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| 1 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 2 | A Multifunctional Anti-Proton Electrolyte for High-Rate and Super-Stable Aqueous Zn-Vanadium Oxide Battery显示文摘Large volumetric expansion of cathode hosts and sluggish transport kinetics in the cathode–electrolyte interface,as well as dendrite growth and hydrogen evolution at Zn anode side are considered as the system problems that cause the electrochemical failure of aqueous Zn-vanadium oxide battery.In this work,a multifunctional anti-proton electrolyte was proposed to synchronously solve all those issues.Theoretical and experimental studies confirm that PEG 400 additive can regulate the Zn^(2+) solvation structure and inhibit the ionization of free water molecules of the electrolyte.Then,smaller lattice expansion of vanadium oxide hosts and less associated by-product formation can be realized by using such electrolyte.Besides,such electrolyte is also beneficial to guide the uniform Zn deposition and suppress the side reaction of hydrogen evolution.Owing to the integrated synergetic modifica-tion,a high-rate and ultrastable aqueous Zn-V_(2)O_(3)/C battery can be constructed,which can remain a specific capacity of 222.8 m Ah g^(-1)after 6000 cycles at 5 A g^(-1),and 121.8 m Ah g^(-1) even after 18,000 cycles at 20 A g^(-1),respectively.Such“all-in-one”solution based on the electrolyte design provides a new strategy for developing high-performance aqueous Zn-ion battery. | Yangwu Chen Dingtao Ma Kefeng Ouyang Ming Yang Sicheng Shen Yanyi Wang Hongwei Mi Lingna Sun Chuanxin He Peixin Zhang | 2022 | Nano-Micro Letters2022，14，9： | 3 |
| 3 | Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws显示文摘Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples.Freshly frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for analysis.Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per sample.We found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and 12.We also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number changes.We further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA profile.Moreover,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant potential.Overall,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression. | Ming Ma Lu Liu Ruirui Shi Jianyun Zhang Xiaotian Li Xuefen Li Jiaying Bai Jianbin Wang Yanyi Huang Tiejun Li | 2021 | International Journal of Oral Science2021，13，2： | 3 |
| 4 | Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3显示文摘Class II HDACs, such as HDAC4, are critical regulators of the immune response in various immune cells;however, its role in innate immunity remains largely unknown.Here, we report that the overexpression of HDAC4 suppresses the production of type I interferons triggered by pattern-recognition receptors (PRRs). HDAC4 repressed the translocation of transcription factor IRF3 to the nucleus, thereby decreasing IRF3-mediated IFN-β expression. In particular, we also determined that HDAC4 can be phosphorylated and simultaneously block the phosphorylation of IRF3 at Ser386 and Ser396 by TBK1 and IKKε, respectively, by interacting with the kinase domain of TBK1 and IKKε. Furthermore, IFN-β may stimulate the expression of HDAC4. Our findings suggest that HDAC4 acts as a regulator of PRR signaling and is a novel mechanism of negative feedback regulation for preventing an overreactive innate immune response. | Qi Yang Jielin Tang Rongjuan Pei XiaoXiao Gao Jing Guo Chonghui Xu Yun Wang QianWang Chunchen Wu Yuan Zhou Xue Hu He Zhao Yanyi Wang Xinwen Chen Jizheng Chen | 2019 | Journal of Molecular Cell Biology2019，11，2： | 2 |
| 5 | Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis显示文摘Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell carcinoma.However,a predictor of oral leukoplakia prognosis has not yet been identified.We investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin sections.Comparison of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with hyperplasia.We also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up information.The malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)group.Together,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia. | Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li | 2021 | Science China(Life Sciences)2021，64，9： | 2 |
| 6 | Experimental Study on Hydrogen Leakage and Emission of Fuel Cell Vehicles in Confined Spaces显示文摘Hydrogen safety is one of the most important safety indicators in fuel cell vehicles(FCVs)(unlike in other types of alternative energy vehicles).This indicator in FCVs is directly related to the user’s personal safety in daily vehicle usage.This paper analyzes the safety standards of FCVs in confined spaces.A sealed test chamber and an appropriate test method are devel-oped to evaluate vehicle safety based on specific test requirements.Two FCVs are subjected to static hydrogen leakage and hydrogen emission testing performed in a confined space.The results reveal that the hydrogen concentration in the vicinity of the vehicles approximates 0.0004%which is much lower than 1%while parked for 8 h during the hydrogen leakage test.In the hydrogen emission test under operating conditions,the concentration of the hydrogen gas emitted from the vehicles exceeds 2300 ppm in the vicinity,which requires careful consideration.Based on experiment and analysis,recommendations for the hydrogen safety standards of FCVs in confined spaces are proposed. | Dong Hao Xiaobing Wang Yanyi Zhang Renguang Wang Guang Chen Jun Li | 2020 | Automotive Innovation2020，3，2： | 2 |
| 7 | A flow cytometry-based assay for quantitative analysis of cellular proliferation and cytotoxicity in vitro 显示文摘 | WANG Yanyi ZHANG Xiaoxiang | 2002 | Journal of Immunological Methods2002，268，3： | 1 |
| 8 | Photoelectric behavior of nanocrystalline TiO2 electrode with a novel terpyridyl ruthenium complex显示文摘 | Wang Zhongsheng Huang Chunhui Huang Yanyi | 2002 | Solar Energy Materials & Solar Cells2002，71，2： | 1 |
| 9 | A highly efficient solar cell made from a dye-modified ZnO-covered TiO2 nanoporous electrode 显示文摘 | WANG Zhongsheng HUANG Chunhui HUANG Yanyi | 2001 | Chemistry of Materials2001，13，2： | 1 |
| 10 | A scaffold with zinc-whitlockite nanoparticles accelerates bone reconstruction by promoting bone differentiation and angiogenesis显示文摘The therapy of bone defects based on advanced biological scaffolds offers the most promising therapeutic strategy for bone reconstruction.It is still challenging to develop scaffolds with the mechanical,osteogenic,angiogenic,and antibacterial properties required for bone defect reconstruction.Here,a novel organic/inorganic composite scaffold(zinc-whitlockite(ZnWH)/G/H)was synthesized using gellan gum(GG),human-like collagen(HLC),and ZnWH nanoparticles.The scaffold had excellent mechanical properties,adjustable swelling ratio,and interconnected pore structure.In addition to its excellent biocompatibility,it could promote osteogenic differentiation by releasing ZnWH nanoparticles to stimulate human bone marrow mesenchymal stem cells(hBMSCs)to upregulate the levels of alkaline phosphatase(ALP),osteocalcin(OCN),and osteopontin(OPN).In addition,this study showed that ZnWH nanoparticles could also promote angiogenesis by upregulating the paracrine secretion of vascular endothelial growth factor(VEGF)in hBMSCs.At the same time,the scaffold could inhibit the proliferation of bacteria.After 12 weeks of treatment in the rabbit femoral defect model,the ZnWH/G/H scaffold significantly accelerated the process of bone reconstruction.Therefore,these results demonstrate that the prepared novel nanocomposite scaffold,ZnWH/G/H,offers a promising candidate for bone regeneration. | Mingming Wang Jiaxin Yao Shihong Shen Chunning Heng Yanyi Zhang Tao Yang Xiaoyan Zheng | 2023 | Nano Research2023，16，1： | 1 |
| 11 | A water-free metal organic deposition method for YBa2Cu3O7?δ thin film fabrication显示文摘 | Rongxia Huang Feng Feng Wei Wu Yunran Xue Yanyi Zhang Kai Shi Timing Qu Yongjie Zhao Xiaohao Wang Xiaowen Zhang Zhenghe Han | 2013 | Superconductor Science and Technology2013，，： | 1 |
| 12 | Constrained future brightening of solar radiation and its implication for China's solar power显示文摘As Earth's primary energy source,surface downward solar radiation(R_(s))determines the solar power potential and usage for climate change mitigation.Future projections of R_(s)based on climate models have large uncertainties that interfere with the efficient deployment of solar energy to achieve China's carbon-neutrality goal.Here we assess 24 models in the latest Coupled Model Inter comparison Project Phase 6 with historical observations in China and find systematic biases in simulating historical R_(s)values likely due to model biases in cloud cover and clear-sky radiation,resulting in largely uncertain projections for future changes in Based on emergent constraints,we obtain credible R_(s)with narrowed uncertainties by~56%in the mid-twenty-first century and show that the mean R_(s)change during 2050-2069 relative to 1995-2014 is 30%more brightening than the raw projections.Particularly in North China and Southeast China with higher power demand,the constrained projections present more significant brightening,highlighting the importance of considering the spatial changes in future R_(s)when locating new solar energy infrastructures. | Yanyi He Kun Yang Martin Wild Kaicun Wang Dan Tong Changkun Shao Tianjun Zhou | 2023 | National Science Review2023，10，1： | 1 |
| 13 | 3D Artificial Array Interface Engineering Enabling Dendrite-Free Stable Zn Metal Anode显示文摘The ripple effect induced by uncontrollable Zn deposition is considered as the Achilles heel for developing high-performance aqueous Zn-ion batteries.For this problem,this work reports a design concept of 3D artificial array interface engineering to achieve volume stress elimination,preferred orientation growth and dendrite-free stable Zn metal anode.The mechanism of MXene array interface on modulating the growth kinetics and deposition behavior of Zn atoms were firstly disclosed on the multi-scale level,including the in-situ optical microscopy and transient simulation at the mesoscopic scale,in-situ Raman spectroscopy and in-situ X-ray diffraction at the microscopic scale,as well as density functional theory calculation at the atomic scale.As indicated by the electrochemical performance tests,such engineered electrode exhibits the comprehensive enhancements not only in the resistance of corrosion and hydrogen evolution,but also the rate capability and cyclic stability.High-rate performance(20 mA cm^(-2))and durable cycle lifespan(1350 h at 0.5 mA cm^(-2),1500 h at 1 mA cm^(-2)and 800 h at 5 mA cm^(-2))can be realized.Moreover,the improvement of rate capability(214.1 mAh g^(-1)obtained at 10 A g^(-1))and cyclic stability also can be demonstrated in the case of 3D MXene array@Zn/VO2battery.Beyond the previous 2D closed interface engineering,this research offers a unique 3D open array interface engineering to stabilize Zn metal anode,the controllable Zn deposition mechanism revealed is also expected to deepen the fundamental of rechargeable batteries including but not limited to aqueous Zn metal batteries. | Jianbin Ruan Dingtao Ma Kefeng Ouyang Sicheng Shen Ming Yang Yanyi Wang Jinlai Zhao Hongwei Mi Peixin Zhang | 2023 | Nano-Micro Letters2023，15，3： | 1 |
| 14 | Anti-aggregation growth and hierarchical porous carbon encapsulation enables the C@VO_(2) cathode with superior storage capability for aqueous zinc-ion batteries显示文摘Self-aggregation and sluggish transport kinetics of cathode materials would usually lead to the poor electrochemical performance for aqueous zinc-ion batteries(AZIBs).In this work,we report the construction of C@VO_(2) composite via anti-aggregation growth and hierarchical porous carbon encapsulation.Both of the morphology of composite and pore structure of carbon layer can be regulated by tuning the adding amount of glucose.When acting as cathode applied for AZIBs,the C@VO_(2)-3:3 composite can deliver a high capacity of 281 m Ah g^(-1) at 0.2 A g^(-1).Moreover,such cathode also exhibits a remarkably rate capability and cyclic stability,which can release a specific capacity of 195 m Ah g^(-1) at 5 A g^(-1) with the capacity retention of 95.4%after 1000 cycles.Besides that,the evolution including the crystal structure,valence state and transport kinetics upon cycling were also deeply investigated.In conclusion,benefited from the synergistic effect of anti-aggregation morphology and hierarchical porous carbon encapsulation,the building of such C@VO_(2) composite can be highly expected to enhance the ion accessible site,boost the transport kinetics and thus performing a superior storage performance.Such design concept can be applied for other kinds of electrode materials and accelerating the development of highperformance AZIBs. | Ming Yang Yanyi Wang Zhongwei Sun Hongwei Mi Shichang Sun Dingtao Ma Peixin Zhang | 2022 | Journal of Energy Chemistry2022，31，4： | 1 |
| 15 | Transcriptome-wide analysis of dynamic variations in regulation modes of grapevine microRNAs on their target genes during grapevine development显示文摘 | Chen Wang Xiangpeng Leng Yanyi Zhang Emrul Kayesh Yanping Zhang Xin Sun Jinggui Fang | 2014 | Plant Molecular Biology2014，，3： | 1 |
| 16 | Nucleic acids analysis显示文摘Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic analysis.During the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological breakthroughs.In this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided. | Yongxi Zhao Xiaolei Zuo Qian Li Feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian Huang Yanyi Huang Guoliang Ke Hua Kuang Fan Li Jiang Li Min Li Na Li Zhenyu Lin Dingbin Liu Juewen Liu Libing Liu Xiaoguo Liu Chunhua Lu Fang Luo Xiuhai Mao Jiashu Sun Bo Tang Fei Wang Jianbin Wang Lihua Wang Shu Wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-Feng Yuan Quan Yuan Chao Zhang Zhi Zhu Chaoyong Yang Xiao-Bing Zhang Huanghao Yang Weihong Tan Chunhai Fan | 2021 | Science China Chemistry2021，64，2： | 1 |
| 17 | Auxiliary diagnostic system for ADHD in children based on AI technology显示文摘Traditional diagnosis of attention deficit hyperactivity disorder(ADHD)in children is primarily through a questionnaire filled out by parents/teachers and clinical observations by doctors.It is inefficient and heavily depends on the doctor’s level of experience.In this paper,we integrate artificial intelligence(AI)technology into a software-hardware coordinated system to make ADHD diagnosis more efficient.Together with the intelligent analysis module,the camera group will collect the eye focus,facial expression,3D body posture,and other children’s information during the completion of the functional test.Then,a multi-modal deep learning model is proposed to classify abnormal behavior fragments of children from the captured videos.In combination with other system modules,standardized diagnostic reports can be automatically generated,including test results,abnormal behavior analysis,diagnostic aid conclusions,and treatment recommendations.This system has participated in clinical diagnosis in Department of Psychology,The Children’s Hospital,Zhejiang University School of Medicine,and has been accepted and praised by doctors and patients. | Yanyi ZHANG Ming KONG Tianqi ZHAO Wenchen HONG Di XIE Chunmao WANG Rongwang YANG Rong LI Qiang ZHU | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，3： | 1 |
| 18 | Clinical value of serum Epstein-Barr virus DNA assay in the diagnosis of nasopharyngeal carcinoma显示文摘 | Dezhong Sun Zhaoke Yang Yugui Fu Yanlin Chen Shoufeng Wang Yun Zhang Yanyi Ma Xiaoyan Zhang | 2014 | Tumor Biology2014，，9： | 1 |
| 19 | Photonics-based high-speed long-distance fiber-wireless-integration communication at the W-band显示文摘With the early approach of 5G period, beyond 5G communication has become an urgent need in the industry. Because of its rich bandwidth, the W-band (75–110-GHz) millimeterwave (mm-wave) is capable of carrying ultra-high-speed signal [1–6]. Therefore, it is extremely competitive in the field of future beyond 5G communication. The feature of photonics-based W-band mm-wave generation technology is that it can effectively solve the problem of bandwidth limitation and electromagnetic interference in electronic devices. | Weiping LI Jianjun YU Yanyi WANG Feng WANG Bowen ZHU Wen ZHOU Feng ZHAO Jianguo YU | 2023 | Science China(Information Sciences)2023，66，2： | 1 |
| 20 | Bank loan information and information asymmetry in the stock market:evidence from China显示文摘In this study,we use bank loan information to construct proxies for corporate transparency and examine whether these measures reflect information asymmetry in the stock market.Our analysis is based on a novel dataset of stock transactions and bank loans of all publicly listed firms on the Shenzhen Stock Exchange,covering January 2008 to June 2013.We find that firms with outstanding loans have a lower level of information asymmetry in the stock market,whereas firms with defaulted loans have a higher level of asymmetry.Further evidence demonstrates that the effect of loan default on information asymmetry in the stock market is more pronounced when these loans are borrowed from joint-equity commercial banks or multiple banks and when the default occurs under inactive market conditions.Our results remain robust to a series of endogeneity and sensitivity tests and provide suggestive evidence of a close connection between the credit loan and stock markets. | Yanyi Ye Yun Wang Xiaoguang Yang | 2022 | Financial Innovation2022，8，1： | 1 |
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