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| 1 | RVA and Farinograph Properties Study on Blends of Resistant Starch and Wheat Flour显示文摘Resistant starch (RS) is the undigested starch that passes through the small intestine to the large intestine. As afunctional low calorie additive, it has special applications in the food industry. Rapid visco analysis (RVA) and theBrabender farinograph were used to study the pasting properties and the viscoelasticity of blends of RS (RS3 and RS2)and three wheat flours. The wheat flours represented strong gluten wheat (SGW), intermediate gluten wheat (IGW), andweak gluten wheat (WGW) flours, at different levels of RS substitution (0, 5, 10, 15, and 20%). The influence of RS3 on thecontrol wheat flours and RS-wheat flour blends were consistent with those of RS2. The peak, trough, and final viscositiesof RS3-wheat flour blends were higher than those of the corresponding RS2-wheat flour blends. The peak, trough,breakdown, final, and setback viscosities of wheat-RS blends decreased with an increase in resistant starch contents from0 to 20% in the blends. The 0-20% RS-wheat flour blends were all able to form doughs. The dough development times,dough stabilities, dough breakdown times, and farinograph quality numbers for the RS-wheat flour blends decreased asthe RS proportion in the blends increased. The values for RS-SGW flour blends were the highest, followed by RS-IGWand then RS-WGW flour blends. The water absorption values for RS-wheat flour blends and the mixing tolerance index forRS-WGW flour blends were found to increase significantly with an increasing proportion of RS from 0 to 20%, but themixing tolerance index for RS-SGW and RS-IGW flour blends showed no significant differences amongst the differentratios. Correlation analysis showed that the Farinograph quality number was highly positively correlated with doughbreakdown time, dough stability, and dough development time (r = 1.000, 0.958, 0.894), and highly negatively correlatedwith the mixing tolerance index (r = -0.890). Data from this study can be used for the development of dough-basedproducts. It also provides a basis for RS-wheat flour blends and quality evaluation in the food industry. | FU Lei TIAN Ji-chun SUN Cai-ling LI Chun | 2008 | Agricultural Sciences in China2008，7，7： | 17 |
| 2 | Monthly discharge forecasting using wavelet neural networks with extreme learning machine显示文摘Accurate and reliable hydrological forecasting is essential for water resource management. Feedforward neural networks can provide satisfactory forecast results in most cases, but traditional gradient-based training algorithms are usually time-consuming and may easily converge to local minimum. Hence, how to obtain more appropriate parameters for feedforward neural networks with more precise prediction within shorter time has been a challenging task. Extreme learning machine(ELM), a new training algorithm for single-hidden layer feedforward neural networks(SLFNs), has been proposed to avoid these disadvantages. In this study, a conjunction model of wavelet neural networks with ELM(WNN-ELM) is proposed for 1-month ahead discharge forecasting. The à trous wavelet transform is used to decompose the original discharge time series into several sub-series. The sub-series are then used as inputs for SLFNs coupled with ELM algorithm(SLFNs-ELM); the output is the next step observed discharge. For comparison, the SLFNs-ELM and support vector machine(SVM) are also employed. Monthly discharge time series data from two reservoirs in southwestern China are derived for validating the models. In addition, four quantitative standard statistical performance evaluation measures are utilized to evaluate the model performance. The results indicate that the SLFNs-ELM performs slightly better than the SVM for peak discharge estimation, and the proposed model WNN-ELM provides more accurate forecast precision than SLFNs-ELM and SVM. | LI Bao Jian CHENG Chun Tian | 2014 | Science China(Technological Sciences)2014，57，12： | 17 |
| 3 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 4 | SbHKT1;4, a member of the high‐affinity potassium transporter gene family from Sorghum bicolor, functions to maintain optimal Na^+/K^+ balance under Na^+ stress显示文摘In halophytic plants, the high‐affinity potassium transporter HKT gene family can selectively uptake Kt in the presence of toxic concentrations of Nat. This has so far not been well examined in glycophytic crops. Here, we report the characterization of SbHKT1;4, a member of the HKT gene family from Sorghum bicolor. Upon Nat stress, SbHKT1;4 expression was more strongly upregulated in salt‐tolerant sorghum accession, correlating with a better balanced Nat/ Kt ratio and enhanced plant growth. Heterogeneous expression analyses in mutants of Saccharomyces cerevisiae and Arabidopsis thaliana indicated that overexpressing SbHKT1;4 resulted in hypersensitivity to Nat stress, and such hypersensitivity could be alleviated with the supply of elevated levels of Kt, implicating that SbHKT1;4 may mediate Kt uptake in the presence of excessive Nat. Further electrophysiological evidence demonstrated that SbHKT1;4 could transport Nat and Kt when expressed in Xenopus laevis oocytes. The relevance of the finding that SbHKT1;4 functions to maintain optimal Nat/Kt balance under Nat stress to the breeding of salt‐tolerant glycophytic crops is discussed. | Tian‐Tian Wang Zhi‐Jie Ren Zhi‐Quan Liu Xue Feng Rui‐Qi Guo Bao‐Guo Li Le‐Gong Li Hai‐Chun Jing | 2014 | Journal of Integrative Plant Biology2014，56，3： | 11 |
| 5 | Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice显示文摘可观的证据显示那种类型 1 个 T 助手(Th1 )- 并且当时,调停 Th17 的有免疫力的回答支持动脉粥样硬化患者匾的形成那 CD4 + CD25 + 规章的 T 房间(Tregs ) 有的 Foxp3 + 保护的效果。然而,因为令人满意的匾破裂模型的缺乏,在匾破裂遗体的多样的 CD4 + 淋巴细胞子集的功能糟糕理解。这里,我们在颈动脉动脉上用一本高脂肪的食谱和领子放置建立了动脉粥样硬化患者匾破裂的一个鼠科的模型,并且在 apolipoprotein 电子大美人与 lipopolysaccharide, phenylephrine 注射和寒冷的联合由短期的刺激触发了匾破裂(ApoE −/−) 老鼠。我们由 PCR,流动 cytometry, ELISA 和 immunohistochemistry 调查了在 Th1 房间, Th17 房间和 Tregs 和匾破裂之间的协会。总共, 75 %(18/24 ) 脆弱的匾,而是没有稳定的匾,显示出的破裂特征。Th17 房间的比例在处理以后在 splenocytes 之中被增加,但是在 Th1 房间和 Tregs 的层次的变化不与破裂有关。而且,处理在浆液并且在匾破裂的区域导致了 interleukin-17 (IL-17 ) 的高水平。在 vitro, IL-17 增加了 apoptosis 的水平,与匾破裂联系的一个主要因素,在有教养的鼠科的脉管的光滑的肌肉房间。Th17 房间和 IL-17 可以涉及短期的刺激在 ApoE −/− 老鼠。 | Tian Ma Qi Gao Faliang Zhu Chun Guo Qun Wang Fei Gao Lining Zhang | 2013 | Cellular & Molecular Immunology2013，10，4： | 9 |
| 6 | Combination of mild therapeutic hypothermia and adipose-derived stem cells for ischemic brain injury显示文摘Mild therapeutic hypothermia has been shown to mitigate cerebral ischemia, reduce cerebral edema, and improve the prognosis of patients with cerebral ischemia. Adipose-derived stem cell-based therapy can decrease neuronal death and infiltration of inflammatory cells, exerting a neuroprotective effect. We hypothesized that the combination of mild therapeutic hypothermia and adipose-derived stem cells would be neuroprotective for treatment of stroke. A rat model of transient middle cerebral artery occlusion was established using the nylon monofilament method. Mild therapeutic hypothermia(33°C) was induced after 2 hours of ischemia. Adipose-derived stem cells were administered through the femoral vein during reperfusion. The severity of neurological dysfunction was measured by a modified Neurological Severity Score Scaling System. The area of the infarct lesion was determined by 2,3,5-triphenyltetrazolium chloride staining. Apoptotic neurons were detected by terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The regeneration of microvessels and changes in the glial scar were detected by immunofluorescence staining. The inflammatory responses after ischemic brain injury were evaluated by in situ staining using markers of inflammatory cells. The expression of inflammatory cytokines was measured by reverse transcription-polymerase chain reaction. Compared with mild therapeutic hypothermia or adipose-derived stem cell treatment alone, their combination substantially improved neurological deficits and decreased infarct size. They synergistically reduced the number of TUNEL-positive cells and glial fibrillary acidic protein expression, increased vascular endothelial growth factor levels, effectively reduced inflammatory cell infiltration and down-regulated the m RNA expression of the proinflammatory cytokines interleukin-1β, tumor necrosis factor-α and interleukin-6. Our findings indicate that combined treatment is a better approach for treating stroke compared with mild therapeutic hypothermia or adipose-derived stem cells alone. | Kai Zhao Rui Li Sheng Bi Yu Li Long Liu Yu-Long Jia Peng Han Chang-Cong Gu Xi-Ze Guo Wan-Ping Zhang Chun Wang Chun-Ying Pei Lin-Lu Tian Li-Xian Li | 2018 | Neural Regeneration Research2018，13，10： | 9 |
| 7 | High density methane inclusions in Puguang Gasfield:Discovery and a T-P genetic study显示文摘Based on measurement of homogenization temperature of inclusions and Raman spectral analysis, high density methane inclusions were discovered in the Triassic reservoirs of Puguang Gasfield. The methane inclusions show a homogenization temperature Th = -117.5― -118.1℃, a corresponding density of 0.3455―0.3477 g/cm3, and a Raman scatter peak v1 shift varying between 2911―2910 cm-1, which signifies a very high density of methane inclusions. The salt water inclusions paragenetic with methane inclusions show a homogenization temperature Th=170―180℃. Based on the composition of methane inclusions as determined by Raman spectra, PVTsim software was used to simulate the trapping pressure for high density methane inclusions in geologic history, and the trapping pressure was found to be as high as 153―160 MPa. Even though Puguang Gasfield is currently a gas pool of normal pressure, and the fluid pressure for the gas pool ranges between 56―65 MPa. However, data from this study indicates that remarkable overpressure may be generated at the stage of mass production of gas cracked from oils in Cretaceous, as high density methane inclusions constitute key evidence for overpressure in gas pool in geologic history. Meanwhile, discovery of small amounts of H2S, CO2 or heavy hydrocarbon in part of the high density methane inclusions indicates that the geochemical environment for trapping of inclusions may be related to formation of H2S. Therefore, the observation results can help to explore the thermochemical sulfate reduction (TSR) conditions for oil cracking and H2S formation. | LIU Delian DAI JinXing XIAO XianMing TIAN Hui YANG Chun HU AnPing MI JingKui SONG ZhiGuang | 2009 | Chinese Science Bulletin2009，54，24： | 8 |
| 8 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 9 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 10 | Effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats显示文摘Objective To study the effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats. Methods Rat tail-suspension model was used to simulate the physiological effects of microgravity and changes in pulmonary blood vessel morphology, pulmonary arterial and venous blood pressure, pulmonary vascular resistance, pulmonary vasomotoricity, as well as the regulation of pulmonary circulation by cytokines produced and released by the lung of rats were measured. Results The walls of pulmonary blood vessels of rats were thickened, and the pulmonary artery was reconstructed with increased pulmonary vascular resistance. The pulmonary blood vessels of rats became more prone to dilation as contractions increased. Rat epithelial Adrenomedulin gene transcription and protein expression were upregulated. The level of basic fibroblast growth Factor of rat was also elevated. Conclusion Findings from the present study on rats revealed that the microgravity can affect pulmonary blood vessel structure, pulmonary arterial pressure, and pulmonary blood vessel self-regulation and cytokine production. | LI Tian Zhi YUAN Ming CHEN Zhen Hong GUO Ying Hua KANG Chun Yan WANG Jing Yu LI Zhi Li WANG De Sheng WANG Hui Juan YUAN Min LIU Chang Ting | 2013 | Biomedical and Environmental Sciences2013，26，2： | 6 |
| 11 | FED:a web tool for foreign element detection of genome-edited organism显示文摘Dear Editor,Genome editing,especially the newly developed CRISPR technology,is now widely implemented for diverse medical and agricultural applications(Puchta,2018).However,for genome editing,the DNA cassettes encoding the editing components are usually assembled and delivered into the cells of organisms(Cong et al.,2013). | Qing Liu Xiaozhen Jiao Xiangbing Meng Chun Wang Cao Xu Zhixi Tian Chuanxiao Xie Genying Li Jiayang Li Hong Yu Kejian Wang | 2021 | Science China(Life Sciences)2021，64，1： | 6 |
| 12 | The Synthesis of Gracillin and Dioscin: Two Typical Representatives of Spirostanol Glycosides显示文摘Two spirostanol saponins (gracillin and dioscin) which have the typical sugar moieties were synthesized facilely by a general approach. | Chuan Chun ZOU, Shu Jie HOU, Ping Sheng LEI*, Xiao Tian LIANG Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050 | 2003 | Chinese Chemical Letters2003，14，4： | 5 |
| 13 | Contributions of anthropogenic and external natural forcings to climate changes over China based on CMIP5 model simulations显示文摘Based on observations and historical simulations from the fifth phase of the Coupled Model Intercomparison Project(CMIP5) archive, the contributions of human activities(including greenhouse gases(GHGs), anthropogenic aerosols(AAs), and land use(LU)) and external natural forcings(Nat) to climate changes in China over the past 50 years were quantified. Both anthropogenic and external natural forcings account for 95%–99% of the observed temperature change from 1951–1975 to 1981–2005. In particular, the temperature changes induced by GHGs are approximately 2–3 times stronger than the observed changes, and AAs impose a significant cooling effect. The total external forcings can explain 65%–78% of the observed precipitation changes over the past 50 years, in which AAs and GHGs are the primary external forcings leading to the precipitation changes; in particular, AAs dominate the main spatial features of precipitation changes in eastern China. Human activities also dominate the long-term non-linear trends in observed temperature during the past several decades, and, in particular, GHGs, the primary warming contributor, have produced significant warming since the 1960 s. Compared to the long-term non-linear trends in observed precipitation, GHGs have largely caused the wetting changes in the arid-semiarid region since the 1970 s, whereas AAs have led to the drying changes in the humid-semihumid region; both LU and Nat can impose certain impacts on the long-term non-linear trends in precipitation. Using the optimal fingerprinting detection approach, the effects of human activities on the temperature changes can be detected and attributed in China, and the effect of GHGs can be clearly detected from the observations in humid-semihumid areas. However, the anthropogenic effects cannot be detected in the observed precipitation changes, which may be due to the uncertainties in the model simulations and to other issues. Although some results in this paper still need improvement due to uncertainties in the coupled models, this study is expected to provide the background and scientific basis for climate changes to conduct vulnerability and risk assessments of the ecological systems and water resources in the arid-semiarid region of China. | ZHAO Tian Bao LI Chun Xiang ZUO Zhi Yan | 2016 | Science China Earth Sciences2016，59，3： | 5 |
| 14 | Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population显示文摘背景最近的研究在不同人口为全身的豺狼座 erythematosus (SLE ) 作为危险性基因识别了信号变换器和抄写 4 的使活跃之物(STAT4 ) 。以便检验在在有 SLE 的病人的基因 STAT4 rs7574865 的单个核苷酸多型性( SNP )的等位基因分发是否与在中国北汉的健康控制的那些不同人口,我们调查了 STAT4 rs7574865 的变体是否与 SLE.Methods 的任何特定的临床的特征被联系我们在在有 SLE 和 497 健康控制的 252 个病人的 STAT4 rs7574865 的 genotyped SNP 。所有题目从中国汉人口的北部分。在 rs7574865 的遗传型被聚合酶链反应(PCR ) 和直接在在那里的 DNA samples.Results PCR 产品定序的后果决定是在在在 SLE 病人和健康控制之间的 rs7574865 的 SNP 的分发的重要差别。与健康控制相比,当 GG 遗传型在为性和年龄调整以后被用作引用遗传型时,在在 rs7574865 和 SLE 的风险的遗传型之间有重要关联。在 SLE 病人的 T 等位基因的频率是强烈比健康控制的显著地高。而且,在在在男、女的 SLE 病人之间的 rs7574865 的 SNP 的分发有重要差别,当时与健康控制相比。在在男病人的 rs7574865 的 T 等位基因的频率比男健康控制或女病人的显著地高。在在 STAT4 rs7574865 和 SLE.Conclusions 的临床的特征的 T 等位基因的频率之间没有重要关联在 STAT4 的 SNP rs7574865 强烈在中国北汉人口与 SLE 的风险被联系。在 STAT4 rs7574869 的遗传型和 T 等位基因是为 SLE 的危险性因素,特别为男 SLE 病人。 | SU Yin ZHAO Yi LIU Xu GUO Jian-ping JIANG Quan LIU Xiang-yuan ZHANG Feng-chun ZHENG Yi LI Xiao-xia SONG Hui HUANG Ci-bo HUANG Yan-hong WANG Tian PAN Si-si LI Chun LIU Xia ZHU Lei ZHANG Chun-fang LI Zhan-guo | 2010 | Chinese Medical Journal2010，，22： | 4 |
| 15 | Diversity and conservation of Chinese wild begonias显示文摘Begonia, one of the most diverse plant taxa and the fifth or sixth largest angiosperm genus, consists of over1800 accepted species. The number of species recognized within this genus has greatly increased over the past 20 years, rising from 80 to 200 species in China alone. Based on recent field surveys, the number of begonia species in China is predicted to be between 250 and 300. Given the large number of begonia species that still remain to be described, further taxonomical work is urgently required. This is especially true for Chinese Begonia, in which there is a huge diversity of habitat, habit, plant size, leaf type, flower and fruit morphology, and most species are narrowly distributed in isolated habitats that are subject to negative disturbances from climate change, as well as agricultural and industrial activities. Although the conservation status for the majority of species has been evaluated using the standards of the International Union for Conservation of Nature, the results don't represent the truth in many species, and also about11.5% of which are data-absent. In addition, illegal collection and over-harvesting of wild begonias for ornamental or medicinal use has increased due to the rapid development of internet commerce. Far more often than predicted, these species should be categorized as rare and endangered and require immediate protection. Ex situ conservation of Chinese begonias started in 1995 and over 60% of the total species have been so far introduced into cultivation by several major botanical gardens in China. However, only few research institutions, limited funds and human resources have been involved in Begonia conservation;moreover, no project has conducted reintroduction. Therefore, more conservation-based work remains to be done. Improved conservation of Chinese begonias in the future depends on further field survey, an improved understanding of population diversity, and integrative approaches, including in situ and ex situ conservation, seed banking, and plant reintroduction. Species-targeted conservation zones should be established for endangered species excluded from the existing nature reserves. Additionally, laws pertaining to plant protection should be extended to prevent the illegal collection and transaction of wild plants, particularly for those species with unique habitats and small populations. | Daike Tian Yan Xiao Yi Tong Naifeng Fu Qingqing Liu Chun Li | 2018 | Plant Diversity2018，40，3： | 4 |
| 16 | Three new sesquiterpene alkaloids from the root of Tripterygium wilfordii显示文摘三新 sesquiterpene 碱, 1-desacetylwilforgine (1 ) , 1-desacetylwilforine (2 ) ,和 9 鈥 ? hydroxy-2-nicotinoylwilforine (3 ) 从 Tripterygium wilfordii 钩 f. 的根被孤立,与六已知的碱一起。他们的结构被建立根据光谱分析。 | Chun Min Wu Lin Mei Zhou Yi Feng Chai Yu Tian Wu Guo Rong Fan | 2010 | Chinese Chemical Letters2010，21，7： | 4 |
| 17 | Dual template approach for the synthesis of hierarchically mesocellular carbon foams显示文摘我们为教主的联盟者中央的合成表明了一条简单、有效的双模板的途径由使用 sorbitan 的非离子的表面活化剂的细胞的碳泡沫是的单音的油酸盐和硅石胶体粒子是的牺牲的模板,和树脂分 / 甲醛碳来源。代表性的碳泡沫有 4 和 10 nm 的双中央毛孔尺寸,并且拥有 580 m 2/g 和 0.80 厘米 3/g 的全部的毛孔体积的特定的表面区域。 | Ming Xian Liu Li Hua Gan Ci Tian Jian Chun Zhu Zi Jie Xu Zhi Xian Hao Long Wu Chen | 2009 | Chinese Chemical Letters2009，20，1： | 3 |
| 18 | A new method of measuring optical turbulence of atmospheric surface layer at Antarctic Taishan Station with ultrasonic anemometer显示文摘To find the optimal location for large-aperture telescopes is a goal of astronomy. Chinese Antarctic astronomy has begun to flourish in recent years, and it is an urgent need in basic astronomical work to measure and analyze the optical turbulence spatiotemporal distribution in the Antarctic region. We analyzed turbulence data measured by a mobile atmospheric parameter measurement system from 30 December 2013 to 10 February 2014 at Antarctic Taishan Station. Because there is a discrepancy between the refractive index structure constant C_n^2 measured by an ultrasonic anemometer with a single-point temperature structure function method and by micro-thermometer, a new method to measure C_n^2 with a temperature spectrum method is proposed herein. Through comparing long-term continuous C_n^2 data derived from ultrasonic anemometer with those via the new method and micro-thermometer, trend, magnitude and measured weak turbulence of ~2×10^(-16)m^(-2/3) are generally satisfactory. The reason for the discrepancy in C_n^2 measurement between the ultrasonic anemometer with the old method and micro-thermometer is investigated. | WU Xiaoqing TIAN Qiguo JIANG Peng CHAI Bo QING Chun CAI Jun JIN Xinmiao ZHOU Hongyan | 2015 | Advances in Polar Science2015，26，4： | 3 |
| 19 | Studies on Agarofurans VIII. Synthesis of the Metabolites of 4-Butyl-a-agarofuran显示文摘The structures of five metabolites (2-6) of agarofuran 1 were confirmed by synthesis. The configuration of the secondary hydroxyl in 7 was determined by Horeau抯 method. The configuration of C-2 in compound 4 and 5 was determined by their stereochemistry and NMR. | Chun Li, Wu Yan Zhang, Ji Yu Guo*, Xiao Tian Liang Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 | 2002 | Chinese Chemical Letters2002，13，1： | 3 |
| 20 | Characteristics of Long-term Nonprogressors and Viremia Controllers Infected with HIV-1 via Contaminated Blood Donations or Transfusions Conducted 20 Years Earlier显示文摘To characterize long‐term nonprogressors(LTNPs)and viremia controllers(VCs),infected with HIV‐1 through contaminated blood donation or transfusion between 1992 and 1996 in Henan,China.LTNPs and VCs were defined by CD4+T lymphocyte(CD4)count and viral load(VL).Of29,294 patients infected with HIV‐1 via contaminated blood donation or transfusion that had conducted for more than 20 years,92 were LTNPs/VCs.There were 70 LTNPs(0.24%),43 | LIU Jia FAN Pan Ying XUE Xiu Juan YAN Jiang Zhou SUN Guo Qing LIU Chun Hua TIAN Sui An LI Ning SUN Ding Yong ZHU Qian WANG Zhe | 2017 | Biomedical and Environmental Sciences2017，30，12： | 3 |
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