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| 1 | White matter hyperintensity progression is associated with incident probable dementia or mild cognitive impairment显示文摘Background White matter hyperintensity(WMH)on brain MRI is associated with developing dementia or mild cognitive impairment(MCI),but WMH progression over time has not been fully investigated as an independent risk factor.Methods We performed a post hoc analysis of the Systolic Blood Pressure Intervention Trial-Memory and Cognition in Decreased Hypertension(SPRINT MIND)trial.The primary outcome was incident probable dementia or MCI(dementia/MCI)before the follow-up MRI at 48 months from enrolment.The primary predictor was WMH progression,defined as the Z score difference between the follow-up and baseline WMH volumes.The secondary predictor was a binary WMH progression threshold(≥1.4 mL vs<1.4 mL).Results Among the 433 included patients,33(7.6%)developed dementia/MCI.There were 156(36.0%)patients who met the WMH progression threshold of≥1.4 mL,in whom the rate of dementia/MCI was 12.8%(20/156)vs 4.7%(13/277)of patients with<1.4 mL WMH progression(p=0.002).In multivariable logistic regression,the Z score of WMH progression was associated with dementia/MCI(OR 1.51,95%CI 1.12 to 2.04,p=0.007)as was the WMH progression threshold of≥1.4 mL(OR 2.89,95%CI 1.23 to 6.81,p=0.015).Conclusions In this post hoc analysis of SPRINT MIND,WMH progression over 48 months was associated with the development of probable dementia or MCI. | Adam de Havenon Kevin N Sheth Sharon D Yeatts Tanya N Turan Shyam Prabhakaran | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 2 | Large artery stiffness predicts ischemic threshold in patients with coronary artery disease显示文摘 | Bronwyn A Kingwell Tamara K Waddell Tanya L Medley James D Cameron Anthony M Dart | 2002 | Journal of the American College of Cardiology2002，，4： | 2 |
| 3 | Inhibin resistance is associated with aggressive tumorigenicity of ovarian cancer cells显示文摘 | MICHAEL D S TANYA J S BARBARA C V | 2005 | Molecular Cancer Research2005，3，1： | 1 |
| 4 | Use of a Tetracycline - Inducible System for Conditional Expression in Mycobacterium tuberculosis and Mycobacterium smeonatis 显示文摘 | Paul Carroll D G Niranjala Muttucumaru Tanya Parish | 2005 | Applied and Environmental Microbiology2005，71，： | 1 |
| 5 | Implementation of an urban canopy parameterization in a mesoscale meteorological model显示文摘 | Tanya L O Avraham L Sylvain D | 2004 | Journal of Applied Meteorology2004，43，： | 1 |
| 6 | Adolescent Body Image and Psychosocial Functioning显示文摘 | Tanya E D Marita P | 2006 | The Journal of Social Psychology2006，146，1： | 1 |
| 7 | Self-similar evolution of self- written waveguides 显示文摘 | TANYA M M PETER D M | 1998 | Opt Lett1998，23，4： | 1 |
| 8 | Modeling the fabrication of hollow fibers: capillary drawing 显示文摘 | ALISTAIR D F KENTARO F TANYA M M | 2001 | Journal of Lightwave Technology2001，19，12： | 1 |
| 9 | Duration of lipid peroxida- tion after acute spinal cord injury in rats and the effect of methylprednisolone显示文摘 | Sean D C Ben C B Tanya M | 2008 | Neurosurg Focus2008，25，5： | 1 |
| 10 | Self-Similar Evolution of SelfWritten Waveguides显示文摘 | Tanya M M Eter D M | 1998 | Optics Letters1998，23，4： | 1 |
| 11 | Evolution of Accreditation in Continuing Nursing Education in America 显示文摘 | Tanya D Whitehead Lora Lacey - Haun | 2008 | The Journal of Continuing EdUcation in Nursing2008，39，11： | 1 |
| 12 | Comparative analgesic and cardiopulmonary effects of bupivacaine and ropivacaine in the epidural space of the conscious dog显示文摘 | Tanya Duke Nigel A Caulkett Stephanie D Ball | 2000 | Veterinary Anaesthesia and Analgesia2000，，27： | 1 |
| 13 | Impedometric herbicide sensors based-on molecularly imprinted polymers 显示文摘 | Tanya P D Vladimir M M Mathias V | 2001 | Anal Chim Acta2001，，435： | 1 |
| 14 | GM1 and tumor necrosis factor-, overexpressed in renal cell carcinoma, synergize to induce T-cell apoptosis 显示文摘 | TANYA D GAURISANKAR S CYNTHIA H | 2008 | Cancer Research2008，68，6： | 1 |
| 15 | Curcumin selectively induces apoptosis in deregulated CyclinDl-ex- pressed cells at G2 phase of cell cycle in a p53-dependent manner显示文摘 | TATHAGATA C SUMAN P TANYA D | 2005 | J BiolChem2005，280，20： | 1 |
| 16 | Mechanisms underlying maintenance of smooth muscle cell quiescence in rat aorta: role of the cyclin dependent kinases and their inhibitors显示文摘 | Izzard Christine T Sonia D Birket T Christopher L | 2002 | Cardiovasc Res2002，53，： | 1 |
| 17 | The decision to disclose environmental information: a research review and agenda 显示文摘 | Tanya M L Paul D H | 2005 | Advances in Accounting2005，21，5： | 1 |
| 18 | Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is an inflammatory disease,which presents with epigastric pain and is clinically diagnosed by amylase and lipase three times the upper limit of normal.The 2012 Atlanta classification stratifies the severity of AP as one of three risk categories namely,mild AP(MAP),moderately severe AP(MSAP),and severe AP(SAP).Challenges in stratifying AP upon diagnosis suggest that a better understanding of the underlying complex pathophysiology may be beneficial.AIM To identify the role of the chemokine receptor 8(CCR8),expressed by T-helper type-2 Lymphocytes and peritoneal macrophages,and its possible association to Interleukin(IL)-6 and AP stratification.METHODS This study was a prospective case-control study.A total of 40 patients were recruited from the Chris Hani Baragwanath Academic Hospital and the Charlotte Maxeke Johannesburg Academic Hospital.Bioassays were performed on 29 patients(14 MAP,11 MSAP,and 4 SAP)and 6 healthy controls as part of a preliminary study.A total of 12 mL of blood samples were collected at Day(D)1,3,5,and 7 post epigastric pain.Using multiplex immunoassay panels,real-time polymerase chain reaction(qRT-PCR)arrays,and multicolour flow cytometry analysis,immune response-related proteins,genes,and cells were profiled respectively.GraphPad Prism^(TM) software and fold change(FC)analysis was used to determine differences between the groups.P<0.05 was considered significant.RESULTS The concentration of IL-6 was significantly different at D3 post epigastric pain in both the MAP group and MSAP group with P=0.001 and P=0.013 respectively,in a multiplex assay.When a FC of 2 was applied to identify differentially expressed genes using RT2 Profiler,CCR8 was shown to increase steadily with disease severity from MAP(1.33),MSAP(38.28)to SAP(1172.45)median FC.Further verification studies using RT-PCR showed fold change increases of CCR8 in MSAP and SAP ranging from 1000 to 1000000 times when represented as Log10,compared to healthy control respectively at D3.The findings also showed differing lymphocyte and monocyte cell frequency between the groups.With monocyte population frequency as high as 70%in MSAP at D3.CONCLUSION The higher levels of CCR8 and IL-6 in the severe patients and immune cell differences compared to MAP and controls provide an avenue for exploring AP stratification to improve management. | Mwangala Nalisa Ekene Emmanuel Nweke Martin D Smith Jones Omoshoro-Jones John WS Devar Rebecca Metzger Tanya N Augustine Pascaline N Fru | 2021 | World Journal of Gastrointestinal Pathophysiology2021，12，6： | 1 |
| 19 | A longitudinal study of job stress in the nursing profession : causes and consequences显示文摘 | Tanya G Margotvan D D | 2006 | Journal of Nursing Management2006，14，4： | 1 |
| 20 | Self-similar evolUtion of self- written waveguides显示文摘 | TANYA M M PETER D M | 1998 | Opt Lett1998，23，4： | 1 |
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