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| 1 | Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease – is this type 3 diabetes?显示文摘 | Eric Steen Benjamin M. Terry Enrique J. Rivera Jennifer L. Cannon Thomas R. Neely Rose Tavares X. Julia Xu Jack R. Wands Suzanne M. de la Monte | 2005 | Journal of Alzheimer’s Disease2005，，1： | 3 |
| 2 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 3 | Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer’s disease显示文摘 | Nataniel Lester-Coll Enrique J. Rivera Stephanie J. Soscia Kathryn Doiron Jack R. Wands Suzanne M. de la Monte | 2006 | Journal of Alzheimer’s Disease2006，，1： | 1 |
| 4 | Distinction af consolidative bronchioloalveolar carcinoma from pneumonia: do CT criteria work显示文摘 | Suzanne LA Caroline C Price H | 1998 | AJR1998，171，： | 1 |
| 5 | Acetaldehyde Adducts in Alcoholic Liver Disease显示文摘 | Mashiko Setshedi Jack R. Wands Suzanne M. de la Monte | 2010 | Oxidative Medicine and Cellular Longevity2010，，3： | 1 |
| 6 | Brain Metabolic Dysfunction at the Core of Alzheimer’s Disease显示文摘 | Suzanne M. de la Monte Ming Tong | 2013 | Biochemical Pharmacology2013，，： | 1 |
| 7 | Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer’s disease显示文摘 | Suzanne M. de la Monte Jack R. Wands | 2005 | Journal of Alzheimer’s Disease2005，，1： | 1 |
| 8 | Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Rita V Krishnamurthi Valery L Feigin Mohammad H Forouzanfar George A Mensah Myles Connor Derrick A Bennett Andrew E Moran Ralph L Sacco Laurie M Anderson Thomas Truelsen Martin O’Donnell Narayanaswamy Venketasubramanian Suzanne Barker-Collo Carlene M M La | 2013 | The Lancet Global Health2013，，5： | 1 |
| 9 | Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma显示文摘 | Philippe Merle Suzanne de la Monte Miran Kim Marc Herrmann Shinji Tanaka Annette Von Dem Bussche Michael C. Kew Christian Trepo Jack R. Wands | 2004 | Gastroenterology2004，，4： | 1 |
| 10 | Distinction of consolidative bronchioloalveolar carcinomar from pneumonia:do CT criteria work 显示文摘 | Suzanne LA Caroline C Price Halford | 1998 | AJR1998，171，： | 1 |
| 11 | Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer’s disease: Link to brain reductions in acetylcholine显示文摘 | Enrique J. Rivera Alison Goldin Noah Fulmer Rose Tavares Jack R. Wands Suzanne M. de la Monte | 2005 | Journal of Alzheimer’s Disease2005，，3： | 1 |
| 12 | Distinction of consolidative bronchioloalveolar carcinoma from pneumonia: do CT criteria work显示文摘 | Suzanne LA Caroline C Price H | 1998 | AJR1998，171，2： | 1 |
| 13 | Results of multimodal treatment for desmoplastic small round cell tumors显示文摘 | Dave R. Lal Wendy T. Su Suzanne L. Wolden Kenneth C. Loh Shakeel Modak Michael P. La Quaglia | 2005 | Journal of Pediatric Surgery2005，，1： | 1 |
| 14 | Whole abdominopelvic radiotherapy for desmoplastic small round-cell tumor显示文摘 | Karyn A Goodman Suzanne L Wolden Michael P La Quaglia Brian H Kushner | 2002 | International Journal of Radiation Oncology Biology Physics2002，，1： | 1 |
| 15 | Distinction of consolidative bronchioloalveolar carcinomar from pneumonia:do CT criteria work 显示文摘 | Suzanne LA Caroline C Price Halford | 1998 | AJR1998，171，： | 1 |
| 16 | Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver显示文摘 | Jong Eun Yeon Sophia Califano Julia Xu Jack R. Wands Suzanne M. De La Monte | 2003 | Hepatology2003，，3： | 1 |
| 17 | Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimer’s Disease显示文摘 | Suzanne M. de la Monte | 2012 | Current Alzheimer Research2012，，1： | 1 |
| 18 | The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids显示文摘 | de la Monte Suzanne M Longato Lisa Tong Ming DeNucci Sarah Wands Jack R | 2009 | International Journal of Environmental Research and Public Health2009，，7： | 1 |
| 19 | Characterization of the AD7c-NTP cDNA expression in Alzheimer's disease and measurement of a 41-kD protein in cerebrospinal fluid显示文摘 | Suzanne M de la Monte Kasra G | 1997 | J Clin Invest1997，100，： | 1 |
| 20 | Review of insulin and insulin-like growth factor expression,signaling, and malfunction in the central nervous system: Relevance toAlzheimer’s disease显示文摘 | Suzanne M. de la Monte Jack R. Wands | 2005 | Journal of Alzheimer’s Disease2005，，： | 1 |
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