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| 1 | Current status of preoperative drainage for distal biliary obstruction显示文摘Preoperative biliary drainage(PBD) was developed to improve obstructive jaundice, which affects a number of organs and physiological mechanisms in patients waiting for surgery. However, its role in patients who will undergo pancreaticoduodenectomy for biliary obstruction remains controversial. This article aims to review the current status of the use of preoperative drainage for distal biliary obstruction. Relevant articles published from 1980 to 2015 were identified by searching MEDLINE and Pub Med using the keywords 'PBD', 'pancreaticoduodenectomy', and 'obstructive jaundice'. Additional papers were identified by a manual search of the references from key articles. Current studies have demonstrated that PBD should not be routinely performed because of the postoperative complications. PBD should only be considered in carefully selected patients, particularly in cases where surgery had to be delayed. PBD may be needed in patients with severe jaundice, concomitant cholangitis, or severe malnutrition. The optimal method of biliary drainage has yet to be confirmed. PBD should be performed by endoscopic routes rather than by percutaneous routes to avoid metastatic tumor seeding. Endoscopic stenting or nasobiliary drainage can be selected. Although more expensive, the use of metallic stents remains a viable option to achieve effective drainage without cholangitis and reintervention. | Harutoshi Sugiyama Toshio Tsuyuguchi Yuji Sakai Rintaro Mikata Shin Yasui Yuto Watanabe Dai Sakamoto Masato Nakamura Reina Sasaki Jun-ichi Senoo Yuko Kusakabe Masahiro Hayashi Osamu Yokosuka | 2015 | World Journal of Hepatology2015，7，18： | 11 |
| 2 | 间歇和连续静脉输注法莫替丁对消化性溃疡患者胃酸的影响显示文摘 | Yozo Watanabe Hidenori Tsumura Hiroshi Sasaki Toshio Morimoto 孙钢 | 2000 | 中华消化杂志2000，20，5： | 6 |
| 3 | Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis by pancreatic duct stenting using a loop-tipped guidewire显示文摘AIM: To examine whether it is possible to prevent the occurrence of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis in patients experiencing difficulties with selective biliary duct cannulation by pancreatic duct stenting using a looptipped guidewire.METHODS: Procedure success rate, frequency of unintended insertion of the guidewire into side branches of the pancreatic duct, and incidence of procedural accidents were examined using a loop-tipped guidewire(Group A, 20 patients), and a conventional straighttype guidewire(Group B, 20 patients).RESULTS: The success rate of the procedure was 100% in both groups. Unintended insertion of the guidewire into a side branch of the pancreatic duct occurred 0.056 ± 0.23(0-1) times in Group A and 2.3 ±1.84(0-5) times in Group B; thus, unintended insertion of the guidewire into a side branch of the pancreatic duct was seen significantly less frequently in Group A. There were no procedural accidents in Group A, whereas pancreatitis occurred in one Group B patient; however, the difference between the two groups was not statistically significant. The serum amylase level after ERCP was 257.15 ± 136.4(88-628) IU/L in Group A, and 552.05 ± 534.57(101-2389) IU/L in Group B, showing a significantly lower value in Group A. Hyperamylasemia was found in two patients(10%) in Group A, and nine(45%) in Group B, showing a significantly lower value in Group A.CONCLUSION: The results suggest that in patients who experience difficulties with biliary cannulation, the use of a loop-tipped guidewire for pancreatic duct stenting may assist with the prevention of post-ERCP pancreatitis, and thereby to a reduction of the risk of post-ERCP pancreatitis or hyperamylasemia. | Yuji Sakai Toshio Tsuyuguchi Harutoshi Sugiyama Masahiro Hayashi Jun-ichi Senoo Reina Sasaki Yuko Kusakabe Masato Nakamura Shin Yasui Rintaro Mikata Masaru Miyazaki Osamu Yokosuka | 2016 | World Journal of Clinical Cases2016，4，8： | 5 |
| 4 | Endoscopic papillary large balloon dilation for bile duct stones in elderly patients显示文摘AIM: To investigate whether endoscopic papillary large balloon dilation(EPLBD) can be safety and effectively performed in patients aged ≥ 80 years. METHODS: Lithotomy by EPLBD was conducted in 106 patients with bile duct stones ≥ 13 mm in size or with three or more bile duct stones ≥ 10 mm. The patients were divided into group A(< 80 years) and group B(≥ 80 years). Procedure success rate, number of endoscopic retrograde cholangiopancreatographies(ERCP), and incidence of complications were examined in both groups.RESULTS: Group B tended to include significantly more patients with peripapillary diverticulum, hypertension, hyperlipemia, cerebrovascular disease/dementia, respiratory disease/cardiac disease, and patients administered an anticoagulant or antiplatelet agent(P < 0.05). The success rate of the initial lithotomy was 88.7(94/106)%. The final lithotomy rate was 100(106/106)%. Complications due to treatment procedure occurred in 4.72(5/106)% of the patients. There was no significant difference in procedure success rate, number of ERCP, or incidence of complications between group A and group B.CONCLUSION: EPLBD can be safely performed in elderly patients, the same as in younger patients. | Yuji Sakai Toshio Tsuyuguchi Harutoshi Sugiyama Reina Sasaki Dai Sakamoto Masato Nakamura Yuuto Watanabe Takao Nishikawa Shin Yasui Rintaro Mikata Osamu Yokosuka | 2015 | World Journal of Clinical Cases2015，3，4： | 4 |
| 5 | Endoscopic management of unresectable malignant gastroduodenal obstruction with a nitinol uncovered metal stent: a prospective Japanese multicenter study显示文摘AIM: To determine the safety and efficacy of endoscopic duodenal stent placement in patients with malignant gastric outlet obstruction.METHODS: This prospective, observational, multicenter study included 39 consecutive patients with malignant gastric outlet obstruction. All patients underwent endoscopic placement of a nitinol, uncovered, selfexpandable metal stent. The primary outcome was clinical success at 2 wk after stent placement that was defined as improvement in the Gastric Outlet Obstruction Scoring System score relative to the baseline.RESULTS: Technical success was achieved in all duodenal stent procedures. Procedure-related complications occurred in 4 patients(10.3%) in the form of mild pneumonitis. No other morbidities or mortalitieswere observed. The clinical success rate was 92.3%. The mean survival period after stent placement was 103 d. The mean period of stent patency was 149 d and the patency remained acceptable for the survival period. Stent dysfunction occurred in 3 patients(7.7%) on account of tumor growth.CONCLUSION: Endoscopic management using duodenal stents for patients with incurable malignant gastric outlet obstruction is safe and improved patients' quality of life. | Reina Sasaki Yuji Sakai Toshio Tsuyuguchi Takao Nishikawa Tatsuya Fujimoto Shigeru Mikami Harutoshi Sugiyama Osamu Yokosuka | 2016 | World Journal of Gastroenterology2016，22，14： | 2 |
| 6 | Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage显示文摘 | Shin-ichi Satoh Tatsuma Utsunomiya Kazuyuki Tsurui Teruki Kobayashi Ichiro Ikegaki Yasuo Sasaki Toshio Asano | 2001 | Life Sciences2001，，12： | 2 |
| 7 | Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction显示文摘 | Kazuo Yano Koh Kawasaki Tsuyoshi Hattori Shunsuke Tawara Yoshinori Toshima Ichiro Ikegaki Yasuo Sasaki Shin-ichi Satoh Toshio Asano Minoru Seto | 2008 | European Journal of Pharmacology2008，，1： | 1 |
| 8 | N-(6-aminohexyl)-5-Chloro-l-naphthalenesulfonamide,a calmodulin antantagonist,inhibits cell proliferation显示文摘 | Hiroyoshi Hidaka Yasuharu Sasaki Toshio Tanaka | 1981 | Proc Natl Acad Sci USA1981，78，7： | 1 |
| 9 | New tapered metallic stent for unresectable malignant hilar bile duct obstruction显示文摘AIM: To examine the usefulness of a new tapered metallic stent(MS) in patients with unresectable malignant hilar bile duct obstruction.METHODS: This new tapered MS was placed in 11 patients with Bismuth Ⅱ or severer unresectable malignant hilar bile duct obstruction, as a prospective study. The subjects were six patients with bile duct carcinoma, three with gallbladder cancer, and two with metastatic bile duct obstruction. Stenosis morphology was Bismuth Ⅱ: 7, Ⅲa: 3, and Ⅳ: 1. UMIN Clinical Trial Registry(UMIN000004758).RESULTS: MS placement was 100%(11/11) successful. There were no procedural accidents. The mean patency period was 208.401 d, the median survival period was 142.000 d, and the mean survival period was 193.273 d. Occlusion rate was 36.4%(4/11); the causes of occlusion were ingrowth and overgrowth in 2 patients each, 18.2%, respectively. Patients with occlusion underwent endoscopic treatment one more time and all were treatable. CONCLUSION: The tapered MS proved useful in patients with unresectable malignant hilar bile duct obstruction because it provided a long patency period, enabled re-treatment by re-intervention, and no procedural accidents occurred. | Yuji Sakai Toshio Tsuyuguchi Takao Nishikawa Harutoshi Sugiyama Reina Sasaki Dai Sakamoto Yuto Watanabe Masato Nakamura Shin Yasui Rintaro Mikata Osamu Yokosuka | 2015 | World Journal of Clinical Cases2015，3，10： | 1 |
| 10 | N- (6-aminohexyl)-5-Chloro-l-naphthalenesulfonamide, a calm- odulin antagonist, inhibits cell proliferation显示文摘 | Hiroyoshi Hidaka Yasuharu Sasaki) Toshio Tanaka | 1981 | Proceedings of the National Academy of Sciences of USA1981，78，7： | 1 |
| 11 | Fabrication and properties of functionally gradient materials显示文摘 | Hirai Toshio | 1991 | Journal of the Ceramic Society of Japan International Edition1991，99，10： | 1 |
| 12 | Crystallization behavior and origin of c-axis orientation in sol-gel derived ZnO: Li thin film on glass substrate显示文摘 | Shinlbu Fujihara Chikako Sasaki Toshio Kimura | 2001 | Appl Surf Sci2001，180，： | 1 |
| 13 | Effects of Li and Mg doping on microstructure and properties of sol-gel ZnO thin films显示文摘 | Shinobu Fujihara Chikako Sasaki Toshio Kimura | 2001 | Journal of the European Ceramic Society2001，，10： | 1 |
| 14 | Fabrication and Properties of Functionally Gradient Materials显示文摘 | Makoto Sasaki Toshio Hirai | 1991 | The Centennial Memorial Issue of the Ceramic Society of Japan1991，99，10： | 1 |
| 15 | Crystallization behavior and origin of c -axis orientation in sol–gel-derived ZnO:Li thin films on glass substrates显示文摘 | Shinobu Fujihara Chikako Sasaki Toshio Kimura | 2001 | Applied Surface Science2001，，3： | 1 |
| 16 | Bubble velocity measurement with a recursiVe cross correlation PIV technique显示文摘 | Wen Cheng Yuichi Mural Toshio Sasaki | 2005 | Flow Measurement and Instrumentation2005，16，： | 1 |
| 17 | Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity显示文摘 | Toshio Uesaka Tadahisa Shono Daisuke Kuga Satoshi O. Suzuki Hiroaki Niiro Kyoko Miyamoto Kenichi Matsumoto Masahiro Mizoguchi Masaru Ohta Toru Iwaki Tomio Sasaki | 2007 | Journal of Neuro - Oncology2007，，2： | 1 |
| 18 | 15th Anniversary of Rebamipide: Looking Ahead to the New Mechanisms and New Applications显示文摘 | Tetsuo Arakawa MD PhD Kazuhide Higuchi MD PhD Yasuhiro Fujiwara MD PhD Toshio Watanabe MD PhD Kazunari Tominaga MD PhD Eiji Sasaki MD PhD Nobuhide Oshitani MD PhD Toshikazu Yoshikawa MD PhD Andrzej S. Tarnawski MD PhD DSc | 2005 | Digestive Diseases and Sciences2005，，1： | 1 |
| 19 | Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2,4-dihydroxypyridine on 5-FU-resistant gastric cancer cells: possible role of a dihydropyrimidine dehydrogenase-independent mechanism显示文摘 | Eiji Sasaki Kazunari Tominaga Hikaru Kuwamura Toshio Watanabe Yasuhiro Fujiwara Nobuhide Oshitani Kazuhide Higuchi Tetsuo Arakawa | 2007 | Journal of Gastroenterology2007，，10： | 1 |
| 20 | Structural characterization of thin-walled microbubble cavities显示文摘Whispering gallery mode(WGM)microbubble cavities are a versatile optofluidic sensing platform owing to their hollow core geometry.To increase the light–matter interaction and,thereby,achieve higher sensitivity,thinwalled microbubbles are desirable.However,a lack of knowledge about the precise geometry of hollow microbubbles prevents us from having an accurate theoretical model to describe the WGMs and their response to external stimuli.In this work,we provide a complete characterization of the wall structure of a microbubble and propose a theoretical model for the WGMs in this thin-walled microcavity based on the optical waveguide approach.Structural characterization of the wavelength-scale wall is enabled by focused ion beam milling and scanning electron microscopy imaging.The proposed theoretical model is verified by finite element method simulations.Our approach can readily be extended to other low-dimensional micro-/nanophotonic structures. | MOHAMMED ZIA JALALUDEEN SHILONG LI KE TIAN TOSHIO SASAKI SÍLE NIC CHORMAIC | 2023 | Photonics Research2023，11，8： | 0 |
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