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| 1 | GABAergic Abnormalities Associated with Sensorimotor Corticostriatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naive Patients with Schizophrenia显示文摘The current study was designed to explore how disruption of specific molecular circuits in the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in both a mouse model and patients with schizophrenia.We used prepulse inhibition(PPI)and brain structural and diffusion MRI scans in 23 mice with conditional ErbB4 knockout in parvalbumin interneurons and 27 matched controls.Quantitative real-time PCR was used to assess the differential levels of GABA-related transcripts in brain regions.Concurrently,we measured structural and diffusion MRI and the cumulative contribution of risk alleles in the GABA pathway genes in firstepisode treatment-naı¨ve schizophrenic patients(n=117)and in age-and sex-matched healthy controls(n=86).We present the first evidence of gray and white matter impairment of right sensorimotor cortico-striatal networks and reproduced the sensorimotor gating deficit in a mouse model of schizophrenia.Significant correlations between gray matter volumes(GMVs)in the somatosensory cortex and PPI as well as glutamate decarboxylase 1 mRNA expression were found in controls but not in knockout mice.Furthermore,these findings were confirmed in a human sample in which we found significantly decreased gray and white matter in sensorimotor cortico-striatal networks in schizophrenic patients.The psychiatric risk alleles of the GABA pathway also displayed a significant negative correlation with the GMVs of the somatosensory cortex in patients.Our study identified that ErbB4 ablation in parvalbumin interneurons induced GABAergic dysregulation,providing valuable mechanistic insights into the sensorimotor cortico-striatal community structure deficits associated with schizophrenia. | Chengcheng Zhang Peiyan Ni Yikang Liu Yang Tian Jinxue Wei Bo Xiang Liansheng Zhao Xiaojing Li Xiaohong Ma Wei Deng Wanjun Guo Rongjun Ni Yamin Zhang Qiang Wang Hailiang Huang Nanyin Zhang Tao Li | 2020 | Neuroscience Bulletin2020，36，2： | 9 |
| 2 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 3 | Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Na?ve Patients with Schizophrenia显示文摘Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia.Meanwhile,progressive neurodegenerative processes have also been reported,leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of schizophrenia.However,a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain structures.To clarify this potential confounding factor,we measured the cortical thickness across the whole brain using highresolution T1-weighted magnetic resonance imaging in 145 first-episode and treatment-naive patients with schizophrenia and 147 healthy controls.The results showed that,in the patient group,the frontal,temporal,parietal,and cingulate gyri displayed a significant age-related reduction of cortical thickness.In the control group,age-related cortical thickness reduction was mostly located in the frontal,temporal,and cingulate gyri,albeit to a lesser extent.Importantly,relative to healthy controls,patients exhibited a significantly smaller age-related cortical thickness in the anterior cingulate,inferior temporal,and insular gyri in the right hemisphere.These results provide evidence supporting the existence of neurodegenerative processes in schizophrenia and suggest that these processes already occur in the early stage of the illness. | Yin Lin Mingli Li Yi Zhou Wei Deng Xiaohong Ma Qiang Wang Wanjun Guo Yinfei Li Lijun Jiang Xun Hu Nanyin Zhang Tao Li | 2019 | Neuroscience Bulletin2019，35，4： | 5 |
| 4 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 5 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 6 | Mesenchymal-Stem-Cell-Induced Immunoregulation Involves FAS-Ligand-/FAS-Mediated T Cell Apoptosis显示文摘 | Kentaro Akiyama Chider Chen DanDan Wang Xingtian Xu Cunye Qu Takayoshi Yamaza Tao Cai WanJun Chen Lingyun Sun Songtao Shi | 2012 | Cell Stem Cell2012，，5： | 2 |
| 7 | Molecular spectrum of thalassemia in tropical Hainan Island of southern China:high allele frequency with low health burden显示文摘Thalassemia is the most common monogenetic disorder prevalent in tropical and subtropical regions.It is mainly classified into aandβ-thalassemia according to which globin chain is affected(Taher et al.,2018).Thalassemia mutations present significant genetic diversity,which causing absent(a~0 andβ~0)or reduced(a+andβ+)synthesis of globin chains.Consequently,homozygotes or compound heterozygotes of different thalassemia alleles can lead to various clinical phenotypes. | Yanquan Lai Fangchao Tao Yu Zou Min Huang Kaiting Lin Yang Li Weilun Huang Wanjun Zhou | 2022 | Journal of Genetics and Genomics2022，49，12： | 1 |
| 8 | Immunological Markers for Central Nervous System Glia显示文摘Glial cells in the central nervous system(CNS)are composed of oligodendrocytes,astrocytes and microglia.They contribute more than half of the total cells of the CNS,and are essential for neural development and functioning.Studies on the fate specification,differentiation,and functional diversification of glial cells mainly rely on the proper use of cell-or stage-specific molecular markers.However,as cellular markers often exhibit different specificity and sensitivity,careful consideration must be given prior to their application to avoid possible confusion.Here,we provide an updated overview of a list of well-established immunological markers for the labeling of central glia,and discuss the cell-type specificity and stage dependency of their expression. | Hao Huang Wanjun He Tao Tang Mengsheng Qiu | 2023 | Neuroscience Bulletin2023，39，3： | 1 |
| 9 | CDK1、CDK2 siRNA干扰对肿瘤细胞凋亡和细胞周期的影响(英文)显示文摘Objective:We investigated the influence of CDK1 and CDK2 expression inhibited by cotransfection of CDK1 and CDK2 siRNA on cell cycle and apoptosis,explored the exact role of cell cycle master regulator in tumor cell apoptosis process.Methods:The siRNA targeting the CDK1 and CDK2 genes were synthesized and simultaneously cotransfected into Hela cells by lipofectamine 2000.48 or 60 h after the cotransfection,CDK1 and CDK2 protein expressions were examined by Western blot.Cell cycle distribution was analyzed by flow cytometry.Cell apoptosis was detected by the Annexin V/PI method.The changes of the transfected cell morphological under a microscope after Wright-Giemsa Staining were studied.Results:CDK1 and CDK2 protein expression was decreased at 48 or 60 h after cotransfection.The accumulation of the G2/M and S phase population in cell cycle of the cotransfected cells at 48 or 60 h after transfection was enhanced obviously compared with control.The ratio of apoptotic cell of cotransfected cells at 48 or 60 h after transfection was increased significantly compared with control.More binucleate or multinucleate cells among cotransfected cells were observed under the microscope.Conclusion:The decreased expression of CDK1 and CDK2 by cotransfection of CDK1 and CDK2 siRNA not only leads to tumor cell cycle arrest in S phase and G2/M phase,but also induces tumor cell apoptosis. | Hui Xiao Wanjun Gong Jingpeng Cao Xiaolan Li Deding Tao Junbo Hu Jianping Gong | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，7： | 1 |
| 10 | The effect of polysaccharide peptide and taxol on hu- man solid tumor tissue in vitro 显示文摘 | DOU Danyang TAO Wanjun LI Lingling | 2011 | J Med Plant Res2011，5，17： | 1 |
| 11 | Shared and Distinct Topographic Alterations of Alpha-Range Resting EEG Activity in Schizophrenia,Bipolar Disorder,and Depression显示文摘DearEditor,Schizophrenia(SCZ),bipolar disorder(BD),and major depressive disorder(MDD)are common psychiatric disorders that share several characteristics such as risk genes,and cognitive,neural,and structural abnormalities[1-3].Despite this,the boundaries between the three disorders are not clearly defined in clinical practice,and the'crosscutting'dimensional assessment of symptoms and clinical phenomena is controversial[2,4].To improve the classification criteria,it is essential to explore the underlying relationships among these disorders and address the fuzzy divergence that exists. | Rui Xue Xiaojing Li Jianning Chen Sugai Liang Hua Yu Yamin Zhang Wei Wei Yan Xu Wei Deng Wanjun Guo Tao Li | 2023 | Neuroscience Bulletin2023，39，12： | 0 |
| 12 | Unmanned air vehicle adaptability and application evaluation for new rice panicle fertilizers:Fertilizer characteristics and mechanical adaptability显示文摘High-efficiency fertilizers suitable for mechanical spraying can improve the fertilizer application and utilization efficiency.In this study,two types of granular compound fertilizers suitable for unmanned air vehicle spraying were developed using urea,potassium chloride,humic acid,and an amino acid synergist according to the fertilization requirements of rice at the booting stage.The physical and chemical properties of the compound fertilizers were analyzed by Fourier transform infrared spectroscopy and scanning electron microscopy.The release kinetics of the fertilizer was studied via a soil column leaching experiment.The effect of fertilizer particles on unmanned air vehicle spraying uniformity was studied via an orthogonal simulation experiment.Results showed that the chemical interaction between compound-fertilizer raw materials formed complexes such as C-NH-C and-CO-NH-,which caused a change in fertilizer particle morphology.This led to chemical monolayer adsorption or internal fertilizer diffusion,which in turn delayed the fertilizer release by 5−10 d.A simulation bench test showed that the fertilizer particle hardness and roundness exceeded 20 N and 85%,respectively,while the particle size was in the range of 2.07−5.13 mm,which resulted in good unmanned air vehicle spraying uniformity with a lateral variation coefficient of less than 15%.Finally,the experimental field results demonstrated that the new compound fertilizers,when sprayed by an unmanned air vehicle,could improve the economic benefit by 916−2742 CNY ha−1 without reducing the nitrogen utilization rate and rice yield.The new compound fertilizers exhibit delayed release,good spraying uniformity,and improved economic benefit,rendering them suitable for large-scale promotion and application. | Shilin Zhu Wei Zhou Li Zhu Boteng Sun Song Huang Zhenyuan Wu Qin Qin Tao Wang Yong Chen Fei Deng Xiaolong Lei Youfeng Tao Hong Cheng Wanjun Ren | 2022 | Technology in Agronomy2022，2，1： | 0 |
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