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| 1 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 2 | CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development显示文摘学习必要基因的早功能是在发展生物学的一个重要、挑战性的问题。这里,我们为很快在二房间的阶段胚胎的一个分裂球导致 CRISPR-Cas9-mediated 变化建立了一个方法,称为的 2 房间 embryo-CRISPR-Cas9 注射(2CC ) ,学习在里面必需品的 vivo 功能(或未知) 在创始人的基因妄想的鼠标。由注射指向兴趣的基因进的 Cre mRNA 和 CRISPR-Cas9 荧光灯记者老鼠, 2CC 方法能在不同发展阶段跟踪野类型、变异的房间,为变异的房间的 phenotypic 分析的出现内部控制。用这个方法,我们在在发展中的鼠标调整有刺激性、禁止的 synaptic 传播识别了必要基因 Tet3 的新奇函数服的外皮。由产生妄想的变异的老鼠, 2CC 方法允许在多重纸巾和房间的基因功能的快速的屏蔽录入妄想的老鼠创始人,显著地扩展基因工具的当前的一套设备。 | Wang, Lingbo Li, Min-Yin Qu, Chao Miao, Wan-Ying Yin, Qi Liao, Jiaoyang Cao, Hua-Teng Huang, Min Wang, Kai Zuo, Erwei Peng, Guangdun Zhang, Shu-Xin Chen, Guodong Li, Qing Tang, Ke Yu, Qian Li, Zhoujie Wong, Catherine C. L. Xu, Guoliang Jing, Naihe Yu, Xiang Li, Jinsong | 2017 | Cell Research2017，27，6： | 5 |
| 3 | Cloning, expression and localization of a trypsin-like serine protease in the spruce budworm, Choristoneura fumiferana显示文摘像胰岛素的脱毛相关的丝氨酸朊酶 cDNA (CfMRSP ) 从云杉芽虫被克隆, Choristoneura fumiferana。全身的 CfMRSP 互补 DNA (cDNA ) 编码了包含了像胰岛素的丝氨酸朊酶的 43 kDa 蛋白质催化领域,而是没有片断领域。C 终端延期包含了五 cystein 残余,它可以允许蛋白质形成通过更暗淡的一个人内部锁住二硫化物契约并且调整 CfMRSP 的活动。种系发生的树分析证明 CfMRSP 与象丝氨酸朊酶 1 Lonomia obliqua 那样的鳞翅类的相当或相同事物聚类,血淋巴朊酶 20 (HP20 ) ,模式识别丝氨酸朊酶先锋(ProHP14 ) 和 Manduca 祷告的像胰岛素的蛋白质一。CfMRSP 的发展表示的北污点分析显示它的抄本首先在外皮被发现并且测试视距在所有期间被生产,从第 4 中间形态幼虫到蛹,但是增加了抄本总是在每根脱毛以后被发现的 CfMRSP 的层次。蛋白质的高水平被免疫组织化学分析在外皮发现。总的来说这些数据建议 CfMRSP 在 molting 和变形期间在外皮起一个作用。 | Wen-Ying He Yi-Ping Zheng Lin Tang Si-Chun Zheng Catherine Beliveau Daniel Doucet Michel Cusson Qi-Li Feng | 2009 | Insect Science2009，16，6： | 3 |
| 4 | Fibrinogen as a Hemostatic Agent显示文摘 | Benny S?rensen Ole Larsen Catherine Rea Mariann Tang Jonathan Foley Christian Fenger-Eriksen | 2012 | Semin Thromb Hemost2012，，03： | 2 |
| 5 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 6 | Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls显示文摘 | Brandie D. Taylor Gong Tang Roberta B. Ness J?rn Olsen David M. Hougaard Kristin Skogstrand James M. Roberts Catherine L. Haggerty | 2015 | Pregnancy Hypertension: An International Journal2015，，： | 1 |
| 7 | Effects of Age, Gender, and Emotional Labor Strategies on Job Outcomes: Moderated Mediation Analyses显示文摘 | Francis Cheung Catherine Tang | 2010 | Applied Psychology2010，2，3： | 1 |
| 8 | Mental health outcomes of job stress among Chinese teachers: role of stress resource factors and burnout显示文摘 | Catherine So- Kum Tang Wine- Tung Au Ralf Schwarzer Gerdamarie Schmitz | 2001 | Journal of Organizational Behavior2001，，22： | 1 |
| 9 | Psychological Capital as a Moderator Between Emotional Labor, Burn- out, and Job Satisfaction Among School Teachers in China 显示文摘 | Francis Cheung Catherine So-kum Tang Shuwen Tang | 2011 | International Journal of Stress Management2011，18，4： | 1 |
| 10 | Chinese Undergraduate Students' Work Values:The Role of Parental Work Experience and Part-Time Work Quality显示文摘 | Francis Yue-lok Cheung and Catherine So-kum Tang | | 0，，39： | 1 |
| 11 | Psychological Capital as a Moderator between Emotional Labor, Burnout, and Job Satisfaction among School Teachers in China 显示文摘 | Francis Cheung Catherine So-Kum Tang & Shuwen Tang | 2011 | International Journal of Stress Management2011，10，3： | 1 |
| 12 | Mental health outcomes of job stress among Chinese teachers:Role of stress resource factors and burnout显示文摘 | Catherine So-Kum Tang Wing-Tung Au Ralf Schwarzer Gerdamarie Schmitz | | 0，，22： | 1 |
| 13 | From process to outcome:the effect of portfolio assessment on student learning显示文摘 | Agnes Tiwari Catherine Tang | 2003 | Nurse Education Today2003，23，4： | 1 |
| 14 | Upstream open reading frames regulate the expression of the nuclear Wnt13 isoforms显示文摘 | Tao Tang Kyle Rector Corey D. Barnett Catherine D. Mao | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 1 |
| 15 | Mental health outcomes of job stress among Chinese teachers: role of stress resource factors and burnout显示文摘 | Catherine So-Kum Tang Wing-Tung An Ralf Schwarzer | 2001 | J Organizat Behav2001，22，8： | 1 |
| 16 | A phase 2 study of the insulin‐like growth factor‐1 receptor inhibitor MK‐0646 in patients with metastatic, well‐differentiated neuroendocrine tumors显示文摘 | Diane L. Reidy‐Lagunes Efsevia Vakiani Michal F. Segal Ellen M. Hollywood Laura H. Tang David B. Solit M. Catherine Pietanza Marinela Capanu Leonard B. Saltz | 2012 | Cancer2012，，19： | 1 |
| 17 | Mental health outcomes of job stress among Chinese teachers:role of tress resource factors and barnout 显示文摘 | Catherine So-Kum Tang Wing-Tung An Ralf Schwarzer | 2001 | J Oragnizat Behav2001，22，8： | 1 |
| 18 | Traumatic stress symptoms in the aftermath of extreme natural disaster显示文摘 | Tang Catherine So-kum T C | 2007 | J Nerv Ment Disease2007，195，1： | 1 |
| 19 | From concept to action: a united, holistic and One Health approach to respond to the climate change crisis显示文摘It is unequivocal that human influence has warmed the planet,which is seriously affecting the planetary health including human health.Adapting climate change should not only be a slogan,but requires a united,holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately.Recognizing the urgent needs to tackle the risk connection between climate change and One Health,the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided. | Renhe Zhang Xu Tang Jian Liu Martin Visbeck Huadong Guo Virginia Murray Catherine Mcgillycuddy Bing Ke Gretchen Kalonji Panmao Zhai Xiaoming Shi Jiahai Lu Xiaonong Zhou Haidong Kan Qunli Han Qian Ye Yong Luo Jianmin Chen Wenjia Cai Huiling Ouyang Riyanti Djalante Alexander Baklanov Lu Ren Guy Brasseur George Fu Gao Lei Zhou | 2022 | Infectious Diseases of Poverty2022，11，1： | 0 |
| 20 | Smoothened蛋白的胆固醇共价修饰对Hedgehog信号通路至关重要显示文摘文章简介长期以来,Hedgehog(Hh)一直被认为是唯一的胆固醇共价修饰蛋白,胆固醇的共价修饰对Hh信号转导、肿瘤发生发展以及胚胎发育至关重要。成熟的Hh蛋白受体Patched解除对Smoothened(SMO)的抑制,再经过一系列途径最终激活转录因子Gli,调控下游基因的表达。 | Xu Xiao Jing-Jie Tang Chao Peng Yan Wang Lin Fu Zhi-Ping Qiu Yue Xiong Lian-Fang Yang Hai-Wei Cui Xiao-Long He Lei Yin Wei Qi Catherine C.L.Wong Yun Zhao Bo-Liang Li 仇文卫 宋保亮 | 2018 | 科学新闻2018，0，4： | 0 |
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