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| 1 | IAE-adaptive Kalman filter for INS/GPS integrated navigation system显示文摘A marine INS/GPS adaptive navigation system is presented in this paper. GPS with two antenna providing vessel’s altitude is selected as the auxiliary system fusing with INS to improve the performance of the hybrid system. The Kalman filter is the most frequently used algorithm in the integrated navigation system, which is capable of estimating INS errors online based on the measured errors between INS and GPS. The standard Kalman filter (SKF) assumes that the statistics of the noise on each sensor are given. As long as the noise distributions do not change, the Kalman filter will give the optimal estimation. However GPS receiver will be disturbed easily and thus temporally changing measurement noise will join into the outputs of GPS, which will lead to performance degradation of the Kalman filter. Many researchers introduce fuzzy logic control method into innovation-based adaptive estimation adaptive Kalman filtering (IAE-AKF) algorithm, and accordingly propose various adaptive Kalman filters. However how to design the fuzzy logic controller is a very complicated problem still without a convincing solution. A novel IAE-AKF is proposed herein, which is based on the maximum likelihood criterion for the proper computation of the filter innovation covariance and hence of the filter gain. The approach is direct and simple without having to establish fuzzy inference rules. After having deduced the proposed IAE-AKF algorithm theoretically in detail, the approach is tested by the simulation based on the system error model of the developed INS/GPS integrated marine navigation system. Simulation results show that the adaptive Kalman filter outperforms the SKF with higher accuracy, robustness and less computation. It is demonstrated that this proposed approach is a valid solution for the unknown changing measurement noise exited in the Kalman filter. | Bian Hongwei Jin Zhihua Tian Weifeng | 2006 | Journal of Systems Engineering and Electronics2006，17，3： | 13 |
| 2 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 3 | Effect of acetic acid on electrochemical deposition of carbon-nitride thin film显示文摘Electrochemical deposition method was employed to prepare CNx thin film from methanol-urea solution,and it was shown that adding a little acetic acid in the solution significantly affected the deposition process.After optimizing the experiment conditions,we obtained polycrystalline grains with sizes of about 3―7μm on the faces of single crystal silicon.X-ray diffraction spectrua indicate that the grains are mainly composed of cubic phase mixed with a small amount of β and α phases. | TIAN Yu WANG JianZhong YU WeiFeng CAO RongGen SONG Yun NING XiJing | 2009 | Science China(Technological Sciences)2009，52，6： | 2 |
| 4 | De-Noising Stochastic Noise in FOG Based on Second-Generation DB4 Wavelet and SURE-Threshold显示文摘An effective de-noising method for fiber optic gyroscopes (FOGs) is proposed. This method is based on second-generation Daubechies D4 (DB4) wavelet transform (WT) and level-dependent threshold estimator called Stein's unbiased risk estimator (SURE). The whole approach consists of three critical parts: wavelet decomposition module, parameters estimation module and SURE de-noising module. First, DB4 wavelet is selected as lifting base of the second-generation wavelet in the decomposition module. Second, in the parameters estimation module, maximum likelihood estimation (MLE) is used for stochastic noise parameters estimation. Third, combined with soft threshold de-noising technique, the SURE de-noising module is designed. For comparison, both the traditional universal threshold wavelet and the second-generation Harr wavelet method are also investigated. The experiment results show that the computation cost is 40% less than that of the traditional wavelet method. The standard deviation of de-noised FOG signal is 0.012 and the three noise terms such as angle random walk, bias instability and quantization noise are reduced to 0.007 2° / h , 0.004 1° /h, and 0.008 1°, respectively. | DANG Shuwen, TIAN Weifeng, JIN Zhihua Department of Instrument Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China | 2009 | Wuhan University Journal of Natural Sciences2009，14，6： | 2 |
| 5 | Negative selection of murine medullary-type single positive thymocytes显示文摘Negative selection depletes self-reactive T cells, thus ensuring self-tolerance. It is usually considered that negative selection imposed on double-positive (DP) thymocytes that reside at the cortico-medullary junction. Negative selection model was set up by injecting mice with anti-T cell receptor (TCR) monoclonal antibody (mAb) intraperitoneally in this work. As shown in phenotypic analysis of thymocytes, negative selection destroys not only cortical-type DP thymocytes, but also medullary-type CD3+TCRαβ+CD4SP and CD3+TCRαβ+CD8SP thymocytes. Negative selection of medullary-type single positive (SP) are more susceptible to apoptosis, while with development of the cells, their resistance to apoptosis increases. Therefore, negative selection does not operate on functionally mature thymocytes at the late stage. This result is a supplement to the traditional theory of negative selection. Negative selection of medullary-type thymocytes is probably to further deplete self-reactive T cells, thus producing precise TCR repertoire and inducing self-tolerance. | TIAN Tian, ZHANG Jun, QIAN Xiaoping, GAO Ling and CHEN Weifeng(Department of Immunology, Peking University Health Science Center, Beijing 100083, China) | 2002 | Progress in Natural Science:Materials International2002，12，5： | 2 |
| 6 | Temperature drift modelling of fibre optic gyroscopes based on a grey radial basis function neural network显示文摘 | Fan Chunling Jin Zhihua Tian Weifeng | | 0，，01： | 1 |
| 7 | A signal-obtaining system of ESG显示文摘 | JIN Zhihua TIAN Weifeng | 2001 | Shipping Engineering2001，，4： | 1 |
| 8 | Temperature Drift Modelling of Fibre Optic Gyroscopes Based on a Grey Radial Basis Function Neural Network显示文摘 | Fan Chunling Jin Zhihua Tian Weifeng | 2004 | Measurement Science and Technology2004，，15： | 1 |
| 9 | Joint tracking algorithm using particle filter and mean shift with target model updating 显示文摘 | Bo Zhang Weifeng Tian Zhihua Jin | 2006 | Chinese Optics Letter2006，4，10： | 1 |
| 10 | Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups显示文摘A mouse chemokine MIP-2(macrophage in-flamatory protein 2) is constitutively expressed not only by peritoneal macrophages, but also by fresh thymic stromal cells, based on RT-PCR detection. Moreover, the specific receptor of MIP-2 is expressed at different levels among four main subgroups of murine thymocytes including DN, DP, CD4SP and CD8SP. By the chemotaxis assays with Boyden chamber, we proved that the recombinant mouse MIP-2 can chemoattract the four main subgroups of thymocytes in different degrees, it mainly chemoattract the DP and SP subgroups. We firstly reported that MIP-2 is involved in the regulation of the directional migration of developing thymocytes. | Gong Shunyou Gao Ling Qian Xiaoping Tian Tian Chen Weifeng | 2001 | Chinese Science Bulletin2001，46，20： | 1 |
| 11 | Petrology, mineralogy, and geochemistry of the Ge-rich coal from the Wulantuga Ge ore deposit, Inner Mongolia, China: New data and genetic implications显示文摘 | Shifeng Dai Xibo Wang Vladimir V. Seredin James C. Hower Colin R. Ward Jennifer M.K. O’Keefe Wenhui Huang Tian Li Xiao Li Huidong Liu Weifeng Xue Lixin Zhao | 2011 | International Journal of Coal Geology2011，，： | 1 |
| 12 | Head Tracking Based on the Integration of Two Different Particle Filters显示文摘 | Zhang Bo Tian Weifeng Jin Zhihua | 2006 | Measurement Science and Technology2006，17，11： | 1 |
| 13 | Modeling the Random Drift of Micro-Machined Gyroscope with Neural Network显示文摘 | Wang Hao Weifeng Tian | 2005 | Neural Processing Letters2005，，3： | 1 |
| 14 | A projection pursuit learning network for modeling temperature drift of fog显示文摘 | BIAN Hongwei JIN Zhihua TIAN Weifeng | 2003 | IEEE Neural Networks and Signal Processing2003，，1： | 1 |
| 15 | A novel method improving the alignment accuracy of SINS on stationary base meas显示文摘 | Zhang chuanbin Tian weifeng and Jin zhihua | 2004 | Sci Technol2004，15，： | 1 |
| 16 | Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism显示文摘Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers. | Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi Weichang Chen Ye Tian Xiangdong Liu Xiong Ma Zhongsheng Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 1 |
| 17 | Temperature drift modeling of fiber optic gyroscopes based on a grey radial basis function neural network显示文摘 | Chunling Fan Zhihua Jin Weifeng Tian and Feng Qian | 2004 | MEASUREMENT SCIENCE AND TECHNOLOGY2004，，： | 1 |
| 18 | Temperature drift modeling and compensation for a dynamically tuned gyroscope by combining WT and SVM method 显示文摘 | Guoping Xu Weifeng Tian Zhihua Jin and Li Qian | 2007 | NOLOGY2007，，： | 1 |
| 19 | A novel hybridEMD-based drift denoising method for a DynamicallyTuned Gyroscope(DTG)显示文摘 | Qian Li Xu Guoping Tian Weifeng | 2009 | Measurement2009，42，： | 1 |
| 20 | Activity classifica- tion and dead reckoning for pedestrian navigation with wearable sensors 显示文摘 | Sun Zuolei Mao Xuchu Tian Weifeng | 2009 | Measurement Science and Techology2009，20，： | 1 |
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