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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540edsfuoqpnvofp6k6nwb.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540edsfuoqpnvofp6k6nwb.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540edsfuoqpnvofp6k6nwb.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 3 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://gffzzdbc7b6aaae734bddhfuoqpnvofp6k6nwb.ffgz.tsg.suse.edu.cn/gsa or http://gffzz4eaf941a184140e3hfuoqpnvofp6k6nwb.ffgz.tsg.suse.edu.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 4 | Overview on Amorphous Alloy Electrical Machines and Their Key Technologies显示文摘Amorphous alloy(AA)is attracting more and more attention in electrical machines due to its excellent low loss characteristics.This paper overviews advances on AA electrical machines over the last 30 years,with particular reference to new and novel topologies and processing techniques of AA electrical machines and their key technologies.These include current states and trends for radial-flux AA electrical machines,axial-flux AA electrical machines,influences of processing techniques on electrical performance of AA iron cores,the characteristics of loss and vibration and noise of AA core and AA machines,optimum design of AA electrical machines,etc.The paper highlights the application prospects of the AA electrical machines. | Renyuan Tang Wenming Tong Xueyan Han | 2016 | Chinese Journal of Electrical Engineering2016，2，1： | 5 |
| 5 | The Tibetan Plateau Surface–Atmosphere Coupling System and Its Weather and Climate Effects: The Third Tibetan Plateau Atmospheric Science Experiment显示文摘The Tibetan Plateau(TP) is a key area affecting forecasts of weather and climate in China and occurrences of extreme weather and climate events over the world. The China Meteorological Administration, the National Natural Science Foundation of China, and the Chinese Academy of Sciences jointly initiated the Third Tibetan Plateau Atmospheric Science Experiment(TIPEX-Ⅲ) in 2013, with an 8–10-yr implementation plan. Since its preliminary field measurements conducted in 2013, routine automatic sounding systems have been deployed at Shiquanhe, Gaize, and Shenzha stations in western TP, where no routine sounding observations were available previously. The observational networks for soil temperature and soil moisture in the central and western TP have also been established. Meanwhile, the plateau-scale and regional-scale boundary layer observations, cloud–precipitation microphysical observations with multiple radars and aircraft campaigns, and tropospheric–stratospheric air composition observations at multiple sites, were performed. The results so far show that the turbulent heat exchange coefficient and sensible heat flux are remarkably lower than the earlier estimations at grassland, meadow, and bare soil surfaces of the central and western TP. Climatologically, cumulus clouds over the main body of the TP might develop locally instead of originating from the cumulus clouds that propagate northward from South Asia. The TIPEX-Ⅲ observations up to now also reveal diurnal variations, macro-and microphysical characteristics, and water-phase transition mechanisms, of cumulus clouds at Naqu station. Moreover, TIPEX-Ⅲ related studies have proposed a maintenance mechanism responsible for the Asian 'atmospheric water tower' and demonstrated the effects of the TP heating anomalies on African, Asian, and North American climates. Additionally, numerical modeling studies show that the Γ distribution of raindrop size is more suitable for depicting the TP raindrop characteristics compared to the M–P distribution, the overestimation of sensible heat flux can be reduced via modifying the heat transfer parameterization over the TP, and considering climatic signals in some key areas of the TP can improve the skill for rainfall forecast in the central and eastern parts of China. Furthermore, the TIPEX-Ⅲ has been promoting the technology in processing surface observations, soundings, and radar observations, improving the quality of satellite retrieved soil moisture and atmospheric water vapor content products as well as high-resolution gauge–radar–satellite merged rainfall products, and facilitating the meteorological monitoring, forecasting, and data sharing operations. | Ping ZHAO Yueqing LI Xueliang GUO Xiangde XU Yimin LIU Shihao TANG Wenming XIAO Chunxiang SHI Yaoming MA Xing YU Huizhi LIU La JIA Yun CHEN Yanju LIU Jian LI Dabiao LUO Yunchang CAO Xiangdong ZHENG Junming CHEN An XIAO Fang YUAN Donghui CHEN Yang PANG Zhiqun HU Shengjun ZHANG Lixin DONG Juyang HU Shuai HAN Xiuji ZHOU | 2019 | Journal of Meteorological Research2019，33，3： | 4 |
| 6 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 7 | Chaperone-mediated autophagy and neurodegeneration:connections,mechanisms,and therapeutic implications显示文摘Lysosomes degrade dysfunctional intracellular components via three pathways: macroautophagy, microautophagy, and chaperone-mediated autophagy(CMA). Unlike the other two, CMA degrades cytosolic proteins with a recognized KFERQ-like motif in lysosomes and is important for cellular homeostasis. CMA activity declines with age and is altered in neurodegenerative diseases. Its impairment leads to the accumulation of aggregated proteins, some of which may be directly tied to the pathogenic processes of neurodegenerative diseases. Its induction may accelerate the clearance of pathogenic proteins and promote cell survival, representing a potential therapeutic approach for the treatment of neurodegenerative diseases. In this review, we summarize the current findings on how CMA is involved in neurodegenerative diseases, especially in Parkinson's disease. | Xiaolei Liu Sihua Huang Xingqin Wang Beisha Tang Wenming Li Zixu Mao | 2015 | Neuroscience Bulletin2015，31，4： | 4 |
| 8 | Studies on the Antistatic Mechanism of Tetrapod- shaped Zinc Oxide Whisker显示文摘 | Zhou Zuowan Chu Longsheng Tang Wenming | 2003 | Journal of Electrostat- ics2003，，57： | 1 |
| 9 | Bin-based model construction and analytical strategies for dissecting complex traits with chromosome segment substitution lines显示文摘Chromosome segment substitution lines have been created in several experimental models,including many plant and animal species,and are useful tools for the genetic analysis and mapping of complex traits.The traditional t-test is usually applied to identify a quantitative trait locus (QTL) that is contained within a chromosome segment to estimate the QTL's effect.However,current methods cannot uncover the entire genetic structure of complex traits.For example,current methods cannot distinguish between main effects and epistatic effects.In this paper,a linear epistatic model was constructed to dissect complex traits.First,all the long substituted segments were divided into overlapping small bins,and each small bin was considered a unique independent variable.The genetic model for complex traits was then constructed.When considering all the possible main effects and epistatic effects,the dimensions of the linear model can become extremely high.Therefore,variable selection via stepwise regression (Bin-REG) was proposed for the epistatic QTL analysis in the present study.Furthermore,we tested the feasibility of using the LASSO (least absolute shrinkage and selection operator) algorithm to estimate epistatic effects,examined the fully Bayesian SSVS (stochastic search variable selection) approach,tested the empirical Bayes (E-BAYES) method,and evaluated the penalized likelihood (PENAL) method for mapping epistatic QTLs.Simulation studies suggested that all of the above methods,excluding the LASSO and PENAL approaches,performed satisfactorily.The Bin-REG method appears to outperform all other methods in terms of estimating positions and effects. | TANG ZaiXiang XIAO Jing HU WenMing YU Bo XU ChenWu | 2012 | Chinese Science Bulletin2012，57，21： | 1 |
| 10 | Studies on theantistatic mechanism of tetrapod-shaped zinc oxide whisker 显示文摘 | Zhou Zuowan Chu Longsheng Tang Wenming etc | 2003 | Journal of Electrotatics2003，57，34： | 1 |
| 11 | Studies on the antistatic mechanism of Tetrapod-shaped zinc oxide whisker显示文摘 | Zhun Zuowan Chu Longsheng Tang Wenming | 2003 | Journal of Electrostatics2003，57，3： | 1 |
| 12 | Micro combustion in sub-millimeter channels for novel modular thermophotovoltaic power generators 显示文摘 | Pan Jianfeng Yang Wenming Tang Aikun | 2010 | Journal of Micromechanics and Microengineering2010，20，12： | 1 |
| 13 | Numerical study of premixed hydrogen/air combustion in a micro planar combustor with parallel separating plates显示文摘 | Tang Aikun Pan Jianfeng Yang Wenming | 2015 | International Journal of Hydrogen Energy2015，40，5： | 1 |
| 14 | Studies on the antistatic mechanism of tetrapod-shaped zinc oxide whisker显示文摘 | Longsheng Chu Wenming Tang | 2003 | Journal of Electrostatis2003，，57： | 1 |
| 15 | Room temperature interfacial reactions in electrodeposited Au/Sn couples显示文摘 | Wenming Tang Anqiang He Qi Liu Douglas G. Ivey | 2008 | Acta Materialia2008，，19： | 1 |
| 16 | Interleaved-Connected Split Planar Resonant Inductor Design in 1 kV SiC LLC Converters显示文摘Design method of split planar resonant inductor in 1 kV SiC logical link control(LLC)converter is proposed,which ensures the converter power density of 93.59 W/in^3 and peak efficiency of 95.73%.Split resonant inductor helps to provide symmetrical resonant current by symmetrical impedance,and improves the distortion of resonant current,which ensures the efficiency of the whole converter.An interleaved winding connecting scheme improves the power density of the planar magnets,which contributes to power density improvement.Design method and calculation process of such split planar resonant inductor are provided.To verify the feasibility of the proposed design method,a 1 kV/48 V 6.6 kW,210 k Hz SiC LLC prototype was built,and the experimental results are given. | TANG Jiacheng YAO Kaiqi ZHU Wenming GAO Zhesi XU Zhiwei ZHANG Zhiliang REN Xiaoyong CHEN Qianhong | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，5： | 1 |
| 17 | Studies on the antistatic mechanism of tetrapod-shaped zinc oxide whisker显示文摘 | Zuowan Zhou Longsheng Chu Wenming Tang | 2003 | Journal of Electrostatics2003，，57： | 1 |
| 18 | Fabrication,characterization and mechanism of a novel Z-scheme photocatalyst Na Nb O3/WO3 with enhanced photocatalytic activity显示文摘 | CHEN Shifu JI Lei TANG Wenming | 2013 | Dalton Transactions2013，42，10： | 1 |
| 19 | The Main Control Factors for Shale Gas Accumulation and Exploration Problems in Shale Gas of South China显示文摘The shale gas exploration in China has achieved remarkable profits,and four national shale gas demonstration zones(Fuling Jiaoshiba,ChangningWeiyuan,Zhaotong,and Yanchang)have been established.Recently,nearly 400 drilling wells have been accomplished,including 143 vertical wells and 130horizontal wells.But the shale gas production | JIANG Zhenxue TANG Xianglu LI Zhuo JI Wenming GAO Xiaoyue YUAN Yuan WANG Pengfei | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 1 |
| 20 | Ll-norm-based common spatial patterns 显示文摘 | WANG Haixian TANG Qin ZHENG Wenming | 2012 | IEEE Transactions on BiomedicalEngineering(S0018-9294)2012，59，3： | 1 |
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