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| 1 | Liver metastasis models of human colorectal carcinoma established in nude mice by orthotopic transplantation and their biologic characteristics显示文摘INTRUDUCTIONSomemodelsofnudemicethatfreshhumancolorectalcarcinomatisueorcelsweresuccesfulytransplantedsubcuteneouslyhavebeenr... | LIU Qiu Zhen 1, TUO Chao Wei 1, WANG Bin 1, WU Bing Quan 2 and ZHANG Yan Hua 1 | 1998 | World Journal of Gastroenterology1998，4，5： | 6 |
| 2 | SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice显示文摘Establishment of the primordial follicle(PF)pool is pivotal for the female reproductive lifespan;however,the mechanism of primordial folliculogenesis is poorly understood.Here,the transcription factor SP1 was shown to be essential for PF formation in mice.Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary.Knockdown of Sp1 expression,especially in pregranulosa cells,significantly suppressed nest breakdown,oocyte apoptosis,and PF formation,suggesting that SP1 expressed by somatic cells functions in the process of primordial folliculogenesis.We further demonstrated that SP1 governs the recruitment and maintenance of Forkhead box L2-positive(FOXL2^+)pregranulosa cells using an Lgr5-EGFP-IRES-CreER^T2(Lgr5-KI)reporter mouse model and a FOXL2^+ cell-specific knockdown model.At the molecular level,SP1 functioned mainly through manipulation of NOTCH2 expression by binding directly to the promoter of the Notch2 gene.Finally,consistent with the critical role of granulosa cells in follicle survival in vitro,massive loss of oocytes in SP1 knockdown ovaries was evidenced before puberty after the ovaries were tranSP1anted under the renal capsules.Conclusively,our results reveal that SP1 controls the establishment of the ovarian reserve by regulating pregranulosa cell development in the mammalian ovary. | Han Cai Bingying Liu Huarong Wang Guanghong Sun Lizhao Feng Ziqi Chen Jiaqi Zhou Jiawei Zhang Tuo Zhang Meina He Tingting Yang Qirui Guo Zhen Teng Qiliang Xin Bo Zhou Hua Zhang Guoliang Xia Chao Wang | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | A COVID-19 Outbreak Emerging in a Food Processing Company——Harbin City,Heilongjiang Province,China,January-February 2021显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)epidemic in China had been effectively controlled for several months,but as the ambient temperature dropped,large gathering-initiated epidemics occurred in northern China,including Hebei,Liaoning,and Jilin provinces. | Lei Hou Hao Zhou Nanxi Meng Xue Yu Xin Wang Tuo Wang Jianfeng Zhang Yan Wang Shie Li Shuzhen Guo Jianxing Yu Muxin Chen Wenhui Shi Ning Xiao Chao Yang Jianxiang Liu | 2021 | China CDC weekly2021，3，32： | 2 |
| 4 | Geochemistry, Sr-Nd-Pb Isotopic Compositions and Zircon U-Pb Geochronology of Neoproterozoic Mafic Dyke in the Douling Complex, South Qinling Belt, China显示文摘Mafic dyke swarm is widely developed in Proterozoic continental lithosphere.The Gangou diabase dyke from the Xixia area,intruded into the Douling complex of the South Qinling belt,yields zircon UPb age of 731 Ma.It has low SiO2 content(49.02 wt.%-49.37 wt.%)and Mg^#(34.0–37.7)and shows characteristics of subalkaline tholeiite series.They show highΣREE(155.5×10^-6–184.7×10^-6),weak negative Eu anomaly(δEu=0.88-0.93),slight depletion of Nb and Ta,and enrichment of LILE.Their major and trace element,Sr-Nd-Pb isotope and clinopyroxene compositions indicate that it originated from the partial melting of the asthenospheric mantle within-plate extension setting and was slightly contaminated by crust compositions.The similarities of formation age,petrogenesis,source characteristic and tectonic setting for Gangou diabase with mafic dykes in Wudang Block and mafic volcanic rocks in Yaolinghe Group indicate that the South Qinling belt underwent strong continental extension in Neoproterozoic during 796–685 Ma most likely correspondence to the breaking-up of the Rodinia supercontinent. | Tong Li Liang Liu Xiao-Ying Liao Yong-Sheng Gai Tuo Ma Chao Wang | 2020 | Journal of Earth Science2020，31，2： | 2 |
| 5 | Three-dimensional characterization of micro-fractures in shale reservoir rocks显示文摘Fractures are crucial for unconventional hydrocarbon exploitation,but it is difficult to accurately observe the 3D spatial distribution characteristics of fractures.Microtomography(micro-CT)technology makes it possible to observe the 3D structures of fractures at micro-scale.In this study,micron-CT scanning is conducted on multiple mud-shale samples of source rocks in the Permian Lucaogou Formation,Junggar Basin.The Avizo^(®) software is applied to process and segment the micron-CT images,so as to obtain the 3D fracture structure model inside rock core.Therefore,the independently-developed CTSTA program is adopted to quantitatively describe the micro-fractures inside rock core,including fracture dimension,extension direction and extension scale.Meanwhile,this study summarizes the classification characteristics of fractures and their anisotropy.On this basis,the fractal dimensions of fractures can also be extracted.Previous studies show that the geometric features of fractures have self-similarity at large and small scales,which can be described by exponential laws;and the fractal dimension is a typical exponent.Through the quantitative description or characterization of 3D fractures at micro-scale,the distribution characteristics of fractures in large scales could be known. | Chao Qi Xiaoqi Wang Wei Wang Jie Liu Jincai Tuo Keyu Liu | 2018 | Petroleum Research2018，3，3： | 1 |
| 6 | Role of the Hedgehog pathway in hepatocellular carcinoma (Review)显示文摘 | Xin Zheng Wen Zeng Xiaohong Gai Qiuran Xu Chao Li Zheyong Liang Hang Tuo Qingguang Liu | 2013 | Oncology Reports2013，，5： | 1 |
| 7 | A Three-dimensional Covalent Organic Framework for CO_(2) Uptake and Dyes Adsorption显示文摘Environmental pollution is one of the most severe problems facing today,including water pollution and the greenhouse effect.Therefore,developing materials with high-efficiency dyes adsorption and CO_(2)uptake is significant.Covalent organic frameworks(COFs),as a burgeoning class of crystalline porous polymers,present a promising application potential in areas related to pollution regulation due to their exciting surface properties.Herein,we report a 3D COF with a high specific surface area(BET about 2072 m^(2)/g)by utilizing tetrahedral and rectangle building blocks connected through[4+4]imine condensation reactions to synthesize.The obtained COF not only can separate dyes from water effectively but also shows a remarkable CO_(2)uptake capacity.This research thus provides a promising material to remove dyes and adsorb CO_(2)in environmental remediation. | SONG Jialong WANG Zitao LIU Yaozu TUO Chao WANG Yujie FANG Qianrong QIU Shilun | 2022 | Chemical Research in Chinese Universities2022，38，3： | 1 |
| 8 | Paired quasi-periodic pulsations of hard X-ray emission in a solar flare显示文摘We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 UT.Several subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak struc-tures.These subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive phase.The periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence level.The paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our observation.The precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands. | Hai-Sheng Zhao Dong Li Shao-Lin Xiong Yan-Qiu Zhang Yang Su Wei Chen Yi Zhao Xiao-Bo Li Jia-Cong Liu Wen-Xi Peng Rui Qiao Xin-Qiao Li Xiang-Yang Wen Li-Ming Song Shi-Jie Zheng Xin-Ying Song Xiao-Yun Zhao Yue Huang Shuang-Nan Zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen Yan-Qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-Wei Guo Jian-Jian He Bin Li Chao Li Chao-Yang Li Gang Li Jian-Hui Li Lu Li Qing-Xin Li Yan-Guo Li Jing Liang Xiao-Hua Liang Jin-Yuan Liao Xiao-Jing Liu Ya-Qing Liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-Li Shi Jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-Li Tuo Chen-Wei Wang Hui Wang Jin Wang Jin-Zhou Wang Ping Wang Wen-Shuai Wang Hong Wu Sheng-Lun Xie Yan-Bing Xu Yu-Peng Xu Wang-Chen Xue Sheng Yang Min Yao Jian-Ying Ye Qi-Bin Yi Chao-Yue Zhang Da-Li Zhang Fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou Yue Zhu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，5： | 0 |
| 9 | Comparison of percutaneous endoscopic cervical discectomy versus anterior cervical discectomy and fusion for cervical disc herniation:a meta-analysis显示文摘Purpose:The purpose of the study is to perform a systematic review and meta-analysis to evaluate the clinical results of percutaneous endoscopic cervical discectomy(PECD)and anterior cervical discectomy and fusion(ACDF)for the treatment of cervical disc herniation(CDH).Methods:Randomized controlled trials or non-randomized controlled trials published from the time when databases were built to October 2020 that compared the clinical effectiveness of PECD and ACDF surgical approaches for the treatment of CDH were acquired hy a comprehensive search in four electronic databases(Pub Med,EMBASE,and Web of Science).A total of 5 studies(559 patients)were included in this systematic review and meta-analysis.Pooled mean differences(MD)and odds ratios(OR)and with 95% CIs were calculated for the outcomes.Results:The results showed that there were no statistically between the PECD group and ACDF group in terms of preoperative VASN score(WMD=0.22;95%CI:-0.52 to 0.97;P=0.56),preoperative VASA score(WMD=-0.13;95%CI:-0.42 to 0.16;P=0.37),postoperative VASN score(WMD=0.14;95%CI:-0.12 to 0.40;P=0.28),postoperative VASA score(WMD=-0.08;95%CI:-0.28 to 0.11;P=0.40),preoperative NDI(WMD=-0.75;95%CI:-5.60 to 4.11;P=0.76),postoperative NDI(WMD=0.22;95%CI:-1.44 to 1.88;P=0.80),,reoperation rate(OR=1.35;95%CI:0.49 to 3.72;P=0.57)or operation time(WMD=-11.76;95%CI:-71.23 to 47.72;P=0.70).PECD group was associated with lower complication rate(OR=0.34;95%CI:0.15 to 0.78;P=0.01)and shorter hospital stay(WMD=-2.59;95%CI:-3.67 to -1.52;P<0.00001).Conclusion:The existing evidence indicates that no superiority exists between the two surgical approaches for the treatment of CDH in terms of functional outcome,operation lime,and reoperation rate,despite that PECD surgical group can achieve lower complication rates and shorter hospital stay than ACDF surgical group. | 李庆达 章雪芳 杨俊松 Chen Chienmin Liu Tuanjiang He Baorong Jiang Chao Tian Xin Yang Mingyi Chai Xin Tuo Yuan Hao Dingjun | 2021 | 美中国际创伤杂志2021，20，2： | 0 |
| 10 | Unveiling clinical significance and tumor immune landscape of CXCL12 in bladder cancer: Insights from multiple omics analysis显示文摘Objective: The interplay between chemokine C-X-C motif ligand 12(CXCL12) and its specific receptors is known to trigger various signaling pathways, contributing to tumor proliferation and metastasis. Consequently,targeting this signaling axis has emerged as a potential strategy in cancer therapy. However, the precise role of CXCL12 in clinical therapy, especially in immunotherapy for bladder cancer(BCa), remains poorly elucidated.Methods: We gathered multiple omics data from public databases to unveil the clinical relevance and tumor immune landscape associated with CXCL12 in BCa patients. Univariate and multivariate Cox regression analyses were employed to assess the independent prognostic significance of CXCL12 expression and formulate a nomogram. The expression of CXCL12 in BCa cell lines and clinical tissue samples was validated using enzymelinked immunosorbent assays(ELISA) and immunohistochemistry(IHC).Results: While transcriptional expression of CXCL12 exhibited a decrease in nearly all tumor tissues, CXCL12 methylation expression was notably increased in BCa tissues. Single-cell RNA analysis highlighted tissue stem cells and endothelial cells as the primary sources expressing CXCL12. Abnormal CXCL12 expression, based on transcriptional and methylation levels, correlated with various clinical characteristics in BCa patients. Functional analysis indicated enrichment of CXCL12 and its co-expression genes in immune regulation and cell adhesion. The immune landscape analysis unveiled a significant association between CXCL12 expression and M2 macrophages(CD163~+ cells) in BCa tissues. Notably, CXCL12 expression emerged as a potential predictor of immunotherapy response and chemotherapy drug sensitivity in BCa patients.Conclusions: Taken together, these findings suggest aberrant production of CXCL12 in BCa tissues,potentially influencing the treatment responses of affected individuals. | Zhouting Tuo Dechao Feng Zhiwei Jiang Liangkuan Bi Chao Yang Qi Wang | 2023 | Chinese Journal of Cancer Research2023，35，6： | 0 |
| 11 | A Universal Inequality for Stability of Coarse Lipschitz Embeddings显示文摘Let X and Y be two pointed metric spaces.In this article,we give a generalization of the Cheng-Dong-Zhang theorem for coarse Lipschitz embeddings as follows:If f:X→Y is a standard coarse Lipschitz embedding,then for each x^(*)∈Lip_(0)(X)there existα,γ>0 depending only on f and Q_(x)*∈Lip_(0)(Y)with‖Q_(x)*‖_(Lip)≤α‖x^(*)‖_(Lip)such that|Q_(x)*f(x)-x^(*)(x)|≤γ‖x^(*)‖_(Lip),for all x∈X.Coarse stability for a pair of metric spaces is studied.This can be considered as a coarse version of Qian Problem.As an application,we give candidate negative answers to a 58-year old problem by Lindenstrauss asking whether every Banach space is a Lipschitz retract of its bidual.Indeed,we show that X is not a Lipschitz retract of its bidual if X is a universally left-coarsely stable space but not an absolute cardinality-Lipschitz retract.If there exists a universally right-coarsely stable Banach space with the RNP but not isomorphic to any Hilbert space,then the problem also has a negative answer for a separable space. | Duan Xu Dai Ji Chao Zhang Quan Qing Fang Long Fa Sun Ben Tuo Zheng | 2023 | Acta Mathematica Sinica,English Series2023，39，9： | 0 |
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