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| 1 | Endoscopic diagnosis for colorectal sessile serrated lesions显示文摘BACKGROUND Hyperplastic polyps are considered non-neoplastic, whereas sessile serrated lesions(SSLs) are precursors of cancer via the ‘‘serrated neoplastic pathway’’. The clinical features of SSLs are tumor size(> 5 mm), location in the proximal colon, coverage with abundant mucus called the ‘‘mucus cap’’, indistinct borders, and a cloud-like surface. The features in magnifying narrow-band imaging are varicose microvascular vessels and expanded crypt openings. However, accurate diagnosis is often difficult.AIM To develop a diagnostic score system for SSLs.METHODS We retrospectively reviewed consecutive patients who underwent endoscopic resection during colonoscopy at the Toyoshima endoscopy clinic. We collected data on serrated polyps diagnosed by endoscopic or pathological examination. The significant factors for the diagnosis of SSLs were assessed using logistic regression analysis. Each item that was significant in multivariate analysis was assigned 1 point, with the sum of these points defined as the endoscopic SSL diagnosis score. The optimal cut-off value of the endoscopic SSL diagnosis score was determined by receiver-operating characteristic curve analysis.RESULTS Among 1288 polyps that were endoscopically removed, we analyzed 232 diagnosed as serrated polyps by endoscopic or pathological examination. In the univariate analysis, the location(proximal colon), size(> 5 mm), mucus cap, indistinct borders, cloud-like surface, and varicose microvascular vessels were significantly associated with the diagnosis of SSLs. In the multivariate analysis, size(> 5 mm;P = 0.033), mucus cap(P = 0.005), and indistinct borders(P = 0.033) were independently associated with the diagnosis of SSLs. Size > 5 mm, mucus cap, and indistinct borders were assigned 1 point each and the sum of these points was defined as the endoscopic SSL diagnosis score. The receiver-operating characteristic curve analysis showed an optimal cut-off score of 3, which predicted pathological SSLs with 75% sensitivity, 80% specificity, and 78.4% accuracy. The pathological SSL rate for an endoscopic SSL diagnosis score of 3 was significantly higher than that for an endoscopic SSL diagnosis score of 0, 1, or 2(P < 0.001).CONCLUSION Size > 5 mm, mucus cap, and indistinct borders were significant endoscopic features for the diagnosis of SSLs. Serrated polyps with these three features should be removed during colonoscopy. | Toshihiro Nishizawa Shuntaro Yoshida Akira Toyoshima Tomoharu Yamada Yoshiki Sakaguchi Taiga Irako Hirotoshi Ebinuma Takanori Kanai Kazuhiko Koike Osamu Toyoshima | 2021 | World Journal of Gastroenterology2021，27，13： | 7 |
| 2 | Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers显示文摘BACKGROUND Accurate diagnosis of the depth of gastric cancer invasion is crucial in clinical practice.The diagnosis of gastric cancer depth is often made using endoscopic characteristics of the tumor and its margins;however,evaluating invasion depth based on endoscopic background gastritis remains unclear.AIM To investigate predicting submucosal invasion using the endoscopy-based Kyoto classification of gastritis.METHODS Patients with gastric cancer detected on esophagogastroduodenoscopy at Toyoshima Endoscopy Clinic were enrolled.We analyzed the effects of patient and tumor characteristics,including age,sex,body mass index,surveillance endoscopy within 2 years,current Helicobacter pylori infection,the Kyoto classification,and Lauren’s tumor type,on submucosal tumor invasion and curative endoscopic resection.The Kyoto classification included atrophy,intestinal metaplasia,enlarged folds,nodularity,and diffuse redness.Atrophy was characterized by non-reddish and low mucosa.Intestinal metaplasia was detected as patchy whitish or grayish-white flat elevations,forming an irregular uneven surface.An enlarged fold referred to a fold width≥5 mm in the greater curvature of the corpus.Nodularity was characterized by goosebump-like multiple nodules in the antrum.Diffuse redness was characterized by uniform reddish nonatrophic mucosa in the greater curvature of the corpus.RESULTS A total of 266 gastric cancer patients(mean age,66.7 years;male sex,58.6%;mean body mass index,22.8 kg/m2)were enrolled.Ninety-three patients underwent esophagogastroduodenoscopy for surveillance within 2 years,and 140 had current Helicobacter pylori infection.The mean Kyoto score was 4.54.Fifty-eight cancers were diffuse-type,and 87 cancers had invaded the submucosa.Multivariate analysis revealed that low body mass index(odds ratio 0.88,P=0.02),no surveillance esophagogastroduodenoscopy within 2 years(odds ratio 0.15,P<0.001),endoscopic enlarged folds of gastritis(odds ratio 3.39,P=0.001),and Lauren’s diffuse-type(odds ratio 5.09,P<0.001)were independently associated with submucosal invasion.Similar results were obtained with curative endoscopic resection.Among cancer patients with enlarged folds,severely enlarged folds(width≥10 mm)were more related to submucosal invasion than mildly enlarged folds(width 5-9 mm,P<0.001).CONCLUSION Enlarged folds of gastritis were associated with submucosal invasion.Endoscopic observation of background gastritis as well as the lesion itself may help diagnose the depth of cancer invasion. | Osamu Toyoshima Shuntaro Yoshida Toshihiro Nishizawa Akira Toyoshima Kosuke Sakitani Tatsuya Matsuno Tomoharu Yamada Takashi Matsuo Hayato Nakagawa Kazuhiko Koike | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，9： | 2 |
| 3 | Kyoto classification in patients who developed multiple gastric carcinomas after Helicobacter pylori eradication显示文摘BACKGROUND Endoscopic Kyoto classification predicts gastric cancer risk;however,the score in the patients with primary gastric cancer after Helicobacter pylori(H.pylori)eradication therapy is unknown.AIM To elucidate the Kyoto classification score in patients with both single gastric cancer and multiple gastric cancers developed after H.pylori eradication.METHODS The endoscopist recorded the Kyoto classification at the endoscope and the Kyoto classification score at the time of the first diagnosis of gastric cancer after H.pylori eradication.The score was compared between single gastric cancer group and multiple gastric cancers group.RESULTS The Kyoto score at the time of diagnosis of 45 cases of gastric cancer after H.pylori eradication was 4.0 points in average.The score was 3.8 points in the single gastric cancer group,and 5.1 points in the multiple gastric cancers group.The multiple group had a significantly higher score than the single group(P=0.016).In the multiple gastric cancers group,all the patients(7/7)had 5 or higher Kyoto score,while in single gastric cancer group,the proportion of patients with a score of 5 or higher was less than half,or 44.7%(17/38).CONCLUSION Patients diagnosed with gastric cancer after H.pylori eradication tended to have advanced gastritis.In particular,in cases of multiple gastric cancers developed after H.pylori eradication,the endoscopic Kyoto classification score tended to be 5 or higher in patients with an open type atrophic gastritis and the intestinal metaplasia extended to the corpus. | Kosuke Sakitani Toshihiro Nishizawa Akira Toyoshima Shuntaro Yoshida Tatsuya Matsuno Tomoharu Yamada Masatoshi Irokawa Yoshiyuki Takahashi Yousuke Nakai Osamu Toyoshima Kazuhiko Koike | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，9： | 2 |
| 4 | Intracranial malignant solitary fibrous tumor metastasized to the chest wall:A case report and review of literature显示文摘BACKGROUND Solitary fibrous tumor(SFT)is a rare fibroblastic mesenchymal neoplasm that affects spindle cell soft tissues with broad-spectrum biological behavior;it is predominantly benign,and rarely metastasizes.SFT occurs mainly in the tissue structure of the serosa in the pleura and the thorax,and can be found throughout the body,though extra-thoracic localization,including the cephalic region,is uncommon.We reported the first case of intracranial malignant SFT metastasized to the chest wall.CASE SUMMARY An 81-year-old Japanese man was referred to our hospital due to progressive gait disturbance and appetite loss.His medical history included partial resection due to brain tumor,four times,and 50-Gray radiation therapy at another hospital,starting when he was 74 years old.An unenhanced head computed tomography(CT)scan revealed an 8 cm×5.1 cm×6.5 cm mixed-density mass at the left frontal lobe,accompanying a midline shift,and an unenhanced chest-abdomen CT scan revealed a 6 cm×4.1 cm×6.5 cm low-density mass in the left chest wall.A CT-guided percutaneous lung biopsy was performed,and the pathological findings were SFT corresponding to brain tumor.Finally,the correct diagnosis of his brain tumor in history of past illness revealed to be SFT,and the unremovable tumor,namely present brain lesions enlarged and metastasized to the chest wall.We established a definitive diagnosis of intracranial malignant SFT metastasized to the chest wall.We notified him and his family of the disease,and offered palliative care.He passed away on the 29 th hospital day.CONCLUSION This case suggests the need for careful,detailed examination,and careful followup when encountering patients presenting with a mass. | Daisuke Usuda Shinya Yamada Toshihide Izumida Ryusho Sangen Toshihiro Higashikawa Ken Nakagawa Masaharu Iguchi Yuji Kasamaki | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 5 | Effects of logging road networks on the ecological functions of dung beetles in Peninsular Malaysia显示文摘 | TetsuroHosaka Masahiro Niino Masahiro Kon Teruo Ochi Toshihiro Yamada Christine Fletcher Toshinori Okuda | 2014 | Forest Ecology and Management2014，326，： | 1 |
| 6 | OGG1, MYH and MTH1 gene variants identified in gastric cancer patients exhibiting both 8-hydroxy-2′-deoxyguanosine accumulation and low inflammatory cell infiltration in their gastric mucosa显示文摘 | Masanori Goto Kazuya Shinmura Hidetaka Yamada Toshihiro Tsuneyoshi Haruhiko Sugimura | 2008 | Journal of Genetics2008，，2： | 1 |
| 7 | Calcium oxide/carbon dioxide reactivity in a packed bed reactor of a chemical heat pump forhigh- temperature gas reactors显示文摘 | Yukitaka Kato Mitsuteru Yamada Toshihiro Kanie | 2001 | Nuclear Engineering and Design2001，210，： | 1 |
| 8 | Texture and color enhancement imaging in magnifying endoscopic evaluation of colorectal adenomas显示文摘BACKGROUND Olympus Corporation has developed texture and color enhancement imaging(TXI)as a novel image-enhancing endoscopic technique.AIM To investigate the effectiveness of TXI in identifying colorectal adenomas using magnifying observation.METHODS Colorectal adenomas were observed by magnified endoscopy using white light imaging(WLI),TXI,narrow band imaging(NBI),and chromoendoscopy(CE).This study adopted mode 1 of TXI.Adenomas were confirmed by histological examination.TXI visibility was compared with the visibility of WLI,NBI,and CE for tumor margin,and vessel and surface patterns of the Japan NBI expert team(JNET)classification.Three expert endoscopists and three non-expert endoscopists evaluated the visibility scores,which were classified as 1,2,3,and 4.RESULTS Sixty-one consecutive adenomas were evaluated.The visibility score for tumor margin of TXI(3.47±0.79)was significantly higher than that of WLI(2.86±1.02,P<0.001),but lower than that of NBI(3.76±0.52,P<0.001),regardless of the endoscopist’s expertise.TXI(3.05±0.79)had a higher visibility score for the vessel pattern of JNET classification than WLI(2.17±0.90,P<0.001)and CE(2.47±0.87,P<0.001),but lower visibility score than NBI(3.79±0.47,P<0.001),regardless of the experience of endoscopists.For the visibility score for the surface pattern of JNET classification,TXI(2.89±0.85)was superior to WLI(1.95±0.79,P<0.01)and CE(2.75±0.90,P=0.002),but inferior to NBI(3.67±0.55,P<0.001).CONCLUSION TXI provided higher visibility than WLI,lower than NBI,and comparable to or higher than CE in the magnified observation of colorectal adenomas. | Osamu Toyoshima Toshihiro Nishizawa Shuntaro Yoshida Tomoharu Yamada Nariaki Odawara Tatsuya Matsuno Miho Obata Ken Kurokawa Chie Uekura Mitsuhiro Fujishiro | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，2： | 1 |
| 9 | Mutations in the hepatocyte nuclear factor-1α gene (MODY3) are not a major cause of early-onset non-insulin-dependent (type 2) diabetes mellitus in Japanese显示文摘 | Hidekazu Nishigori Shirou Yamada Tomoko Kohama Toshihiro Utsugi Hiroyuki Shimizu Toshiyuki Takeuchi J. Takeda | 1998 | Journal of Human Genetics1998，，2： | 1 |
| 10 | Journal of Materials Science显示文摘 | Toshihiro Yamada Motohiro Satoh Akiomi Kohno | 1991 | 26:8871991，26，： | 1 |
| 11 | Distribution of greenhouse gases, nitrite, and δ13C of dissolved inorganic carbon in Lake Biwa: Implications for hypolimnetic metabolism显示文摘 | TOSHIHIRO MIYAJIMA YOSHIHIRO YAMADA EITARO WADA TAKUO NAKAJIMA TADATOSHI KOITABASHI YUKO T. HANBA KOICHI YOSHII | 1997 | Biogeochemistry1997，，2： | 1 |
| 12 | Variations in life history parameters and their influence on rate of population increase of different pathogenic isolates of the pine wood nematode, Bursaphelenchus xylophilus显示文摘 | Yu Wang Toshihiro Yamada Daisuke Sakaue Kazuo Suzuki | 2005 | Nematology2005，，3： | 1 |
| 13 | Characterization of common cis-regulatory elements responsible for the endosperm-specific expression of members of the rice glutelin multigene family显示文摘 | Fumio Takaiwa Utako Yamanouchi Toshihiro Yoshihara Haruhiko Washida Fumio Tanabe Akira Kato Kyouji Yamada | 1996 | Plant Molecular Biology1996，，6： | 1 |
| 14 | Aprepitant in patients with advanced non-small-cell lung cancer receiving carboplatin-based chemotherapy显示文摘 | Yasuhiro Ito Masato Karayama Naoki Inui Shigeki Kuroishi Hideki Nakano Yutaro Nakamura Koshi Yokomura Mikio Toyoshima Toshihiro Shirai Masafumi Masuda Takashi Yamada Kazumasa Yasuda Hiroshi Hayakawa Takafumi Suda Kingo Chida | 2014 | Lung Cancer2014，，： | 1 |
| 15 | Residual Stress Estimation of a Silicon Carbide-Kovar Joint显示文摘 | Toshihiro Yamada Motohiro Satoh Akiomi Kohno | 1991 | Journal of Materials Science1991，26，11： | 1 |
| 16 | Residual stress estimation of a silicon carbide2ko2var joint 显示文摘 | Toshihiro Yamada Motohiro Satob A Kiomi Kohno Rajiv Asthana | 1991 | Journal of Materials Science1991，26，： | 1 |
| 17 | Fabrication of highly conductive Ta-doped SnO 2 polycrystalline films on glass using seed-layer technique by pulse laser deposition显示文摘 | Shoichiro Nakao Naoomi Yamada Taro Hitosugi Yasushi Hirose Toshihiro Shimada Tetsuya Hasegawa | 2009 | Thin Solid Films2009，，11： | 1 |
| 18 | Classification of clinical subtypes, patient survival, kidney prognosis, and relapse in patients with MPO-ANCA-associated vasculitis: a single-center experience显示文摘 | Kimimasa Nakabayashi Yoshihiro Arimura Ken Yoshihara Toshihiro Fukuoka Miho Karube Tunee Yamato Hitoshi Koji Noriko Ikegaya Takako Ohtuka Sohko Kawashima Miyako Sudo Akira Yamada | 2009 | Modern Rheumatology2009，，4： | 1 |
| 19 | Residual stress estimation of a silicon carbide-kovar joint 显示文摘 | TOSHIHIRO YAMADA MOTOHIRO SATOH AKIOMI KOHNO | 1991 | Journal of Materials Science1991，，26： | 1 |
| 20 | Association between Single-Nucleotide Polymorphisms in Selectin Genes and Immunoglobulin A Nephropathy显示文摘 | Takashi Takei Aritoshi Iida Kosaku Nitta Toshihiro Tanaka Yozo Ohnishi Ryo Yamada Shiro Maeda Tatsuhiko Tsunoda Sachiyo Takeoka Kyoko Ito Kazuho Honda Keiko Uchida Ken Tsuchiya Yasushi Suzuki Tomoaki Fujioka Takashi Ujiie Yutaka Nagane Satoru Miyano Ichie | 2002 | The American Journal of Human Genetics2002，，3： | 1 |
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