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| 1 | NK cell-based immunotherapy for malignant diseases显示文摘生来的杀手(NK ) 房间对癌症在主人免疫起关键作用。在反应,癌症开发机制逃离 NK 房间攻击或导致有缺点的 NK 房间。当前的 NK 基于房间的癌症免疫疗法试图用几条途径克服 NK 房间麻痹。一条途径使用扩展 allogeneic NK 房间,它没被象自体同源的 NK 房间一样的自我 histocompatibility 抗原禁止,为采纳细胞的免疫疗法。另一条采纳转移途径使用稳定的 allogeneic NK 房间线,它为质量控制和大规模生产是更实际的。第三条途径是新鲜 NK 房间或 NK 房间线的基因修正高度表示 cytokines, Fc 受体或妄想的肿瘤抗原受体。治疗学的 NK 细胞能从各种各样的来源被导出,包括细胞,干细胞或甚至导致的 pluripotent 干细胞( iPSCs ),和许多激发器能被用于的外设或绳索血在实验室或好生产实践( GMP )的大规模生产设备包括可溶的生长因素,使不能调动的分子或抗体,和另外的细胞的使活跃之物。到在临床的试用的癌症的对待几类型的 NK 房间治疗的一张表这里被考察。基于 NK 的免疫疗法的几条不同途径例如织物特定的 NK 房间,漂亮面向受体的 NK 房间和化学上对待的 NK 房间,被讨论。一些新技术或策略到由非侵略的成像的监视器 NK 房间治疗,预定 NK 房间治疗由的效率在 vivo 实验并且在临床的试用评估 NK 房间治疗途径也被介绍。 | Min Cheng Yongyan Chen Weihua Xiao Rui Sun Zhigang Tian | 2013 | Cellular & Molecular Immunology2013，10，3： | 61 |
| 2 | Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines显示文摘Hepatitis B virus(HBV) infection is one of the most serious and prevalent viral diseases in the world. Although several anti-HBV drugs have been used clinically, their side and adverse effects limit treatment efficacy. Therefore, it is necessary to identify novel potential anti-HBV agents. The flavonol quercetin has shown activity against some retroviruses, but its effect on HBV remains unclear. In the present study, quercetin was incubated with Hep G2.2.15 cells, as well as Hu H-7 cells transfected with an HBV plasmid. Quercetin was shown to significantly reduce Hepatitis B surface antigen(HBs Ag) and Hepatitis B e antigen(HBe Ag), secretion and HBV genomic DNA levels in both cell lines. In addition, co-incubation with lamivudine(3TC), entecavir(ETV), or adefovir(Ade) further enhanced the quercetin-induced inhibition of HBV replication. This inhibition was partially associated with decreased heat shock proteins and HBV transcription levels. The results indicate that quercetin inhibited HBV antigen secretion and genome replication in human hepatoma cell lines, which suggests that quercetin may be a potentially effective anti-HBV agent. | Zhikui Cheng Ge Sun Wei Guo Yayun Huang Weihua Sun Fei Zhao Kanghong Hu | 2015 | Virologica Sinica2015，30，4： | 20 |
| 3 | NK cells in immunotolerant organs显示文摘象肝,子宫和肺那样的机关拥有特点 immunotolerant 特征,为支撑自我动态平衡使这些机关重要。这些机关包含一相对大量否定规章的有免疫力的房间,它被相信参加有免疫力的回答的规定。因为自然漂亮细胞在这些器官组成所有淋巴细胞的一个大比例,增加的注意被给了这些细胞在维持 immunotolerance 起的作用。这里,我们在这些 immunotolerant 机关考察分发,区别, phenotypic 特征和自然漂亮房间的功能的特征,除了这些房间上的本地微型环境的影响并且这些因素怎么贡献器官特定的疾病。 | Haoyu Sun Cheng Sun Zhigang Tian Weihua Xiao | 2013 | Cellular & Molecular Immunology2013，10，3： | 13 |
| 4 | Tissue-resident lymphocytes: from adaptive to innate immunity显示文摘Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems.For multiple decades,it has been believed that CD8+memory T cells and natural killer(NK)cells constantly and uniformly recirculate.Only recently was the existence of noncirculating memory T and NK cells that remain resident in the peripheral tissues,termed tissue-resident memory T(TRM)cells and tissue-resident NK(trNK)cells,observed in various organs owing to improved techniques.TRM cells populate a wide range of peripheral organs,including the skin,sensory ganglia,gut,lungs,brain,salivary glands,female reproductive tract,and others.Recent findings have demonstrated the existence of TRM in the secondary lymphoid organs(SLOs)as well,leading to revision of the classic theory that they exist only in peripheral organs.trNK cells have been identified in the uterus,skin,kidney,adipose tissue,and salivary glands.These tissue-resident lymphocytes do not recirculate in the blood or lymphatic system and often adopt a unique phenotype that is distinct from those of circulating immune cells.In this review,we will discuss the recent findings on the tissue residency of both innate and adaptive lymphocytes,with a particular focus on CD8+memory T cells,and describe some advances regarding unconventional T cells(invariant NKT cells,mucosal-associated invariant T cells(MAIT),andγδT cells)and the emerging family of trNK cells.Specifically,we will focus on the phenotypes and functions of these subsets and discuss their implications in anti-viral and anti-tumor immunity. | Haoyu Sun Cheng Sun Weihua Xiao Rui Sun | 2019 | Cellular & Molecular Immunology2019，16，3： | 12 |
| 5 | Synergistic effect of ozonation and ionizing radiation for PVA decomposition显示文摘Ozonation and ionizing radiation are both advanced oxidation processes(AOPs) without chemical addition and secondary pollution. Also, the two processes' efficiency is determined by different p H conditions, which creates more possibilities for their combination. Importantly,the combined process of ozonation and ionizing radiation could be suitable for treating wastewaters with extreme p H values, i.e., textile wastewater. To find synergistic effects, the combined process of ozonation and ionizing radiation mineralization was investigated for degradation of polyvinyl alcohol(PVA) at different p H levels. A synergistic effect was found at initial p H in the range 3.0–9.4. When the initial p H was 3.0, the combined process of ozonation and ionizing radiation gave a PVA mineralization degree of 17%. This was 2.7 times the sum achieved by the two individual processes, and factors of 2.1 and 1.7 were achieved at initial p H of7.0 and 9.4, respectively. The combined process of ozonation and ionizing radiation was demonstrated to be a feasible strategy for treatment of PVA-containing wastewater. | Weihua Sun Lujun Chen Yongming Zhang Jianlong Wang | 2015 | Journal of Environmental Sciences2015，27，8： | 7 |
| 6 | Atrypid Brachiopods from the Upper Devonian Wangchengpo Formation(Frasnian)of southern Guizhou,China—Extinction Patterns in the Frasnian of South China显示文摘The Wangchengpo Frasnian section of Dushan County contains two atrypid brachiopod assemblages. The lower is characterized by the Atryparia (Costatrypa) dushanensis fauna that appears at the base of the Hejiazhai Member approximately in the falsiovalis to transitans conodont zones; the upper is characterized by the Radiatrypa yangi fauna, which appears in the Lujiazhai Member approximately correspondent with the hassi to Upper rhenana conodont zones. Atrypid brachiopods, together with other brachiopods from the Dushan section show that the Hejiazhai Member is of Frasnian age. Preliminary analyses of Frasnian atrypid brachiopods from sections of South China indicate that there are nine genera and subgenera including Atryparia (Costatrypa), Kyrtatrypa, Spinatrypa, Isospinatrypa, Spinatrypina, Iowatrypa, Desquamatia (Desquamatia), Desquamatia (Seratrypa), and Radiatrypa. Atrypid species diversity did not change much through the Frasnian. On a regional scale in South China, most atrypid species went extinct prior to the Frasnian/Famennian boundary. At any specific locality or section, these atrypids became extinct about 20–40 m below the Frasnian/Famennian (F/F) boundary, within the linguiformis conodont Zone, marking this as the major extinction level. Three new atrypid species are described: Atryparia (Costatrypa) dushanensis, Iowatrypa pseudobodini, and Radiatrypa yangi. | MA Xueping Paul COPPER SUN Yuanlin LIAO Weihua | 2005 | Acta Geologica Sinica(English Edition)2005，79，4： | 7 |
| 7 | Atomic mobilities and diffusivities in Al alloys显示文摘Knowledge of diffusivity is a prerequisite for understanding many scientific and technological disciplines.In this paper,firstly major experimental methods,which are employed to provide various diffusivity data,are briefly described.Secondly,the fundamentals of various computational methods,including first-principles method,embedded atomic method/molecular dynamic simulation,semi-empirical approaches,and phenomenological DICTRA technique,are demonstrated.Diffusion models recently developed for order/disorder transitions and stoichiometric compounds are also briefly depicted.Thirdly,a newly established diffusivity database for liquid,fcc_A1,L12,bcc_A2,bcc_B2,and intermetallic phases in the multicomponent Al alloys is presented via a few case studies in binary,ternary and quaternary systems.And the integration of various computational techniques and experimental methods is highlighted.The reliability of this diffusivity database is validated by comparing the calculated and measured concentration profiles,diffusion paths,and Kirkendall shifts in various binary,ternary and quaternary diffusion couples.Next,the established diffusivity databases along with thermodynamic and other thermo-physical properties are utilized to simulate the microstructural evolution for Al alloys during solidification,interdiffusion and precipitation.A special discussion is presented on the phase-field simulation of interdiffusion microstructures in a series of Ni-Al diffusion couples composed of γ,γ',and β phases under the effects of both coherent strain and external compressive force.Future orientations in the establishment of next generation of diffusivity database are finally addressed. | DU Yong ZHANG LiJun CUI SenLin ZHAO DongDong LIU DanDan ZHANG WeiBin SUN WeiHua JIE WanQi | 2012 | Science China(Technological Sciences)2012，55，2： | 6 |
| 8 | A review:Synthesis,modification and photocatalytic applications of ZnIn_(2)S_(4)显示文摘Solar energy is an ideal energy source for solving energy shortages and serious environmental problems.In the past few decades,photocatalytic technology which uses solar energy to deal with the above problems has caused great interest.ZnIn_(2)S_(4),as a layered ternary metal chalcogenide compound,has a series of advantages such as the wide light absorption range and adjustable bandgap.It has been applied in the different fields of photocatalysis in recent years.This review introduced the crystal structures and growth mechanism of ZnIn_(2)S_(4)and summarized the preparation methods of ZnIn_(2)S_(4).Also,the promoted strategies of ZnIn_(2)S_(4)based photocatalytic system and their applications in the pollutant removal,hydrogen evolution,reduction of CO_(2),nitrogen fixation,and chemical synthesis was summarized.Furthermore,the challenges and development directions of the current ZnIn_(2)S_(4)based photocatalytic system were proposed.It is hoped that this review will help researchers design a better ZnIn_(2)S_(4)based photocatalytic system. | Jie Wang Sijia Sun Run Zhou Yangzi Li Zetian He Hao Ding Daimei Chen Weihua Ao | 2021 | Journal of Materials Science & Technology2021，，19： | 6 |
| 9 | Microstructure Characterization of High-heat-input Welding Joint of HSLA Steel Plate for Oil Storage Construction显示文摘In this paper, microstructure and mechanical properties of welding metals in 610 MPa high strength low alloy (HSLA) were studied after high-heat-input welding. Both the base material and the weld joint proved excellent strength and toughness by vibratory electrogas arc (VEGA) welding under 90 to 100 kJ/cm heat-input. The heat-affected zone (HAZ) was comprised of fine-grain zone (FGZ) and coarse-grain zone (CGZ), which characterizes fine granular structure and lathing-bainite substructure. It has found that large quantity of dispersed TiN and M23C6 precipitates restrain structure growing in HAZ and strengthen the weldment together with dislocations in the welded joint. | Weihua Sun Guodong Wang Jiming Zhang Dianxiu Xia Hao Sun | 2009 | Journal of Materials Science & Technology2009，25，6： | 4 |
| 10 | Distribution of airborne SARS-CoV-2 and possible aerosol transmission in Wuhan hospitals, China显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused an outbreak of CO V ID-19(2019 coronavirus infectious disease)that has led to a global public health crisis.The spread of SARS-CoV-2 can be rapid;but there is still considerable controversy about its main route of transmission[l,2];that is,whether transmission is by contact or through the air[2,3].Recently the W H O(World Health Organization)released a document that recognized the possibility of aerosol transmission of SARS-CoV-2 for indoor environments and enclosed spaces[4].The purpose of the present study was to evaluate the airborne transmission of SARS-CoV-2 through a field investigation of its occurrence in the air and other samples collected from health facilities in W uhan;China. | Jia Hu Chengfeng Lei Zhen Chen Weihua Liu Xujuan Hu Rongjuan Pei Zhengyuan Su Fei Deng Yu Huang Xiulian Sun Junji Cao Wuxiang Guan | 2020 | National Science Review2020，7，12： | 4 |
| 11 | Numerical simulation of nonlinear propagation of sound waves in a finite horn显示文摘Nonlinear acoustic propagation generated by a piston in a finite horn is numerically studied.A quasi-one-dimensional nonlinear model with varying cross-section uses high-order low-dispersion numerical schemes to solve the governing equation.Because of the nonlinear wave distortion and reflected sound waves at the mouth,broadband time-domain impedance boundary conditions are employed.The impedance approximation can be optimized to identify the complex-conjugate pole-residue pairs of the impedance functions,which can be calculated by fast and efficient recursive convolution.The numerical results agree very well with experimental data in the situations of weak nonlinear wave propagation in an exponential horn,it is shown that the model can describe the broadband characteristics caused by nonlinear distortion.Moreover,finite-amplitude acoustic propagation in types of horns is simulated,including hyperbolic,conical,exponential and sinusoidal horns.It is found that sound pressure levels at the horn mouth are strongly affected by the horn profiles,the driving velocity and frequency of the piston.The paper also discusses the influence of the horn geometry on nonlinear waveform distortion. | HOU Wei PAN Haoran SONG Weihua JING Xiaodong SUN Xiaofeng | 2015 | Chinese Journal of Acoustics2015，34，2： | 4 |
| 12 | A consensus linkage map of common carp (Cyprinus carpio L.) to compare the distribution and variation of QTLs associated with growth traits显示文摘The ability to detect and identify quantitative trait loci (QTLs) in a single population is often limited. Analyzing multiple populations in QTL analysis improves the power of detecting QTLs and provides a better understanding of their functional allelic variation and distribution. In this study, a consensus map of the common carp was constructed, based on four populations, to compare the distribution and variation of QTLs. The consensus map spans 2371.6 cM across the 42 linkage groups and comprises 257 microsatellites and 421 SNPs, with a mean marker interval of 3.7 cM/marker. Sixty-seven QTLs affecting four growth traits from the four populations were mapped to the consensus map. Only one QTL was common to three populations, and nine QTLs were detected in two populations. However, no QTL was common to all four populations. The results of the QTL comparison suggest that the QTLs are responsible for the phenotypic variability observed for these traits in a broad array of common carp germplasms. The study also reveals the different genetic performances between major and minor genes in different populations. | ZHENG XianHu KUANG YouYi LV WeiHua CAO DingChen ZHANG XiaoFeng LI Chao LU CuiYun SUN XiaoWen | 2013 | Science China(Life Sciences)2013，56，4： | 4 |
| 13 | Competition for electrons between reductive dechlorination and denitrification显示文摘 | Lifeng Cao Weihua Sun Yuting Zhang Shimin Feng Jinyun Dong Yongming Zhang Bruce E. Rittmann | 2017 | Frontiers of Environmental Science & Engineering2017，11，6： | 3 |
| 14 | An Improved Filter of Progressive TIN Densification for LiD AR Point Cloud Data显示文摘Based on the classic filter of progressive triangulated irregular network(TIN) densification, an improved filter is proposed in this paper. In this method, we divide ground points into grids with certain size and select the lowest points in the grids to reconstruct TIN in the process of iteration. Compared with the classic filter of progressive TIN densification(PTD), the improved method can filter out attached objects, avoid the interference of low objects and obtain relatively smooth bare-earth. In addition, this proposed filter can reduce memory requirements and be more efficient in processing huge data volume. The experimental results show that the filtering accuracy and efficiency of this method is higher than that of the PTD method. | WANG Huan WANG Shugen CHEN Qi JIN Weihua SUN Mingwei | 2015 | Wuhan University Journal of Natural Sciences2015，20，4： | 3 |
| 15 | Modeling, Optimization, and Control of Solution Purification Process in Zinc Hydrometallurgy显示文摘The solution purification process is an essential step in zinc hydrometallurgy. The performance of solution purification directly affects the normal functioning and economical benefits of zinc hydrometallurgy. This paper summarizes the authors' recent work on the modeling, optimization, and control of solution purification process. The online measurable property of the oxidation reduction potential(ORP) and the multiple reactors, multiple running statuses characteristic of the solution purification process are extensively utilized in this research. The absence of reliable online equipment for detecting the impurity ion concentration is circumvented by introducing the oxidationreduction potential into the kinetic model. A steady-state multiple reactors gradient optimization, unsteady-state operationalpattern adjustment strategy, and a process evaluation strategy based on the oxidation-reduction potential are proposed. The effectiveness of the proposed research is demonstrated by its industrial experiment. | Bei Sun Chunhua Yang Hongqiu Zhu Yonggang Li Weihua Gui | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，2： | 3 |
| 16 | Highly energetic and flammable metallic glasses显示文摘Energetic materials are solids that release a large amount of energy in combustion. The evaluation depends on both combustion heat and ignition temperature. Conventional non-metallic materials have low ignition temperature but small combustion heat,whereas metals have large combustion heat but high ignition temperatures. We show that many metallic glasses, combining the merits of both metals and non-metals, have large combustion heat, approximately twice that of the non-metals, and low ignition temperature that is several hundreds of Kelvin lower than that of the metals. The ease in igniting metallic glass results from the low thermal conductivity of the materials and the storage of energy in their liquid-like atomic structure. Metallic glass ribbons outweigh metallic nanoparticles due to their high production efficiency, low cost and nontoxicity. The findings suggest that metallic glasses are alternative energetic materials. | BangSheng Yu YongHao Sun HaiYang Bai WeiHua Wang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，7： | 3 |
| 17 | THE PHASE-OFFSET OVERLAPPED WAVE TECHNIQUE显示文摘A new digital communication technology based on the Phase-Offset Overlapped Waves (POOW) has been introduced in this letter.The waves can be considered as a special multicarrier different from traditional ones.The sud-waves in a coded word's period of the POOW are sine waves and have the same frequencies,but different starting phases.The most important characteristic is that these sub-waves are the piecewise functions and not orthogonal in a code word period.The decoding can be implemented by solving a linear equation group.This code has very high efficiency and thus the data transmissin rate is increased greatly. | Liang Dequn (Dalian Maritime University, Dalian 116026)Liang Weihua (Dalian University of Science and Technology, Dalian 116026)Sun Changnian (Telecom Sino Group, Sunnyvale, California, USA, 94086) | 2003 | Journal of Electronics(China)2003，20，2： | 3 |
| 18 | Derivation and characterization of human embryonic stem cell lines from poor quality embryos显示文摘Poor quality embryos discarded from in vitro fertilization (IVF) laboratories are good sources for deriving human embryonic stem cell (hESC) lines. In this study, 166 poor quality embryos donated from IVF centers on day 3 were cultured in a blastocyst medium for 2 days, and 32 early blastocysts were further cultured in a blastocyst optimum culture medium for additional 2 days so that the inner cell masses (ICMs) could be identified and isolated easily. The ICMs of 17 blastocysts were isolated by a mechanical method, while those of the other 15 blastocysts were isolated by immunosurgery. All isolated ICMs were inoculated onto a feeder layer for subcultivation. The rates of ICM at- tachment, primary ICM colony formation and the efficiency of hESC derivation were similar between the ICMs isolated by the two methods (P>0.05). As a result, four new hESC lines were established. Three cell lines had normal karyotypes and one had an unbalanced Robertsonian translocation. All cell lines showed normal hESC characteristics and had the differentiation ability. In conclusion, we established a stable and effective method for hESC isolation and culture, and it was confirmed that the mechanical isolation was an effective method to isolate ICMs from poor embryos. These results further indicate that hESC lines can be derived from poor quality embryos discarded by IVF laboratories. | Weiqiang Liu, Yifei Yin, Xiaolin Long, Yumei Luo, Yonghua Jiang, Wenhong Zhang, Hongzi Du, Shaoying Li, Yuhong Zheng, Qing Li, Xinjie Chen, Baoping Liao, Guohong Xiao, Weihua Wang, Xiaofang Sun Guangzhou Key Laboratory of Reproductive and Genetics Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China | 2009 | Journal of Genetics and Genomics2009，36，4： | 3 |
| 19 | Recruited CD68^(+)CD206^(+)macrophages orchestrate graft immune tolerance to prompt xenogeneic-dentin matrix-based tooth root regeneration显示文摘Successful regenerative medicine strategies of xenogeneic extracellular matrix need a synergistic balance among inflammation,fibrosis,and remodeling process.Adaptive macrophage subsets have been identified to modulate inflammation and orchestrate the repair of neighboring parenchymal tissues.This study fabricated PPARγ-primed CD68+CD206+M2 phenotype(M2γ),and firstly verified their anti-inflammatory and tissue-regenerating roles in xenogeneic bioengineered organ regeneration.Our results showed that Th1-type CD3^(+)CD8^(+)T cell response to xenogeneic-dentin matrix-based bioengineered root complex(xeno-complex)was significantly inhibited by M2γmacrophage in vitro.PPARγactivation also timely recruited CD68^(+)CD206^(+)tissue macrophage polarization to xeno-complex in vivo.These subsets alleviated proinflammatory cytokines(TNF-α,IFN-γ)at the inflammation site and decreased CD3^(+)CD8^(+)T lymphocytes in the periphery system.When translated to an orthotopic nonhuman primate model,PPARγ-primed M2 macrophages immunosuppressed IL-1β,IL-6,TNF-α,MMPs to enable xeno-complex to effectively escape immune-mediated rejection and initiate graft-host synergistic integrity.These collective activities promoted the differentiation of odontoblast-like and periodontal-like cells to guide pulp-dentin and cementum-PDLs-bone regeneration and rescued partially injured odontogenesis such as DSPP and periostin expression.Finally,the regenerated root showed structure-biomechanical and functional equivalency to the native tooth.The timely conversion of M1-to-M2 macrophage mainly orchestrated odontogenesis,fibrogenesis,and osteogenesis,which represents a potential modulator for intact parenchymal-stromal tissue regeneration of targeted organs. | Hui Li Jingjing Sun Hefeng Yang Xue Han Xiangyou Luo LiJun Liao Bo Yang Tian Zhu Fangjun Huo Weihua Guo Weidong Tian | 2021 | Bioactive Materials2021，6，4： | 2 |
| 20 | Blockchain for Transparent Data Management Toward 6G显示文摘The wealth of user data acts as a fuel for network intelligence toward the sixth generation wireless networks(6G).Due to data heterogeneity and dynamics,decentralized data management(DM)is desirable for achieving transparent data operations across network domains,and blockchain can be a promising solution.However,the increasing data volume and stringent data privacy-preservation requirements in 6G bring significantly technical challenge to balance transparency,efficiency,and privacy requirements in decentralized blockchain-based DM.In this paper,we investigate blockchain solutions to address the challenge.First,we explore the consensus protocols and scalability mechanisms in blockchains and discuss the roles of DM stakeholders in blockchain architectures.Second,we investigate the authentication and authorization requirements for DM stakeholders.Third,we categorize DM privacy requirements and study blockchain-based mechanisms for collaborative data processing.Subsequently,we present research issues and potential solutions for blockchain-based DM toward 6G from these three perspectives.Finally,we conclude this paper and discuss future research directions. | Xuemin(Sherman)Shen Dongxiao Liu Cheng Huang Liang Xue Han Yin Weihua Zhuang Rob Sun Bidi Ying | 2022 | Engineering2022，8，1： | 2 |
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