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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 3 | The directed relation graph method for mechanism reduction in the oxidative coupling of methane显示文摘 | Yuxuan Xin Zhejian Song Y.Z. Tan Dezheng Wang | 2007 | Catalysis Today2007，，1： | 2 |
| 4 | Efficient production of chemicals from microorganism by metabolic engineering and synthetic biology显示文摘The use of traditional chemical catalysis to produce chemicals has a series of drawbacks,such as high dependence on fossil resources,high energy consumption,and environmental pollution.With the development of synthetic biology and metabolic engineering,the use of renewable biomass raw materials for chemicals synthesis by constructing efficient microbial cell factories is a green way to replace traditional chemical catalysis and traditional microbial fermentation.This review mainly summarizes several types of bulk chemicals and high value-added chemicals using metabolic engineering and synthetic biology strategies to achieve efficient microbial production.In addition,this review also summarizes several strategies for effectively regulating microbial cell metabolism.These strategies can achieve the coupling balance of material and energy by regulating intracellular material metabolism or energy metabolism,and promote the efficient production of target chemicals by microorganisms. | Yang Zhang Jing Yu Yilu Wu Mingda Li Yuxuan Zhao Haowen Zhu Changjing Chen Meng Wang Biqiang Chen Tianwei Tan | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 2 |
| 5 | Construction of Highly Emissive Pt(Ⅱ) Metallacycles upon Irradiation显示文摘Photoswitchable or photoactivatable fluorescent species have been found wide applications within supramolecular chemistry and materials science.In this study,we successfully constructed two highly emissive Pt(Ⅱ)metallacycles from the diarylethene ligands via coordination-driven self-assembly.Different from the most known fluorescent metallacycles,the obtained metallacycles have displayed'turn-on'fluorescence switching.They are non-fluorescent in solution,but they emit highly yellow or orange fluorescence under ultraviolet irradiation.The metallacycles were well characterized by 1H NMR,31P NMR and ESI-TOF-MS.The photochromic properties of the resultant metallacycles were investigated by 1H NMR,31P NMR,UV/Vis spectrum and fluorescence spectrum.Notably,NMR studies revealed that these two metallacycles featured excellent cyclization efficiency(90% conversion efficiency).Moreover,the closed-ring isomers of the metallacycles displayed relatively high quantum yield(ФF=0.5).DFT simulations demonstrated that the antiparallel configuration of the diarylethene ligand had an angle closed to 120°,which was more stable in energy compared to the parallel configuration,thus allowing for the facile construction of highly emissive metallacycles.We believe that such highly emissive metallacycles which are in-situ prepared upon irradiation can be used as new fluorescence materials for sensing and bioimaging in the future. | Yi Qin Ying Zhang Guangqiang Yin Yuxuan Wang Changwei Zhang Lijun Chen Hongwei Tan Xiaopeng Li Lin Xu Haibo Yang | 2019 | Chinese Journal of Chemistry2019，37，4： | 2 |
| 6 | Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology:Implications for Alzheimer's disease therapy显示文摘Alzheimer's disease(AD),characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates,is the most common neurodegenerative disorder with limited therapeutic agents.Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates,and transcription factor EB(TFEB)is a master regulator of autophagy and lysosomal biogenesis.Thus,small-molecule autophagy enhancers targeting TFEB hold promise for AD therapy.Here,we found that celastrol,an active ingredient isolated from the root extracts of Tripterygium wilfordii(Lei Gong Teng in Chinese)enhanced TFEB-mediated autophagy and lysosomal biogenesis in vitro and in mouse brains.Importantly,celastrol reduced phosphorylated Tau aggregates and attenuated memory dysfunction and cognitive deficits in P301S Tau and 3xTg mice,two commonly used AD animal models.Mechanistical studies suggest that TFEB-mediated autophagy-lysosomal pathway is responsible for phosphorylated Tau degradation in response to celastrol.Overall,our findings indicate that Celastrol is a novel TFEB activator that promotes the degradation of phosphorylated Tau aggregates and improves memory in AD animal models.Therefore,Celastrol shows potential as a novel agent for the treatment and/or prevention of AD and other tauopathies. | Chuanbin Yang Chengfu Su Ashok Iyaswamy Senthil Kumar Krishnamoorthi Zhou Zhu Sichang Yang Benjamin Chunkit Tong Jia Liu Sravan G.Sreenivasmurthy Xinjie Guan Yuxuan Kan Aston Jiaxi Wu Alexis Shiying Huang Jieqiong Tan Kingho Cheung Juxian Song Min Li | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 2 |
| 7 | Remarkably enhanced piezo-photocatalytic performance in BaTiO_(3)/CuO heterostructures for organic pollutant degradation显示文摘Introducing polarization field of piezoelectric materials is an effective strategy to improve photocatalytic performance.In this study,a new type of BaTiO_(3)/CuO heterostructure catalyst was designed and synthesized to achieve high piezo-photocatalytic activity through the synergy of heterojunction and piezoelectric effect.The BaTiO_(3)/CuO heterostructure shows a significantly enhanced piezo-photocatalytic degradation efficiency of organic pollutants compared with the individual BaTiO_(3) nanowires(NWs)and CuO nanoparticles(NPs).Under the co-excitation of ultrasonic vibration and ultraviolet radiation,the optimal degradation reaction rate constant k of polarized BaTiO_(3)/CuO heterostructure on methyl orange(MO)dye can reach 0.05 min^(−1),which is 6.1 times of photocatalytic rate and 7 times of piezocatalytic rate.The BaTiO_(3)/CuO heterostructure with remarkable piezo-photocatalytic behavior provides a promising strategy for the development of high-efficiency catalysts for wastewater purification,and it also helps understand the coupling mechanism between piezoelectric effect and photocatalysis. | Chenye YU Mengxi TAN Chengdong TAO Yuxuan HU Chuanbao LIU Huimin MENG Yanjing SU Lijie QIAO Yang BAI | 2022 | Journal of Advanced Ceramics2022，11，3： | 1 |
| 8 | The national multi-center artificial intelligent myopia prevention and control project显示文摘In recent years,the incidence of myopia has increased at an alarming rate among children and adolescents in China.The exploration of an effective prevention and control method for myopia is in urgent need.With the development of information technology in the past decade,artificial intelligence with the Internet of Things technology(AIoT)is characterized by strong computing power,advanced algorithm,continuous monitoring,and accurate prediction of long-term progression.Therefore,big data and artificial intelligence technology have the potential to be applied to data mining of myopia etiology and prediction of myopia occurrence and development.More recently,there has been a growing recognition that myopia study involving AIoT needs to undergo a rigorous evaluation to demonstrate robust results. | Xun Wang Yahan Yang Yuxuan Wu Wenbin Wei Li Dong Yang Li Xingping Tan Hankun Cao Hong Zhang Xiaodan Ma Qin Jiang Yunfan Zhou Weihua Yang Chaoyu Li Yu Gu Lin Ding Yanli Qin Qi Chen Lili Li Mingyue Lian Jin Ma Dongmei Cui Yuanzhou Huang Wenyan Liu Xiao Yang Shuiming Yu Jingjing Chen Dongni Wang Zhenzhe Lin Pisong Yan Haotian Lin Chinese Association of Artificial Intelligence,Medical Artificial Intelligence Branch of Guangdong Medical Association | 2021 | Intelligent Medicine2021，1，2： | 1 |
| 9 | Baptistee Debombourg's art of glass显示文摘With the unveiling of K1l's new cultural extravaganza-the K11 Art Carnival in Wuhan,its highlighted exhibition'Elevation'by contemporary French artist Baptiste Debombourg opened at Chi K11 Art Space on July 30.'Elevation'is Debombourgs biggest solo exhibition in the world so far.It is a retrospectivedisplaywhichfeatures his four iconic installations'Aerial,''Overflow,''Dark Matter,'and'Rheology'as well as dozens of his glass works.In all these works,Debombourg has exploited the fragility yet resistance of glass,deconstructed and recomposed this material into gasinducing pieces of art that may remind people of boulders,tides,or glaciers. | Pan Qian Ge Yuxuan Xiao Mengxing Tan Ziyi | 2022 | Changjiang Weekly2022，，30： | 0 |
| 10 | Photonics-aided THz-wireless transmission over 400 m at 335 GHz显示文摘The terahertz(THz)band(0.3–10 THz),with abundant bandwidth,can satisfy the need for large-capacity transmission of fiber-wireless integration communication systems,which has attracted more and more attention[1–3]. | LI WeiPing YU JianJun ZHU BoWen WANG Feng TAN YuXuan WANG YanYi ZHU Min ZHANG Jiao ZHOU Wen ZHAO Feng YU JianGuo | 2022 | Science China(Technological Sciences)2022，65，12： | 0 |
| 11 | Understanding the Main Line,Characteristics and Practice Path of Historical Initiative:Under the Guidelines of the 20th National Congress of the CPC显示文摘Theoretically based on historical materialism,the historical initiative of the Communist Party of China(CPC)is a precious character of creating new prospects amid changing circumstances consciously and proactively to acquire benefits for Chinese people.Integrated into its centenary history and showing highlights in different historical periods,the CPC’s historical initiative features dialectical unity between problem orientation and mission pursuit,upholding fundamental principles and breaking new ground,regularity and consciousness,as well as the leadership of the CPC and the pioneering spirit of the people.To accomplish the Second Centenary Goal and advance national rejuvenation,the CPC will follow the path of socialism with Chinese characteristics under the guidance of Marxism,stay committed to achieving national rejuvenation,unite and rely on the people,and stimulate the spirit of innovation and creation,thereby pooling more proactive spiritual strengths to make greater contributions in the new era. | ZHANG Yuesheng TAN Yuxuan | 2023 | Frontiers of Economics in China-Selected Publications from Chinese Universities2023，18，1： | 0 |
| 12 | Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1显示文摘Aging increases the risks of various diseases and the vulnerability to death.Cellular senescence is a hallmark of aging that contributes greatly to aging and aging-related diseases.This study demonstrates that extracellular vesicles from human urine-derived stem cells(USC-EVs)efficiently inhibit cellular senescence in vitro and in vivo.The intravenous injection of USC-EVs improves cognitive function,increases physical fitness and bone quality,and alleviates aging-related structural changes in different organs of senescence-accelerated mice and natural aging mice.The anti-aging effects of USC-EVs are not obviously affected by the USC donors’ages,genders,or health status.Proteomic analysis reveals that USC-EVs are enriched with plasminogen activator urokinase(PLAU)and tissue inhibitor of metalloproteinases 1(TIMP1).These two proteins contribute importantly to the anti-senescent effects of USC-EVs associated with the inhibition of matrix metalloproteinases,cyclin-dependent kinase inhibitor 2A(P16INK4a),and cyclin-dependent kinase inhibitor 1A(P21cip1).These findings suggest a great potential of autologous USC-EVs as a promising anti-aging agent by transferring PLAU and TIMP1 proteins. | Shanshan Rao Zehui He Zun Wang Hao Yin Xiongke Hu Yijuan Tan Tengfei Wan Hao Zhu Yi Luo Xin Wang Hongming Li Zhenxing Wang Xinyue Hu Chungu Hong Yiyi Wang Mingjie Luo Wei Du Yuxuan Qian Siyuan Tang Hui Xie Chunyuan Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 13 | 352-Gbit/s single line rate THz wired transmission based on PS-4096QAM employing hollow-core fiber显示文摘We successfully demonstrate 32-Gbaud Probabilistically Shaped 4096-ary Quadrature Amplitude Modulation(PS-4096QAM)TeraHertz(THz)signal wired transmission at 325 GHz over the 1-m Hollow-Core Fiber(HCF)in a photon-assisted THz-wave communication system.By employing advanced Digital Signal Processing(DSP)and the PS technique,the 352-Gbit/s line rate(288-Gbit/s net rate)delivery with a net Spectral Efficiency(SE)of 9 bit/s/Hz is realized in the experiment,satisfying the 0.86-Normalized Generalized Mutual Information(NGMI)Low-Density Parity-Check(LDPC)threshold. | Junjie Ding Yuxuan Tan Yanyi Wang Jiao Zhang Menghui He Feng Zhao Li Zhao Wen Zhou Yiwei Shi Min Zhu Jianjun Yu | 2023 | Digital Communications and Networks2023，9，3： | 0 |
| 14 | Dithienylethene metallodendrimers with high photochromic efficiency显示文摘It has been challenging to achieve multi-photochromic systems without affecting the individual photoswitching properties of the constituent units. Herein, we present the design and synthesis of a new family of platinum-acetylide dendrimers containing up to twenty-one photochromic dithienylethene(DTE)units that exhibit both high photochromic efficiency and individual switching properties. Upon irradiation with ultraviolet(UV) and visible(vis) light, the resultant metallodendrimers display high conversion yield and good fatigue resistance. More interestingly, cyclization-cycloreversion kinetics revealed that the photochromic property of each DTE unit in these metallodendrimers is unaffected by its neighbor and the full ring-closure of up to twenty-one DTE units in one single dendrimer has been achieved. | Yuxuan Wang Qifeng Zhou Xiaoxiao He Ying Zhang Hongwei Tan Jianhua Xu Cuihong Wang Wei Wang Xiping Luo Jinquan Chen Lin Xu | 2022 | Chinese Chemical Letters2022，33，3： | 0 |
| 15 | Celecoxib enhances the response of tumor cells to cisplatin through upregulating PUMA in non–small cell lung cancer carrying wild-type p53显示文摘Celecoxib,a cyclooxygenase-2 inhibitor,can enhance the efficacy of chemotherapy;however,its effect seems inconsistent.In this study,we investigated whether celecoxib would increase the antiproliferative effects of cisplatin in human lung cancer cells.Our data demonstrated the synergistic effects of celecoxib with cisplatin in wild-type p53 cells and their antagonistic effects inmutated or deleted p53 cells.Combination indices of 0.82 to 0.93 reflected a synergistic effect between celecoxib and cisplatin in lung cancer cells with wild-type p53.Combination indices of 1.63 to 3.00 reflected antagonism between celecoxib and cisplatin in lung cancer cells with mutated or deleted p53.Compared with that in cells with mutated or deleted p53,apoptosis significantly increased with the addition of celecoxib and cisplatin in wild-type p53 cells(P<0.05).Moreover,the results in vivo were similar to those in vitro:celecoxib combinedwith cisplatin slowed tumor growth in wild-type p53 groups and not in mutated or deleted p53 groups.In addition,celecoxib promoted p53 translocation into the nucleus and upregulated active p53 expression in wild-type p53 cells.Celecoxib combined with cisplatin upregulated PUMA(PUMA is a downstream gene of p53)after active p53 increased in wild-type p53 cells.In summary,the combination of celecoxib and cisplatin demonstrates clear synergistic effects in wild-type p53 cells and antagonistic effects inmutated or deleted p53 cells.The synergistic effect was achieved by apoptosis,induced by upregulating PUMA.Our results will provide a new treatment strategy for patients carrying wild-type p53,insensitive to cisplatin. | Yuxuan Xiao Ziyu Wang Meng Gu Jinjing Tan Weiying Li | 2024 | Oncology and Translational Medicine2024，10，2： | 0 |
| 16 | Hierarchical Federated Learning: Architecture, Challenges, and Its Implementation in Vehicular Networks显示文摘Federated learning(FL)is a distributed machine learning(ML)framework where several clients cooperatively train an ML model by exchanging the model parameters without directly sharing their local data.In FL,the limited number of participants for model aggregation and communication latency are two major bottlenecks.Hierarchical federated learning(HFL),with a cloud-edge-client hierarchy,can leverage the large coverage of cloud servers and the low transmission latency of edge servers.There are growing research interests in implementing FL in vehicular networks due to the requirements of timely ML training for intelligent vehicles.However,the limited number of participants in vehicular networks and vehicle mobility degrade the performance of FL training.In this context,HFL,which stands out for lower latency,wider coverage and more participants,is promising in vehicular networks.In this paper,we begin with the background and motivation of HFL and the feasibility of implementing HFL in vehicular networks.Then,the architecture of HFL is illustrated.Next,we clarify new issues in HFL and review several existing solutions.Furthermore,we introduce some typical use cases in vehicular networks as well as our initial efforts on implementing HFL in vehicular networks.Finally,we conclude with future research directions. | YAN Jintao CHEN Tan XIE Bowen SUN Yuxuan ZHOU Sheng NIU Zhisheng | 2023 | ZTE Communications2023，21，1： | 0 |
| 17 | Hubei celebrations for 50th anniversary of normalization of diplomatic relations between China and Japan显示文摘On July 22,the launching ceremony of celebrations in Hubei relatedto the 5oth anniversary of the normalization of diplomatic relationsbetween China and Japan,as well as festivities related to the JapaneseCarnival Wuhan Station,took place on Han Street.The ceremony wasjointly organized by the Hubei and Wuhan foreign affairs ofices,alongwith the Executive Committee of the Japanese Carnival. | Fan Tingting Tan Ziyi Ge Yuxuan | 2022 | Changjiang Weekly2022，，29： | 0 |
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