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| 1 | Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells显示文摘动脉粥样硬化患者损害被丰富的类脂化合物和长期的发炎的累积描绘。以前的研究显示了导出巨噬细胞的脂蛋白脂肪分解酵素(LPL ) 由加速类脂化合物累积和支持 inflammatory cytokine 分泌物支持动脉粥样硬化前进。尽管 apelin-13 被认为是一个 atheroprotective 因素,它是否能调整 LPL 的表示,仍然保持不清楚。这研究的目的是在 THP-1 导出巨噬细胞的泡沫房间在 LPL 和内在的机制的表示上探索 apelin-13 的效果。Apelin-13 显著地减少了在 10 和 100 nM 的集中的全部的胆固醇,免费胆固醇,和胆固醇酉旨的细胞的层次。ELISA 分析证实有 apelin-13 的处理减少了支持 inflammatory cytokine 分泌物,例如 interleukin-6 (IL-6 ) , interleukin-1 (IL-1 ) 和肿瘤坏死 factor-alpha (TNF-) 。apelin-13 禁止了由西方的污点和即时 PCR 分析揭示了的 LPL 的表示,这也被发现。生物信息学分析和双酶的记者试金直接显示了那 miR-361-5p downregulated 由指向 LPL 的 3UTR 的 LPL 的表示。另外, apelin-13 + miR-361-5p 显著地模仿 downregulated 在房间的 LPL 的表示。最后,我们表明了那 apelin-13 downregulated 通过激活 PKC 的活动的 LPL 的表示。一起拿,我们的结果显示出那 apelin-13 downregulated 经由激活在 THP-1 导出巨噬细胞的泡沫房间表明小径的 APJ/PKC/miR-361-5p 的 LPL 的表示,导致类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制。因此,我们的研究由 apelin-13 提供重要新卓见进类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制,并且在动脉粥样硬化作为一个有希望的治疗学的目标加亮 apelin-13。 | Xin Zhang Qiong Ye Duo Gong Yuan Lv Haipeng Cheng Chong Huang Lingyan Chen Zhenwang Zhao Liang Li Xie Wei Min Zhang Xiaodan Xia Xiaohua Yu Xilong Zheng Shuzhi Wang Zongbao Wang Chaoke Tang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 6 |
| 2 | Joint effects of Penta-BDE and heavy metals on Daphnia magna survival,its antioxidant enzyme activities and lipid peroxidation显示文摘The joint toxicity of Penta-BDE(Pe-BDE)and heavy metals including cadmium and copper on Daphnia magna(D.magna)was evaluated on the basis of determining the 48 h survival,antioxidative enzyme responses,and lipid peroxidation.The response was classified as additive,greater than additive,or less than additive by comparing the measured“toxic units,TU”with one.Based on the survival of D.magna,less-than-additive interactions were found in most of mixtures treatments.This may be attributed to the different toxicity mechanism between Pe-BDE and metals.Cu and Cd played a greater role in toxicity than what Pe-BDE did.As for the superoxide dismutase(SOD)and catalase(CAT)activity,most response was less than additive.For the glutathione S-transferases(GST)activity,most of the greater-thanadditive responses were found in the Cu plus Pe-BDE treatments,but the additive responses occurred in Cd plus Pe-BDE treatments and binary metal treatments.For lipid peroxide levels,which were measured as malondialdehyde(MDA)levels,less-than-additive response occurred in the 50%Cd plus 50%Cu and ternary mixture treatments.Results suggested that Pe-BDE,Cd,and Cu could induce different patterns of antioxidant enzyme responses,such as antioxidant/prooxidant responses,depending on their capability to produce reactive oxygen species and antioxidant enzymes to detoxify them. | Baohua TANG Lingyan ZHU Qixing ZHOU | 2011 | Frontiers of Environmental Science & Engineering2011，5，1： | 5 |
| 3 | Phosphoester modified poly(ethylenimine) as efficient and low cytotoxic genevectors显示文摘Cyclic phosphoester monomer ethyl ethylene phosphate (EEP) modified poly(ethylenimine) (PEI),denoted as PEI-EEP,was developed for gene delivery.Three PEI-EEP polymers were synthesized and their structures were characterized by 1H and 31P NMR methods.All the PEI-EEP polymers could condense DNA efficiently at N/P ratios higher than 0.5/1.The physiochemical characteristics of PEI-EEP/DNA complexes were analyzed by particle size and zeta potential measurements.The particle sizes of complexes were around 160–250 nm,and their zeta potentials were around 30–45 mV at the N/P ratios ranging from 10/1 to 50/1.In vitro cell viability and transfection ability were evaluated in HEK293 and HeLa cells using PEI as the control.The cytotoxicity of PEI-EEP and PEI-EEP/DNA complexes was lower than that of PEI and its complexes with DNA.The transfection efficiency of PEI-EEP/DNA complexes was correlated to modification degrees with phosphoester.When the modification of phosphoester to PEI was moderate,the PEI-EEP1/DNA and PEI-EEP2/DNA complexes exhibited comparable or even higher transfection ability than PEI/DNA complex at its optimal N/P ratio in the absence of serum.However,transfection efficiency of PEI-EEP3 reduced dramatically.More importantly,the PEI-EEP exhibited higher transfection efficiency in the presence of 10% serum than that without serum.Therefore,PEI-EEP polymers may be attractive vectors for non-viral gene therapy. | DU JinZhi TANG LingYan YUAN YouYong WANG Jun | 2011 | Science China Chemistry2011，54，2： | 3 |
| 4 | High-order maximum-principle-preserving and positivity-preserving weighted compact nonlinear schemes for hyperbolic conservation laws显示文摘In this paper,the maximum-principle-preserving(MPP)and positivitypreserving(PP)flux limiting technique will be generalized to a class of high-order weighted compact nonlinear schemes(WCNSs)for scalar conservation laws and the compressible Euler systems in both one and two dimensions.The main idea of the present method is to rewrite the scheme in a conservative form,and then define the local limiting parameters via case-by-case discussion.Smooth test problems are presented to demonstrate that the proposed MPP/PP WCNSs incorporating a third-order Runge-Kutta method can attain the desired order of accuracy.Other test problems with strong shocks and high pressure and density ratios are also conducted to testify the performance of the schemes. | Lingyan TANG Songhe SONG Hong ZHANG | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，1： | 3 |
| 5 | Syntenic quantitative trait loci and genomic divergence for Sclerotinia resistance and ?owering time in Brassica napus显示文摘Oilseed rape(Brassica napus) is an allotetraploid with two subgenomes descended from a common ancestor. Accordingly, its genome contains syntenic regions with many duplicate genes, some of which may have retained their original functions, whereas others may have diverged. Here, we mapped quantitative trait loci(QTL) for stem rot resistance(SRR), a disease caused by the fungus Sclerotinia sclerotiorum, and flowering time(FT) in a recombinant inbred line population. The population was genotyped using B.napus 60 K single nucleotide polymorphism arrays and phenotyped in six(FT) and nine(SSR) experimental conditions or environments. In total, we detected 30 SRR QTL and 22 FT QTL and show that some of the major QTL associated with these two traits were co-localized,suggesting a genetic linkage between them. Two SRR QTL on chromosome A2 and two on chromosome C2 were shown to be syntenic, suggesting the functional conservation of these regions. We used the syntenic properties of the genomic regions to exclude genes for selection candidates responsible for QTL-associated traits. For example, 152 of the 185 genes could be excluded from a syntenic A2–C2 region. These findings will help to elucidate polyploid genomics in future studies, in addition to providing useful information for B. napus breeding programs. | Fengqi Zhang Junyan Huang Minqiang Tang Xiaohui Cheng Yueying Liu Chaobo Tong Jingyin Yu Tehrim Sadia Caihua Dong Lingyan Liu Baojun Tang Jianguo Chen Shengyi Liu | 2019 | Journal of Integrative Plant Biology2019，61，1： | 3 |
| 6 | Highly sensitive potentiometric immunosensor for hepatitis B surface antigen diagnosis显示文摘A highly sensitive potentiometric immunosensor for the diagnoses of epidemic dis- eases has been developed by means of self-assembly to immobilize hepatitis B surface antibody (HBsAb) for the detection of hepatitis B surface antigen (HBsAg) as a model. At first, the Nafion containing ?SO3 groups was immobilized on a platinum electrode surface to absorb the ?NH3 ? + groups of antibody molecules via the opposite-charged adsorption technique, in the meantime, hepatitis B surface antibodies were adsorbed onto the surface of Au nanoparticles, then hepatitis B surface antibodies and Au nanopartilces were entrapped into polyvinyl butyral on the surface of Nafion film. The modified procedure was further characterized by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The influence and factors influencing the per- formance of resulting immunosensor were studied in detail. The resulting immunosensor exhib- ited sigmoid curve with log HBsAg concentrations, high sensitivity, wide linear range from 26 to 1280 ng·mL?1 with a detection limit of 3.1 ng·mL?1, rapid potentiometric response (<3 min) and long-term stability (>4 months). Analytical results of clinical samples show that the developed immunoassay is comparable with the enzyme-linked immunosorbent assays (ELISAs) method, implying a promising alternative approach for detecting HBsAg in the clinical diagnosis. | YUAN Ruo TANG Dianping CHAI Yaqin ZHANG Lingyan LIU Yan ZHONG Xia DAI Jianyuan | 2005 | Science China Chemistry2005，48，1： | 2 |
| 7 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 8 | A multiresolution finite volume scheme for two-dimensional hyperbol- ic conservation laws显示文摘 | Tang Lingyan Song Songhe | 2008 | Journal of Computational and Applied Mathematics2008，214，： | 1 |
| 9 | A multiresolution finite volume scheme for two-dimensional hyperbolic conservation laws 显示文摘 | Tang Lingyan Song Songhe | 2008 | J Comput Appl Math2008，214，： | 1 |
| 10 | Fabrication of the beam splitters for soft X-ray laser application显示文摘The soft X-ray interferometry is completed by the Mach-Zehnder interferometer using a soft X-ray laser, and it is also an important method to measure the electron densities of a laser-produced plasma near the critical surface. It is apparently demonstrated in this paper that the incident angle of each optical element in the soft X-ray Mach- Zehnder interferometer should be near normal incidence based on the polarized characteristics of the soft X-ray mul-tilayers, and the product of reflectivity and transmission of the beam splitter should be taken as a standard of design according to the structure of the soft X-ray Mach-Zehnder interferometer. The beam splitters used in the soft X-ray interferometry at 13.9 nm are fabricated using the ion beam sputtering. The figure error of the beam splitter has reached the nanometer magnitude, in which the product of reflectiv-ity and transmission of the beam splitter is more than 1.6%. | WANG Zhanshan WU Yonggang TANG Weixing QIN Shuji CHEN Lingyan XU Xiangdong HONG Yilin FU Shaojun ZHU Jie CUI Mingqi | 2003 | Chinese Science Bulletin2003，48，18： | 1 |
| 11 | Heat shock transcription factor 1 attenuates TNFα-induced cardiomyocyte death through suppression of NFκB pathway显示文摘 | Lianpin Wu Chaohui Hu Mingyuan Huang Minghua Jiang Lingyan Lu Jifei Tang | 2013 | Gene2013，，1： | 1 |
| 12 | Progress in quantitative research on the relationship between atmospheric oxidation and air quality显示文摘Atmospheric oxidizing capacity(AOC)is an essential driving force of troposphere chemistry and self-cleaning,but the definition of AOC and its quantitative representation remain uncertain.Driven by national demand for air pollution control in recent years,Chinese scholars have carried out studies on theories of atmospheric chemistry and have made considerable progress in AOC research.This paper will give a brief review of these developments.First,AOC indexes were established that represent apparent atmospheric oxidizing ability(AOIe)and potential atmospheric oxidizing ability(AOIp)based on aspects of macrothermodynamics and microdynamics,respectively.A closed study refined the quantitative contributions of heterogeneous chemistry to AOC in Beijing,and these AOC methods were further applied in Beijing-Tianjin-Hebei and key areas across the country.In addition,the detection of ground or vertical profiles for atmospheric OH·,HO_(2)·,NO_(3)·radicals and reservoir molecules can now be obtained with domestic instruments in diverse environments.Moreover,laboratory smoke chamber simulations revealed heterogeneous processes involving reactions of O_(3)and NO_(2),which are typical oxidants in the surface/interface atmosphere,and the evolutionary and budgetary implications of atmospheric oxidants reacting under multispecies,multiphase and multi-interface conditions were obtained.Finally,based on the GRAPES-CUACE adjoint model improved by Chinese scholars,simulations of key substances affecting atmospheric oxidation and secondary organic and inorganic aerosol formation have been optimized.Normalized numerical simulations of AOIe and AOIp were performed,and regional coordination of AOC was adjusted.An optimized plan for controlling O_(3)and PM2.5was analyzed by scenario simulation. | Yuesi Wang Xin Jin Zirui Liu Gehui Wang Guiqian Tang Keding Lu Bo Hu Shanshan Wang Guohui Li Xinqin An Chao Wang Qihou Hu Lingyan He Fenfen Zhang Yuanhang Zhang | 2023 | Journal of Environmental Sciences2023，，1： | 1 |
| 13 | A Maximum-Principle-Preserving Third Order Finite Volume SWENO Scheme on Unstructured Triangular Meshes显示文摘We modify the construction of the third order finite volume WENO scheme on triangular meshes and present a simplified WENO(SWENO)scheme.The novelty of the SWENO scheme is the less complexity and lower computational cost when deciding the smoothest stencil through a simple mechanism.The LU decomposition with iterative refinement is adopted to implement ill-conditioned interpolation matrices and improves the stability of the SWENOscheme efficiently.Besides,a scaling technique is used to circument the growth of condition numbers as mesh refined.However,weak oscillations still appear when the SWENO scheme deals with complex low density equations.In order to guarantee the maximum-principle-preserving(MPP)property,we apply a scaling limiter to the reconstruction polynomial without the loss of accuracy.A novel procedure is designed to prove this property theoretically.Finally,numerical examples for one-and two-dimensional problems are presented to verify the good performance,maximum principle preserving,essentially non-oscillation and high resolution of the proposed scheme. | Yunrui Guo Lingyan Tang Hong Zhang Songhe Song | 2018 | Advances in Applied Mathematics and Mechanics2018，10，1： | 1 |
| 14 | 树种菌根类型通过细根生物量和凋落物动态影响土壤呼吸和土壤碳储存显示文摘热带森林是高生产力但同时也是脆弱的生态系统之一。一些全球范围的造林项目计划未来十年在热带地区种植数百万棵树。树种菌根类型影响森林土壤碳储存已成为共识,但在热带地区,树种菌根类型如何影响土壤呼吸(Rs)和碳储存,目前仍知之甚少。为研究树种菌根类型对Rs和土壤碳储存的影响,本实验在一个近30年热带同质园的3种丛枝菌根(AM)树种和3种外生菌根(EM)树种的单种林中,测量了其Rs和表层20 cm的碳含量,以及有关的生物因子(如根生物量、凋落物动态、土壤微生物)和非生物因子(如微气候)。研究结果表明,AM单种林的Rs、土壤碳含量,以及凋落物周转速率和细根生物量显著高于EM单种林。分析表明,与其他生物和非生物因子比较,树种菌根类型对Rs和土壤碳含量的影响最大。进一步分析表明,菌根类型是通过细根生物量和凋落物动态(凋落物产量、凋落物现存量、凋落物周转速率)直接和间接影响Rs和土壤碳含量。本研究结果强调了树种菌根类型对森林碳循环的影响,表明在热带地区种植AM树种可能比种植EM树种更能促进土壤固碳。 | Guodong Zhang Guiyao Zhou Xuhui Zhou Lingyan Zhou Junjiong Shao Ruiqiang Liu Jing Gao Yanghui He Zhenggang Du Jianwei Tang Manuel Delgado-Baquerizo | 2023 | Journal of Plant Ecology2023，16，1： | 0 |
| 15 | An improved third-order HWCNS for compressible flow simulation on curvilinear grids显示文摘Due to the very high requirements on the quality of computational grids,stability property and computational efficiency,the application of high-order schemes to complex flow simulation is greatly constrained.In order to solve these problems,the third-order hybrid cell-edge and cell-node weighted compact nonlinear scheme(HWCNS3)is improved by introducing a new nonlinear weighting mechanism.The new scheme uses only the central stencil to reconstruct the cell boundary value,which makes the convergence of the scheme more stable.The application of the scheme to Euler equations on curvilinear grids is also discussed.Numerical results show that the new HWCNS3 achieves the expected order in smooth regions,captures discontinuities sharply without obvious oscillation,has higher resolution than the original one and preserves freestream and vortex on curvilinear grids. | Mingyang Cheng Lingyan Tang Yu Liu Huajun Zhu | 2021 | Advances in Aerodynamics2021，3，1： | 0 |
| 16 | Research on mineral processing of low quality kalium-natrium feldspar显示文摘In light of characteristic of low quality feldspar ores in Wanzai County,Jiangxi Province,steel ball was taken as grinding medium,and selective grinding could make impurity separate from feldspar effectively. Through the flow of flotation-desliming-high gradient magnetic separation,the feldspar Concentration 1 was obtained with the yield of 70.19 %,containing Fe2O3 0.17 % and TiO2 0.07 %. The feldspar Concentrate 1 could meet the quality requirement of high-grade construction ceramic. And the slime that was deslimed in the flow was also separated and recovered; the feldspar Concentration 2 was obtained with the yield of 13.18 %,containing Fe2O3 0.31 % and TiO2 0.17 %. The feldspar Concentrate 2 can be used for raw material of low-end ceramic. And gangue,with the yield of 16.63 %,was thrown away in this flow,the separating efficiency was high. Employing this flow could also bring high economy benefit and low influence of pollution to environment. | Zhang Lingyan Bu Junfen Lai Weiqiang Tang Huawei Zheng Guangjun | 2008 | Engineering Sciences2008，6，4： | 0 |
| 17 | A Well-Balanced Weighted Compact Nonlinear Scheme for Pre-Balanced Shallow Water Equations显示文摘It is well known that developing well-balanced schemes for the balance laws is useful for reducing numerical errors.In this paper,a well-balanced weighted compact nonlinear scheme(WCNS)is proposed for shallow water equations in prebalanced forms.The scheme is proved to be well-balanced provided that the source term is treated appropriately as the advection term.Some numerical examples in oneand two-dimensions are also presented to demonstrate the well-balanced property,high order accuracy and good shock capturing capability of the proposed scheme. | Mingyang Cheng Lingyan Tang Yaming Chen Songhe Song | 2022 | Advances in Applied Mathematics and Mechanics2022，14，5： | 0 |
| 18 | U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen显示文摘 | Rui Duan Yun Lu Lingyan Hou Lina Du Lequn Sun Xingfan Tang | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 0 |
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