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| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | A Rare Allele of GS2 Enhances Grain Size anc Grain Yield in Rice显示文摘谷物尺寸决定谷物重量并且影响谷物质量。调整谷物尺寸的几主要量的特点 loci (QTL ) 被克隆;然而,我们调整米饭谷物的尺寸的内在的机制的理解仍然保持碎片。这里,我们报导克隆和主导的 QTL 的描述,染色体 2 上的谷物尺寸(GS2 ) 编码调整生长的因素 4,一个 transcriptional 管理者。GS2 本地化到原子核并且可以充当抄写使活跃之物。影响 microRNA 的有约束力的地点的 GS2 的一个稀罕变化, OsmiR396c,原因提高了 GS2/OsGRF4 的表示。GS2 表示的增加导致更大的房间和房间的增加的数字,它因此提高谷物重量和产量。进米饭栽培变种的 GS2/OsGRF4 的这稀罕等位基因的介绍能显著地提高谷物重量和增加谷物产量,用在引起产量很高的米饭变化的可能的应用。 | Jiang Hu Yuexing Wang Yunxia Fang Longjun Zeng Jie Xu Haiping Yu Zhenyuan Shi Jiangjie Pan Dong Zhang Shujing Kang Li Zhu Guojun Dong Longbiao Guo Dali Zeng Guangheng Zhang Lihong Xie Guosheng Xiong Jiayang Li Qian Qian | 2015 | Molecular Plant2015，8，10： | 57 |
| 3 | Predictors and clinical outcomes for spontaneous rupture of hepatocellular carcinoma显示文摘AIM:To determine the risk factors for hepatocellular carcinoma(HCC) rupture,and report the management and long-term survival results of patients with spontaneous rupture of HCC.METHODS:Among 4209 patients with HCC who were diagnosed at Eastern Hepatobiliary Surgery Hospital from April 2002 to November 2006,200(4.8%) patients with ruptured HCC(case group) were studied retrospectively in term of their clinical characteristics and prognostic factors.The one-stage therapeutic approach to manage ruptured HCC consisted of initial management by conservative treatment,transarterial embolization(TACE) or hepatic resection.Results of various treatments in the case group were evaluated and compared with the control group(202 patients) without ruptured HCC during the same study period.Continuous data were expressed as mean ± SD or me-dian(range) where appropriate and compared using the unpaired t test.Categorical variables were compared using the Chi-square test with Yates correction or the Fisher exact test where appropriate.The overall survival rate in each group was determined using the Kaplan-Meier method and a log-rank test.RESULTS:Compared with the control group,more patients in the case group had underlying diseases of hypertension(7.5% vs 3.0%,P =0.041) and liver cirrhosis(87.5% vs 56.4%,P < 0.001),tumor size >5 cm(83.0% vs 57.4%,P < 0.001),tumor protrusion from the liver surface(66.0% vs 44.6%,P < 0.001),vascular thrombus(30.5% vs 8.9%,P < 0.001) and extrahepatic invasion(36.5% vs 12.4%,P < 0.001).On multivariate logistic regression analysis,underlying diseases of hypertension(P = 0.002) and liver cirrhosis(P < 0.001),tumor size > 5 cm(P < 0.001),vascular thrombus(P = 0.002) and extrahepatic invasion(P < 0.001) were predictive for spontaneous rupture of HCC.Among the 200 patients with spontaneous rupture of HCC,105 patients underwent hepatic resection,33 received TACE,and 62 were managed with conservative treatment.The median survival time(MST) of all patients with spontaneous rupture of HCC was 6 mo(range,1-72 mo),and the overall survival at 1,3 and 5 years were 32.5%,10% and 4%,respectively.The MST was 12 mo(range,1-72 mo) in the surgical group,4 mo(range,1-30 mo) in the TACE group and 1 mo(range,1-19 mo) in the conservative group.Ninety-eight patients in the control group underwent hepatic resection,and the MST and median diseasefree survival time were 46 mo(range,6-93 mo) and 23 mo(range,3-39 mo) respectively,which were much longer than that of patients with spontaneous rupture of HCC undergoing hepatic resection(P < 0.001).The 1-,3-,and 5-year overall survival rates and the 1-,3-and 5-year disease-free survival rates in patients with ruptured HCC undergoing hepatectomy were 57.1%,19.0% and 7.6%,27.6%,14.3% and 3.8%,respectively,compared with those of 77.1%,59.8% and 41.2%,57.1%,40.6% and 32.9% in 98 patients with-CONCLUSION:Prolonged survival can be achieved in selected patients undergoing one-stage hepatectomy,although the survival results were inferior to those of the patients without ruptured HCC. | Qian Zhu Jing Li Jian-Jun Yan Liang Huang Meng-Chao Wu Yi-Qun Yan | 2012 | World Journal of Gastroenterology2012，18，48： | 40 |
| 4 | Reprogramming of ovine adult fibroblasts to pluripotency via drug-inducible expression of defined factors显示文摘在 enucleated 鸡蛋的体的房间的 Reprogramming 做了多丽,绵羊,在 1996 的第一个成功地克隆的哺乳动物。然而,绵羊的机制体的房间 reprogramming 还没被探讨了。而且,绵羊胚胎的茎(ES ) 细胞仍然不是可得到的,它限制精确修改基因的绵羊的产生。在这研究,我们报导体的房间能是的那只绵羊直接 reprogrammed 到导致的 pluripotent 用定义因素(Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, SV40 大 T 和 hTERT ) 的茎(iPS ) 房间。我们的观察显示从绵羊的体的细胞比从另外的种,在 iPS,细胞被报导了的体的细胞对改编更困难。我们证明绵羊 iPS 房间表示 ES 房间标记,包括碱的磷酸酶, Oct4, Nanog, Sox2, Rex1,阶段特定的胚胎的 antigen-1, TRA-1-60, TRA-1-81 和 E-cadherin。绵羊 iPS 房间展出了正常 karyotypes 并且能在 vitro 并且在 teratomas 区分进所有三细菌层。我们的学习可以帮助在绵羊揭示体的房间 reprogramming 的机制并且提供一个平台为绵羊 ES 房间探索文化条件。而且,绵羊 iPS 房间可以直接被用来产生精确修改基因的绵羊。 | Lei Bao Lixiazi He Jijun Chen Zhao Wu Jing Liao Lmgdun Rao Jiangtao Ren Hui Li Hui Zhu Lei Qian Yijun Gu Huimin Dai Xun Xu Jinqiu Zhou Wen Wang Chun Cui Lei Xiao | 2011 | Cell Research2011，21，4： | 32 |
| 5 | Endovascular treatment of iliac vein compression syndrome显示文摘背景肠骨的静脉压缩症候群( IVCS ),在恰好普通的肠骨的动脉和 vertebrae 之间的左普通肠骨的静脉的征兆的压缩,不是研究是回顾地与在1997年1月和9月2008,296日病人之间的左 IVCS.Methods 在病人评估长期的结果和 endovascular 治疗的意义的这的一个不平常的 condition.The 目的在第二上演的左普通肠骨的 vein.In 的收到的 interventional 治疗, 170 个盒子经历了 | MENG Qing-you LI Xiao-qiang QIAN Ai-min SANG Hong-fei RONG Jian-jie ZHU Li-wei | 2011 | Chinese Medical Journal2011，，20： | 31 |
| 6 | Correlation of red cell distribution width with the severity of coronary artery disease: a large Chinese cohort study from a single center显示文摘 | MA Feng-lian LI Sha LI Xiao-lin LIU Jun QING Ping GUO Yuan-lin XU Rui-xia ZHU Cheng-gang JIA Yan-jun LIU Geng DONG Qian WU Na-qiong JIANG Li-xin LI Jian-jun | 2013 | Chinese Medical Journal2013，，6： | 32 |
| 7 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 8 | 中国乙型肝炎和非肝炎男性间的精液质量和辅助生殖技术治疗结果的比较显示文摘本研究旨在确定乙型肝炎病毒(HBV)感染对精子质量和辅助生殖技术治疗结局的影响。分析2008年1月至2009年12月于浙江大学附属妇产科医院寻求辅助生育治疗的916例男性(457例乙型肝炎病毒携带者和459例阴性对照男性)的精液参数;将2004年1月至2009年12月期间的男性乙肝病毒携带的587个常规体外受精(In vitro fertilisation,IVF)周期和325个单精子卵细胞浆内注射(Intracytoplasmic sperm injection,ICSI)周期作为阳性观察组,根据取卵日期、女方年龄及ART受精方式通过统计软件以1:1比例匹配,设立夫妇双方均为HBsAg阴性的对照组(587个IVF周期,324个ICSI周期),分析两组间的辅助生殖治疗结局。与对照组相比,乙肝携带者表现有较低的精液体积、精子总数以及较差的精子活动力和形态学表现(P〈0.05);乙肝男性夫妇接受ICSI治疗后,双原核(2PN)受精率、优质胚胎率、胚胎着床率以及临床妊娠率均显著性降低俨〈0.05);而两组病人间的IVF治疗结局差异无显著性(P〉0.05)。通过Logistic回归分析发现乙肝病毒感染作为一个独立的因素增加少弱精子症的发生以及降低ICSI治疗周期的胚胎着床率和临床妊娠率(P〈0.05)。我们的研究结果提示了男性乙型肝炎病毒感染与较差的精子质量和ICSI治疗结局有关,而对IVF治疗结局没有明显的影响。 | Xu-Ping Zhou Xiao-Ling Hu Yi-Min Zhu Fan Qu Sai-lun Sun Yu-Li Qian | 2011 | Asian Journal of Andrology2011，13，3： | 27 |
| 9 | Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System显示文摘 | Lu, Yuming Ye, Xiao Guo, Renming Huang, Jing Wang, Wei Tang, Jiuyou Tan, Longtao Zhu, Jian-kang Chu, Chengcai Qian, Yangwen | 2017 | Molecular Plant2017，10，9： | 28 |
| 10 | Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017显示文摘Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD. | Tianjiao Ji Taoli Han Xiaojuan Tan Shuangli Zhu Dongmei Yan Qian Yang Yang Song Aili Cui Yan Zhang Naiying Mao Songtao Xu Zhen Zhu Dandan Niu Yong Zhang Wenbo Xu | 2019 | Biosafety and Health2019，1，1： | 26 |
| 11 | Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist显示文摘瞄准:屏蔽 beta2 肾上腺素能的受体(从同样潜在的药为气喘带使用敏感基于房间的收缩筋试金的根值 Aconiti Lateralis Preparata (RALP ) 的 β
2-AR) 收缩筋。方法:β
2-AR 基因被汉语稳定地表示仓鼠卵巢(CHO ) 房间稳定地也表示周期的腺苷单音的磷酸盐(安培) 反应连接元素的提高的绿荧光灯的蛋白质记者基因。房间被用来从高效的液体屏蔽收缩筋 RALP 的一篇摘录的色析法的部分。有最高的活动的部分为进一步复合的隔离和结构活动关系的学习被选择。它的活跃混合物被层析和集体 spectrometry 进一步识别。结果:RALP 的粗略的摘录的指导 Bioactivity 的分别导致了有效混合物的隔离和描述,也就是 hignamine。它能 dose-dependently 与 EC 50 价值与醋胆素放松孤立的畿尼猪气管长带预约离子(2.60 ± 0 .36 ) × 10 −5 mol/L。进一步,在 vivo,研究也显示了那 hignamine 能保护组织安在畿尼猪劝诱延长气喘的潜伏期的试验性的气喘模型。结论:作为在 RALP 的摘录存在的 β
2-AR 收缩筋, Hignamine 是贡献 bronchoconstriction 的成功的消除的关键混合物。 | Gang BAI Yang YANG Qian SHI Ze LIU Qi ZHANG Yuan-yuan ZHU | 2008 | Acta Pharmacologica Sinica2008，29，10： | 24 |
| 12 | Mapping of a new gene for brown planthopper resistance in cultivated rice introgressed from Oryza eichingeri显示文摘Wild rice species is an important source of useful genes for cultivated rice improvement Some accessions of Oryza eichingeri (In = 24, CC) from Africa confer strong resistance to brown planthopper (BPH), whitebacked planthopper (WBPH) and bacterial blight (KB). In the present study, restriction fragments length polymorphism (RFLP) and simple sequence repeats (SSR) analysis were performed on disomic backcross plants between Oryza saliva (2n =24, AA) and O. eichingeri in order to identify the presence of O, eichingeri segments and further to localize BPH-resistant gene. In the introgression lines, 1-6 O. eichingeri segments were detected on rice chromosomes 1, 2, 6, or/and 10. The dominant BPH resistant gene, tentatively named Bphl3(t), was mapped to chromosome 2, being 6.1 and 5.5 cM away from two microsatellite markers RM240 and RM250, respectively. The transfer and localization of this gene from O. eichingeri will contribute to the improvement of BPH resistance in cultivated rice. | LIU Guoqing YAN Huihuang FU Qiang QIAN Qian ZHANG Zhitao ZHAI Wenxue ZHU Lihuang | 2001 | Chinese Science Bulletin2001，46，17： | 24 |
| 13 | Climate changes in East China since the Late-glacial inferred from high-resolution mountain peat humification records显示文摘High-resolution peat humification records were obtained from Dajiuhu of the Shennongjia Mountains and Qianmutian of the Tianmu Mountains to study climate changes in East China.The analyses of pollen,organic matters,TOC,and Rb/Sr indicate a high degree of peat humification and thus strong decomposition of organic matter when climate was dry.Conversely,when climate was humid,the degree of humification is low because peat was preserved in a waterlogged condition.Peat humification from Dajiuhu occurred not only during the Younger Dryas(about 11.4-12.6 cal ka BP),the Blling-Allerd Warm Period(12.6-15.2 cal ka BP),and the Oldest Dryas(about 15.2-16.0 cal ka BP),but also during the early Holocene(about 11.4-9.4 cal ka BP),the 8.2 cal ka BP cold event,and the Holocene Optimum(about 7.0-4.2 cal ka BP).Both peat humification records since nearly 5 ka BP are consistent,showing that mountain peatland has synchronous responses to the East Asia monsoon-induced precipitation.The LOI data confirm the above observation.The monsoon precipitation since nearly 5 ka BP recorded in these two peat profiles can be divided into three phases.During 4.9-3.5 ka BP,precipitation amount was high but fluctuated greatly.During 3.5-0.9 ka BP,precipitation amount was low.During 0.9-0 ka BP,degree of humification reduced gradually,indicating the increase of monsoon precipitation.Contrast to other high-resolution records from East China monsoon region shows that the monsoon precipitation records of the two peat profiles since nearly 16 ka BP are controlled by a common forcing mechanism of summer solar radicalization in the Northern Hemisphere. | MA ChunMei ZHU Cheng ZHENG ChaoGui YIN Qian ZHAO ZhiPing | 2009 | Science China Earth Sciences2009，52，1： | 22 |
| 14 | Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects显示文摘 | Qian SHI Ze LIU Yang YANG Peng GENG Yuan-yuan ZHU Qi ZHANG Fang BAI Gang BAI | 2009 | Acta Pharmacologica Sinica2009，30，5： | 23 |
| 15 | Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma显示文摘AIM:To investigate the promoter methylation status and mRNA expression of DKK-3 and WIF-1 gene in hepatocellular carcinoma(HCC).METHODS:DKK-3 and WIF-1 acted as Wnt-antagonists and tumor suppressors,but hypermethylation of the gene promoter and low mRNA expression activated Wnt signaling aberrantly and induced the development of HCC.Methylation status of the DKK-3 and WIF-1 gene promoter was investigated using methylation specific polymerase chain reaction(PCR) in tumor and adjacent non-cancerous tissues from 33 HCC patients and 20 normal liver tissues served as control.The expression of DKK-3 and WIF-1 mRNA was also determined by real-time quantitative reverse transcriptase PCR.The relationship between methylation,mRNA expression,and clinical data,as well as methylation and mRNA expression of the two genes were analyzed.RESULTS:The methylation of DKK-3 and WIF-1 genes in HCC increased significantly compared with adjacent non-cancerous tissues and normal control tissues(χ2 =7.79,P < 0.05;χ2 = 4.89,P < 0.05),and no significant difference in methylation between adjacent non-cancerous tissues and normal control tissues was observed.In HCC tissues,significant differences in the DKK-3 promoter methylation were observed in age and cirrhosis,and significant differences of the WIF-1 promoter methylation were observed in HBsAg and cirrhosis.The average expression of DKK-3 mRNA in HCC and adjacent non-cancerous tissues was increased significantly compared with normal control tissues.The average expression of WIF-1 mRNA showed no significant difference among the three tissues.The mRNA expression of DKK-3 gene in HCC was decreased as the pathological grade increased.CONCLUSION:The aberrant promoter methylation and decreased expression of DKK-3 and WIF-1 may be an important mechanism in HCC,and may be a far-reaching significance in early diagnosis and therapy of HCC. | Zhen Ding Ye-Ben Qian Li-Xin Zhu Qi-Ru Xiong | 2009 | World Journal of Gastroenterology2009，15，21： | 22 |
| 16 | Stenting of iliac vein obstruction following catheter-directed thrombolysis in lower extremity deep vein thrombosis显示文摘 | MENG Qing-YOU LI Xiao-qiang JIANG Kun QIAN Ai-min SANG Hong-fei RONG Jian-jie DUAN Peng-fei ZHU Li-wei | 2013 | Chinese Medical Journal2013，，18： | 22 |
| 17 | LSCHL4 from Japonica Cultivar, Which Is Allelic to NAL 1, Increases Yield of Indica Super Rice 93-11显示文摘在米饭的高产量的基本房屋是改进叶光合的效率和坐标 sourcesink relationshipin 米饭植物。与词法特点和米饭的叶绿素内容有关的量的特点 loci ( QTL )在出发到成熟的阶段离开 weredetected ,并且与旗帜叶形状和叶绿素内容有关的主要 QTL ( qLSCHL4 )在 recombinant 在两个阶段被检测生来的线构造了 usingthe indica 米饭栽培变种 93-11 和装饰用的梨树米饭栽培变种 Nipponbare 。基于地图的克隆和表示分析证明 LSCHL4 对 NAL1 突变而产生之遗传,基因以前在米饭的狭窄的叶异种报导了。与从 Nipponbare 带 LSCHL4 的向量转变的 Overexpression 线和 93-11 (NIL-9311 ) 的一根 near-isogenic 线显著地增加了叶叶绿素内容,扩大旗帜叶尺寸,和改进圆锥花序类型。NIL-9311 的 averageyield 比 93-11 的高是 18.70% 。这些结果显示 LSCHL4 有多种的功能。探索并且节节上升更产量很高的等位基因类似于为超级米饭繁殖的 LSCHL4 提供一个有效方法在提起米饭产量完成新突破并且产生解决全球食物 safety.Key 词的问题的新 ideasfor: | Guang-Heng Zhang Shu-Yu Li Li Wang Wei-Jun Ye Da-Li Zeng Yu-Chun Rao You-Lin Peng Jiang Hu Yao-Long Yang Jie Xu De-Yong Ren Zhen-Yu Gao Li Zhu Guo-Jun Dong Xing-Ming Hu Mei-Xian Yan Long-Biao Guo Chuan-You Li Qian Qian | 2014 | Molecular Plant2014，7，8： | 23 |
| 18 | Chemical characteristics of fine particles and their impact on visibility impairment in Shanghai based on a 1-year period observation显示文摘In this work, a one-year observation focusing on high time resolution characteristics of components in fine particles was conducted at an urban site in Shanghai. Contributions of different components on visibility impairment were also studied. Our research indicates that the major components of PM_(2.5) in Shanghai are water-soluble inorganic ions and carbonaceous aerosol, accounting for about 60% and 30% respectively. Higher concentrations of sulfate(SO42-) and organic carbon(OC) in PM_(2.5) occurred in fall and summer, while higher concentrations of nitrate(NO_3^-) were observed in winter and spring. The mass concentrations of Cl^- and K^+ were higher in winter. Moreover, NO_3^- increased significantly during PM_(2.5) pollution episodes. The high values observed for the sulfate oxidizing rate(SOR), nitrate oxidizing rate(NOR) and secondary organic carbon(SOC) in OC indicate that photochemical reactions were quite active in Shanghai. The IMPROVE(Interagency Monitoring of Protected Visual Environments) formula was used in this study to investigate the contributions of individual PM_(2.5) chemical components to the light extinction efficient in Shanghai. Both NH_4NO_3 and(NH_4)_2SO_4 had close relationships with visibility impairment in Shanghai. Our results show that the reduction of anthropogenic SO_2, NO_x and NH_3 would have a significant effect on the improvement of air quality and visibility in Shanghai. | Min Zhou Liping Qiao Shuhui Zhu Li Li Shengrong Lou Hongli Wang Qian Wang Shikang Tao Cheng Huang Changhong Chen | 2016 | Journal of Environmental Sciences2016，28，10： | 22 |
| 19 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 20 | Comparative analysis of twenty-five compounds in different parts of Astragalus membranaceus var.mongholicus and Astragalus membranaceus by UPLC-MS/MS显示文摘As a traditional Chinese medicine,the root of Astragalus membranaceus var.mongholicus(AMM)or A.membranaceus(AM)has been widely used in China and other Asian countries for thousands of years.Till now,the flavonoids,phenolic acids and saponins are considered as the main active components contributing to their therapeutic effect in these plants.In order to clarify the distribution and contents of these compounds in different organs of these plants,a rapid and sensitive analytical method for simultaneous determination of 25 active compounds including seven types(i.e.dihydroflavones,isoflavane,isoflavones,flavones,pterocarpans,phenolic acid and saponins)within 10 min was established using ultra-pressure liquid chromatography coupled with tandem mass spectrometry(UPLCeMS/MS).Then,the established method was fully validated and successfully applied to the determination of the contents of these analytes in different parts(root,rhizome,stem,leaf and flower)of AMM and AM.The results indicated that the contents of the same type of compounds in two different species plants were significantly different.Moreover,the obvious differences were also found for the distribution and contents of different type of compounds in five organs of the same species.The present study could provide necessary information for the rational development and utilization of AMM and AM resource. | Yuan Li Sheng Guo Yue Zhu Hui Yan Da-Wei Qian Han-Qing Wang Jian-Qiang Yu Jin-Ao Duan | 2019 | Journal of Pharmaceutical Analysis2019，9，6： | 23 |
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