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| 1 | The C_2H_2 -type Zinc Finger Protein ZFP182 is Involved in Abscisic Acid-Induced Antioxidant Defense in Rice显示文摘C2H2 -type zinc finger proteins (ZFPs) are thought to play important roles in modulating the responses of plants to drought, salinity and oxidative stress. However, direct evidence is lacking for the involvement of these ZFPs in abscisic acid (ABA)-induced antioxidant defense in plants. In this study, the role of the rice (Oryza sativa L. sub. japonica cv. Nipponbare) C 2 H 2 -type ZFP ZFP182 in ABA-induced antioxidant defense and the relationship between ZFP182 and two rice MAPKs, OsMPK1 and OsMPK5 in ABA signaling were investigated. ABA treatment induced the increases in the expression of ZFP182, OsMPK1 and OsMPK5, and the activities of superoxide dismutase (SOD) and ascorbate peroxidase (APX) in rice leaves. The transient gene expression analysis and the transient RNA interference (RNAi) analysis in protoplasts showed that ZFP182, OsMPK1 and OsMPK5 are involved in ABA-induced up-regulation in the activities of SOD and APX. Besides, OsMPK1 and OsMPK5 were shown to be required for the up-regulation in the expression of ZFP182 in ABA signaling, but ZFP182 did not mediate the ABA-induced up-regulation in the expression of OsMPK1 and OsMPK5. These results indicate that ZFP182 is required for ABA-induced antioxidant defense and the expression of ZFP182 is regulated by rice MAPKs in ABA signaling. | Hong Zhang Lan Ni Yanpei Liu Yunfei Wang Aying Zhang Mingpu Tan Mingyi Jiang | 2012 | Journal of Integrative Plant Biology2012，54，7： | 23 |
| 2 | USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors显示文摘(K63 ) 离氨酸 63 连接了 RIG-I 戏的 ubiquitination 在类型的激活的一个关键角色我干扰素小径,然而,为它的 deubiquitination 负责的分子的机制仍然糟糕被理解。这里,我们报导 deubiquitination 酶 ubiquitin 特定的朊酶(USP3 ) 3 否定地调整类型的激活我干扰素由指向 RIG-I 发信号。USP3 击倒 RIG-I 的明确地提高的连接 K63 的 ubiquitination, upregulated IRF3 的 phosphorylation 并且扩充了类型的生产我干扰素 cytokines 和抗病毒的免疫。我们进一步证明在 unstimulated 或 uninfected 房间在 USP3 和 RIG-I-like 受体( RLR )之间没有相互作用,但是在病毒的感染或 ligand 刺激之上, USP3 绑在 RLR 的 caspase 激活招募领域然后通过它的锌手指的合作劈开 polyubiquitin 链Ub有约束力的领域和 USP 催化领域。变化分析表明到 RIG-I 上的 polyubiquitin 链的 USP3 的那绑定是为它 polyubiquitin 链的劈开的前提步。我们的调查结果在 RIG-I 激活识别 USP3 的一个以前未被认出的角色并且提供卓见进 USP3 由禁止 RIG-I 发信号和抗病毒的免疫的机制。 | Jun Cui Yanxia Song Yinyin Li Qingyuan Zhu Peng Tan Yunfei Qin Helen Y Wang Rong-Fu Wang | 2014 | Cell Research2014，24，4： | 20 |
| 3 | Tianwen-1 MINPA observations in the solar wind显示文摘The Mars Ion and Neutral Particle Analyzer(MINPA)is one of the three scientific instruments onboard the Tianwen-1 orbiter to investigate the Martian space environment.During Tianwen-1’s transfer orbit to Mars,the MINPA was switched on to measure the solar wind ions.Here,we present the first results of the MINPA observations in the solar wind.During cruise,nearly half of the MINPA ion field-of-view(FOV)was blocked by the lander capsule;thus only the solar-wind ions with azimuthal speeds pointing towards the unblocked FOV sectors could be detected.We perform a detailed comparison of the MINPA’s solar wind observations with data from Earth-based missions when MINPA reached its count-rate peak,finding a general consistency of the ion moments between them.The blocking effect due to the lander is evaluated quantitatively under varying solar-wind velocity conditions.Despite the blocking effect,the MINPA’s solar wind measurements during the transfer orbit suggest a good performance. | AiBing Zhang LingGao Kong WenYa Li Lei Li BinBin Tang ZhaoJin Rong Yong Wei JiJie Ma YiTeng Zhang LiangHai Xie YuXian Wang JianSen He Bin Liu WenJing Wang Bin Su JiaWei Li Xu Tan Fang Wang TaiFeng Jin FuHao Qiao Peter Wurz Yan Zhu YunFei Bai YiRen Li XinBo Zhu YueQiang Sun YongLiao Zou Chi Wang | 2022 | Earth and Planetary Physics2022，6，1： | 5 |
| 4 | Boosting of the enhanced permeability and retention effect with nanocapsules improves the therapeutic effects of cetuximab显示文摘Objective:The introduction of therapeutic antibodies(tAbs)into clinical practice has revolutionized tumor treatment strategies,but their tumor therapy efficiency is still far below expectations because of the rapid degradation and limited tumor accumulation of tAbs.Methods:We developed a nanocapsule-based delivery system to induce the self-augmentation of the enhanced permeability and retention(EPR)effect.This system constantly penetrated across the blood-tumor barrier into the tumor while avoiding the attack of tAbs by the immune system.The biodistribution and therapeutic effect were tested with single dose administration of nanocapsule-tAbs in vivo.Results:The accumulation of Nano(cetuximab)within subcutaneous PC9 tumors was gradually enhanced over 6 days after single dose administration,which was contrary to the biodistribution of native cetuximab.Nano(cetuximab)accumulated in tumor tissues via the EPR effect and released cetuximab.The released cetuximab acted on vascular endothelial cells to destroy the blood-tumor barrier and induce self-augmentation of the EPR effect,which in turn contributed to further tumor accumulation of long-circulating Nano(cetuximab).Compared with single dose administration of native cetuximab,Nano(cetuximab)showed an effective tumor suppressive effect for 3 weeks.Conclusions:The nanocapsule-based delivery system efficiently delivered tAbs to tum or tissues and released them to boost the EPR effect,which facilitated further tumor accumulation of the tAbs.This novel self-augmentation of the EPR effect facilitated by the biological characteristics of tAbs and nanotechnology contributed to the improvement of the therapeutic effect of tAbs,and stimulated new ideas for antibody-based tumor therapy. | Chao Yang Yanli Tan Hongzhao Qi Junhu Zhou Lixia Long Qi Zhan Yunfei Wang Xubo Yuan Chunsheng Kang | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 5 | Quantification constraints on time gap for comagmatic gold deposits:Evidence from chronological statistics显示文摘The time gap between diagenesis and mineralization (TGDM) for comagmatic gold deposits (CGD) plays an important role in confirming the genetic relationship between gold deposits and their related intrusions. With the help of preciously published isotopic ages of some typical gold deposits and their related rocks in China,the authors have discussed and quantified the distribution characteristics and scope of the TGDM. Statistical analyses and Kolmogorov tests showed that mineralizing events are either contemporaneous with or slightly postdate their cognate magma. The TGDM conforms with normal distributions at a 0.05 confidence level and clusters between 0 and 16.0 Ma with a mean of 7.0 Ma. Thus,if the TGDM of CGD is less than 16.0 Ma,it is reasonable to consider,with the aid of other evidence,the possibility of its comagmatic genetic affiliation. The authors also emphasized that to get a precise time gap it is necessary to strengthen the diagenesis-mineralization geological background of the deposits studied,and to pay attention to the study of time gap in combination with trace elements and isotope tracing. | TAN Jun WEI Junhao LI Shuiru ZHANG Chunhua LI Yanjun GUO Lingli YAN Yunfei | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 1 |
| 6 | Structural Modification of Al65Cu16.5Ti18.5 Amorphous Powder through Annealing and Post Milling: Improving Thermal Stability显示文摘To improve thermal stability of the Al65Cu16.5Ti18.5 amorphous powder,structural modification of the amorphous powder was performed through annealing and post milling.Annealing above the crystallization temperature(Tx) not only induced nanoscale intermetallics to precipitate in the amorphous powder,but also increased Cu atomic percentage within the residual amorphous phase.Post milling induced the amorphization of the nanocrystal intermetallics and the formation of Cu9Al4 from the residual amorphous phase.Thus,a mixed structure consisting of amorphous phase and Cu9Al4 was obtained in the powder after annealing and post milling(the APMed powder).The phase constituent in the APMed powder did not change during the post annealing,which exhibited significantly improved thermal stability in comparison with the as-milled amorphous powder. | Zhen Tan Lu Wang Yunfei Xue Xingwang Cheng Long Zhang | 2016 | Journal of Materials Science & Technology2016，32，12： | 1 |
| 7 | Aptamers selected by cell-SELEX for application in cancer studies显示文摘 | Yunfei Zhang Yan Chen Da Han Ismail Ocsoy Weihong Tan | 2010 | Bioanalysis2010，，5： | 1 |
| 8 | Ion specificity in NaCl solution confined in silicon nanochannels显示文摘Ion specificity of Na+and Cl ions for NaCl solution confined in silicon nanochannels is investigated with molecular dynamics(MD)simulations.The MD simulation results demonstrate that ion specificity for Na+and Cl ions exhibits clearly in nanochannels with high surface charge density.The two types of ions show different density distributions perpendicular to the channel surface due to the ion specificity when they act as counterions near negatively and positively charged surfaces,respectively.Both the two counterion distributions cannot be predicted by Poisson-Boltzmann equation within 0.75 nm near the surface.In addition,the ion specificity is also demonstrated through affecting the water density distributions.In the nanochannel with negatively charged surfaces,the presence of the Na+ions reduces the number of water peaks in water density distribution profile.In comparison,when the Cl ions act as counterions near positively charged surfaces,they do not affect the number of the water peaks.Besides the influence on the water density distribution,ion specificity also exhibits through affecting the water molecule orientation in the adsorbed layer.It is found that Cl ions make the water molecules in the adsorbed layer align more orderly than Na+ions do when the two types of ions act as the counterions near the positively and negatively charged surfaces with the same surface charge density. | QIU YingHua TAN QiYan SI Wei CHEN YunFei | 2014 | Science China(Technological Sciences)2014，57，1： | 1 |
| 9 | Aptamers selected by cell-SELEX for application in cancer studies显示文摘 | Yunfei Zhang Yan Chen Da Han Ismail Ocsoy Weihong Tan | 2010 | Bioanalysis2010，，5： | 1 |
| 10 | Synthesis and charac-terization of a novel superabsorbent polymer of N, O-carboxymethyl chitosan graft copolymerized with vinyl monomers显示文摘 | Chen Yu Liu Yunfei Tan Huimin | 2009 | Carbohydrate Polymers2009，75，2： | 1 |
| 11 | Study of carboxymethyl chitosan based polyampholyte superabsorbent polymer I : Opti- mization of synthesis conditions and pH sensitive property study of carboxymethyl chitosan-g-poly ( acrylic acid-co-dim- enthyldiallylammonium chloride ) superabsorbent polymer显示文摘 | Chen Yu Liu Yunfei Tan Huimin | 2010 | Carbohydrate Polymers2010，81，： | 1 |
| 12 | Identification of quantitative trait loci for growth traits in red swamp crayfish(Procambarus clarkii)显示文摘Genetic breeding is an important approach to improve the economic traits of aquaculture animals.Unfortunately,the genetic basis for important economic traits of red swamp crayfish,including growth-related traits,has not yet been reported.In the present study,two full-sib families and two natural populations were employed to identify quantitative trait loci(QTLs)for growth-related traits of red swamp crayfish.In total,28 QTLs for five growth-related traits,including body weight,body length,carapace length,carapace width,and abdomen length,were repeatedly identified in more than two families/populations,by means of association analysis;nine of these displayed a heterosis effect.The phenotypic variations of the five investigated traits explained by the 28 QTLs ranged from 4.2%to 19.0%.Eight additive and three heterosis QTLs were further successfully validated using comparative analysis of favoured alleles between the small and big size crayfish groups in the natural population.In conclusion,this study investigated the genetic basis of growth-related traits in red swamp crayfish,which is of great significance for their application in the future molecular breeding of the species. | Junxiao Sun Cuirong Luo Bo Peng Guohui Peng Yunfei Tan Xufeng Bai | 2023 | Aquaculture and Fisheries2023，8，6： | 0 |
| 13 | Inter-and intramolecular adhesion mechanisms of mussel foot proteins显示文摘Mussel foot proteins(Mfps) secreted in the byssal plaque of marine mussels are widely researched for their relevance to mussel adhesion in water. As the abundant residue in the amino acid sequences of major adhesive proteins, 3,4-dihydroxyphenylalanine(Dopa) or its catecholic moiety plays a key role in both Mfp binding to surface and cohesive cross-linking of Mfps in byssal plaques. The binding performance of an Mfp significantly depends on the content and redox state of Dopa, whereas the types of interaction vary in line with different surface chemistries and p H conditions. Thorough understanding of mussel adhesion from a molecular perspective is crucial to promote the application of synthetic mussel-bionic adhesives. This article presents a brief review of the research progress on the adhesion mechanisms of Mfps, which further emphasizes the contributions of Dopamediated interactions and considers other amino acids and factors. The involved inter-and intramolecular interactions are responsible for not only the diverse adhesion capacities of an adhesive byssal plaque as mussel's adhesion precursor but also the formation and properties of the plaque structure. | KAN YaJing WEI ZhiYong TAN QiYan CHEN YunFei | 2020 | Science China(Technological Sciences)2020，63，9： | 0 |
| 14 | TRIM14通过抑制p62介导的cGAS的选择性自噬降解促进固有免疫反应显示文摘环GMP-AMP合成酶(cGAS)是细胞内识别DNA病毒,激活免疫反应的重要受体,但是对于它翻译后修饰的调控分子机制还不甚了解。 | Meixin Chen Qingcai Meng Yunfei Qin Puping Liang Peng Tan Lian He Yubin Zhou Yongjun Chen 黄军就 Rong-Fu Wang 崔隽 | 2017 | 科学新闻2017，19，4： | 0 |
| 15 | USP38介导的NLRP4信号小体通过编辑TBK1的泛素化调控I型干扰素反应显示文摘TBK1是Ⅰ型干扰素通路中的关键激酶,但是对于其活性和蛋白稳定性的调控机制还不是非常明确。 | Meng Lin Zhiyao Zhao Zhifen Yang Qingcai Meng Peng Tan Weihong Xie Yunfei Qin Rong-Fu Wang 崔隽 | 2017 | 科学新闻2017，19，4： | 0 |
| 16 | Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma显示文摘Background Metabolism reprogramming plays a vital role in glioblastoma(GBM)progression and recurrence by producing enough energy for highly proliferating tumor cells.In addition,metabolic reprogramming is crucial for tumor growth and immune-escape mechanisms.Epidermal growth factor receptor(EGFR)amplification and EGFR-vIII mutation are often detected in GBM cells,contributing to the malignant behavior.This study aimed to investigate the functional role of the EGFR pathway on fatty acid metabolism remodeling and energy generation.Methods Clinical GBM specimens were selected for single-cell RNA sequencing and untargeted metabolomics analysis.A metabolism-associated RTK-fatty acid-gene signature was constructed and verified.MK-2206 and MK-803 were utilized to block the RTK pathway and mevalonate pathway induced abnormal metabolism.Energy metabolism in GBM with activated EGFR pathway was monitored.The antitumor effect of Osimertinib and Atorvastatin assisted by temozolomide(TMZ)was analyzed by an intracranial tumor model in vivo.Results GBM with high EGFR expression had characteristics of lipid remodeling and maintaining high cholesterol levels,supported by the single-cell RNA sequencing and metabolomics of clinical GBM samples.Inhibition of the EGFR/AKT and mevalonate pathways could remodel energy metabolism by repressing the tricarboxylic acid cycle and modulating ATP production.Mechanistically,the EGFR/AKT pathway upregulated the expressions of acyl-CoA synthetase short-chain family member 3(ACSS3),acyl-CoA synthetase long-chain family member 3(ACSL3),and long-chain fatty acid elongation-related gene ELOVL fatty acid elongase 2(ELOVL2)in an NF-κB-dependent manner.Moreover,inhibition of the mevalonate pathway reduced the EGFR level on the cell membranes,thereby affecting the signal transduction of the EGFR/AKT pathway.Therefore,targeting the EGFR/AKT and mevalonate pathways enhanced the antitumor effect of TMZ in GBM cells and animal models.Conclusions Our findings not only uncovered the mechanism of metabolic reprogramming in EGFR-activated GBM but also provided a combinatorial therapeutic strategy for clinical GBM management. | Xiaoteng Cui Jixing Zhao Guanzhang Li Chao Yang Shixue Yang Qi Zhan Junhu Zhou Yunfei Wang Menglin Xiao Biao Hong Kaikai Yi Fei Tong Yanli Tan Hu Wang Qixue Wang Tao Jiang Chuan Fang Chunsheng Kang | 2023 | Cancer Communications2023，43，12： | 0 |
| 17 | Glycerol solutions of highly concentrated biomineral counter-ions towards water-responsive mineralization: Demonstration on bacterial cellulose and its application in hard tissue repair显示文摘Mineralization has found widespread use in the fabrication of composite biomaterials for hard tissue regeneration.The current mineralization processes are mainly carried out in neutral aqueous solutions of biomineral counter-ions(a pair of cation and anion that form the corresponding minerals at certain conditions),which are stable only at very low concentrations.This typically results in inefficient mineralization and weak control over biomineral formation.Here,we find that,in the organic solvent glycerol,a variety of biomineral counter-ions(e.g.,Ca/PO_(4),Ca/CO_(3),Ca/SO_(4),Mg/PO_(4),or Fe/OH)corresponding to distinct biominerals at significantly high concentrations(up to hundreds-fold greater than those of simulated body fluid(SBF))are able to form translucent and stable solutions(mineralizing solution of highly concentrated counter-ions(MSCIs)),and mineralization can be triggered upon them with external solvents(e.g.,water or ethanol).Furthermore,with pristine bacterial cellulose(BC)membrane as a model,we demonstrate an effective and controllable mineralization performance of MSCIs on organic substrates.This approach not only forms the homogeneous biominerals on the BC fibers and in the interspaces,but also provides regulations over mineralization rate,mineral content,phase,and dopants.The resulting mineralized BC membranes(MBCs)exhibit high cytocompatibility and favor the proliferation of rat bone marrow mesenchymal stem cells(rBMSC).Following this,we prepare a mineralized bone suture(MBS)from MBC for non-weight bearing bone fixation,which then is tested on a rabbit median sternotomy model.It shows firm fixation of the rabbit sternum without causing discernible toxicity or inflammatory response.This study,by extending the mineralization to the organic solution system of highly concentrated counter-ions,develops a promising strategy to design and build targeted mineral-based composites. | Yunfei Zhao Xiaohao Liu Zhi Zhou Chaobo Feng Nan Luo Jiajun Yan Shuo Tan Yang Lu Feng Chen Bing-Qiang Lu Shisheng He | 2024 | Nano Research2024，17，3： | 0 |
| 18 | Transparent Thermally Tunable Microwave Absorber Prototype Based on Patterned VO2 Film显示文摘Transparent microwave absorbers that exhibit high optical transmittance and microwave absorption capability are ideal,although having a fixed absorption performance limits their applicability.Here,a simple,transparent,and thermally tunable microwave absorber is proposed,based on a patterned vanadium dioxide(VO_(2))film.Numerical calculations and experiments demonstrate that the proposed VO_(2)absorber has a high optical transmittance of 84.9%at 620 nm;its reflection loss at 15.06 GHz can be thermally tuned from–4.257 to–60.179 dB,and near-unity absorption is achieved at 523.750 K.Adjusting only the patterned VO_(2)film duty cycle can change the temperature of near-unity absorption.Our VO_(2)absorber has a simple composition,a high optical transmittance,a thermally tunable microwave absorption performance,a large modulation depth,and an adjustable temperature tuning range,making it promising for application in tunable sensors,thermal emitters,modulators,thermal imaging,bolometers,and photovoltaic devices. | Zhengang Lu Yilei Zhang Heyan Wang Chao Xia Yunfei Liu Shuliang Dou Yao Li Jiubin Tan | 2023 | Engineering2023，，10： | 0 |
| 19 | The hippo kinases MST1/2 in cardiovascular and metabolic diseases:A promising therapeutic target option for pharmacotherapy显示文摘Cardiovascular diseases(CVDs)and metabolic disorders are major components of noncommunicable diseases,causing an enormous health and economic burden worldwide.There are common risk factors and developmental mechanisms among them,indicating the far-reaching significance in exploring the corresponding therapeutic targets.MST1/2 kinases are well-established proapoptotic effectors that also bidirectionally regulate autophagic activity.Recent studies have demonstrated that MST1/2 influence the outcome of cardiovascular and metabolic diseases by regulating immune inflammation.In addition,drug development against them is in full swing.In this review,we mainly describe the roles and mechanisms of MST1/2 in apoptosis and autophagy in cardiovascular and metabolic events as well as emphasis on the existing evidence for their involvement in immune inflammation.Moreover,we summarize the latest progress of pharmacotherapy targeting MST1/2 and propose a new mode of drug combination therapy,which may be beneficial to seek more effective strategies to prevent and treat CVDs and metabolic disorders. | Yunfei Yin Mingyue Tan Lianhua Han Lei Zhang Yue Zhang Jun Zhang Wanqian Pan Jiaxiang Bai Tingbo Jiang Hongxia Li | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
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