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| 1 | Recent advances in friction and lubrication of graphene and other 2D materials:Mechanisms and applications显示文摘Two-dimensional materials having a layered structure comprise a monolayer or multilayers of atomic thickness and ultra-low shear strength.Their high specific surface area,in-plane strength,weak layer-layer interaction,and surface chemical stability result in remarkably low friction and wear-resisting properties.Thus,2D materials have attracted considerable attention.In recent years,great advances have been made in the scientific research and industrial applications of anti-friction,anti-wear,and lubrication of 2D materials.In this article,the basic nanoscale friction mechanisms of 2D materials including interfacial friction and surface friction mechanisms are summarized.This paper also includes a review of reports on lubrication mechanisms based on the film-formation,self-healing,and ball bearing mechanisms and applications based on lubricant additives,nanoscale lubricating films,and space lubrication materials of 2D materials in detail.Finally,the challenges and potential applications of 2D materials in the field of lubrication were also presented. | Lincong LIU Ming ZHOU Long JIN Liangchuan LI Youtang MO Guoshi SU Xiao LI Hongwei ZHU Yu TIAN | 2019 | Friction2019，7，3： | 29 |
| 2 | Identification of quantitative trait loci associated with salt tolerance at seedling stage from Oryza rufipogon显示文摘土壤咸度是影响工厂生长和庄稼生产的主要不能生活的压力之一。在现在的学习,在米饭幼苗舞台的盐忍耐用 87 根基因渗入线(IL ) 被评估,它从在精英 indica 栽培变种 Teqing 和普通野米饭(Oryza rufipogon Griff ) 的就职之间的一个十字被导出。实质的变化为包括盐忍耐 20 的四个特点(圣) 被观察,相对的根干燥重量(RRW ) ,干燥重量(RSW ) 和相对总数弄干的相对射击重量(RTW ) 。圣断然显著地所有另外的三个特点地被相关。与这四个特点联系的 15 通常认为的量的特点 loci (QTL ) 的一个总数用单个点的分析被检测,它位于染色体 1, 2, 3, 6, 7, 9 和 10 与解释 phenotypic 变化的 8%26% 。O。在 13 QTL (86.7%) 的导出 rufipogon 的等位基因能在 Teqing 背景改进盐忍耐。影响 RRW, RSW 和 RTW 的四 QTL 簇在染色体上被发现 6, 7, 9 和 10 分别地。在这四 QTL 簇之中,包括三 QTL (qRRW10, qRSW10 和 qRTW10 ) 的主要的簇在染色体 10 的长手臂上在制造者 RM271 附近被发现,并且 O。分别地,当 phenotypic 变化由这解释为三个特点的三单个 QTL 从 19% ~ 26% 变化了时,在这三 loci 的导出 rufipogon 的等位基因与 22.7% , 17.3% 和 18.5% 的添加剂效果增加了 RRW, RSW 和 RTW。另外,几腌容忍的 IL 被选择并且能被用于识别并且利用有利的盐从普通野米饭的容忍的基因并且在盐使用容忍的米饭繁殖编程序。 | Lei Tian,Lubin Tan,Fengxia Liu,Hongwei Cai,Chuanqing Sun State Key Laboratory of Plant Physiology and Biochemistry,National Centre for Evaluation of Agricultural Wild Plant(Rice), Laboratory of Crop Heterosis and Utilization of Ministry of Education Beijing Key Laboratory of Crop Genetic Improvement and Genome of Ministry of Agriculture,Department of Plant Genetics and Breeding,China Agricultural University,Beijing 100193,China | 2011 | Journal of Genetics and Genomics2011，38，12： | 26 |
| 3 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 4 | Deep learning based classification of rock structure of tunnel face显示文摘The automated interpretation of rock structure can improve the efficiency,accuracy,and consistency of the geological risk assessment of tunnel face.Because of the high uncertainties in the geological images as a result of different regional rock types,as well as in-situ conditions(e.g.,temperature,humidity,and construction procedure),previous automated methods have limited performance in classification of rock structure of tunnel face during construction.This paper presents a framework for classifying multiple rock structures based on the geological images of tunnel face using convolutional neural networks(CNN),namely Inception-ResNet-V2(IRV2).A prototype recognition system is implemented to classify 5 types of rock structures including mosaic,granular,layered,block,and fragmentation structures.The proposed IRV2 network is trained by over 35,000 out of 42,400 images extracted from over 150 sections of tunnel faces and tested by the remaining 7400 images.Furthermore,different hyperparameters of the CNN model are introduced to optimize the most efficient algorithm parameter.Among all the discussed models,i.e.,ResNet-50,ResNet-101,and Inception-v4,Inception-ResNet-V2 exhibits the best performance in terms of various indicators,such as precision,recall,F-score,and testing time per image.Meanwhile,the model trained by a large database can obtain the object features more comprehensively,leading to higher accuracy.Compared with the original image classification method,the sub-image method is closer to the reality considering both the accuracy and the perspective of error divergence.The experimental results reveal that the proposed method is optimal and efficient for automated classification of rock structure using the geological images of the tunnel face. | Jiayao Chen Tongjun Yang Dongming Zhang Hongwei Huang Yu Tian | 2021 | Geoscience Frontiers2021，12，1： | 13 |
| 5 | IAE-adaptive Kalman filter for INS/GPS integrated navigation system显示文摘A marine INS/GPS adaptive navigation system is presented in this paper. GPS with two antenna providing vessel’s altitude is selected as the auxiliary system fusing with INS to improve the performance of the hybrid system. The Kalman filter is the most frequently used algorithm in the integrated navigation system, which is capable of estimating INS errors online based on the measured errors between INS and GPS. The standard Kalman filter (SKF) assumes that the statistics of the noise on each sensor are given. As long as the noise distributions do not change, the Kalman filter will give the optimal estimation. However GPS receiver will be disturbed easily and thus temporally changing measurement noise will join into the outputs of GPS, which will lead to performance degradation of the Kalman filter. Many researchers introduce fuzzy logic control method into innovation-based adaptive estimation adaptive Kalman filtering (IAE-AKF) algorithm, and accordingly propose various adaptive Kalman filters. However how to design the fuzzy logic controller is a very complicated problem still without a convincing solution. A novel IAE-AKF is proposed herein, which is based on the maximum likelihood criterion for the proper computation of the filter innovation covariance and hence of the filter gain. The approach is direct and simple without having to establish fuzzy inference rules. After having deduced the proposed IAE-AKF algorithm theoretically in detail, the approach is tested by the simulation based on the system error model of the developed INS/GPS integrated marine navigation system. Simulation results show that the adaptive Kalman filter outperforms the SKF with higher accuracy, robustness and less computation. It is demonstrated that this proposed approach is a valid solution for the unknown changing measurement noise exited in the Kalman filter. | Bian Hongwei Jin Zhihua Tian Weifeng | 2006 | Journal of Systems Engineering and Electronics2006，17，3： | 13 |
| 6 | Cloud services with big data provide a solution for monitoring and tracking sustainable development goals显示文摘To achieve the Sustainable Development Goals(SDGs),high-quality data are needed to inform the formulation of policies and investment decisions,to monitor progress towards the SDGs and to evaluate the impacts of policies.However,the data landscape is changing.With emerging big data and cloud-based services,there are new opportunities for data collection,influencing both official data collection processes and the operation of the programmes they monitor.This paper uses cases and examples to explore the potential of crowdsourcing and public earth observation(EO)data products for monitoring and tracking the SDGs.This paper suggests that cloud-based services that integrate crowdsourcing and public EO data products provide cost-effective solutions for monitoring and tracking the SDGs,particularly for low-income countries.The paper also discusses the challenges of using cloud services and big data for SDG monitoring.Validation and quality control of public EO data is very important;otherwise,the user will be unable to assess the quality of the data or use it with confidence. | Bingfang Wu Fuyou Tian Miao Zhang Hongwei Zeng Yuan Zeng | 2020 | Geography and Sustainability2020，1，1： | 9 |
| 7 | The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice显示文摘Hepatic ischemia/reperfusion injury(HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development of liver injury. Herein, we investigated the potential contribution of gut microbes to HIRI.Ischemia/reperfusion surgery was performed to establish a murine model of HIRI. 16 S r RNA gene sequencing and metabolomics were used for microbial analysis. Transcriptomics and proteomics analysis were employed to study the host cell responses. Our results establish HIRI was significantly increased when surgery occurred in the evening(ZT12, 20:00) when compared with the morning(ZT0, 08:00);however, antibiotic pretreatment reduced this diurnal variation. The abundance of a microbial metabolite3,4-dihydroxyphenylpropionic acid was significantly higher in ZT0 when compared with ZT12 in the gut and this compound significantly protected mice against HIRI. Furthermore, 3,4-dihydroxyphenylpropionic acid suppressed the macrophage pro-inflammatory response in vivo and in vitro. This metabolite inhibits histone deacetylase activity by reducing its phosphorylation. Histone deacetylase inhibition suppressed macrophage pro-inflammatory activation and diminished the diurnal variation of HIRI. Our findings revealed a novel protective microbial metabolite against HIRI in mice. The potential underlying mechanism was at least in part, via 3,4-dihydroxyphenylpropionic acid-dependent immune regulation and histone deacetylase(HDAC) inhibition in macrophages. | Rui Li Li Xie Lei Li Xiaojiao Chen Tong Yao Yuanxin Tian Qingping Li Kai Wang Chenyang Huang Cui Li Yifan Li Hongwei Zhou Neil Kaplowitz Yong Jiang Peng Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 8 | Stability improvement under high efficiency—next stage development of perovskite solar cells显示文摘With efficiency of perovskite solar cells(PSCs) overpassing 23%, to realize their commercialization, the biggest challenge now is to boost the stability to the same level as conventional solar cells. Thus, tremendous effort has been directed over the past few years toward improving the stability of these cells. Various methods were used to improve the stability of bulk perovskites,including compositional engineering, interface adjustment, dimensional manipulation, crystal engineering, and grain boundary decoration. Diverse device configurations, carrier transporting layers, and counter electrodes are investigated. To compare the stability of PSCs and clarify the degradation mechanism, diverse characterization methods were developed. Overall stability of PSCs has become one central topic for the development of PSCs. In this review, we summarize the state-of-the-art progress on the improvement of device stability and discuss the directions for future research, hoping it provides an overview of the current status of the research on the stability of PSCs and guidelines for future research. | Danni Yu Yue Hu Jiangjian Shi Haoying Tang Wenhao Zhang Qingbo Meng Hongwei Han Zhijun Ning He Tian | 2019 | Science China Chemistry2019，62，6： | 7 |
| 9 | Influences of a Kind of Groove-blade on the Flow Field in a Compressor显示文摘This paper presents an experimental investigation of effects of a kind of streamwise-grooved blades on the flowfield in a compressor cascade.The flow field downstream the cascade and the boundary layer on the suctionsurface were measured using a mini 5-hole pressure probe at different incidence angles.The flow field in thegroove cascade was compared with that in the smooth cascade.The measurement results indicate that:(1)thegroove surface can restrain the development of the boundary layer on the suction surface;(2)the grooves canrestrain the radial migration of the low-energy fluids in the boundary layer on the suction surface;(3)the grooveblades can reduce total pressure loss and flow blockage in the cascade at the incidence angles of 0°,5°and 8°;(4)the maximum benefit of 8.6% loss reduction was obtained at the incidence angle of 5° while negative benefit of-3.0% loss reduction occurred at the incidence angle of-5°. | Hongwei MA Wuying YAN Qiao TIAN | 2006 | Journal of Thermal Science2006，15，3： | 5 |
| 10 | A Synthesizing Land-cover Classification Method Based on Google Earth Engine: A Case Study in Nzhelele and Levhuvu Catchments, South Africa显示文摘This study designed an approach to derive land-cover in the South Africa with insufficient ground samples, and made a case demonstration in Nzhelele and Levhuvu catchments, South Africa. The method was developed based on an integration of Landsat 8, Sentinel-1, and Shuttle Radar Topography Mission(SRTM) Digital Elevation Model(DEM), and the Google Earth Engine(GEE) platform. Random forest classifier with 300 trees is employed as land-cover classification model. In order to overcome the defect of insufficient ground data, the stratified sampling method was used to generate the training and validation samples from the existing land-cover product. Likewise, in order to recognize different land-cover categories, the percentile and monthly median composites were employed to expand input metrics of random forest classifier. Results showed that the overall accuracy of the land-cover of Nzhelele and Levhuvu catchments, South Africa in 2017–2018 reached to 76.43%. Three important results can be drawn from our research. 1) The participation of Sentinel-1 data can slightly improve overall accuracy of land-cover while its contribution on land-cover classification varied with land types. 2) Under-fitting problem was observed in the training of non-dominant land-cover categories using the random sampling, the stratified sampling method is recommended to make sure the classification accuracy of non-dominant classes. 3) When related reflectance bands participated in the training process, individual Normalized Difference Vegetation index(NDVI), Enhanced Vegetation Index(EVI), Soil Adjusted Vegetation Index(SAVI), Normalized Difference Built-up Index(NDBI) have little effect on final land-cover classification result. | ZENG Hongwei WU Bingfang WANG Shuai MUSAKWA Walter TIAN Fuyou MASHIMBYE Zama Eric POONA Nitesh SYNDEY Mavengahama | 2020 | Chinese Geographical Science2020，30，3： | 4 |
| 11 | In vitro and in vivo evaluations of Mg-Zn-Gd alloy membrane on guided bone regeneration for rabbit calvarial defect显示文摘To develop a biodegradable membrane with guided bone regeneration(GBR),a Mg-2.0Zn-1.0Gd alloy(wt.%,MZG)membrane with Ca-P coating was designed and fabricated in this study.The microstructure,hydrophilicity,in vitro degradation,cytotoxicity,antibacterial effect and in vivo regenerative performance for the membrane with and without Ca-P coating were evaluated.After coating,the membrane exhibited an enhance hydrophilicity and corrosion resistance,showed good in vitro cytocompatibility upon MC3T3E-1 cells,and exhibited excellent antibacterial effect against E.coli,Staphylococcus epidermis and Staphylococcus aureus,simultaneously.In vivo experiment using the rabbit calvarial defect model confirmed that Ca-P coated MZG membrane underwent progressive degradation without inflammatory reaction and significantly improved the new bone formation at both 1.5 and 3 months after the surgery.All the results strongly indicate that MZG with Ca-P coating have great potential for clinical application as GBR membranes. | Jiawen Si Hongzhou Shen Hongwei Miao Yuan Tian Hua Huang Jun Shi Guangyin Yuan Guofang Shen | 2021 | Journal of Magnesium and Alloys2021，9，1： | 4 |
| 12 | Experimental Investigation of Effects of Suction-Side Squealer Tip Geometry on the Flow Field in a Large-scale Axial Compressor using SPIV显示文摘It is well known that the non-uniform tip geometry is a promising passive flow control technique in turbomachinery.However,detailed investigation of its effects on the unsteady flow field of turbomachinery is rare in the existiug hteratures.This paper presents an experimental investigation of effects of suction side squealer tip configuration on both the steady and unsteady flow field of an isolated compressor rotor.The flow field at 10%chord downstream from the trailing edge was measured using a mini five-hole probe.Meanwhile,the unsteady flow field inside the passage was investigated using stereo particle image velocimetry(SPIV).The steady results show that the SSQ tip configuration exerts positive effect on the static pressure rise performance of this compressor,and the radial equilibrium at the rotor outlet is obviously rearranged.The SSQ tip configuration would create a stronger tip leakage vortex at the formation phase,and it experiences a faster dissipation process around the rear chord.Also,the splitting process of the tip leakage vortex is severer,which is the main cause of the relatively higher probability of the presence of the streamwise reverse flow.The quantitatively analysis of the tip leakage vortex indicates that the velocity loss inside the blockage region is direct response of the evolutionary procedure of the tip leakage vortex.It keeps increasing until the end of the splitting process.Although the blockage coefficient grows sustainably,the velocity loss will reduce once the turbulent mixing procedure is dominant. | MA Hongwei WEI Wei WANG Lixiang TIAN Yangtao | 2015 | Journal of Thermal Science2015，24，4： | 4 |
| 13 | Deformation analysis of transversely isotropic coal-rock mass with porous and cracks显示文摘Coal-rock as a typical sedimentary rock has obvious stratification,namely it has transversely isotropic feature.Meanwhile,deformation leads to coal-rock mass having the characteristics of different porous and crack structures as well as local anisotropy.Equivalent axial and circumferential strain' formulas of the pure coal-rock mass specimen with a single crack were derived through the establishment of equivalent mechanical model of standard cylindrical coal-rock specimen,and have been widely used to a variety of media combined different structures containing multiple cracks.The complete stress strain curve of a real coal-rock specimen was obtained by the CTC test.Additionally,according to the comparison with the theoretical value,the theoretical mechanical model could well explain the deformation characteristics of coal-rock mass and verify its validity.Further,following features were analyzed:strain normalized coefficient and elastic modulus(Poisson's ratio) in vertical and parallel direction to the stratification,stratification angle,porosity,pore radius,normal and tangential stiffness of crack,and the relationship of different crack width with different tangential stiffness of crack.Through the analysis above,it substantiate this claim that the theoretical model with better reliability reflects the transversely isotropic nature of the coal-rock and the local anisotropy caused by the porous and cracks. | Xue Dongjie Zhou Hongwei Kong Lin Tang Xianli Zhao Tian Yi Haiyang Zhao Yufeng | 2012 | International Journal of Mining Science and Technology2012，22，6： | 3 |
| 14 | Stereoscopic PIV Measurements of the Flow Field in a Turbine Cascade显示文摘This paper presents experimental measurements of the flow field in a Low-speed Turbine Cascade using a stereoscopic particle-image velocimetry(SPIV). During the measurements, a pair of frame-straddling-based CCD cameras were configured at different sides of the laser light sheet, and appropriate tracing particles(DEHS) were employed. The measurements were conducted at the incidence angle of 0 degree and exit Reynolds number of 1.7 × 105 with the tip clearance 1.18% of blade chord. The tip flow features, such as the evolution and breakdown of tip leakage vortex, the horseshoe vortex, turbulence characteristics of tip leakage flow, were studied for the flow field analysis. The results showed that the tip leakage flow/vortex mainly dominate flow fields in the tip region. The tip leakage vortex performs as a concentrated vortex before its breaking down and splitting into small vortices. The highest turbulence intensity mainly occurs in the tip region along with the trajectory of tip leakage vortex, and when the vortex breaks down, the turbulence intensity reduces rapidly. Additionally, the SPIV with this configuration also shows an advantage in investigating the flow structures and mechanism inside the turbine cascade. | TIAN Yangtao MA Hongwei MA Rong | 2017 | Journal of Thermal Science2017，26，1： | 3 |
| 15 | Experimental Study of Turbulent Boundary Layers on Groove/Smooth Flat Surfaces显示文摘This paper presents an experimental investigation of the turbulent boundary layers on both groove and smooth flat surfaces. The flow structures were shown in a water tunnel using the hydrogen-bubble flow visualization technique. The measurement results indicate that: (1) the grooves can effectively reduce accumulation of low-speed fluids, decrease the number of the low-speed streaks and depress oscillation of the streaks in the sublayer; (2) the grooves can restrain forming of the horseshoe vortices in the buffer region; (3) the grooves bate oscillation and kinking of the quasi-streamwise vortices and restrain production of the hairpin vortices and the ring vortices, reducing both frequency and intensity of the turbulence bursting; (4) the grooves directly affect the flow structures in the sublayer of the boundary layer and then modulate the flow field up to the buffer region and the logarithmic region by restraining development and interaction of the vortices. | Hongwei MA Qiao TIAN Hui WU | 2005 | Journal of Thermal Science2005，14，3： | 3 |
| 16 | Time-domain Approach to the Performance Analysis of GPS Phase Locked Loop显示文摘The frequency-domain approach is widely used in Global positioning system(GPS) receiver tracking loop performance analysis.In realization,the Digital phase-locked loop(DPLL) is used.There is difference between phase errors by traditional frequency-domain analysis and real receiver output because of discretization errors.In order to get more precise result,this paper uses timedomain difference equations to analyze the phase tracking errors under the influence of thermal noise and the dynamic stress on different orders of PLL.The simulation results show that the traditional frequency-domain approach has phase error deviation under long integration time(i.e.,more than 10ms),while the time-domain approach has good accordance with receiver simulation output.Thus,the proposed time-domain approach can provide more precise solution for PLL performance analysis. | ZHOU Hongwei JIN Tian LYU Fangyao WANG Lihua | 2017 | Chinese Journal of Electronics2017，26，2： | 3 |
| 17 | A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity显示文摘Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation.A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance,such as program death-1(PD-1/PD-L1)pathway in the tumor environment.However,the determinants of response to anti-PD-1 monoclonal antibodies(mAbs)treatment remain incompletely understood.In murine models,PD-1 blockade alone fails to induce effective immune responses to poorly immunogenic tumors,but is successful when combined with additional interventions,such as cancer vaccines.Novel cancer vaccines combined with antibody may offer promising control of cancer development and progression.In this investigation,we generated a novel tumor cell vaccine simultaneously expressing anti-PD-1 mAbs and granulocyte-macrophage colony stimulating factor(GM-CSF)in CT26 colon cancer and B16-F10 melanoma.The antitumor effect of the vaccine was verified by therapeutic and adoptive animal experiments in vivo.The antitumor mechanism was analyzed using Flow cytometry,Elispot and in vivo intervention approaches.The results showed that tumor cell vaccine secreting PD-1 neutralizing antibodies and GM-CSF induced remarkable antitumor immune effects and prolonged the survival of tumor-bearing animals compared with animals treated with either PD-1 mAbs or GM-CSF alone.Antitumor effects and prolonged survival correlated with strong antigen-specific T-cell responses by analyzing CD11c^(+)CD86^(+)DC,CD11b^(+)F4/80^(+)MΦcells,increased ratio of Teff/Treg in the tumor microenvironment,and higher secretion levels of Th1 proinflammatory cytokines in serum.Furthermore,the results of ELISPOT and in vivo blocking strategies further confirmed that the antitumor immune response is acquired by CD4 and CD8 T immune responses,primarily dependent on CD4 Th1 immune response,not NK innate immune response.The combination of PD-1 blockade with GM-CSF secretion potency creates a novel tumor cell vaccine immunotherapy,affording significantly improved antitumor responses by releasing the state of immunosuppressive microenvironment and augmenting the tumor-reactive T-cell responses. | Hongwei Tian Gang Shi Qin Wang Yiming Li Qianmei Yang Chunlei Li Guoyou Yang Min Wu Qian Xie Shuang Zhang Yang Yang Rong Xiang Dechao Yu Yuquan Wei Hongxin Deng | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 18 | Results of Clinical Trial of Superficially-placed Tumor Therapy with Carbon Ions at Heavy Ion Research Facility in Lanzhou(HIRFL显示文摘 | Zhang Hong Li Sha Wang Xiaohu Li Qiang Zhao Weiping Dai Zhongying Wei Shihua Gao Liying Xiao Guoqing Xu Hushan Hu Zhengguo Mao Ruishi Yue Yangjun Ran Juntao Tian Zhongze Song Mingtao Zhao Hongwei Zhan Wenlong | 2007 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2007，，1： | 2 |
| 19 | Role of a Single Shield in Thermocouple Measurements in Hot Air Flow显示文摘To investigate the role of a single shield on steady temperature measurement using thermocouples in hot air flow,a methodology for solving convection, conduction, and radiation in one single model is provided. In order to compare with the experimental results, a cylindrical computational domain is established, which is the same size with the hot calibration wind-tunnel. In the computational domain, two kinds of thermocouples, the bare-bead and the single-shielded thermocouples, are simulated respectively. Surface temperature distribution and the temperature measurement bias of the two typical thermocouples are compared. The simulation results indicate that: 1)The existence of the shield reduces bead surface heat flux and changes the direction of wires inner heat conduction in a colder surrounding; 2) The existence of the shield reduces the temperature measurement bias both by improving bead surface temperature and by reducing surface temperature gradient; 3) The shield effectively reduces the effect of the ambient temperature on the temperature measurement bias; 4) The shield effectively reduces the influence of airflow velocity on the temperature measurement bias. | ma hongwei shi lei tian yangtao | 2017 | Journal of Thermal Science2017，26，6： | 2 |
| 20 | MXR7 facilitates liver cancer metastasis via epithelial-mesenchymal transition显示文摘MXR7 is a cell-surface protein and highly expressed in hepatocellular carcinoma(HCC). The aim of this study is to determine the expression profile of MXR7 in HCC and investigate the influence of MXR7 on invasion and metastasis of HCC cells. For this purpose, immunohistochemical assay was used to identify the differential expression of MXR7 in 94 HCC specimens. Expression of MXR7 in 4 pairs of HCC and portal vein tumor thrombus(PVTT) was also tested. The motility of HCC cells were characterized by transwell migration and matrigel invasion assays. In vivo metastasis potential was determined via tail vein injection assay.Moreover, compared with noninvasive HCC tumors or human HCC cell lines with low metastatic potential, invasive HCC samples and HCC cell lines with high metastatic potential exhibited higher MXR7 expression. Furthermore, forced expression of MXR7 in SMMC-7721 promoted cell proliferation, migration and invasion in vitro and accelerated tumor growth and metastasis in vivo. Conversely, knockdown of MXR7 expression in HuH7 cells inhibited proliferation and motility of cells. Mechanically,overexpression of MXR7 promoted epithelial-mesenchymal transition(EMT) progress, and MXR7 depletion repressed the EMT phenotype. In conclusion, MXR7 is a mediator of EMT and metastasis in HCC and may serve as a novel therapeutic target. | guishuai lv yexiong tan hongwei lv tian fang changzheng wang ting li yanting yu congli hu wen wen hongyang wang wen yang | 2017 | Science China(Life Sciences)2017，60，11： | 2 |
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