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| 1 | Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma显示文摘A previous report has confirmed the existence and clinical significance of vasculogenic mimicry(VM)in glioma.However,its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and,thus,might be unconvincing.The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma.Patients were classified as VM-positive or | Wang SY Ke YQ Lu GH Song ZH Yu L Xiao S Sun XL Jiang XD Yang ZL Hu CC | 2013 | 中国神经肿瘤杂志2013，11，3： | 22 |
| 2 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 3 | Recent advances and emerging trends of rare-earth-ion doped spectral conversion nanomaterials in perovskite solar cells显示文摘Organic-inorganic lead halide based perovskite solar cells(PSCs)have attracted unprecedented research interest over last decade.The high performance,combined with merits of low fabrication costs and ease of synthesis make PSCs promising alternate to state of the art silicon(Si)based solar cells.Howeve r,some inherent shortcomings of PSCs are hindering their market dominance over conventional photovoltaic technologies such as transmission loss of sub-bandgap photons,poor stability and hysteresis effects.Recently,use of rare earth(RE)ions doped nanomaterials in PSCs,has been identified as an effective means to address the aforementioned issues by expanding the range of absorption spectra minimizing the non-absorption loss of solar photons,enhancing light scattering and improving operational stability.This article reviews the recent progress in doping rare-earth(RE)ions in the building blocks of PSCs such as semiconductor electrodes and photoactive perovskite layers,and its use as a separate spectral conversion layer in PSCs.The effect of size,shape,constitution and concentration of RE-nanoparticles on the overall performance and device stability will be analyzed in detail.Moreover,we provide an outlook on the opportunities this newly developed field offers and the critical challenges faced in rationally and effectively using RE-ion-doped nanomaterials in PSCs for better operational stability and enhanced performance. | Syed Afaq Ali Shah Muhammad Hassan Sayyad Jinghua Sun Zhongyi Guo | 2022 | Journal of Rare Earths2022，40，11： | 4 |
| 4 | Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats显示文摘 | Yang Y Liu X Long Y Wang F Ding JH Liu SY Sun YH Yao HH Wang H Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 4 |
| 5 | Design,synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents显示文摘A series of amino organophosphorus imidazoles were designed and synthesized as a novel structural type of antimicrobial agents.Bioactive evaluation in vitro showed that compound 3f exhibited equipotent or superior anti-methicillin-resistant Staphylococcus aureus(anti-MRSA) and anti-S. cerevisiae efficiencies(minimal inhibitory concentration(MIC)=2 μg/mL) to clinical drugs,and the combinations with antibacterial or antifungal drugs enhanced the antimicrobial efficiency. Highly active molecule 3f showed low propensity for bacteria to develop resistance, and the preliminary action mechanism studies demonstrated that 3f was membrane-active, but had no significant intercalation towards MRSA DNA. The computational study on 3f reasonably explained its high antimicrobial activity. Experimental data revealed that ground-state 3f-HSA complexes were formed mainly through hydrophobic interactions and hydrogen bonds with a spontaneous process, and the non-radioactive energy transfer from HSA to 3f occurred beyond F鰎ster resonance energy transfer theory. The participation of metal ions in 3f-HSA supramolucular system could increase the concentration of free compound 3f, and shorten its storage time and half-life in the blood to improve the maximum antimicrobial efficacy. | Wei-Wei Gao Syed Rasheed VijaiKumarReddy Tangadanchu Yi Sun Xin-Mei Peng Yu Cheng Feng-Xiu Zhang Jian-Mei Lin Cheng-He Zhou | 2017 | Science China Chemistry2017，60，6： | 3 |
| 6 | Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats显示文摘 | Wang S Hu LF Zhang Y Sun T Sun YH Liu SY Ding JH Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 7 | Rational Design and Application of an Indolium-Derived Heptamethine Cyanine with Record-Long Second Near-Infrared Emission显示文摘Heptamethine cyanine dyes,typified by indocyanine green,have been extensively employed as bioimaging indicators and theranostic agents.Significant efforts have been made to develop functional heptamethine cyanine dyes with outstanding bioimaging and theranostic utilities.In this work,we rationally designed and successfully developed a novel indolium-like heptamethine cyanine dye by installing indolium-derived polycyclic aromatic hydrocarbons on the terminal ends of a conjugated polyene backbone.This dye showed excellent photostability and showed bright fluorescent emission in the second near-infrared(NIR-Ⅱ)window with a peak at approximately 1120 nm.Such long wavelength emission prompted a superior bioimaging resolution in vivo.In particular,this NIR-Ⅱ dye had the remarkable capability of marking the blood vessels of the hindlimbs,abdomens,and brains of mice.More significantly,this dye involved a typical indolium-like heptamethine skeleton and exhibited two strong absorption bands in the 700–1300 nm NIR range,which endowed it with an intrinsic tumor-targeting capability and a high photothermal conversion efficiency(up to 68.2%),serving for the photothermal therapy of tumors under the guidance of NIR-Ⅱ fluorescence imaging.This work provides an efficient design strategy for achieving indolium-like heptamethine cyanine dyes with further NIR-Ⅱ emission. | Xiaoxie Ma Yurou Huang Syed Ali Abbas Abedi Heejeong Kim Tan Teck Boon Davin Xiaogang Liu Wen-Chao Yang Yao Sun Sheng Hua Liu Jun Yin Juyoung Yoon Guang-Fu Yang | 2022 | CCS Chemistry2022，4，6： | 2 |
| 8 | Optical coherence tomography characteristics of responses to intravitreal bevacizumab in idiopathic choroidal neovascularization显示文摘AIM: To investigate factors associated with responses to intravitreal bevacizumab(IVB) in naive idiopathic choroidal neovascularization(i CNV) by high domain optical coherence tomography(OCT).·METHODS: We retrospectively reviewed clinical data of40 eyes of i CNV patients who received a single or multiple IVB on an as-needed basis(1.25 mg/0.05 m L).One month after the first injection, subretinal fluid(SRF)volume was evaluated and the eyes were divided into 3groups based on responses to IVB. Good, moderate, and poor responses were defined as 61%-99%, 30%-60%,and <30% resolution of SRF on OCT after IVB in i CNV,respectively. OCT findings were analyzed to find factors associated with difference in response levels.Comparisons were made using Wilcoxon's matched-pairs signed-rank test, the Mann-Whitney U test for means with continuous data and Fisher's exact test for categorical data.·RESULTS: The mean number of IVB was 1.28±1.50 and mean follow up time was 3.60 ±1.20 mo. At postoperative1 mo, there were 8(20%) eyes in good response, 20(50%)in moderate response and 12(30%) eyes in poor response group and at last visit there were 28 good responders(70%), 8(20%) moderate responders and 4(10%) poor responders. Statistically significant difference was detected between good responders and non good responders in choroidal neovessels thickness(P =0.029),SRF height(P =0.049) and SRF volume(P =0.031) at post treatment 1mo.· CONCLUSION: OCT is a valuable diagnostic tool.Decrease in choroidal neovessels thickness, SRF height and volume predicts favorable response of i CNV to IVB therapy. | Syed Nasir Ali Shah Qian-Yan Kang Xiao-Juan Fan Yue-Ming Sun | 2016 | International Journal of Ophthalmology(English edition)2016，9，2： | 2 |
| 9 | The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-Ⅰ Interferon Response显示文摘Dengue virus(DENV) and Zika virus(ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery of new antiviral agents is critical.Herein, a scorpion venom peptide(Smp76) characterized from Scorpio maurus palmatus was successfully expressed and purified in Escherichia coli BL21(DE3). The recombinant Smp76(rSmp76) was found to effectively inhibit DENV and ZIKV infections in a dose-dependent manner in both cultured cell lines and primary mouse macrophages. Interestingly,rSmp76 did not inactivate the viral particles directly but suppressed the established viral infection, similar to the effect of interferon(IFN)-b. Mechanistically, rSmp76 was revealed to upregulate the expression of IFN-b by activating interferon regulatory transcription factor 3(IRF3) phosphorylation, enhancing the type-Ⅰ IFN response and inhibiting viral infection.This mechanism is significantly different from traditional virucidal antimicrobial peptides(AMPs). Overall, the scorpion venom peptide Smp76 is a potential new antiviral agent with a unique mechanism involving type-Ⅰ IFN responses,demonstrating that natural AMPs can enhance immunity by functioning as immunomodulators. | Zhenglin Ji Fangfang Li Zhiqiang Xia Xingchen Guo Minjun Gao Fang Sun Yuting Cheng Yingliang Wu Wenxin Li Syed Abid Ali Zhijian Cao | 2018 | Virologica Sinica2018，33，6： | 2 |
| 10 | Ocular flmgal isolates and antifungal susceptibility in northern China 显示文摘 | Sun XG Wang ZX Wang ZQ Luo SY Li R | 2007 | Am J Ophthalmol2007，143，： | 1 |
| 11 | Overexpression of Bcl-2 blocks TNF-related apoptosis-inducing ligand (TRAIL)induced apoptosis in human lung cancer cells显示文摘 | Sun SY Yue P Zhou JY | 2001 | Biochem Biophys Res Commun2001，280，： | 1 |
| 12 | Correlation between the expression of the BAG-1 gene and elinieopathologie factors in colorectal cancer显示文摘 | Sun NF Meng QY Hu SY | 2011 | J Cancer Res Clin Oneol2011，137，10： | 1 |
| 13 | Apoptosis as a novel target for cancer chemoprevention显示文摘 | Sun SY Hail N Jr Lotan R | 2004 | J Natl Cancer Inst2004，96，9： | 1 |
| 14 | Apoptosis as a novel target for cancer chemoprevention 显示文摘 | Sun SY Hail N Jr Lotan R | 2004 | J Natl Cancer lnst2004，96，9： | 1 |
| 15 | Epidemiologic investigation on an outbreak of hepatitis C显示文摘 | Sun YD Meng ZD Wang SY | | 0，，： | 1 |
| 16 | Overexpression of BCL2 blocks TNF-related-apoptosis-inducing ligand(TRAIL)-induced apoptosis in human lung cancer cells显示文摘 | Sun SY Yue P Zhou JY | 2001 | Biochem Biophys Res Commun2001，280，3： | 1 |
| 17 | Marsdenia tenacissima extract enhances gefitinib efficacy in non-small cell lung cancer xenografts显示文摘 | Han SY Zhao W Sun H Zhou N Zhou F An G | 2015 | Phytomedicine2015，22，5： | 1 |
| 18 | Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition显示文摘 | Sun SY Rosenberg LM Wang X | 2005 | Cancer Res2005，65，16： | 1 |
| 19 | Metabolic syndrome and the development of chronic kidney disease among 118 924 non- diabetic Taiwanese in a retrospective cohort 显示文摘 | Sun F Tao QS Zhan SY | 2010 | Nephrology (Carlton)2010，15，1： | 1 |
| 20 | Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfal expression显示文摘 | Hsieh TP Sheu SY Sun JS | 2010 | Phytomedicine2010，17，6： | 1 |
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