zn_(28.9)Y_(3.7) Ternary Alloy Subjected to the Pouring Temperature显示文摘The microstructure,chemical composition and morphology evolution of icosahedral quasicrystalline phase of Mg67.4Zn28.9Y3.7 ternary alloy were investigated in detail at different pouring temperatures by X-ray diffraction(XRD),scanning electron microscopy(SEM) and energy-dispersive spectrum(EDS).Low interfacial energy favors the formation of I-phase.The experimental results show that the primary I-phase reveals petal-shaped with five and six branches,where each branch has facetted growth morphology with the size ranging from 50 to 100 μm.As the temperature decreases,the polygon-shaped I-phase forms,attributed to the decomposition of branch of petal-shaped I-phase,and then it grows bigger and some of the fine polygons join together to form large polygons.Besides these,(α-Mg+I-phase) eutectic structures disappear and the relative amount of Mg7Zn3 phase increases as the pouring temperature decreases.The chemical composition and morphology evolution of I-phase were also discussed. | Man Zhu Gencang Yang Diqing Wan Suling Cheng Yaohe Zhou | 2009 | Journal of Materials Science & Technology2009，25，4： | 1 |
| 6 | Distribution of YAP in 10 populations of China显示文摘The Y_chromosome Alu polymorphism was studied in 10 populations in China. The Alu insertion is present in 54/571 individuals (9%). Among 10 populations, the frequency of YAP element is quite high (49%) in the Tibetans and at moderate or low levels (15%-4%) in the Yi, Hui and Uygur. The Alu insertion is absent in the Han in Guangdong and Shaanxi, and in the Manchu and Zhuang, while a single Tujia individual and a single Yao individual are found to have the Alu insertion. | Xu Liping Xu Jiujin Zhu Suling Bao Weidong Du Ruofu | 1998 | Chinese Science Bulletin1998，43，12： | 1 |
| 7 | MSY2: a slowly evolving minisatellite on the hman Y chromosome which provides a useful polymorphic marker in Chinese populations显示文摘 | Weidong Bao Suling Zhu Arpita Pandya Tatiana Zerjal Jiujin Xu | 2000 | Gene2000，244，： | 1 |
| 8 | Prmt1 upregulated by Hdc deficiency aggravates acute myocardial infarction via NETosis显示文摘Neutrophils are mobilized and recruited to the injured heart after myocardial infarction,and neutrophil count has been clinically implicated to be associated with coronary disease severity.Histidine decarboxylase(HDC)has been implicated in regulating reactive oxidative species(ROS)and the differentiation of myeloid cells.However,the effect of HDC on neutrophils after myocardial infarction remains unclear.Here,we found that neutrophils were disorderly recruited into the ischemic injured area of the myocardium of Hdc deficiency(Hdc^(−/−))mice.Moreover,Hdc deficiency led to attenuated adhesion but enhanced migration and augmented ROS/neutrophil extracellular traps(NETs)production in neutrophils.Hdc^(−/−)mouse-derived NETs promoted cardiomyocyte death and cardiac fibroblast proliferation/migration.Furthermore,protein arginine methyltransferase 1(PRMT1)was increased in Hdc^(−/−)mouse-derived neutrophils but decreased with exogenous histamine treatment.Its expression could be rescued by blocking histamine receptor 1(H1R),inhibiting ATP synthesis or reducing SWItch/sucrose non fermentable(SWI/SNF)chromatin remodeling complex.Accordingly,histamine or MS023 treatment could decrease ROS and NETs ex vivo,and ameliorated cardiac function and fibrosis,along with the reduced NETs in plasma in vivo.Together,our findings unveil the role of HDC in NETosis by histamine–H1R–ATP–SWI/SNF–PRMT1–ROS signaling and provide new biomarkers and targets for identifying and tuning the detrimental immune state in cardiovascular disease. | Zhiwei Zhang Suling Ding Zhe Wang Xiaowei Zhu Zheliang Zhou Weiwei Zhang Xiangdong Yang Junbo Ge | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 9 | IgE Reactivity of Potential Allergens from the Swimming Crab Portunus trituberculatus and the Research of ELISA Reagent for Detecting Crab Food Anaphylaxis显示文摘Crustacean is one of the major allergic foods.It is of great significance to identify more crab allergens and research the detection methods for crab food anaphylaxis.In this study,IgE reactivity to three recombinant proteins from Portunus trituberculatus,including tropomyosin(rPtTM),myosin light chain(rPtMLC),and pancreatic lipase(rPtPL),were detected by enzyme-linked im-munosorbent assay(ELISA).The expressions of tropomyosin(TM)in various tissues of P.trituberculatus were detected by Western blot(WB).Furthermore,microplates were coated with rPtTM and the ELISA conditions were optimized.The cut-off value was deter-mined by the receiver operating characteristic(ROC)curve.Among 51 crab-allergic sera,21(41.2%)showed positive IgE to rPtTM.Other 70 crab-allergic sera more frequently recognized rPtPL(9/70;12.9%),followed by rPtMLC(1/70;1.4%).WB results showed that TM was mainly expressed in the muscle,followed by the heart and a small amount in gills and the testis.The optimal results showed that the coating condition of rPtTM was 50 ng per well with coating for 3 h at 37℃.The optimal blocking condition was 1.2%BSA with blocking for 3 h at 37℃,and the optimal dilution of the second antibody was 1:1500.The ROC curve showed that the ELISA reagent had high sensitivity(83.52%)and specificity(98.00%)when the cut-off value was 0.45.All results indicated that tropomyosin is the major allergen of P.trituberculatus,and myosin light chain and pancreatic lipase are the potential allergens.Addi-tionally,the ELISA reagent developed with the rPtTM was feasible for laboratory detection of crab anaphylaxis. | QIU Xueni ZHOU Qiongyan ZHU Xiaoxia LIN Wei MU Changkao LI Ronghua YE Yangfang SONG Weiwei SHI Ce LIU Lei WANG Huan WANG Chunlin XU Suling | 2022 | Journal of Ocean University of China2022，21，2： | 0 |
| 10 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 11 | Activation of histamine/H R signaling pathway promotes cardiac differentiation and maturation of human induced pluripotent stem cells显示文摘The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes(hiPSC CMs)is crucial for regenerative medicine,disease modeling,drug screening and the study of the development events during cardiac specification.However,their applications have been hampered by the differentiation efficiency,poor maturation and high interline variability.Recent studies have reported that histamine plays important roles in hema topoietic stem cell proliferation and neutrophil maturation.However,its roles in cardiovascular tissue regeneration have not been thoroughly investigated.In the current study,we identified a novel physiological function of the histamine/histamine 1 receptor(H,R)signal in regulating the differentiation of hiPSC-CMs and heart development. | Zhu Xiaowei Ding Suling Zhu Baoling Wang Xiangfei Zou Yunzeng Yang Xiangdong Ge Junbo | 2021 | 解剖学杂志2021，44，S01： | 0 |
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