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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 3 | Analysis of risk factors for postoperative pancreatic fistula following pancreaticoduodenectomy显示文摘AIM:To explore the morbidity and risk factors of postoperative pancreatic fistula(POPF)following pancreaticoduodenectomy.METHODS:The data from 196 consecutive patients who underwent pancreaticoduodenectomy,performed by different surgeons,in the General Hospital of the People’s Liberation Army between January 1st,2013and December 31st,2013 were retrospectively collected for analysis.The diagnoses of POPF and clinically relevant(CR)-POPF following pancreaticoduodenectomy were judged strictly by the International Study Group on Pancreatic Fistula Definition.Univariate analysis was performed to analyze the following factors:patient age,sex,body mass index(BMI),hypertension,diabetes mellitus,serum CA19-9 level,history of jaundice,serum albumin level,blood loss volume,pancreatic duct diameter,pylorus preserving pancreaticoduodenectomy,pancreatic drainage and pancreaticojejunostomy.Multivariate logistic regression analysis was used to determine the main independent risk factors for POPF.RESULTS:POPF occurred in 126(64.3%)of the patients,and the incidence of CR-POPF was 32.7%(64/196).Patient characteristics of age,sex,BMI,hypertension,diabetes mellitus,serum CA19-9 level,history of jaundice,serum albumin level,blood loss volume,pylorus preserving pancreaticoduodenectomy and pancreaticojejunostomy showed no statistical difference related to the morbidity of POPF or CR-POPF.Pancreatic duct diameter was found to be significantly correlated with POPF rates by univariate analysis and multivariate regression analysis,with a pancreatic duct diameter≤3 mm being an independent risk factor for POPF(OR=0.291;P=0.000)and CR-POPF(OR=0.399;P=0.004).The CR-POPF rate was higher in patients without external pancreatic stenting,which was found to be an independent risk factor for CR-POPF(OR=0.394;P=0.012).Among the entire patient series,there were three postoperative deaths,giving a total mortality rate of 1.5%(3/196),and the mortality associated with pancreatic fistula was 2.4%(3/126).CONCLUSION:A pancreatic duct diameter≤3 mm is an independent risk factor for POPF.External stent drainage of pancreatic secretion may reduce CR-POPF mortality and POPF severity. | Qi-Yu Liu Wen-Zhi Zhang Hong-Tian Xia Jian-Jun Leng Tao Wan Bin Liang Tao Yang Jia-Hong Dong | 2014 | World Journal of Gastroenterology2014，20，46： | 32 |
| 4 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 5 | Releasing characteristics of phosphorus and other substances during thermal treatment of excess sludge显示文摘磷,氮混合物, organics,和在过量污泥的热处理期间的一些金属阳离子的释放特征被调查。在加热不仅磷,而且氮混合物期间, organics,和一些金属阳离子能在丰富被释放,这被发现。在集中的大约 90 mg/L 的最大的 orthophosphate ( ortho-P )版本为挥发性脂肪酸( VFA )在 1 h.Except 在 50 ℃ 被观察,比较地小的总氮( TN ),全部的器官的碳( TOC ),并且金属阳离子进一步在一样的 time.Suchresults 力量帮助被释放磷 recovery.VFAs 的过程是更加释放的仅仅 at50 ℃醋性,奶油,并且支撑离子的酸接着是最丰富的部件,他们的释放侧面与时间展出了好线性关系( R^2 = 0.9977,0.9624 , and0.8908 ,分别地)。Mg^(2+) 和在热处理期间与时间和温度增加的 K^+ 的集中,而是 Mg^(2+) 和 K^+ 的 Ca^(2+) decreased.The 版本与 TP 版本同意了很好(R2= 0.9892 并且 0.9476,分别地) 。在试验性的范围的温度有很小的影响在线性关系,特别 Mg^(2+) 。而且,推迟的固体(MLSS ) 被发现在 50 ℃作为释放 ortho-Pand 总数磷(TP ) 是为热污泥处理的一个重要因素的混合白酒的参数增加了非常单一当 MLSS 从 4000 to8000 被增加时 mg/L。 | XUE Tao HUANG Xia | 2007 | Journal of Environmental Sciences2007，19，10： | 26 |
| 6 | Genome analysis of Taraxacum kok-saghyz Rodin provides new insights into rubber biosynthesis显示文摘The Russian dandelion Taraxacum kok-saghyz Rodin(TKS), a member of the Composite family and a potential alternative source of natural rubber(NR) and inulin, is an ideal model system for studying rubber biosynthesis. Here we present the draft genome of TKS, the first assembled NR-producing weed plant. The draft TKS genome assembly has a length of 1.29 Gb, containing 46 731 predicted protein-coding genes and68.56% repeats, in which the LTR-RT elements predominantly contribute to the genome enlargement. We analyzed the heterozygous regions/genes, suggesting its possible involvement in inbreeding depression.Through comparative studies between rubber-producing and non-rubber-producing plants, we found that enzymes of the mevalonate(MVA) pathway and rubber elongation might be critical for rubber biosynthesis, and several key isoforms have been isolated and shown to be predominantly expressed in the latex, indicating their crucial functions in rubber biosynthesis. Moreover, for two important families in rubber elongation, the CPT/CPTL and REF/SRPP families, diverse evolutionary tracks have been revealed. These results provide valuable resources and new insights into the mechanism of NR biosynthesis,and facilitate the development of alternative NR-producing crops. | Tao Lin Xia Xu Jue Ruan Shizhong Liu Shigang Wu Xiujuan Shao Xiaobo Wang Lin Gan Bi Qin Yushuang Yang Zhukuan Cheng Suhua Yang Zhonghua Zhang Guosheng Xiong Sanwen Huang Hong Yu Jiayang Li | 2018 | National Science Review2018，5，1： | 22 |
| 7 | Effect of Cesarean Section on the Severity of Postpartum Hemorrhage in Chinese Women: The Shanxi Study显示文摘 | Chang XU Qiang FU Hong-bing TAO Xiao-jun LIN Man-li WANG Shu-xu XIA Hao-ling XIONG | 2018 | Current Medical Science2018，38，4： | 22 |
| 8 | Shrinking the malaria map in China: measuring the progress of the National Malaria Elimination Programme显示文摘Background:Remarkable progress has been made towards the elimination of malaria in China since the National Malaria Elimination Programme(NMEP)was launched in 2010.The incidence of locally-acquired malaria cases has declined rapidly and endemic areas have also dramatically shrunk.In total,3078 malaria cases were reported in 2014,but only 56 cases were indigenous.In order to further promote the elimination programme,we reviewed the progress of and experiences associated with malaria elimination in China,and identified the challenges and priorities for the next stage of the programme.Methods:Data were collected from the web-based China Information System for Disease Control and Prevention,and the China Annual Report of Malaria Elimination.The progress towards the elimination of malaria from 2010 to 2014 was measured.Results:During the implementation of the NMEP from 2010 to 2014,local malaria incidence has declined continuously,only remaining in the Yunnan Province and Tibet Autonomous Region in 2014.By the end of 2015,75.6%(1636/2163)of the malaria-endemic counties passed the sub-national elimination assessment.The main challenges are cases of border malaria and imported malaria from other countries.Sustainable support and investment from the government,the establishment of an effective surveillance and response system,and risk assessments for the potential reintroduction of malaria are priorities for the next stage of the elimination programme.Conclusions:The NMEP in China has been successfully implemented thus far and the malaria map has shrunk dramatically.The priorities for malaria elimination are interventions to block transmission at border areas,management of imported malaria cases,preventing malaria reintroduction,capacity building,and sustainability of malaria surveillance and response. | Tao Hu Yao-Bao Liu Shao-Sen Zhang Zhi-Gui Xia Shui-Sen Zhou Jun Yan Jun Cao Zhan-Chun Feng | 2016 | Infectious Diseases of Poverty2016，5，1： | 23 |
| 9 | Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma显示文摘Serum enzymes that play potential roles in tumor growth have recently been reported to have prognostic relevance in a diverse array of tumors.However,prognosis-related serum enzymes are rarely reported for nasopharyngeal carcinoma(NPC).To clarify whether the level of serum enzymes is linked to the prognosis of NPC,we reviewed the pretreatment data of lactate dehydrogenase(LDH),alkaline phosphatase (ALP),and glutamyl transferase (GGT) in 533 newly diagnosed NPC patients who underwent radical radiotherapy between May 2002 and October 2003 at Sun Yat-sen University Cancer Center.Patients were grouped according to the upper limit of normal values of LDH,ALP,and GGT.The Kaplan-Meier method and log-rank test were used for selecting prognostic factors from clinical characteristics and serum enzymes,and the chi-square test was applied to analyze the relationships of clinical characteristics and serum enzymes.Finally,a Cox proportional hazards model was used to identify the independent prognostic factors.We found that increased levels of LDH had poor effects on both overall survival and distant metastasis-free survival(P=0.009 and 0.035,respectively),and increased pretreatment level of serum ALP had poor effects on both overall survival and local recurrence-free survival(P=0.037 and 0.039,respectively).In multivariate analysis,increased LDH level was identified as an independent prognostic factor for overall survival.Therefore,we conclude that increased pretreatment serum LDH and ALP levels are poor prognostic factors for NPC. | Guo Li Jin Gao Ya-Lan Tao Bing-Qing Xu Zi-Wei Tu Zhi-Gang Liu Mu-Sheng Zeng Yun-Fei Xia | 2012 | Chinese Journal of Cancer2012，31，4： | 21 |
| 10 | Determining "abnormal" levator hiatus distensibility using three-dimensional transperineal ultrasound in Chinese women显示文摘The dimension of the levator hiatus is a possible predictor of pelvic organ prolapse (POP). Thisretrospective study investigated 360 women who went to urogynecological clinic for pelvic floor discomfort.Levator hiatus dimensions were obtained by three-dimensional transperineal ultrasound and results werecompared between women with and without significantly objective prolapse (International Continence SocietyPOP quantification, grade 2 or higher). Receiver operating characteristic (ROC) curve analyses were performed todetermine valid screening index for detecting abnormal levator hiatus distensibility. Women with significantlyobjective prolapse had significantly higher levator hiatus dimensions than those without (all P 〈 0.001). ROCcurve analyses confirmed that hiatal area (HA) of 19.5 cm2 during Valsalva maneuver can be used as single-screening index for abnormal levator hiatus distensibility with sensitivity of 0.80 and specificity of 0.70. In thisstudy, we used a two-step method and achieved higher sensibility (0.80 vs. 0.87) without reducing specificity (0.70vs. 0.71) compared with a single-screening index method. As a result, we suggest that HA ≥ 19.5 cm2 duringValsalva maneuver is an indicator of abnormal levator hiatus distensibility in Chinese women and that the two-step method has higher sensitivity in detecting abnormal distensibility. | Chaoran Dou Qin Li Tao Ying Yulin Yan Xia Wang Bing Hu | 2018 | Frontiers of Medicine2018，12，5： | 21 |
| 11 | Rapid rehabilitation technique with integrated traditional Chinese and Western medicine promotes postoperative gastrointestinal function recovery显示文摘BACKGROUND During the perioperative period, the characteristic therapy of traditional Chinese medicine is effective in improving postoperative rehabilitation. In large-scale hospitals practicing traditional Chinese medicine, there is accumulating experience related to the promotion of fast recovery in the perioperative period.AIM To evaluate the efficacy and safety of Yikou-Sizi powder hot compress on Shenque acupuncture point combined with rapid rehabilitation technique.METHODS This prospective, multicenter, randomized, controlled study included two groups: Treatment group and control group. The patients in the treatment group and control group received Yikou-Sizi powder hot compress on Shenque acupuncture point combined with rapid rehabilitation technique and routine treatment, respectively. Clinical observation regarding postoperative recovery of gastrointestinal function was performed, including the times to first passage of flatus, first defecation, and first normal bowel sounds. The comparison between groups was conducted through descriptive analysis, χ~2, t, F, and rank-sum tests.RESULTS There was a statistically significant difference in the time to postoperative first defecation between the treatment and control group(87.16 ± 32.09 vs 109.79 ±40.25 h, respectively;P < 0.05). Similarly, the time to initial recovery of bowel sounds in the treatment group was significantly shorter than that in the control group(61.17 ± 26.75 vs 79.19 ± 33.35 h, respectively;P < 0.05). However, there was no statistically significant difference in the time to initial exhaust between the treatment and control groups(51.54 ± 23.66 vs 62.24 ± 25.95 h, respectively;P >0.05). The hospitalization expenses for the two groups of patients were 62283.45 ±12413.90 and 62059.42 ± 11350.51 yuan, respectively. Although the cost of hospitalization was decreased in the control group, the difference was not statistically significant(P > 0.05). This clinical trial was safe without reports of any adverse reaction or event.CONCLUSION The rapid rehabilitation technique with integrated traditional Chinese and Western medicine promotes the recovery of postoperative gastrointestinal function and is significantly better than standard approach for patients after colorectal surgery. | Li-Xing Cao Zhi-Qiang Chen Zhi Jiang Qi-Cheng Chen Xiao-Hua Fan Shi-Jun Xia Jin-Xuan Lin Hua-Chan Gan Tao Wang Yang-Xue Huang | 2020 | World Journal of Gastroenterology2020，26，23： | 21 |
| 12 | Discrimination of abiogenic and biogenic alkane gases显示文摘We have combined the analytical data of the carbon isotope distribution pattern, R/Ra and CH4/3He values of abiogenic and biogenic (referring to the thermogenic and bacterial or microbial) alkane gases in China with those of alkane gases from USA, Russia, Germany, Australia and other countries. Four discrimination criteria are derived from this comparative study: 1) Carbon isotopic composition is generally greater than -30‰ for abiogenic methane and less than -30‰ for biogenic methane; 2) Abiogenic alkane gases have a carbon isotopic reversal trend (δ 13C1> δ 13C2> δ 13C3> δ 13C4) with δ 13C1>-30‰ in general; 3) Gases with R/Ra >0.5 and δ 13C11 δ 13C2>0 are of abiogenic origin; 4) Gases (meth- ane) with CH4/3He≤106 are of abiogenic origin, whereas gases with CH4/3He≥1011 are of biogenic origin. | DAI JinXing ZOU CaiNeng ZHANG ShuiChang LI Jian NI YunYan HU GuoYi LUO Xia TAO ShiZhen ZHU GuangYou MI JingKui LI ZhiSheng HU AnPing YANG Chun ZHOU QingHua SHUAI YanHua ZHANG Ying MA ChengHua | 2008 | Science China Earth Sciences2008，51，12： | 17 |
| 13 | Effects of Contour Hedgerow Intercropping on Nutrient Losses from the Sloping Farmland in the Three Gorges Area,China显示文摘Eutrophication is recognized as one of the major environmental problems in the Three Gorges Reservoir.Contour hedgerows have been used as a major soil and water conservation measure in this area.Accordingly,a two-year study was conducted to investigate the effects of contour hedgerow intercropping on nutrient loss from sloping farmland in this area.Four treatments were applied:(1) Maize + Soybean,(2) Maize,(3) Maize + Alfalfa,and(4) Maize + Hemerocallis citrina Baroni.Results indicated that nutrient loss in the control treatment(Maize) was serious,especially the average loss flux of total nitrogen(2245.8 mg) and total phosphate(2434.2 mg) in a typical rainfall event.However,the nutrient losses by runoff in the other three treatments with contour hedgerow intercropping showed significant reduction.Compared with the control treatment,the total nitrogen loss in the Alfalfa and Hemerocallis citrina Baroni decreased by 80.9% and 85.0%,respectively,and the total phosphorus loss in the two treatments decreased by 91.2% and 92.5%,respectively.Therefore,it is concluded that nutrient losses could be reduced by using contour hedgerows in the Three Gorges Region.Reducing runoff volume and sediment loss was the main mechanisms of contour hedgerow intercropping to reduce nutrient loss. | WANG Tao ZHU Bo XIA Lizhong | 2012 | Journal of Mountain Science2012，9，1： | 17 |
| 14 | Photocatalytic degradation of Acid Blue 62 over CuO-SnO_2 nanocomposite photocatalyst under simulated sunlight显示文摘新奇 CuO-SnO2 nanocomposite 氧化物光催化剂被简单一起沉淀方法准备,并且由 X 光检查衍射,传播电子显微镜学, N2 吸附解吸附作用测量和紫外力的弥漫的反射光谱学描绘了。相片 CuO-SnO2 的催化活动,在氙光的照耀下面使用作为探查反应的酸蓝色 62 的相片降级评估,也被发现与锻烧温度和到 Sn 的 Cu 的臼齿的比率有关。最大的相片 CuO-SnO2 光催化剂的催化活动被观察为 3 h 在 500 ° C 被锻烧(到 Sn 的 Cu 的臼齿的比率是 1:1 ) 由于有好结晶化和高表面区域的样品。它也显示出许多更高的相片在在与 Degussa P25 TiO2 相比的模仿的日光照耀下面的处理染料废水的催化活动。 | XIA Hui-li ZHUANG Hui-sheng ZHANG Tao XIAO Dong-chang | 2007 | Journal of Environmental Sciences2007，19，9： | 17 |
| 15 | Diagnostic value of gamma-glutamyltransferase/aspartate aminotransferase ratio, protein induced by vitamin K absence or antagonist II, and alpha-fetoprotein in hepatitis B virus-related hepatocellular carcinoma显示文摘BACKGROUND Researchers have investigated the diagnostic value of protein induced by vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), and obtained abundant clinical diagnostic data. However, PIVKA-II and AFP have unsatisfactory specificity and sensitivity in the diagnosis of early-stage HBV-related HCC. Gamma-glutamyltransferase (γ-GT) and aspartate aminotransferase (AST) are common biomarkers for evaluating liver function, and we hypothesized that the γ-GT/AST ratio in combination with PIVKA-II and AFP would improve the diagnosis of early-stage HBV-related HCC. AIM To evaluate the diagnostic value of γ-GT/AST ratio alone or in combination with PIVKA-II and AFP in HBV-related HCC. METHODS Serum levels of γ-GT, AST, PIVKA-II, and AFP were detected and analysed in 176 patients with HBV-related HCC and in 359 patients with chronic hepatitis B. According to tumour size and serum level of HBV DNA, HBV-related HCC patients were divided into the following categories: Early-stage HCC patients, HCC patients, HBV DNA positive (HBV DNA+) HCC patients, and HBV DNA negative (HBV DNA-) HCC patients. Receiver-operating characteristic (ROC) curves were used to analyse and compare the diagnostic value of the single and combined detection of various biomarkers in different types of HBV-related HCC. RESULTS Tumour size was positively correlated with serum levels of PIVKA-II and AFP in HCC patients (r = 0.529, aP < 0.001 and r = 0.270, bP < 0.001, respectively), but there was no correlation between tumour size and the γ-GT/AST ratio (r = 0.073, P = 0.336). The areas under the receiver-operating characteristic curves (AUROCs) of the γ-GT/AST ratio in early-stage HCC patients, HBV DNA+ HCC patients and HBV DNA- HCC patients were not significantly different from that in the total HCC patients (0.754, 0.802, and 0.705 vs 0.779, respectively;P > 0.05). When PIVKA-II was combined with the γ-GT/AST ratio in the diagnosis of earlystage HCC, HCC, and HBV DNA+ HCC, the AUROCs of PIVKA-II increased, with values of 0.857 vs 0.835, 0.925 vs 0.913, and 0.958 vs 0.954, respectively. When AFP was combined with the γ-GT/AST ratio in the diagnosis of early-stage HCC, HCC, HBV DNA+ HCC, and HBV DNA- HCC, the AUROCs of AFP increased, with values of 0.757 vs 0.621, 0.837 vs 0.744, 0.868 vs 0.757, and 0.840 vs 0.828, respectively. CONCLUSION The γ-GT/AST ratio may be better than PIVKA-II and AFP in the diagnosis of early-stage HBV-related HCC, and its combination with PIVKA-II and AFP can improve the diagnostic value for HBV-related HCC. | Qiang Wang Qi Chen Xia Zhang Xiao-Lan Lu Qin Du Tao Zhu Guo-Yuan Zhang Dong-Sheng Wang Qu-Ming Fan | 2019 | World Journal of Gastroenterology2019，25，36： | 17 |
| 16 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 17 | Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis显示文摘Catalpol, iridoid glycoside,在根值 Rehmanniae 的根存在。一些研究证明了 catalpol 为这效果在导致 streptozotocin 的糖尿病的模型,而是内在的机制有显著血糖过低的效果充分没被阐明。因为 mitochondrial 机能障碍在糖尿病的病理起一个重要作用并且因为改善 mitochondrial 功能可以为糖尿病的处理提供一条新途径,这研究被设计。Catalpol 口头上地予导致的高脂肪的 diet/streptozotocin (HFD/STZ ) 和 metformin 被以为 4 个星期的糖尿病的老鼠日报。身体重量(BW )(IPGTT ) , fasting 血葡萄糖(FBG ) 水平,和葡萄糖处理被测量在期间或在处理以后。结果整个 catalpol 管理的四个连续星期在 BW 没有明显的变化显示出 FBG 水平的剂量依赖者减小。Catalpol 治疗实质地在糖尿病的老鼠减少了浆液总数胆固醇和 triglyceride 层次。另外, catalpol 高效地增加了 mitochondrial ATP 生产并且在骨胳的肌肉织物颠倒了 mitochondrial 膜潜力和 mtDNA 拷贝数字的减少。而且, catalpol (200 mg/kg ) 在骨胳的肌肉救了 mitochondrial 超微结构,与传播电子显微镜学检测了。peroxisome 的相对 mRNA 水平(PGC1 ) 当这效果被 catalpol 颠倒时,激活 proliferator 的受体 gamma 激活剂 1 显著地在糖尿病的老鼠的肌肉组织被减少,导致一条剂量依赖者起来规定。一起拿,我们发现 catalpol 能够经由在 HFD/STZ-induced 糖尿病的老鼠的骨胳的肌肉改进 mitochondrial 功能的阴沉的 FBG 水平。 | Xia Li Zhimeng Xu Zhenzhou Jiang Lixin Sun Jinzi Ji Jingshan Miao Xueji Zhang Xiaojie Li Shan Huang Tao Wang Luyong Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 16 |
| 18 | Observation and analysis of near-surface atmospheric aerosol optical properties in urban Beijing显示文摘Year-round measurements of the mass concentration and optical properties of fine aerosols(PM_(2.5)) from June 2009 to May 2010 at an urban site in Beijing were analyzed.The annual mean values of the PM_(2.5) mass concentration,absorption coefficient(Ab),scattering coefficient(Sc) and single scattering albedo(SSA)at 525 nm were 67±66μg/m^3,64 ±62 Mm^(-1),360 ±405 Mm^(-1) and 0.82 ±0.09,respectively.The bulk mass absorption efficiency and scattering efficiency of the PM_(2.5) at 525 nm were 0.78 m^2/g and 5.55 m^2/g,respectively.The Ab and Sc showed a similar diurnal variation with a maximum at night and a minimum in the afternoon,whereas SSA displayed an opposite diurnal pattern.Significant increases in the Ab and Sc were observed in pollution episodes caused by the accumulation of pollutants from both local and regional sources under unfavorable weather conditions.Aerosol loadings in dust events increased by several times in the spring,which had limited effects on the Ab and Sc due to the low absorption and scattering efficiency of dust particles.The frequency of haze days was the highest in autumn because of the high aerosol absorption and scattering under unfavorable weather conditions.The daily PM_(2.5)concentration should be controlled to a level lower than 64 μg/m^3 to prevent the occurrence of haze days according to its exponentially decreased relationship with visibility. | Junshan Jing Yunfei Wu Jun Tao Huizheng Che Xiangao Xia Xiaochun Zhang Peng Yan Deming Zhao Leiming Zhang | 2015 | Particuology2015，13，1： | 16 |
| 19 | 经腹股沟及腹股沟下显微精索静脉结扎术:精索静脉曲张的最佳手术治疗方式的荟萃分析显示文摘以往精索静脉曲张各种治疗方法疗效的荟萃分析存在不一致的结果。因此,我们进行了多种干预措施的荟萃分析,评估10种精索静脉曲张栓塞/硬化治疗方法的有效性和安全性,包括腹腔镜、腹膜后开放、经腹股沟开放和腹股沟下开放静脉结扎,腹股沟下显微和经腹股沟显微精索静脉结扎术,经皮静脉栓塞,TauberJl~行硬化,硬化逆行和期待治疗(无处理)。我们系统回顾了从1966年至2013年8月的35个随机对照试验和观察性研究。经腹股沟、腹股沟下显微手术、腹股沟开放、腹腔镜精索静脉结扎与期待治疗相比显著提高夫妻怀孕率(优势比[OR]分别为:3.48,2.68,2.92和2.9)。与腹膜后开放手术相比,经腹股沟显微手术显著提高患者的精子密度(平均差【MD]:10.60,95%CI:1.92—19.60)并改善精子运动(MD:9.09,95%CI:4.88—13.30)。经腹股沟下和腹股沟显微手术在复发率方面的表现优于开放腹膜后手术(OR分别为0.05,O.06)。Tauber顺行硬化和腹股沟下显微精索静脉结扎术的鞘膜积液形成的风险最低。与腹膜后开放精索静脉曲张术相比,腹股沟显微精索静脉结扎术的总的并发症率最低(OR=O.07,95%CI:0.02。0.19)。其次是腹股沟下显微(OR:O.09,95%CI:0.02.0.19)。经腹股沟显微和腹股沟下显微精索静脉曲张结扎术对提高患者怀孕率有良好的效果,能显著增加精子数量,并有着较低的并发症率。本文研究结果仍需要经过良好设计的随机对照临床研究进一步证实。 | Jun Wang Shu-Jie Xia Zhi-Hong Liu Le Tao Ji-Fu Ge Chen-Min Xu Jian-Xin Qiu | 2015 | Asian Journal of Andrology2015，17，1： | 16 |
| 20 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
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